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Journal of Global Pharma Technology
Published by Universitas Udayana
ISSN : 09758542     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
ournal of Global Pharma Technology is a monthly, open access, Peer review journal of Pharmacy published by JGPT Journal publishes peer-reviewed original research papers, case reports and systematic reviews. The journal allows free access to its contents, which is likely to attract more readers and citations to articles published in JGPT. JGPT publishes original research work that contributes significantly to the scientific knowledge in pharmacy and pharmaceutical sciences- Pharmaceutics, Novel Drug Delivery, Pharmaceutical Technology, Cosmeticology, Biopharmaceutics and Pharmacokinetics, Pharmacognosy, Natural Product Research, Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis, Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Biotechnology and Applied Computer Technology. For this purpose we would like to ask you to contribute your excellent papers in pharmaceutical sciences.
Arjuna Subject : Kedokteran - Onkologi
Articles 2,396 Documents
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Application of Edible Coating by Carboxymethyl Cellulose, Chitosan, Konjac Glucomannan and Their Synergistic Effect on Storage of Mango (Mangifera Indica) Nguyen Phuoc Minh
Journal of Global Pharma Technology Volume 10 Issue 05: (2018) May2018
Publisher : Journal of Global Pharma Technology

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Abstract

Mango (Mangifera indica) is a tropical fruit that has economic importance in Central Highland of Vietnam. It has good nutritional values such as vitamins, carotenoids, polyphenols, fibers and antioxidants. Mango fruit is very perishable and considerable postharvest quality defect is occurred due to ripening and senescence. Major obstacles of mango during preservation and shipping are weight loss, ripening, and formation of brown spots resulting in decreasing of its value. Mango is very susceptible to chilling injury. The use of the edible coating materials for prolonging shelf-life of mango is essential. The present study aimed to identify the effect of carboxymethyl cellulose (CMC), chitosan, CMC + glucomannan, chitosan + glucomannan as edible coating in storage of mango fruits. Results demonstrated that 0.5% chitosan: 0.25% konjac glucomannan as edible coating could be used to coating mango fruit and maintaining its shelf life to 15 days.Keywords: Mango, CMC, Chitosan, Glucomannan, Coating, shelf-life.
Primitive Neuroectodermal Tumor (PNET) at the Level of Thoracic Spine: A Case Report Magetsari Rahadyan
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Introduction Primitive neuroectodermal tumors (PNET) are malignant tumors thought to arise from the neural ectoderm and comprise of undifferentiated small round cells that affect soft tissue and bone. These tumors occur primarily in children and adolescents (thirteen to sixteen years old), with a tendency to recur quickly and metastasize especially to lungs, bone marrow, brain and lymph nodes. PNET are uncommon malignancies that are increasingly reported in the literature and located in the spine are extremely rare. In this study we present a case of 14 years old girl with PNET of the thoracic spine which recur after initial resection. Case Report a 14 years old girl presented with low back pain and progressive weakness of both of lower limbs of three months duration. On physical examination, motor and sensory function was lost, motoric strength in the lower limbs was grade 1/5 with hypoesthesia below L1 level. Magnetic resonance imaging (MRI) of the spine showed burst pathologic fracture of the 12th thoracic spine with suspicious malignant lesion in the 12th thoracic spine. Initially the condition was treated with laminectomy, decompression, stabilization and open biopsy. Histopathology and immunohistochemistry of the lesion revealed the diagnosis of PNET. During the early postoperative course, she had instance neurological recovery and was able to walk unassisted. But, 1 month later the neurologic deficit recurred and she was treated with extended laminectomy with tumor debulking. Then the patient received chemotherapy and planned for radiotherapy. Conclusion Primitive neuroectodermal tumors (PNET) are extremely rare and are aggressive with poor outcomes. Good modalities play a significant role in the identification of the feasibility of surgical excision of the tumors, detection of distant metastasis, and evaluation of the efficacy of therapeutic interventions.Keywords:  Primitive neuroectodermal tumor (PNET), Malignant Tumor, Rare Tumor, Spinal Tumor.
The Spectrophotometric Determination of Thiamine Hydrochloride Drug by Coupling with Diazotized Procainamide Khansaa I . Abass
Journal of Global Pharma Technology Volume 12 Issue 01
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Abstract

For the determination of thiamine hydrochloride (THC) in both pure and formulated  forms, a simple, sensitive and accurate spectrophotometric method was described. The technique is based on diazotization of the primary amine group of Procainamide with sodium nitrite and hydrochloric acid followed by combining with thiamine hydrochloride to create Light red azo dye showing peak absorption at (502) nm. Beer's law has followed the concentration range (2.5-40) μg.mL‾¹,with (0.1490) μg.mL‾¹ detection limit. The molar absorptivity and Sand ellʾs sensitivity were detected to be respectively (7285.0320) L.mol‾¹.cm‾¹and (0.0463) μg.cm‾². The method for determining in thiamine hydrochloride pharmaceutical preparation has been applied successfully.Keywords: Thiamine hydrochloride, Spectrophotometric determination, Procainamide, Diazotization and coupling.
Vitronectin, Integrin Vitronectin Receptor Other Biochemical Markers to Assess the Development of Liver Cirrhosis Huda Jaber Waheed
Journal of Global Pharma Technology Volume 09 Issue 08
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Abstract

