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Nusantara Scientific Medical Research Journal

nsmrj
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Published by Nusantara Scientific Medical

ISSN : - EISSN : 29853508 DOI : https://doi.org/10.58549/nsmrj.v2i01.35

Core Subject : Health,

Dentistry Health Professions Medicine & Pharmacology Nursing Veterinary

Nusantara Scientific Medical Research Journal (E-ISSN: 2985-3508) is a journal that publishes Focus & Scope research articles, which include: Dentistry Nursery Midwifery Pharmacy Medical Science Biology Chemistry Nutraseutical Functional Food This journal is published by the Nusantara Scientific Medical, which is published April, August and December.

Arjuna Subject : Kedokteran - Farmakologi (Medis)

Articles 17 Documents

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Comparison of Examination Results of Acid-Fast Bacilli (AFB) Ziehl Neelsen (ZN) Method on BTA Preparations that are Directly Stained with Delayed Preparations Asni Hasanuddin; Rony Setianto; Belinda Arbitya Dewi
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Tuberculosis is a direct infectious disease caused by the bacterium Mycobacterium tuberculosis. Most tuberculosis germs attack the lungs, which is known as Pulmonary Tuberculosis (pulmonary TB), but can also affect other organs, which is called extrapulmonary TB. Pulmonary TB germs in the form of rods, have special properties, namely acid resistance to staining. The purpose of this study was to determine the results of examination of acid fast bacilli (AFB) by the Ziehl Neelsen method on smear preparations which were immediately stained and left to stand for three days. The research was conducted using a descriptive approach with a sample of 10 people using a purposive sampling technique. In this study, staining was carried out twice, namely direct staining and delayed staining for 3 days and examined under a microscope. The results showed that there was no difference between the preparedness that was immediately colored and the one that was postponed for three days.

Antibacterial Activity Ethanolic Extract of Ocimum basilicum L. Leaves in Inhibiting the Growth of Escherichia coli and Pseudomonas aeruginosa Muhammad Fauzan Lubis; Hafid Syahputra; Ririn Astyka
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Infectious disease is the biggest problem in the world. The problem with this infection is related to antibiotic resistance if its use is not consistent. Utilization of kemangi leaves, which are always used as fresh vegetables, has potential as an antibacterial in inhibiting the growth of Escherichia coli and Pseudomonas aeruginosa bacteria. This study aims to analyze the inhibition of an ethanol extract of kemangi leaves against Escherichia coli and Pseudomonas aeruginosa. The Kirby-Bauer method with the disc diffusion method was used to determine the minimum inhibitory diameter and to calculate the activity index value. The test results at a concentration of 500 mg/mL showed activity in the strong category, namely 13.70 ± 0.10 mm (Escherichia coli) and 12.93 ± 0.06 mm (Pseudomonas aeruginosa), and the minimum inhibitory concentration was at a concentration of 3.125 mg/mL. Conclusion the ethanol extract of kemangi leaves shows antibacterial activity.

Formulation of Hand Sanitizer Gel from Chitosan Shell of Fresh Water Lobster (Cherax Quadricarinatus) Irvan Andreansyah; Ridwanto Ridwanto
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Certain aberrant disorders impair the operation of a portion or the entire body. Infectious diseases can be spread by touching a person's hands or after contact with inanimate objects contaminated with bacteria, which can cause a variety of ailments, including diarrhoea. Using hand sanitizer as the primary deterrent is one of the methods to avoid this transmission. This time, the primary element is a natural substance, such as chitosan. Chitosan can be extracted from the shells of freshwater crayfish and utilized as an antibacterial agent in hand sanitizer formulations. This project intends to produce chitosan from crab shells. Crustacean chitosan can be utilized as an active ingredient in hand sanitizer gel. The production of chitosan begins with the demineralization, deproteination, and deacetylation processes. The resulting chitosan was then used to make hand sanitizer gels with 1, 2, and 3% concentrations. Organoleptic, homogeneity, pH, dispersion, and viscosity tests were then conducted on the gel preparation. The results revealed that the hand sanitizer preparations subjected to organoleptic tests on F1, F2, and F3 did not exhibit any changes in odor, shape, or color; the homogeneity test revealed the absence of coarse grains; the pH obtained on average was within the skin pH range; and the spreadability test revealed that the average was in the range of 5-7 cm, indicating that the formula satisfies the specifications.

