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Giftania Wardani Sudjarwo
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INDONESIA
Journal of Pharmacy Science and Technology
Published by Universitas Hang Tuah
ISSN : -     EISSN : 26140993     DOI : https://doi.org/10.30649/pst
Core Subject : Health,
Medicine & Pharmacology
The Journal of Pharmaceutical Science and Technology is a journal for scientific publications on all pharmaceutical aspects including pharmaceutical science (pharmaceutical technology, pharmaceutical chemistry, pharmaceutical biology, pharmacognosy, microbiology and pharmaceutical biotechnology), community pharmacy, clinical pharmacy until explore the potential of marine biota. This journal is published twice a year to provide a means for pharmacists and other health professionals to share research results to improve the science of pharmaceuticals. The Journal of Pharmaceutical Science and Technology is intended to present the best quality research articles in pharmaceutical science, community pharmacy and clinical pharmacy to become scientific guides in fields related to science and pharmaceutical technology. This journal is a peer-reviewed journal and publishes original research articles on all aspects of science and pharmaceutical technology. This journal accepts original articles as well as for other categories such as review articles and case reports for all aspects of pharmaceutical science, pharmacy clinics and community pharmacy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 38 Documents
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ANALISIS KEPARAHAN INTERAKSI OBAT-OBAT POTENSIAL DI APOTEK DAERAH PESISIR PANTAI SURABAYA Ana Khusnul Faizah; Hardyono Hardyono; Yuli Ainun Najih
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.23

Abstract

Potential drug-drug interactions (pDDIs) is one the drug related problems when two or more drugs given at the same time. DDIs are often predictable and avoidable. One of pharmacist roles is to assess prescription includes indication, dose, duplication therapy, adverse drug reaction, contraindication and DDIs, to identify, prevent and resolve DRPs. The objective of this study is to evaluate potential drug-drug interactions (pDDIs) in patients in east coast pharmacy in Surabaya. This study was performed by cross sectional of retrospective prescription in east coast pharmacy in Surabaya during March until May 2016. There were 780 prescriptions. Prevalence of pDDIs were 20,5%.Moderate pDDIs dominated 70% followed by minor (21%), major (8%) and contraindication (1%). The mechanisms of pDDIs is 82% by pharmacokinetic and 12% by pharmacodynamic. A Pharmacist should participate to identify and prevent harmful DDIs.
PEMBENTUKAN KOKRISTAL KETOKONAZOL-ASAM SUKSINAT YANG DIBUAT DENGAN METODE PENGGILINGAN (GRINDING) Yuli Ainun Najih; Dwi Setyawan; Achmad Radjaram
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.30

Abstract

The Co-crsytal formation ketoconazole (KTZ) - succinic acid (SA) has been performed by molar ratio (1:1) using milling method (grinding).. Milling is done using Planetary Ball mill PM 200 MA-type tool, Retsch with 75 rpm milling speed. The physical mixture of KTZ and AS molar ratio (1:1) was prepared in the absence of a dry grinding solution with milling time of 5, 15, 30, 45 and 60 min at a constant velocity. The milling results are seen by using powder X-ray diffraction (PXRD) at an angle (2θ = 7.8o). From the results of X-ray powder diffraction there is an increase in the percentage of crystalline (% w/w). The result of the grinding time curve with the percentage of crystal (%w/w), the result that the percentage of crystalline (% w/w) increases linearly with increasing milling time (min) based on the maximum intensity data of each milling time by the line equation (y = 0.690x + 51.09) and correlation coefficient r = 0.9905. As conclusion, based on kinetic formation of cocristal with milling method obtained for slope value = 0,690 % cocrystall (%b/b)/min.
EFFECT OF GLUTATHIONE ON MDA (MALONDYALDEHIDE) PLASMA AND SOD (SUPEROXYDE DYSMUTASE) ERYTHROCYTE ON WHITE RAT ( RATTUS NORVEGICUS ) INDUCED BY PARACETAMOL Liza Yudistira Yusan; Karma Budiman; Choesnan Effendi
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.33

Abstract

Glutathione has a role to neutralize free radicals and reactive oxygen compounds, as well as to maintain exogenous antioxidants. Indicators to show the side effect of paracetamol is elevation of transaminase enzymes in plasma. The increase of free radicals is indicated by an increase in MDA (Malondyaldehide) and a decrease in SOD (Superoxyde Dysmutase). The aim of the study is to know the effects of external gluthathion on MDA and SOD levels in rats induced by Paracetamol (PCT). This study used four groups for each treatment : the first group (only given food standards); The second group (fed standard plus PCT); The third group (fed standard plus PCT and GSH dose of 600 mg / kg); The fourth group (fed standard plus PCT and GSH dose of 1200 mg / kg). GSH reduced significantly MDA plasma level (p=0,004), but in SOD level there is no differences among these groups. In our conclusion, GSH can be used alternatively to minimize the toxic effects of Paracetamol
ANALYSIS OF CALCIUM (Ca) CONTENT IN GUPPY FISH (Poecilia reticulata) AT KALIRUNGKUT WITH ICPS Yellen Audina Wijaya; Kusuma Hendrajaya
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.48

