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Parapemikir Jurnal Ilmiah Farmasi
Published by Politeknik Harapan Bersama Tegal
ISSN : 20895313     EISSN : 25495062     DOI : 10.30591
Core Subject : Health, Science,
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics
Parapemikir journals based on the results of research in the field of Pharmacy science and community covering Social Behavior and Pharmacy Administration including Pharmacy, Biopharmaceuticals, Drug Submission Systems, Physical Pharmacy, Pharmaceutical Technology, Microbiology and Biotechnology Pharmacy, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry , Pharmaceutical Chemistry, Biological Pharmacy, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicine, Pharmacy Management, Farmakoekonomi, Farmakoepidemiology, Social Pharmacy, Pharmacy Policy.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 11 Documents
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Search results for , issue "Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi" : 11 Documents clear
Identifikasi Bahan Tambahan Pangan yang Berbahaya (Rhodamin B dan Borak) pada Jajanan di Lingkungan Jl. Kartini Kecamatan Tegal Timur Kota Tegal Adevia Maulidya Chikmah; Iroma Maulida
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1466

Abstract

School children are state assets as human resources for the success of nation building. However, elementary school children are also one of the nutritionally vulnerable groups due to the need for macronutrient nutrients such as energy, protein, fat and other nutrients for the growth and development of bones, teeth, muscles and blood[9] . Breakfast habits need to be considered to provide energy for the body and so that children are more receptive to learning. But children have a lot of activity so they often forget to eat. 1 Snack is often an alternative for children who have not had breakfast. There are several types of food additives that are dangerous if mixed in snacks, including rhodamine B and borax. Research is intended to identify the presence of hazardous food additives, namely Rhodamin B and borax in snacks in the neighborhood of Jl. Kartini East Tegal District, Tegal City in 2017. This research is descriptive with a population that is snacks that do not have food labels sold along Kartini Street, Tegal City which looks chewy for snacks containing borax and bright red / striking for snacks containing rhodamine B. The number of samples we examined were 31 snacks consisting of 22 snacks as borak samples and 9 rhodamin B sample snacks. The test equipment was used Borax Kit and Rhodamin Kit. The results showed that there were 7 (31.8%) borax-containing snacks and 3 (33.3%) containing rhodamine B. In this study the factors of education, socio-economic, knowledge and attitudes of traders were not examined. Therefore, it is necessary to further examine the factors of education, socio-economics, knowledge and attitudes of traders towards preservatives at risk. Keywords— Borax, Rhodamin B, Additive Substance
Evaluasi Penggunaan Obat Pada Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisis Di Rsud Toto Kabila Periode 2017-2018 Teti Sutriyati Tuloli; Madania Madania; Moh Adam Mustapa; Evania P. Tuli
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1470

Abstract

Chronic Renal Failure (CRF) is kidney damage with a decrease in Glomerular Filtration Rate (LFG) of less than 60mL/min/1.73 m2 during (at least) 3 months. Hemodialysis therapy is the most widely used CRF therapy. Due to certain conditions, in addition to receiving hemodialysis therapy, patients with CRF alsoreceive oral drug therapy. This is intended to overcome complications both from CRF and hemodialysis therapy itself. This study aims to evaluate drugs use in patients with CRF with hemodialysis based on four aspects, namely the proper patient, the proper medication, the proper indication and the proper dose according to the standard of therapy. This research was a descriptive study using a cross sectional design with data collection done retrospectively on patients undergoing hemodialysis in Regional General Hospitalof Toto Kabila Hospital January 2017-October 2018. 43 patients were taken as samples by purposive sampling method that met the criteria. The data obtained were analyzed by univariate analysis.The results showed that the use of drugs in kidney failure patients undergoing hemodialysis in Regional General Hospitalof Toto Kabila Hospital in the period of January2017-October 2018 based on the four aspects were as follows: proper patient of 100%; proper drug of 86.05% and improper drug of 13.95%; proper indication of 83.72% and improper indication of 16.28%; proper dosage of 53.49%; and improper dosage of 46.51%.Overall, the drugs use evaluation results show that the drugs use on patients with Chronic Rena Failure undergoing hemodialysis in Regional General Hospitalof Toto Kabila Hospital in the period January 2017-October 2018 can be included in the good category.Keywords— Chronic Kidney Failure, Hemodialysis, Gorontalo
Polimorfisme P2Y12 Terhadap Agregasi Platelet Pada Pasien Penyakit Jantung Koroner oktaviarika dewi hermawatiningsih
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1446

