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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 201 Documents
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PHYSICAL STABILITY TEST HAIR TONIC COMBINATION Cinnamon (Cinnamomum burmanii) ESSENTIAL OIL AND VCO (VIRGIN COCONUT OIL) WITH CYCLING TEST METHOD AND IRRITATION TEST ON THE RABBIT Junvidya Heroweti; Danang Novianto Wibowo; Arini Najikhatal Ulya; Desmita Linda
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7903

Abstract

Cinnamon (Cinnamomum burmanii) and VCO (Virgin Coconut Oil) essential oils contain cinnamaldehyde and lauric acid which have potential for hair growth, they can affect the physical stability of hair tonic preparations. This study aims to determine the physical stability and determine the effect of the irritation effect on hair tonic preparations of a combination of cinnamon essential oil and VCO. Cinnamon essential oil hair tonic preparations were made with a concentration of 1% (F1), 3% (F2), and 5% (F3) and then tested for physical characteristics including organoleptic tests, homogeneity, pH, density test, and viscosity. Evaluation of physical stability was carried out using the cycling test method. Data were statistically analyzed using One Way Anova. The results of the irritation test were analyzed descriptively using the primary irritation index obtained from the appearance of erythema and edema on the rabbit's skin. Observation of the physical stability test on organoleptic and homogeneity showed that formula I had a cloudy white color, a characteristic cinnamon aroma, a slightly thick liquid, and was homogeneous; formula 2 and 3 has a clear color, characteristic of cinnamon aroma, slightly viscous and homogeneous liquid; stable pH in formula 2; stable density in formulas 1, 2 and 3; and stable viscosity in formulas 2 and 3. The results of the hair tonic irritation test showed that the primary irritation index for F1, F2, and F3 was 0.0; 0.3; 0.3 and it can be concluded that F2 and F3 can irritate with very mild categories.
ROOT CAUSE ANALYSIS (RCA) OF E-CATALOGUE PROCUREMENT OF MEDICINE USING E-PURCHASING IN PUBLIC HEALTH CENTER IN KLATEN REGENCY OF CENTRAL JAVA Liana Roh Widiyani; Enade Perdana Istyastono; Nunung Priyatni
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7970

Abstract

E-catalogue procurement of medicine is a method of electronic procurement using a particular website developed by the Government to increase the effectiveness, efficiency, and transparency of medicine procurement. In Klaten Regency, e-catalogue procurement of medicine in the Public Health Center (PHC) experiences obstacles. The study aimed to evaluate performance of e-catalogue procurement of medicine, analyze the root problem and formulate strategies to improve the performance based on the root problems. This descriptive study involved seven PHCs with data on medicine procurement in 2021. Quantitative data analysis was conducted by evaluating six performance indicators of medicine procurement. Qualitative data analysis was conducted by interviewing 17 respondents, analyzing root problems, and formulating improvement strategies The study showed that all PHCs had good medicine availability at 87.71% average, but low realization of e-catalogue procurement occurred in two PHCs. Lead time beyond the contract period occurred in two PHCs. All PHCs experienced low suitability of procurement funds and percentage of procurement through e-catalogue. Percentage of budget allocation for medicine procurement varied between 1.59% to 7.29%. Analysis of the root problem showed obstacles in human resources, mechanism of procurement, policies, system, budget, and environment aspect. It was concluded that the obstacles rooted on the lack of team role and synergy of PHC, District Pharmacy Unit, and District Health Office according to their authority, the lack of pharmaceutical industry and distributor commitments in the provision of e-catalogue medicine for PHC, and also the urgent needs of system and regulatory improvement by the Government.
NARINGIN'S POTENTIAL AS A HEPATITIS B VIRUS REPLICATION INHIBITOR: AN IN-SILICO STUDY OF SECONDARY METABOLITE COMPOUND Muhammad Khalil; Muh. Nur Akbar; Ardiyas Robi Saputra; Subhan Hadi Kusuma
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8564