Abstract

The aim of this study was to observe the calcium level in guppy fish from the ditch in Kalirungkut Village, Surabaya that potentially to be used as the source of raw material of animal feed in the form of fish flour. The destruction method used a wet destruction by using HNO3 and HCl. To analize qualtitatively and quantitatively of calcium used an ICPS instrument. By qualitative analysis, the peak was shown at wavelength 393,366 nm, proving the existence of calcium in a fish sample. And by quantitative analysis, guppy fish contains calcium with an average level of 4.28%. This indicates that guppy fish potentially to be used as a source of raw material for animal feed which is seen from the calcium levels having requirement of 2.5-5% calcium content
STUDI KEPATUHAN PASIEN DIABETES MELLITUS RAWAT JALAN di RSUD KABUPATEN SIDOARJO Efer Memento Yotlely Romera; Angelica Kresnamurti; Dyah Ayu Febiyanti
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

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Abstract

Diabetes mellitus is a metabolic disease that has symptoms due to elevated blood glucose levels above normal values and requires regular treatment. Patient adherence is very important to reduce the risk of complications in diabetes mellitus patient. This research aims to determine correlation the patient adherence in taking antidiabetic drugs with two different methods, Pill count and MMAS-8 method. This research used cross-sectional with non-probability sampling methods. There were 21 outpatients in Sidoarjo Hospital included in this research. Based on the result by pill count, obtained 14 respondents adherent (66.67%) and non-adherent respondents was 7 (33.33%), while the result of MMAS-8 method was 8 respondents (38.10%) with high adherence, 10 respondents (47.62%) with moderate adherence and 3 respondents (14.29%) with low adherence. Comparison between pill count and MMAS-8 was carried out using the SPSS statistical program, and 50% result had expected count value less than 5, so did not qualify for chi-square (χ2). Therefore, the Fisher exact test was done as the alternative way by viewing the exact-sig value in the column Fisher exact-test and obtained the value of 0.247 with a significance value of 0.05. So it shows there is no correlation between the measurements result of adherence with the method MMAS-8 and pill count.
UJI DAYA ADSORPSI ARANG AKTIF DARI TUMBUHAN MANGROVE Avicennia marina Rina Andayani; Mahmiah
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

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Abstract

Indonesia has the largest mangrove forest in the world. In addition, Indonesia is also a country with the largest number of mangrove species in the world. This creates a huge potential in the utilization of mangroves in many areas of life, one of them is in the health field. Where, the majority of the plants widely used in the health sector are land plants. Charcoal has been used in the field of health for thousands years. Charcoal generally utilized in the field of health in the form of activated charcoal. Activated charcoal or activated carbon is charcoal that has been through an activation process, chemical or physical. Activated charcoal can be made from any substance containing carbon. Given that wood is a renewable raw material, the use of wood as a material manufacture of activated charcoal is recommended. In this study, the material to be used in the manufacture of activated charcoal was wood from the mangrove plant Avicennia marina. The activation process used in this study was chemical activation using ZnCl2. This study included three stages: (1) carbonization; (2) activation of charcoal; (3) adsorption test of activated charcoal. The results showed that the higher the ratio of ZnCl2 mass / charcoal mass used in the activation process, the higher the adsorption capacity of activated charcoal produced. The highest % removal of CH3COOH was obtained at a ratio of ZnCl2 mass/charcoal mass of 2 which was 30.73%.
EFEK EKSTRAK ETANOL DAUN GEDI MERAH (Abelmoschus manihot L.) TERHADAP GAMBARAN HISTOLOGI GINJAL TIKUS PUTIH JANTAN (Rattus norvegicus) MODEL UROLITHIASIS Irma Santi; Rahmawati Rahmawati; Lili Tari
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