Aim of study: To evaluate some fibrosis markers such as vitronectin, serum vitronectin receptor (VNR) and the amino terminal propeptide of type III procollagen (P-III-P) in the sera of liver cirrhosis patients and to monitor the behavior of these markers in disease progression. Material and Methods: About (60) volunteer participated in current study; 30 patients and 30 patients. The patients were divided according to severity of the disease by Child-Pugh Score to three classes: (10) patients class A, (10) class B patients and (10) class C. Procollagen III peptide, serum vitronectin and vitronectin receptor were measured in serum by ELISA. Results: A Significant increases were found in serum vitronectin, receptor and sP-III-P in all patients' sub-groups when compared to control. VNR seems to detect early liver cirrhosis and distinguish between patients (A and B classes) and advanced disease with cirrhosis. Conclusion: According to our data, the area under curve of serum VNR is greater than vitronectin and Sp-III-P so it can be act as a marker of liver cirrhosis and also could be used to monitor the severity of disease.  
Synthesis, Characterization of Di-1, 3-Oxazepine and Evaluation of their Antimicrobial Activity against Molecular Diagnostic Bacterial Isolates Nadia A. Salih
Journal of Global Pharma Technology .
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Abstract

This work presents Two Schiff bases derived from 4, 4'-Diaminodiphenylmethane, distinguished by the para substituted halogen of benzaldehyde. These Schiff bases used to synthesis of four compounds of di-1, 3-oxazepine by direct condensation with tetrachloro phthalic anhydride and tetrabromophtalic anhydride. All structures were characterized by using spectroscopic techniques such as FT- IR, 1H-NMR, 13C-NMR. The synthesized compounds were screened as an anti-bacterial agent against bacterial strains (Gram positive S. aureus and Gram-negative P. aeruginosa and K. pneumonia) which were diagnosed using high specific method “genetic method for S. aureus and P. aeruginosa and Vitec 2 for K. pneumonia.Keywords: Schiff bases, 1, 3-Oxazepine, Tetrachlorophthalic anhydride, Antibacterial activity.
Hospitalized Adults with Acute Bacterial Meningitis: Etiology and Antimicrobial Susceptibility Profiles Zainab Khamees Abbas
Journal of Global Pharma Technology Volume 11 Issue 05.
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Abstract

Eeffective management of acute bacterial meningitis depending on the diagnosis of bacteria that cause disease, as well as, identification of the effective antibiotic or antibiotics against most of these causative agents, the objective of this study was to detect the causative agents of acute bacterial meningitis isolated from C.S.F of inpatients adults. Since June 2017 and July 2018; 135 C.S.F. specimens were collected, 53 (39.26 %) were positive for C.S.F culture, and 71 specimens were negative. Of 53 acute meningitis patients, there were 66% male and 34% female, predominant causative agents was S. pneumoniae (20.8%), followed by N. meningitides (18.9%) and K. pneumoniae (15.1%). Antimicrobial susceptibility profiles differ depending on the causative agents, the results shows a high sensitivity to Amikacin, Vancomycin, Gentamicin, and  Ciprofloxacin, S. pneumoniae were high sensitive to Vancomycin, Gentamicin, Chloramphenicol, as well as, Ciprofloxacin, While H. influenzae  and N. meningitides exhibited considerable susceptibility to Chloramphenicol.Key words: Meningitis; C.S.F; Antibiotics.
Male Infertility: An Epidemiological and Clinical Profile at the Andrology Unit of Dr. Soetomo Hospital, Surabaya, Indonesia Antonius Wahyudi
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
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Abstract

Objective: To discover and to lay out epidemiological features and clinical characteristics of patients with infertility problems who seek treatment at the Andrology Unit of Dr. Soetomo Hospital. Methods: A cross sectional study was conducted to men with infertility who sought treatment in the Andrology Unit of Dr. Soetomo Hospital ranging from January to December 2017. Only patients who lived together with their spouses were included as research subjects. Results: The average age of the patients was 33.76 years (age ranged from 25 to 46 years) and the average age of their spouses was 30.4 years (age ranged from 19 to 42 years). The average duration of infertility is 4.25 years (between 1 year and 13 years). Average age of puberty was 14.5 years old. First consultations were late with average of 4.46 years. From overall infertile patients, 90% of them were categorized as primary infertility. History of smoking was found in 84 people (68.29%), history of wearing tight pants 27 people (21.95%). In terms of Body Mass Index(BMI), we found that underweighted patients comprise 7% (9 patients) from total liable subjects, while 55 people (55%) were in the area of ideal body mass, 46 people were overweight (35%), whereas obesity was found in 13 subjects (10%). The results of semen analysis showed that the most case were asthenoteratozoospermia 34 people (27.6%). A careful history, physical examination and semen analysis can determine the cause of male infertility. The cause of male infertility in Surabaya, Indonesia is very complex, which involves older age, delayed consultation and background as risk factors that cause abnormalities in semen analysis. Keywords: Male infertility, epidemiology, andrology, Dr. Soetomo Hospital, Surabaya, Indonesia.
Synthesis and Characterization of Mixed Ligand Complexes Contain Curcumin, Schiff Base and Azide (N3‾) with Some Metal ions and Evaluation their Antibacterial Activity Sagid M. Lateef
Journal of Global Pharma Technology .
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Abstract

