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Jurnal Farmasi Klinik - Best Practice (JFKlin)
Published by Rumah Sakit Umum Pusat Fatmawati
ISSN : 3032467X     EISSN : 29647584     DOI : 10.58815
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Klinik - Base Practice (JFKlin) is a peer-reviewed journal published by RSUP Fatmawati. It focus on the field of health sciences with the specialty of pharmaceutical sciences, pharmaceutical services in hospitals and community. JFKlin has been published twice a year in Indonesian and started from 2022 JFKlin will be fully published in Open Journal System (OJS).
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Farmakologi
Articles 12 Documents
 1   2 
Evaluasi Penggunaan Antibiotik Pada Pasien Sepsis dengan COVID-19 di Rumah Sakit Umum Pusat Fatmawati Jakarta Periode Januari – Desember 2021 Linda Triana Yudhorini
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.13

Abstract

Latar Belakang : Sepsis masih menjadi masalah kesehatan dunia dengan angka kematian yang cukup tinggi berkisar 20 – 50%. Corona Virus Disease 2019 (COVID-19) merupakan suatu penyakit yang menyerang sistem pernapasan dan dapat ditularkan oleh individu yang terinfeksi melalui droplet yang dikeluarkan saat batuk, bersin, berbicara atau bernapas (WHO, 2020). Penggunaan terapi antibiotik yang rasional dengan segera dapat menurunkan angka kematian. Sebaliknya, penggunaan terapi antibiotik tidak rasional akan meningkatkan terjadinya resistensi yang berdampak pada tingginya morbiditas, mortalitas dan biaya kesehatan. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik dengan metode gyssens pada pasien sepsis. Metode penelitian : penelitian ini merupakan penelitian observasional dengan metode deskriptif analitik yang dilakukan di RSUP Fatmawati Jakarta. Subyek penelitian adalah 40 pasien covid yang menderita sepsis pada periode Januari hingga Desember 2021 yang memenuhi kriteria inklusi yaitu pasien usia > 18 tahun dan mendapatkan terapi antibiotik. Hasil Penelitian :Pasien sepsis umumnya berusia ≤ 65 tahun (82,5%), berjenis kelamin perempuan (47,5%), sepsis (35%), syok sepsis (65%), sumber infeksi sepsis, pneumonia komunitas (82,5%), komorbid (100%), jenis komorbid, covid 19 (100%), ARDS (42,5%), Diabetes Melitus (40%), lama rawat ≤ 14 hari (69%), menggunakan JKN/BPJS 100%, pulang/membaik (7,5%). Berdasarkan distribusi penggunaan antibiotik, sebagian besar (95,1%) pasien menggunakan antibiotik empiris, dilakukan uji kultur mikroorganisme (42,5%), bakteri gram negatif terbanyak adalah acinetobacter baumanii (25%), bakteri gram positif tidak ditemukan. Antibiotik tunggal digunakan pada 19,5% pasien dengan presentase terbanyak adalah levofloksasin (14,55%). Sedangkan 80,5% pasien menggunakan antibiotik kombinasi dengan presentase terbanyak adalah kombinasi levofloksasin dan meropenem (24,4%). Berdasarkan evaluasi antibiotik menggunakan metode gyssens diperoleh hasil 69% pasien menggunakan antibiotik yang rasional dan 31% pasien menggunakan antibiotik yang tidak rasional dan tersebar dalam kategori VI (0%), V(0%), IV a (1,1%), IV b (1,1%), IV c (0%), III a (14,9%), III b (2,3%), II a (6,9%), II b (4,6%), IIc (0%), dan I (0%). Kesimpulan: Penggunaan antiobiotik yang rasional sebanyak 69% dan penggunaan antibiotik yang tidak rasional sebanyak 31%. Indikator mutu PPRA (Program Pengendalian Resistensi Antimikroba) tercapai yaitu kategori 5 sebanyak 0% (≤ 5%)
Evaluation Of The Use Of Cyclophosphamide In Children Diagnosed With Steroid Resistant Nephrotic Syndrome Treated In The 3rd Floor Treatment At Fatmawati Hospital Satriani Sinukaban; Bobby Setiadi Darmawan
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.14