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Abstract

Urolithiasis or kidney stones is a disease caused by urine sediment in the urinary tract. It can be observed histologically by investigating the presence of crystals and tissue damage such as degeneration hydropis, hemorrhage, and necrosis. The aim of this reseach is to prove the effect of ethanol extract of red gedi leaves (Abelmoschus manihot L) on histological of white rat kidney (Rattus norvegicus) urolithiasis model. This reseach used 15 rat devided into 5 groups. Group 1 was the normal group; group 2 was induced by ethylene glycol 0,75% and ammonium chloride 1 %; group 3,4 and 5 were a test group induced by ammonium chloride 1 %; group 3,4 and 5 were a test ammonium chloride 0.75 % and 1 % and ethanol extract of red gedi leaves with succesive doses of 10 mg/kgBW, 20 mg/kgBW, 40 mg/kgBW. The data were analyzed statistically using Kruskal wallis test and Mann-Whitney’s advanced test. The result showed that the group of red gedi leaf extract with doses 40 mg/kgBW statically has the best effect as antiurolithiasis on the white rats. As conclusion, extract of red gedi leaves can be used to urolithiasis.
DOCUMENTATION OF TRADITIONAL DRUG AND MEDICINE PLANTS USED COMMUNITY IN TALANG SELUAI VILLAGE SUB DISTRICT ULU OGAN DISTRICT OGAN KOMERING ULU, SOUTH SUMATERA PROVINCE Ria Mariani; Atun Qowiyyah; Mimim Rojena
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.47

Abstract

Plant utilization is an option for medication including plant utilization that carried out by the community of Talang Seluai village. This research hasbeen done in Talang Seluai Village, ulu ogan district, ogan komering ulu area, South Sumatra province, to list medical plant and medical traditional recipes. This research was conducted in october to december 2016.This research was done by descriptive research using a qualitative methodology. The qualitative research was conducted by interview semi structural based on a list of questions. The result showed that the plants of which used medicinally by the village community of Talang seluai, there were 26 species in 18 families, one plant was not detectable, Yakhian, belongs to Leguminosae. Lamiaceae is the most used plant of all. Leaves was the most used and garden was the most collected among them and boiled in the water was the most drug processing used. At Talang Seluai, there were six traditional drug herbs, consist of two internal drugs (diarrhea and rheumatic medicines) and four external drugs (rheumatic, inflammation, wound and skin disorders).
EFEKTIFITAS NEPHROPROTEKTOR EKSTRAK RUMPUT LAUT MERAH (Eucheuma cottonii) PADA MENCIT YANG DIINDUKSI DENGAN LOGAM BERAT TIMBAL Giftania Wardani Sudjarwo; Nuraini Farida
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.35

Abstract

This study aimed to determine the effect of the red seaweed extracts on levels of SGOT and SGPT serum mice exposed to lead per oral. The sample used were 50 male divided into 5 groups: negative control (mice were given daily with CMC /carboxy methyl cellulose 0.5 %) ; positive control (mice were given daily with CMC 0.5 % and lead 20 mg/kg BW orally once in a day for 10 days); and the treatment group ( mice were given the red seaweed extracts 200 mg; 400 mg; 800 mg/kg BW orally once daily for 28 days and lead 20 mg/kg BW on 7 th day, one hour after red seaweed extracts administration during 21 days. On day 14 measured levels of MDA, SGOT and SGPT. Data were analyzed by one-way ANOVA, followed by LSD test. The results showed that oral administration of lead acetate 20 mg/kg BW for 21 days resulted in a significant increase in SGOT, SGPT and MDA level. Treatment with red seaweed extracts 800 mg/kg BW significantly (P< 0.05) decreased the elevated SGPT, SGOT and MDA levels, compared to positive control. It can be concluded that the red seaweed extracts have a nephrotoprotective activity against lead acetat induced hepatotoxicity in mice
STANDARISASI SIMPLISIA DAUN TEMPUYUNG (SONCHI FOLIUM) HASIL BUDIDAYA di UBAYA TRAINING CENTER TRAWAS MOJOKERTO Nikmatul Ikhrom Eka Jayani; Helena Oktaviani Handojo
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.59

Abstract

The objective of this research was to determine the specific, non specific parameter and total flavonoid content of dried Sonchi Folium, which are cultivated from the UTC (Ubaya Training Center), Trawas, Mojokerto. Crude material herbal Sonchi Folium was successfully prepared by collecting, wet sorting, washing, cutting and dry sorting. Dried Sonchi Folium were treated as chooped, crude drug powder. Specific and non specific parameter of Sonchi Folium standardization based on (MMI) Materia Medica Indonesia. Specific parameters test including macroscopic and microscopic properties of Sonchi Folium meet a criteria of MMI. The total flavonoid in ethanolic extract with AlCl3 methods was 1,38% QE (Quercetin equivalent). Non-specific parameters test resulted in the loss on drying 11,23% (standart <10%), total ash content 19,42% (standart <17%), acid insoluble ash content 0,58% (standart <0.25%), water soluble content 20,04% (standart >17.1%) and ethanol soluble content 6,44% (standart > 7.5%), only water soluble content meet a standart criteria.

Page 1 of 4 | Total Record : 38

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