Relationship Between Hemoglobin Levels (Hb) and Nutritional Status with Academic Achievements of STIK KESOSI TLM Students in 2022 Nofri Eka Yuliandi; Apriani Apriani; Laili Safitri; Aris Cristian Manulang
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Students who excellence academically are always associated with good health status. One indicator of health status that is commonly used is hemoglobin (Hb) and nutritional status. Hb levels can be an indicator of anemia and nutritional status can be a measure of a person's brain development ability. The purpose of this study was to determine the relationship between hemoglobin (Hb) levels and nutritional status with the academic achievement of TLM STIK KESOSI students in 2022. The research design was cross-sectional, and sampling was carried out in October - November 2022. Sampling using a non-random technique, with a total sample of as many as 36 students. Data collection was carried out by measuring Hb levels, body weight, and height. The data obtained were analyzed by univariate and bivariate. The results showed that 47.2% of students were in the category of normal nutritional status, and 91.7% were not anemia. The relationship between Hb levels and student nutritional status on student academic achievement showed no significant relationship (P> 0.05). In conclusion, normal or not Hb levels and nutritional status did not affect student learning achievement. However, efforts are still needed to maintain the stability of Hb levels and nutritional status in students. So that the impact is not only to increase academic achievement but also to maintain the quality of long-term health.

Organeleptic Test for Fortified Packaging Milk by Utilizing Calcium from Egg Shell Waste Chandra Halim; Muhammad Fadli; Dicki Darmawan; Dwinta Nurul Fadillah Bintang; Farhan Rahmadani
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

In terms of national needs, the necessity for eggs reached 4,742,240 tons employing massive impact on the production of egg shell waste. Nevertheless, packaging milk released in the market contains low calcium and unsatisfies the nutritional needs of adult calcium, namely 1000 mg/day. Therefore, it is necessary to add waste of calcium-rich egg shells so the nutritional needs of calcium can be fulfilled and reduces the egg shell waste at the same time. The research method used is combination of experimental methods, interviews, and literature study. The data is analyzed by using descriptive statistics and non-parametric statistical tests to draw conclusions. Based on the data obtained, the best variation is the milk control with a total value of 580 points, 33 points different from 2:1 variation. The giving of egg shell waste reduces the milk aroma which is preferable for people who dislike its aroma. Through non-parametric statistical tests, it was investigated that there was no significant difference in adding egg shell flour to make fortified milk except for egg shell control. Therefore, egg shell flour can be used as additional material to enrich the calcium, to reduce the milk aroma and the amount of organic waste in Indonesia.

Effectiveness of Resam Fern Leaves Extract (Gleichenia linearis) as Bioinsecticide on Mortality of Black Ant (Dolichoderus thoracicus) Chandra Halim; Wahdana Apriyani; Reh Desiva Christima Br Ginting; Dita Ariyani; Amirul Mirdas
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Insecticides are type of pesticide used to eradicate or control pests. Generally, there are two types of insecticides, namely natural and synthetic insecticides. Natural insecticides are scarce due to their inability to eradicate pests such as black ants. Meanwhile, the use of synthetic insecticides is very practical and fast but can cause pollution that is harmful to humans, animals and other living things. Thus, natural insecticides are needed that can eradicate black ants effectively and efficiently and do not pollute the environment or poison other organisms. The research method used is combination of experimental methods, observation, and literature studies. In determining the best insecticide variation for mortality, a black ant mortality rate was measured using timer for 50 black ants. After the data was obtained, it was analyzed descriptively to determine the value of the mortality rate for each experimental sample. Based on the data obtained, the best variation of natural insecticides was the control variation of fern leaf extract with 3.646 seconds per ant. This is because fern leaf extract in insecticides contains tannin compounds which have several benefits as active pesticide ingredients. Thus, fern insecticides are effective in exterminating black ants.

Analysis of Examination Results of Erythrocyte Index in Pulmonary TB Patients Labuang Baji General Hospital, Makassar City Asni Hasanuddin; Rony Setianto; Belinda Arbitya Dewi
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

The high rate of transmission of tuberculosis (TB) in Makassar City is very concerning. Data from the Makassar Health Office (Dinkes) in 2019 there were 5,412 TB cases. The data then decreased during the pandemic to 3,260 cases in 2020. And 3,911 cases in 2021 with a recovery rate of 83% in 2019 and 85% in 2020. The purpose of this study was to determine the value of the erythrocyte index in patients with pulmonary tuberculosis at the Hospital of Labuang Baji, Makassar City. The type of research used is laboratory observation with descriptive method. The population in this study were all patients with pulmonary tuberculosis as many as 11 people with pulmonary tuberculosis. The results obtained are known for the MCV value, 8 tuberculosis patients have a normal MCV value, 2 patients have a low MCV value and one has a high MCV value, for the MCH value, 6 tuberculosis patients have a normal MCH value, 4 patients have a high MCH value. low and one patient had a high MCH value, for the MCHC value 4 people with tuberculosis had a normal MCHC value and 7 patients had a low MCHC value.