Abstract

A total of 32 children with nephrotic syndrome were treated with cyclophosphamide, the remissions and side effects that often occurred during therapy were counted. This research was conducted using a retrospective descriptive method. The results showed that the remission was 59.4%. The mean duration of the call to remission was 14 weeks and the mean dose of cyclophosphamide was 589 mg. As many as 59.4% of patients experienced no side effects, while 40.6% experienced side effects. Side effects that occurred included vomiting (3.1%); nausea (3.1%); hair loss (6.3%); nausea and vomiting (12.5%); vomiting and hair loss (6.3%); nausea and hair loss (6.3%); and nausea, vomiting, and hair loss (3.1%). Keywords: Steroid-Resistant Nephrotic Syndrome, Cyclophosphamide
PENGGUNAAN SITOSTATIKA PADA PASIEN KANKER DEWASA DI RUANG KEMOTERAPI RSUP FATMAWATI PERIODE BULAN JANUARI SAMPAI JUNI TAHUN 2020 apt. Dra. Magdalena Niken Oktovina, M.Si magdalena
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.15

Abstract

Chemotherapy is one of the treatment modalities for systemic cancer which is often chosen, especially to treat advanced, local and metastatic cancers. The administration of cytostatics is carried out in a special room to avoid exposure to cytostatics and for the safety of patients and officers giving cytostatics. The administration of cytostatics is adjusted to the diagnosis of cancer. Therefore, the researcher wanted to know how the use of cytostatics in cancer patients in the Chemotherapy room of Fatmawati Hospital, especially in adult patients. This study aims to determine the characteristics of adult cancer patients who undergo chemotherapy in the chemotherapy room, and the use of cytostatics based on drug class and type, and how the characteristics of adult patients relate to the use of cytostatics. The research method was carried out by taking data from adult patients diagnosed with cancer and administering chemotherapy from January to June 2020 in the chemotherapy room by paying attention to inclusion and exclusion criteria. The results showed 1272 adult patients who administered chemotherapy and 3785 cytostatic preparations from January to June 2020. From the evaluation, it was found that the most cancer patient characteristics based on gender were 78.22% women with an age range of ≥40 - 60 years of 60.14 % and the most disease diagnoses were breast cancer at 50.63%. The use of cytostatics based on group is antimetabolite with pyrimidine analogues (Fuorouracil (5-FU) and Gemcitabine) and folic acid analogues (Methotrexate) with a value of 28.22%. The highest use of cytostatic types was Fluorouracil (5-FU), which was 19.47%. The relationship between patient characteristics and use of cytostatics is in gender, age and indication of drug use (disease diagnosis). The results of this study are very useful considering the scarcity of literature due to the limited implementation units that carry out the provision of sitostatics such as Fatmawati General Hospital. Therefore, it can be suggested for further research related to the relationship between drug use and cancer diagnosis in the context of drug availability and cost analysis, as well as evaluation of the side effects that occur when administering cytostatics through documented interviews with patients. Keyword : Chemotherapy, Sitostatics, Cancer, Fatmawati General Hospital.
Drug Related Problem pada Pasien Spinal Cord Injury di Bagian Rehabilitasi Medik Rumah Sakit Umum Pusat Fatmawati Jakarta Periode Januari - Juli 2019 Linda Triana Yudhorini
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.16

Abstract

The excellent service paradigm for patients (patient oriented) for Clinical Pharmacists in Hospitals is a responsibility to improve the quality of patient drug therapy, including preventing drug-related problems (DRP). Research Methods: The method used in this study is a descriptive analytical method and data has taken with retrospective study. Drug therapy assessment especially the drug related problem has found in large rounds (visites) of Spinal Cord Injury patients in the Medical Rehabilitation Section of Fatmawati Hospital, Jakarta. Large rounds / visites are carried out by a clinical team consisting of Doctors, Clinical Pharmacist, Nurses, Psychologists, Nutritionists, Physiotherapists, Occupational Therapists, Orthhetic Prosthetics and Social Medical Officers. Research Results: After 28 rounds / visits were carried out from January to July 2019 with a total of 267 patients, it was found that 82% of patients had drug related problems. The types of DRP that occur regarding drug interactions are 73%, treatment time is 24%, and side effects are 3%. Conclusion: The drug related problems (DRP) that were found in the round / visit activities from January to July 2019 were 82% and those that were not found by DRP were 18%. Keywords: Drug Related Problems, Spinal Cord Injury, Visits, Large Round
Evaluasi Terapi Obat pada Pasien Sepsis Neonatal Di Ruang Perinatologi RSUP Fatmawati Januari– Februari Tahun 2016 Setianti Haryani; Yusna Fadlyyah Apriyanti
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.17