The research included the synthesis and characterization of new Schiff Base (L3) by reaction 2-aminopyridine and isatin , also included synthesis and characterization of mixed Ligand  complexes using curcumin (essential "HL1", Schiff base (secondary Ligand "L3"), and Azide ion (N3‾) ( secondary Ligand)  with some metal ions and evaluation of antibacterial activity in general formula:  [M(L1)(L3)(N3)H2O]  where : M = [Co(II) , Ni(II) , Cu(II)]  M (L1) (L3) (N3)]       where:  M= [Mn (II), Zn (II), Cd (II), Hg (II)]  With M: L1: L3, 1:1:1 Mole ratio using ethanol as a solvent. The complexes were characterized by using physical methods and spectroscopic (FT -IR, UV-Vis, mass)  along with C.H.N. ,the chloride content and designate the percentage of the metal in addition to measurements of  molar conductivity From the above data we suggested an octahedral geometry for all complexes. Antibacterial activity of ligands and  their complexes was estimated for four types of   bacterial Staphylococcus aureu, Bacillus subtilis, Eterobactern, Escherichia Coli, the results of antibacterial activity showed that their compounds prepared effective against bacteria.Keywords: Curcumin, Schiff base, Mixed ligands complexes.
Mother’s Knowledge and Attitude about Breast Feeding Influence Her Empowerment to Decision for a Successfully Breast Feeding Homa Mosaffa Khomami
Journal of Global Pharma Technology Volume 08 Issue 03
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Abstract

Background: The World Health Organization (WHO) and the American Academy of Pediatrics (AAP) recommend breastfeeding as the appropriate method of infant feeding. Empowering women to breastfeed gives women the ability to act and the right to do so. Empowerment of women, similar to freedom of choice breastfeeding, could be the one of goals of a positive quality of life. The present paper has been carried out to investigate knowledge and attitude of mothers refer to Lahijan Urban Health center during one year after delivery about breast feeding benefits. Materials and methods: This research was a descriptive cross-sectional study which had been done with quantitative and qualitative method in between 2013-2014. Data collection method was direct interview and questionnaire. 120 mothers were selected by Stratified Random sampling method. For data collection and data analysis use descriptive and analytical statistics. Then frequency tables achievement and for data analysis use correlation, analysis variance, X2 and T-test. Results: According to present study, most of the samples were in the range of 21-30 years old (57.5%) and most of them received information about breastfeeding(87.5%), resource of information was a collection of different resource(62.7%), Actually , half of samples had low knowledge(50.8%) and middle attitude (57.5%)about breastfeeding benefits. Pearson correlation showed a direct and positive relationship between knowledge and attitude of case studied (p< 0.0001, R= 0.35).Analysis variant Test showed a significant difference between mothers graduate and their knowledge (p< 0.0001). Discussion: study results showed the most of mothers had low and middle knowledge about breastfeeding benefit and then they need to education. Keywords: Breast Feeding, Empowerment, Knowledge, Attitude.
Effect of Different Solvent on Total Phenolic, Total Flavonoid, and Sun Protection Factor of Belimbing Wuluh (Averrhoa Bilimbi linn.) Fruits Fraction Ryan Radix Rahardhian
Journal of Global Pharma Technology Volume 11 Issue 01.
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Abstract

Ultraviolet (UV) radiation is related with a variety of damaging effects. Averrhoa bilimbi Linn (AB) known as Belimbing Wuluh in Indonesia, it contains phenolic compounds such as flavonoids, where the compound has the potential as a sunscreen. Objective: the study was to determine the Total Phenolic Content (TPC), Total Flavonoid Content (TFC) and investigate Sun Protection Factor (SPF) activity from different solvent for fractionation of AB among N Hexane (NH), Ethyl Acetate (EA), and Water. Methods: TPC, TFC, and Sun SPF were investigated using in vitro assay with spectrophotometric UV-Vis coupled chemometric using principal component analysis (PCA). In this study, TPC was determined using Folin-Ciocalteu reagent, the outcomes were expressed in (mg of gallic acid equivalent (GAE)/g sample), TFC content was determined by colorimetric using AlCl3 methods, the results were expressed in (mg of rutin equivalent (RE)/g sample), and SPF using Dutra calculation. Result:  EA showed the highest SPF (15, 38±1, 3).The similar fraction having the highest TPC (56, 87±1, 5212) mg (RE)/g of EA) and the highest TFC (24, 99±3, 2895) mg (GAE)/g of EA). When principal component analysis (PCA) was applied, high correlation among TFC and SPF activities was found. Conclusion: Hence, AB potential as sun screens.Keywords: Averrhoa bilimbi, Total Flavonoid Content, Total Phenolic Content, Sun Protection Factor, Chemometric.

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