Inhibition of Apoptosis of Liver Cells of Mice Infected With Plasmodium berghei Through The Expression of Caspase-3 Using Sargassum duplicatum Extract Abdul M Ukratalo
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

The process of apoptosis is an integrated process between external and internal factors involving several enzymes (Caspase-9, -8, -7, -6, -3) that act as major players in the process of apoptosis. This research aims to determine the potential of brown algae methanol extract Sargassum duplicatum against inhibition of apoptosis of liver cells of mice infected with Plasmodium berghei through the expression of caspase-3. Mice weighing 20–30 grams in Plasmodium berghei infection as much as 0.1 ml per head and left until the percent of parasitemia reaches 1-5%. Then mice (Mus musculus) were given methanol extract of Sargassum duplicatum seaweed at a dose of 1 gr / 100 ml, 10 gr / 100 ml, 100, gr / 100 ml, and 200 gr / 100 ml for 4 consecutive days and observed until day 6. After that, a histological preparation was made with immunohistochemistry staining to see the expression of caspase-3. The results of the observations will be analyzed descriptively. The results showed that Sargassum duplicatum methanol extract was able to inhibit liver cell apoptosis in mice infected with Plasmodium berghei. The decrease in Caspase-3 expression in this study is thought to be caused because the brown algae Sargassum duplicatum contains flavonoid compounds, tannins, and saponins which can reduce the pro-inflammatory cytokine caspase-3 through the role of NF-kB which is a transcription factor that plays a role in stimulating and coordinating innate and adaptive immune responses.

Improved Quality of Spermatozoa Mice (Mus musculus) Model of Diabetes Mellitus Type 1 After Being Given Cinnamon Bark Methanol Extract (Cinnamomum burmanii Bl.) Abdul M Ukratalo; Titus Frendi Wedilen; Ian Risaldy Tofure; Dodikrisno Ekaputra Manery; Muhammad Reza Ramadhany
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Diabetes mellitus has to do with male fertility, a hormone disorder that affects spermatogenesis. This study aims to determine the effect of cinnamon bark methanol extract (Cinnamomum burmani) on the quality of diabetes mellitus mice spermatozoa. This study used a complete randomized design with 4 treatments and 3 repeats. 22 mice were divided into 4 groups. Mice have injected with streptozotocin dose of 0.1 mL and observed blood sugar levels were, if sugar levels increased, they are given cinnamon bark methanol extract at a dose of 250 mg/kg BB and 500 mg/kg BB, and blood sugar levels are measured. After that, the mice are dissected for observation of spermatozoa's morphology, viability, and motility after administration of the extract. The results showed that cinnamon bark methanol extract at a dose of 250 mg/kg BB and 500 mg/kg BB can reduce the number of abnormal spermatozoa and increase the viability and motility of diabetes mellitus mice spermatozoa. This indicates that cinnamon bark extract as an antioxidant has a positive effect in maintaining structure and development, as well as the function of spermatogenesis cells so that in the presence of these active substances, the number of seed cells that experience developmental failure, degeneration, death due to free radicals can be suppressed or reduced.

Evaluation of the Antihyperuricemia Activity of Bajakah Tampala Stem Ethanol Extract (Spatholobus littoralis Hassk.) in Male White Mice (Mus musculus) Nurul Hidayah; Gabena Indrayani Dalimunthe
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 1 No. 1 (2022): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Hyperuricemia is elevated blood uric acid. Blood uric acid can harm health. Allopurinol can lower uric acid, but it has harmful side effects. The community has treated various diseases with Bajakah stems. This study examined Bajakah Tampala stem ethanol extract secondary metabolites and antihyperuricemia activity. This research identified the bajakah tampala stem plant (Spatholobus littoralis Hassk.), manufactured simplicia, characterized simplicia, phytochemically screened, prepared the ethanol extract, and tested its antihyperuricemia activity against male white mice (Mus musculus). The simplicia and Bajakah tampala stem ethanol extract contained flavonoids, tannins, steroids/triterpenoids, alkaloids, and saponins. At 400 mg/kgBB (3.88 mg/dl), the bajakah tampala stem ethanol extract reduces uric acid at the 6th hour, similar to allopurinol at 10 mg/kgBB (3.46 mg/dl).

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Nasri

Contact Email nusantarascientific.journal@gmail.com

Phone +6285943109283

Journal Mail Official nusantarascientific.journal@gmail.com

Editorial Address Jalan Jamin Ginting No. 55 Mangga, Kec. Medan Tuntungan, Kota Medan, Sumatera Utara 20142

Location Kota medan, Sumatera utara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Nasri

Contact Email
nusantarascientific.journal@gmail.com

Phone
+6285943109283

Journal Mail Official
nusantarascientific.journal@gmail.com

Editorial Address
Jalan Jamin Ginting No. 55 Mangga, Kec. Medan Tuntungan, Kota Medan, Sumatera Utara 20142

Location
Kota medan,

Sumatera utara

INDONESIA