Abstract

Sepsis neonatal merupakan sindroma klinis dari penyakit sistemik akibat infeksi selama satu bulan pertama kehidupan. Bakteri, virus, jamur dan protozoa dapat menyebabkan sepsis bayi baru lahir. Pemberian antibiotika yang sesuai merupakan salah satu kriteria dalam tata laksana sepsis. Kesulitan mendapatkan hasil kultur berupa jenis bakteri dan uji kepekaan antibiotika dengan segera menyebabkan masalah pada pemilihan jenis, waktu dan lama pemberian antibiotika, sehingga pemberian antibiotika hanya berdasarkan empiris yang berpotensi menimbulkan resistensi dikemudian hari. Kajian ini bertujuan untuk mengevaluasi terapi obat pada pasien sepsis neonatal di ruang perina. Kajian dilakukan dengan cara observasi dan pencatatan langsung dari rekam medik pasien serta hasil wawancara. Sebanyak 42 sampel dilakukan pemantauan terapi obat. Karakteristik dominan bayi yang mengalami sepsis di ruang perina adalah 61,9% bayi laki-laki, terdapat 59,5% persalinan non spontan, dengan umur kehamilan 64,3% prematur, BBLR 69,1% dan 81% sepsis awitan dini. Hasil laboratorium sangat signifikan ditunjukkan oleh bayi yang mengalami sepsis neonatal di ruang perina adalah trombositopenia (76,2%), leukositosis (66,7%), peningkatan C-Reactive Protein (CRP) (54,7%), leukositopenia (7,1%), dan immature (IT Ratio) ≥0,2 (4,7%). Kuman/Bakteri yang muncul pada hasil kultur kebanyakan bakteri gram negatif yaitu Enterobacter aerogenes (5), Klebsiella sp (3), Acinotebacter baumanii (2), Bukholderia cepacia (2), Serratia sp (1) dan bakteri gram positif yaitu Staphylococcus epidermidis (2). Penggunaan antibiotika terbanyak pada pasien sepsis neonatal di ruang Perina adalah antibiotik kombinasi Amoksisillin dan Gentamisin sebagai pengobatan lini pertama yaitu sebanyak 38 pasien, diikuti tahap lini kedua penggunaan kombinasi Cefotaksim dan Mikasin (25 pasien) atau Fosfomycin Na (1 pasien), dan lini ketiga penggunaan Ceftazidim (14 pasien) atau Meropenem (12 pasien). Kata kunci : sepsis neonatal, antibiotika, BBLR, CRP
Evaluasi Penggunaan Obat Kemoterapi Pada Pasien Kanker Payudara Di RSUP Fatmawati Periode Februari 2021 Setianti Haryani
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.19

Abstract

Breast cancer is a malignancy that originates from glandular cells, glandular ducts and breast supporting tissues excluding breast skin (PerMenKes, 2018). Treatment of breast cancer can use chemotherapy drugs alone or a combination of several chemotherapy drugs. Chemotherapy drugs are given in stages, generally for 6-8 cycles so that the curative effect is achieved and the side effects received by the patient can be reduced. This study aims to evaluate the use of chemotherapy drugs in breast cancer patients at Fatmawati General Hospital for the period of February 2021. This research is a non-experimental type of research with a retrospective evaluative descriptive design from patient medical records and analyzed descriptively quantitatively. This research method used a descriptive design with retrospective observational data collection, namely by collecting medical record data from breast cancer patients, this study used purposive sampling and obtained 34 patients who met the inclusion criteria. The study showed that the most age of breast cancer patients who underwent chemotherapy at Fatmawati General Hospital in February 2021 were patients with an age range of 36-45 years, with 18 patients (52.94%), the most common type of chemotherapy drug regimen used was the CAF regimen (Cyclophosphamide + Doxorubicin + 5 FU) in 8 patients (23.53%), therapy with the CAF regimen was given starting from the patient's age in the late adult range (46-55 years) until past the late elderly (> 65 years), drug therapy with the CAF regimen as the first-line standard (first line) is the most widely used with doses according to the National Guidelines for Medical Services for Management of Breast Cancer and a deviation between 1-13%, other regimens a combination of Carboplatin and Paclitaxel in 5 patients (14.71%) with doses and deviations ranging from 0-79% more lower than the literature. Key words: Breast Cancer, Chemotherapy, Chemotherapy Drug Regimen, CAF, CEF
Studi Evaluasi Mekanisme Hand Rub (Hand Sanitizer) Berbasis Alkohol Terhadap Methicillin-Resistant Staphylococcus Aureus (MRSA) Dengan Metode Pengamatan Scanning Electron Microscope (SEM) Ahmad Subhan
Jurnal Farmasi Klinik Best Practice Vol 1 No 1 (2022): Jurnal Farmasi Klinik - Base Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v1i1.20