Abstract

Naringin is a secondary metabolite compound of the flavonoid group which is generally found in plants that are consumed and traditionally used as medicine. The aim of this study was to examine the potential of naringin as a candidate for hepatitis B virus replication inhibitor using an in-silico approach. This research uses exploratory descriptive method with molecular docking analysis was carried out using the blind docking technique. The 3D structures of naringin and reference ligands were collected from the PubChem database, and the 3D structures of target proteins were collected from the PDB database. The target protein used is the hepatitis B virus capsid protein with PDB ID: 5GMZ. Docking analysis was performed using AutoDock Vina which is integrated into PyRx. Docking results were visualized using the PyMol software and Biovia Discovery Studio 2019. The results of the analysis showed that the binding affinity of all simulation models between naringin and the HBV capsid protein ranged from -7.1 to -7.9 kcal/mol. The binding site formed between naringin and the receptor corresponds to the reference ligand, involving the same 12 amino acid residues, namely PHE 23, PRO 25, LEU 30, THR 33, TRP 102, ILE 105, SER 106, PHE 110, TYR 118, ILE 139, LEU 140, and SER 141. Based on these results, it can be concluded that the naringin compound has the same bioactivity as the reference ligand in inhibiting viral replication, so that naringin has the potential as a candidate for hepatitis B virus replication inhibitor
USE OF ANTICOAGULANT IN COVID-19 PATIENTS AT PKU MUHAMMADIYAH GAMPING HOSPITAL YOGYAKARTA Nurhasani -; Woro Supadmi; Endang Yuniarti
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7038

Abstract

Based on WHO data, there is about 14% average of patients who suffer from a severe level of Covid-19 disease and 5% of patients admitted to the ICU (Intensive Care Unit) are known to have symptoms of thromboembolism and coagulopathy disorders. The current management of Covid-19 therapy requires heparin. This research aims to find out the accuracy of the heparin regimen, to determine the improvement of the patient's clinical condition, the side effects of heparin based on clinical response, to analyze the relationship between the accuracy of the therapeutic regimen and the improvement of the patient's clinical condition, and also to know the incidence of side effects after heparin use. The type of this research was descriptive-analytic with a cohort design with retrospective data collection. The data were collected by taking medical records at PKU Muhammadiyah Gamping Hospital Yogyakarta. Moreover, the data were collected including heparin therapy regimens with subjective condition and patient objective during the therapy. The data obtained were analyzed by using univariate analysis technique and bivariate analysis technique. The results showed there were 61 patients who fulfilled the inclusion criteria. The evaluation of the accuracy the heparin therapy regimen obtained 95.08% correct results and 4.92% incorrect results. The analysis result of the accuracy the therapeutic regimen showed a significant relationship with clinical improvement with parameters APTT number (p=0.006; RR=0.155; CI = 0.085-0.283). Whereas, there was not found a significant relationship between the accuracy of the therapeutic regimen with the incidence of side effects (p>0.05).
FORMULATION AND TESTING OF ANTI DANDRUFF HAIR TONIC LEAF EXTRACT OF GEDONG MANGO (Mangifera indica L.var.Gedong) AGAINST MUSHROOMS Pityrosporum ovale Yayan Rizikiyan; Lela Sulastri; Yuniarti Falya; Rima Yulia Senja; Hudzaifah Famera Fosanda; Atiqoh Nurul Hakim
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.7911

Abstract

Gedong mango plant (Mangifera indica L.var.Gedong) is a plant that has potential as herbal medicine, especially in its leaves because it contains many secondary metabolites such as flavonoids, saponins, gallic tannins, catecat tannins, quinones and steroids or triterpenoids which can be used as antioxidants, antimicrobial and dandruff. This study aims to gedong mango leaf extract concentrations of 5%, 7%, and 10% in hair tonic preparations and to test the antidandruff activity. Gedong mango leaf simplicia (Mangifera indica L.var.Gedong) was extracted using the Microwave Assisted Extraction (MAE) method with Natural Deep Eutectic Solvents (NADES) sodium acetate dan lactic acid solvents with a molar ratlactic1:3. Hair tonic preparations are made in three formulas with the active ingredient of mango gedong leaf extract at a concentration of 5%, 7%, and 10%. Evaluation of hair tonic pr, separation air tonic preparation evaluation includes organ anoleptic, homogeneity, pH, and viscosity and eststy test of hair tonic anti-dandruffas carriedtestt by the healthy method against the fungus Pityrosporhealthyvale. Hair tonic of mango gedong leaf extract with concentrations of 5%, 7%, and 10% on organoleptic observations, homogeneity, pH, and viscosity met the requirements. The hair tonic has the potential as an antidandruff because it has antidandruff activity against the fungus Pityrosporum ovale and is classified as moderate to strong.
OPTIMIZATION AND PHYSICAL STABILITY OF KEMBANG BULAN (Tithonia diversifolia [A.Gray] EXTRACT CREAM FORMULA Diah Nur Kurnianingrum; Abdul Karim Zulkarnain
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8404