Abstract

Genetic polymorphism of P2Y12 receptor is one of the factors responsible for the variation in response to antiplatelet therapy. Variations in response to P2Y12 receptors can cause Coronary Artheri Disease (CAD) in CHD patients. This research was conducted in RSUD Sidoarjo East Java  from  November  to December 2017 which aims to determine the effect of P2Y12 polymorphism on platelet aggregation in CHD patients. The research method used is Polymerase Chain Reaction (PCR) for P2Y12 genetic polymorphism and Light Transmittance Aggregometry (LTA) method for platelet aggregation measurement. From 30 samples, it was found that all samples had homozygot (wild type) type P2Y12 polymorphism with bp value of about 156 bp. Inferential analysis  was conducted  to determine the relationship between polymorphism of P2Y12 with platelet aggregation obtained p value = 0,130. From these results it can be said  that  between the genetic polymorphism of P2Y12 and platelet aggregation has no significant relationship.  Keywords : antiplatelet; clopidogrel; platelet aggregation; polymorphism P2Y12.
Peningkatan Kelarutan Fisetin Dengan Teknik Kosolvensi Muhammad Dzakwan; Widodo Priyanto
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1388

Abstract

Fisetin adalah senyawa flavonoid yang memiliki beragam aktivitas, salah satunya adalah sebagai antioksidan. Fisetin memiliki kelarutan dan bioavailabilitas yang rendah sehingga penerapannya terbatas untuk oral dan dermal. Tujuan penelitian adalah meningkatkan kelarutan fisetin dengan metode kosolvensi menggunakan tiga pelarut berbeda, yaitu air, etanol dan propilen glikol dengan berbagai konsentrasi. Hasil penelitian menunjukkan kelarutan fisetin meningkat signifikan sebesar 206.002 ± 0,014 mg / mL dengan penambahan campuran pelarut air, etanol dan propilen glikol (60: 25: 15% v/v). Campuran pelarut yang kurang polar dapat meningkatkan kelarutan  obat melalui mekanisme interaksi hidrofobik. Campuran pelarut air-etanol-propilen glikol (60: 25: 15% v / v) menunjukkan potensi pelarutan tertinggi.Kata kunci: Fisetin, kosolvensi, kelarutan. pelarut
Ekstrak Daun Tembakau (Nicotiana tabacum) Sebagai Akarisida Pada Caplak (Boophilus microplus) Nurul Fajriani M; Abdul Wahid Jamaluddin; Adryani Ris
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1420

Abstract

Ticks as blood sucking ectoparasites in cattle can cause a variety of diseases, malnutrition to livestock emaciation. One of the natural acaricides is Tobacco which contains Flavonoids, Tanins and Saponins. The purpose of this study was to determine the activity of Akarisida tobacco leaf extract against Boophilus microplus ticks. In this study 50 ticks were used which were then divided into 5 setting groups with each group twice repeated. The negative control group was given 1% Na CMC, the positive control group was given bestrin forte synthetic medicine, group 3 was given 10% Tobacco Leaf Extract (EDT), group 4 was given 15% EDT, and group 5 was given 20% EDT. After spending 2 hours for 6 hours and determine which group will beat the tick the fastest. Data analysis using Anova One Way statistics. Boophilus microplus starts at a concentration of 10%, and the fastest to determine tick (the first 2 hours period is EDT 20%). Keywords— Boophilus microplus, tobacco leaf, tobacco leaf extract, akarisida
Study of Drug Use and Evaluation of Paracetamol-Diazepam Mixed Capsule Preparations havizur rahman; Dyah Ayu Mulya Patmasari
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1386

Abstract

The purpose of this study was to predict the potential effect of theoretical use and evaluation of Paracetamol and Diazepam capsules concoction preparation in poly-nerve patients in outpatient depot Pharmacy Installation of Raden Mattaher Hospital. Methods of data collection used observation techniques with retrospective study data collection techniques. It was found that 12 patients used the Paracetamol 500 mg concoction capsules and 0.5 mg Diazepam given twice a day, used every day with a minimum usage period of 1 month and a maximum of 56 months, 5 of whom were over 60 years old. The capsule concoction that is made is not derived from the pure active ingredient of Paracetamol and Diazepam, but is a trademark tablet drug which is crushed without BA and BE evaluation of the concoction form. So, it can be concluded that the use of Paracetamol and Diazepam concoction capsules is predicted to pose a risk of causing hepatotoxic and physical and psychological dependence and capsule concoction drugs that are made do not meet the criteria set by the FDA.
Gambaran Penyakit Komplikasi pada Pasien Diabetes di RSUD Kardinah Kota Tegal Meliyana Perwita Sari; Anggy Rima Putri; Nanang Kurnia Achmadi
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1471

Abstract

Diabetes Mellitus is called the silent killer because this disease can affect all organs of the body and cause various kinds of complaints. Diseases that will be caused include eye vision, cataracts, heart disease, kidney disease, sexual impotence, wounds that are difficult to heal and rot / gangrene, lung infections, vascular disorders, strokes, and so on. The purpose of this study was to determine the description of complications in diabetic patients in Outpatient Hospital Kardinah, Tegal City. This research is a descriptive observation study using a cross sectional design. Data retrieval is done by means of total sampling and collecting patient data retrospectively using secondary data in the form of medical records for the period October - December 2017 taken at Outpatient Hospital Kardinah, Tegal City. The highest percentage of characteristics of diabetic patients with sex complications was 55.1%. While most complications suffered by patients with diabetes with complications are diabetic patients with other complications (other diseases and more than one complication). The most widely used antidiabetic group is metformin with a percentage of 88.8%.Keywords—Complications of disease, diabetes millitus, antidiabetic drugs
Uji Praklinik Kombinasi Obat Herbal Kopi Pinogu (Coffea canephora var Robusta) Dan Bunga Cengkeh (Syzygium aromaticum) Terhadap Penurunan Kadar Asam Urat Pada Mencit Moh Adam Mustapa; Muhammad Taupik; Friskawati Hanapi
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1468