Abstract

The current pandemic caused by the current Corona Virus Infection Disease (Covid 19), as well as those caused by Methicillin-resistant Staphylococcus aureus (MRSA) clones in the previous period, have seriously threatened human life. These conditions require materials that can break the chain of transmission from human to human and the environment to human. Alcohol-based hand rubs/hand sanitizers are widely used, generally containing ethanol, isopropanol or n-propanol, or a combination of the two types. Alcohol has excellent germicidal activity in vitro against gram-positive and gram-negative vegetative bacteria (including multidrug-resistant pathogens such as MRSA and VRE) as well as against viruses. This study aimed to determine the effect of alcohol-based hand rub (hand sanitizer) on Methicillin-resistant staphylococcus aureus (MRSA) using the scanning electron microscope (SEM) observation method. The hand rub product used in this study is a modified version of the WHO standard formula, which is the best formula based on formulation stability tests in previous studies. Methicillin-resistant staphylococcus aureus (MRSA) used in this study was the result of swab wounds of patients undergoing treatment at the research hospital. The SEM examination was carried out at the Indonesian Institute of Sciences (LIPI) Serpong using the SEM JSM IT200. The results showed that at 5,000X magnification, it was seen that MRSA underwent a lysisin colony at each of the cell wall structure with the occurrence of colony deformation which caused the separation of each cell from the main colony. At 10,000X magnification, Methicillin-resistant Staphylococcus aureus (MRSA) colonies appeared to be lysed in the cell wall structure with deformation and coagulation in the main colonies of MRSA cells. In 10,000X observations of single cells showed a lysis of the MRSA cell wall structure and it damage the structures surrounding the cell, which caused cell death. Keywords: hand rub, alcohol base, IFO, Ahmad, Subhan, fatmawati, MRSA, SEM
Determinan Implementasi Vaksin COVID-19 di Perguruan Tinggi di Kota Jayapura Widyawati Ratnasariani
Jurnal Farmasi Klinik Best Practice Vol 2 No 1 (2023): Jurnal Farmasi Klinik Best Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v2i1.22

Abstract

Vaksin COVID-19 diharapkan dapat mengurangi risiko transmisi, tingkat keparahan dan kematian. Penelitian ini bertujuan menganalisis faktor yang memengaruhi penerimaan vaksin COVID-19 di perguruan tinggi di Kota Jayapura. Jenis penelitian kuantitatif dengan menggunakan desain cross sectional. Populasi sebanyak 1.197 tenaga pendidik (dosen) dan tenaga kependidikan (staf) di UNIYAP, USTJ, dan UNCEN. Kemudian, sampling diambil dengan metode purposive diperoleh 307 orang. Alat ukur menggunakan kuesioner, disebarkan secara daring dan luring. Terkumpul melalui luring sebanyak 181 orang (58,9%). Analisis data menggunakan chi square dan regresi logistik berganda. Hasil penelitian menunjukkan bahwa sebagian besar responden telah divaksin COVID-19 (82,7%). Berdasarkan hasil uji chi square faktor yang memiliki hubungan dengan penerimaan vaksin di perguruan tinggi di Kota Jayapura adalah riwayat penyakit komorbid (p=0,000) dan sikap (p=0,000). Sedangkan, faktor yang tidak memiliki hubungan dengan penerimaan vaksin COVID-19 adalah jenis kelamin (p=0,367), usia (p=0,137), perilaku merokok (p=0,402), dan pengetahuan (p=0,159). Hasil uji regresi logistik berganda menunjukkan faktor paling dominan terhadap penerimaan vaksin COVID-19 adalah sikap (p=0,000;PR=2,926). Namun, hasil regresi logistik berganda per universitas menyatakan bahwa faktor paling dominan terhadap penerimaan vaksin COVID-19 di UNIYAP adalah riwayat penyakit komorbid (p=0,000;PR=40,95), USTJ yaitu perilaku merokok (p=0,000;PR=40,95), dan UNCEN yaitu sikap (p=0,000;PR=40,95). Sebagian besar responden memiliki pendidikan terakhir Magister (S2) sehingga memiliki pengetahuan baik, akan tetapi pengetahuan baik tidak memengaruhi sikap responden terhadap vaksin. Penyakit komorbid yang dimiliki responden diantaranya hipertensi, PJK, diabetes, serta alergi berat dan asma
Analisis Pelaksanaan Pemeriksaan (Testing) COVID-19 di Papua I Dewa Gede Airlangga Subratha
Jurnal Farmasi Klinik Best Practice Vol 2 No 1 (2023): Jurnal Farmasi Klinik Best Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v2i1.23