Abstract

Based on recent studies, the ethanolic extract of Kembang Bulan leaves (Tithonia diversifolia[A.Gray]) has an anti-keloid effect. This study aims to determine the optimum formula for cream preparations with paraffinum liquidum, cetyl alcohol, and stearyl alcohol. Inappropriate comparison of additional ingredients results in the physical properties of the preparation becoming unstable during storage. The optimum formula was obtained from the optimization using Simplex Lattice Design (SLD) by software Design Expert version 10.0. The parameters measured were viscosity, pH, spreadability, adhesive ability, and accelerated study (centrifugation). The optimum cream formula consists of 19.11% b / b; Cetyl alcohol with a level of 2.01% b / b; stearyl alcohol with a level of 1.49% b / b with a viscosity of 134.35 dPa.s, a spread of 5.78 cm, pH 6.243, and adhesive ability of 13.61 seconds. The cream base produced is milky white, has a viscosity of 143.99 dPa.s, a spread of 5.7 cm, pH 6.305, and adhesion to 14.57 seconds. There is a significant difference in viscosity and pH of the experimental and software prediction. However, there is no significant difference in adhesive ability and spreadability response. The cream base and ethanolic extract of Kembang Bulan leaves have a significant difference in physical stability except for its spreadability. During the 4 weeks of storage, both of the creams are relatively stable. The cream is stable after centrifugation.
MODELING OF MICE AS TEST ANIMALS FOR A PRECLINICAL STUDY OF HYPOLIPIDEMIC AGENTS Setiyo Budi Santoso; Widarika Santi Hapsari; Renny Setyowati
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8463

Abstract

Animal models suitable for preclinical research are necessary for the discovery of hypolipidemic agents. Various publications have presented alternative dyslipidemia animal models, but identifying a feasible and stable method would serve as a solid reference for researchers. This investigation aimed to establish a sustained dyslipidemia induction that persists after several days of intervention with a hypolipidemic agent. Six groups of mice, each consisting of five primary test animals and one reserve test animal, were used. After a seven-day acclimatization period, we induced each group for 14 days using three different methods: (1) 5% body weight of quail egg yolks (5% QEY), (2) 10% body weight of used cooking oil (10% UCOs), and (3) a combination of 5% QEY and 10% UCOs. Once all mice reached their peak lipid levels, we evaluated lipid performance through a seven-day intervention with simvastatin (0.026 mg/20-gram body weight) in one of the paired groups. A 14-day combined induction of 5% QEY and 10% UCOs resulted in a 39% elevation in mouse lipids compared to baseline levels. Our findings offer an alternative to traditional dyslipidemia models. However, the development of an animal model for dyslipidemia still poses challenges. Therefore, the identification of novel biomarkers capable of targeting dyslipidemia in humans is crucial.
PHYSICAL CHARACTERIZATION AND SUNSCREEN ACTIVITY OF NUTMEG OIL NANOEMULSION WITH ISOPROPYL MYRISTATE VARIATIONS Siti Setianingsih; Rizky Adityo Saputro; Vironica Rizky Fauziah; Wahyu Setyo Wibowo; Ayu Shabrina
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8481