Abstract

Decreasing uric acid levels can be given with coffee plants Pinogu (Coffea canephora var robusta) which is combined with clove flowers (Syzygium aromaticum) as a hyperuricemia drug. This study aims to measure the effect of the combination of Pinogu coffee herbal medicine and clove flower seen from the decrease in uric acid levels of male white mice made hyperuricemia by chicken liver juice. This study uses a pure experimental design with pre and post test design. Where animals are grouped into seven groups, each group consisting of 5 male white mice. Each group was induced 1 mL / 20 g BB chicken liver juice and left for 24 hours then blood was taken after 2 hours, 3 hours and 4 hours of treatment. Group I as a negative control was given Na-CMC, group II was given allopurinol suspension 0.0538 g / kg BB, group III was given a combination of Pinogu coffee and clove flowers 0.209 g / kg BB, group IV was given a combination of Pinogu coffee and clove flower 0.39936 g / kg BB, group V was given a combination of Pinogu coffee and clove flower 0.404 g / kg BB, group VI was given a single Pinogu coffee extract 0.195 g / kg BB, and group VII was given clove flower extract 0.0140 g / kg BW. The results showed that the combination of Pinogu coffee herbal medicine (Coffea canephora var robusta) and clove flower (Syzygium romaticum) can reduce uric acid levels in male white mice (Mus musculus). The combination of Pinogu coffee and clove flower 0.209 g / kg BW gives the optimal effect of reducing blood uric acid levels in mice by 64.93%. Keywords— Gout, Pinogu Coffee, Clove Flowers
Penentuan Kadar Fenol Total Dan Uji Aktivitas Antioksidan Kombinasi Ekstrak Herba Pegagan (Centella asiatica L. Urban) Dan Buah Mahkota Dewa (Phaleria macrocarpa(Scheff.) Boerl.) Purgiyanti Purgiyanti; Anny Victor Purba; Hendig Winarno
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1395

Abstract

Many diseases that were originally caused by free radicals, so that free radicals and antioxidants observed extensively in the world of health. Gotu kola herb and fruit Mahkota Dewa were supposed to have antioxidant activity that can reduce the activity of free radicals. The purpose of this study was to determinethe total phenol content and the antioxidant activity of the combination of herbal extracts of Gotu kola (Centella asiatica L. Urban) and Mahkota Dewa fruit (Phaleria macrocarpa (Scheff.) Boerl.) Gotu kola herb extracts and Mahkota Dewa fruit extracts obtained by maceration using ethanol 70% with the ratio between crude drug powder and solvent was 1: 5. The antioxidant activity was determined by DPPH (2,2-diphenyl-1 picrylhydrazyl). Total phenol content was determined using UV-Vis spectrophotometry reagent Folin- Ciocalteau the results expressed in gallic acid equivalents (mg GAE / 100 g extract). The result shows that the combination of the ethanol extract of Centellaasiatica herb and Mahkota Dewa fruit in the ratio of 1: 1 has a total phenol content of 3.67 mg GAE / 100 g of extract and active as an antioxidant with IC50 value of 67.07 mg / mL, and vitamin C as active comparison as an antioxidant with IC50 value of 8.81 mg / mL. This study shows that a combination of herbal extracts between Gotu Kola and MahkotaDewa have potentials as natural antioxidants.Keywords— Gotu Kola herb, Mahkota Dewa fruit, total phenols, Folin-Ciocalteau,DPPH
Pengaruh Pemilihan Anti-Psikotik Pada Pasien Depresi Tanpa dan Dengan Gejala Psikotik Terhadap Lama Hari Rawat Inap Palupi Poppy Diah; Buanasari Buanasari
Parapemikir : Jurnal Ilmiah Farmasi Vol 8, No 2 (2019): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v8i2.1469

Abstract

Antipsychotic therapy is given frequently to the patient with depressive symptoms. Antipsychotics are used to enhance the effects of antidepressants in the depressive patients. The aim of this study was to evaluate the length of stay of antipsychotic therapy selection in the depressive patient without/with psychosis symptoms. This study was conducted by quantitative method, multicenter, non-experimental approach, and cohort design study. Data were collected from medical records of 187 patients diagnosed with depression without/with psychosis symptoms from the various mental-illness hospital in Central Java Province. There was a significant difference (p 0.05) in the length of stay with the selection of antidepressants in depressive patients without psychotic symptoms, and there was no significant difference (p 0.05) in the length of stay with the selection of antipsychotic agents in depressive patients without/with psychotic symptoms.Keywords— Length of stay, depression, without/with psychosis symptoms, antipsychotic

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