Abstract

Testing merupakan diagnosis awal untuk mengetahui status seseorang apabila terinfeksi virus Covid-19. Tujuan penelitian mengetahui pelaksanaan testing Covid-19 di Kota Jayapura. Penelitian ini merupakan penelitian kuantitatif dengan desain cross sectional. Populasi penelitian berupa petugas testing Covid-19 dan sampel berjumlah 35 orang dengan teknik sampling jenuh yaitu Litbangkes (n=14), Labkesda (n=11), dan BPOM (n=10) yang diperoleh dari pengisian kuesioner dalam bentuk google form (24 orang) dan kuesioner offline (11 orang). Analisis data yang digunakan berupa uji chi square dan regresi logistik berganda. Perempuan paling dominan (62,9%) dalam melaksanakan testing dengan usia dewasa awal yaitu 26-35 tahun (45,7%) dan memiliki masa kerja baru < 6 tahun (62,9%). SDM di Laboratorium Kota Jayapura mencukupi namun memiliki rangkap pekerjaan (71,4%) dan beban kerja (82,9%). Anggaran pelaksanaan testing tercukupi dalam pemeliharaan mesin (68,6%), APD (54,3%), BSC (82,9%) dengan menerima kompensasi insentif (54,3%). Laboratorium Kota Jayapura menggunakan mesin PCR dalam pelaksanaan testing Covid-19 dengan metode lebih dari 4 langkah. APD (80%), mesin (97,1%), stok reagen (68,6%), dan BSC (85,7%) tercukupi. Spesimen dikirim/diterima oleh Laboratorium < 24 jam (54,3%) dengan waktu tunggu hasil pemeriksaan ≤ 48 jam dan hasil pemeriksaan spesimen dilaporkan melalui aplikasi allrecord-tc19 dalam waktu 1x24 jam. Hasil pengujian dari penelitian menunjukkan bahwa terdapat hubungan antara SDM (p-value 0,026; PR 13,143) dan pencatatan dan pelaporan (p-value 0,041; PR 0,167) dengan pelaksanaan testing Covid-19. Namun hubungan antara anggaran 19 (p-value 0,130; PR 4,750), fasilitas (p-value 1,000; PR 1,098) dan metode (p-value1,000; PR 1,250) dengan pelaksanaan testing Covid-19 tidak signifikan. Pencatatan dan Pelaporan merupakan faktor yang paling dominan memengaruhi pelaksanaan testing Covid-19 (p-value 0,013; Exp (B) 13,277).
Evaluasi Pelaksanaan Review Pengobatan Pasien COVID-19 Oleh Apoteker Berdasarkan Snars 1.1 Di Instalasi Rawat Inap Anggrek RSUP Fatmawati Jakarta Periode Juli-Agustus Tahun 2021 Ahmad Subhan
Jurnal Farmasi Klinik Best Practice Vol 2 No 1 (2023): Jurnal Farmasi Klinik Best Practice
Publisher : RSUP Fatmawati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58815/jfklin.v2i1.24

Abstract

Fatmawati Hospital is referral hospital for COVID-19 patients that seeks to ensure safety in patient care based on SNARS 1.1. COVID-19 is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARSCoV-2) This descriptive study was conducted in an observational retrospective manner to evaluate the implementation of a treatment review by pharmacists based on SNARS 1.1 for COVID-19 patients in the Orchid Room of Fatmawati Hospital for the period of July-August 2021, data collection using total sampling. Pharmacists are expected to review 4 documents including pharmacological medical instructions and monitoring of patient drug administration, information and education of inpatient integrated patients and families, provision of patient information and/education and Integrated Patient Progress Records. Implementation of medication review is said to compliant if pharmacist reviews 4 documents, less compliant if reviews 3 documents, less compliant if reviews 2 documents and is not compliant if there is only 1 document reviewed. Results evaluation showed: from 322 medical records that met the inclusion criteria 215 (66.77%). Based on gender, female patients were 56.28%, with the most length of stay was 7-14 days 43.26%, and the outcome improved was 65.58%. review of treatment by pharmacists based on SNARS 1.1 adhered to 13.03%, less compliant 20%, less compliant 34.88% and nonadherent 32.09%. The results of statistical analysis using the chi square test concluded that there was a significant relationship between the implementation of medication reviews by pharmacists and patient care outcomes with p value = 0.006 and there was no significant relationship between the implementation of medication reviews by pharmacists and the length of stay (LOS) of patients with p value. = 0.109.

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