Abstract

The nutmeg seed oil contains myristicin which can absorb UV rays. Nanoemulsion with isopropyl myristate can be used to increase the activity of sunscreen. This study aimed to determine the physical characteristics and effectivity of nutmeg oil (NMO) nanoemulsion with isopropyl myristate as an enhancer. The nanoemulsion was made with 6.4% NMO and variations of isopropyl myristate 1% (FI), 3% (FII), and 5% (FIII). The nanoemulsions were evaluated for physical characteristics such as appearance, pH, viscosity, transmittance percentage, particle size, and polydispersity index (PI). The in vitro SPF value was tested using a spectrophotometer, and sunscreen effectivity was determined by the Minimum Erythemal Dose (MED) value. Data obtained were analyzed using one-way ANOVA. This study showed that the colour of the NMO nanoemulsion was light yellow and clear, with a transmittance percentage of 97.5-97.9%. The pH FI, FII, and FIII results were 6.79±0.03, 6.84±0.04, and 7.02±0.03. The viscosity was 1.63 ± 0.81 to 1.82 ± 0.85 d.Pas with Newtonian rheology. The particle size was 14.3 ± 1.41 nm to 16.0 ± 2.13 nm, with PI less than 0.5. SPF value were 16.34 ± 5.50 (FI); 16.70 ± 5.20 (FII) and 17.80 ± 3.20 (FIII). MED values were 220.5 ± 6.34 (FI), 225.4 ±5.41 (FII), and 240.2 ±3.45 (FIII) minutes. The MED value showed that FIII was significantly different from FI and FII. Isopropyl myristate at 5% in nanoemulsion increases the effectivity of sunscreen.
THE RELATIONSHIP BETWEEN THE LEVEL OF KNOWLEDGE AND PERCEPTION OF THE USE OF TRADITIONAL MEDICINE IN THE PEOPLE OF KLATEN CITY IN 2022 Tista Ayu Fortuna; Arifah Sri Wahyuni; Nadya Tiara Putri
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8647

Abstract

The use of traditional medicine in today's society is increasing with labels "back to nature" which is realized through the utilization of Indonesia's natural potential. Based on an incidental survey study in Klaten City, the affecting factor the use of traditional medicine in this region is knowledge and perception. Public knowledge related to the utilization of traditional medicine is assumed to be lacking because of the assumption that traditional medicine is much safer than chemical drugs. There is an assumption based on the side effects of traditional medicine being lower than chemical drugs. This study aims to assess the contribution of perception and knowledge to the use of traditional medicine. The research uses a cross-sectional study and the data collection instruments through questionnaires. The sampling technique used was purposive sampling with a total of 1089 respondents. Data collection used a questionnaire instrument whose results were analyzed using the Chi-Square statistical test. From these results can be concluded that types of knowledge involve definitions, type, efficacy, side effects, how to use, perceptions, convenience, currentness, and policy that can affect the use of traditional medicine. The results of data analysis show that the contribution of knowledge and perception to the use of traditional medicine has a coefficient of determination of 0.742
COST-EFFECTIVENESS ANALYSIS OF CEFTRIAXONE AND CEFIXIME IN TYPHOID FEVER PATIENTS HOSPITALIZED AT BERKAH PANDEGLANG REGIONAL HOSPITAL FOR THE PERIOD 2020-2021 Yusransyah Yusransyah; Yuni Rahmawati; Baha Udin; Nia Marlina Kurnia
Jurnal Farmasi Sains dan Praktis Vol 9 No 2 (May-August 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i2.8648

Abstract

Typhoid fever is an infectious disease among humans caused by the bacterium Salmonella typhi. With the high Multi-Drug Resistance (MDR) of Salmonella typhi, selecting the right antibiotic is a factor that must be considered in addition to cost constraints. Therefore, cost-effectiveness is needed. This study aims to determine the cost-effectiveness of typhoid fever patients using ceftriaxone and cefixime antibiotics. The data used are retrospective, and the sampling was done by purposive sampling. This study was conducted at Berkah Pandeglang Regional Hospital. Sample in this study, namely typhoid fever patients of the period 2020-2021, who meet the inclusion and exclusion criteria. In this study, 16 samples were obtained. The results of this study showed that the total average direct medical costs for the ceftriaxone group were IDR 78.632.500 In contrast, the cefixime group was IDR 75.527.300. The ACER value of typhoid fever patients who used Ceftriaxone + cefixime was IDR 91,646.27, Ceftriaxone was IDR 77,463.89, and cefixime was IDR 88,027.15. The patients with typhoid fever who used Ceftriaxone were more cost-effective than those who used Cefixime

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