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Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta

ISSN : 24606065 EISSN : 25483013 DOI : 10.15408/jkv

Core Subject : Science,

Chemistry

Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of chemistry.

Arjuna Subject : Umum - Umum

Articles 10 Documents

Search results for , issue "Jurnal Kimia VALENSI Volume 2, No. 2, November 2016" : 10 Documents clear

Kajian Kinerja Organoclay Bentonit Terinterkalasi Poli-DADMAC sebagai Flokulasn Limbah Cair Tahu Nurhayati Rohmah; Irwan Nugraha
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Abstrak Telah dilakukan kajian kinerja organoclay bentonit terinterkalasi polyi-DADMAC sebagai flokulan limbah cair tahu. Tujuan dari penelitian ini adalah untuk menguji efektifitas organoclay bentonit terinterkalasi poly-DADMAC sebagai flokulan limbah cair tahu. Organoclay bentonit terinterkalasi poly-DADMAC disintesis dengan mereaksikan 10 g bentonit dengan 100 mL poly-DADMAC 4%. Pergeseran yang terjadi pada spektra hasil analisis XRD dan FTIR menunjukan keberhasilan proses interkalasi bentonit dengan poly-DADMAC. Koagulasi flokulasi dilakukan dengan metode jar test pada kecepatan pengadukan cepat 120 rpm selama 1 menit dan pengadukan lambat 20 rpm. Kajian kinerja flokulan organoclay meliputi variasi jenis flokulan, massa flokulan, lama waktu kontak flokulasi dan variasi jenis pengenceran. Nilai efektifitas penurunan COD maksimum pada 35.7 % terjadi pada penambahan jenis flokulan organoclay dengan massa 0.05 g dan waktu kontak flokulasi 40 menit. Proses koagulasi-flokulasi limbah cair tahu menggunakan flokulan organoclay mampu menghasilkan penurunan nilai COD limbah dari 1145.76 mg/L menjadi 833.28 mg/L. Akan tetapi., koagulasi-flokulasi limbah cair tahu pada penelitian ini tidak menurunkan pH limbah secara ekstrim, rentang penurunan pH adalah dari 3.836 menjadi 3.448. Kata kunci : Flokulan, organoclay, bentonit-polyDADMAC, limbah cair tahu Abstract Studies of Bentonite intercalated organoclay performance polyi-DADMAC as flocculants wastewater of tahu has been done. The purpose of this study was to examine the effectiveness of Bentonite intercalated organoclay poly-DADMAC as flocculants wastewater of Tahu. Bentonite intercalated organoclay poly-DADMAC are synthesized by reacting 10 g of bentonite with 100 mL of poly-DADMAC 4%. The shift in spectral analysis of XRD and FTIR results showed the success of the process of intercalation of bentonite with poly-DADMAC. Coagulation-flocculation using Jar test with the rapid stirring speed of 120 rpm for 1 minute and 20 rpm slow stirring. Organoclay flocculant performance review includes a variation type of flocculant, flocculant mass, contact time flocculation and variations in the type of dilution. Rated maximum effectiveness of COD reduction occurs at 35.7% in the type of flocculant addition of organoclay with a mass of 0.05 g and a contact time of 40 minutes flocculation. Coagulation-flocculation process of wastewater of Tahu using flocculants organoclay decrease COD from 1145.76 mg / L to 833.28 mg / L. However, coagulation-flocculation of wastewater of Tahu did not lower the pH of the waste significantly, decreasing pH occurs from 3.836 to 3.448.Keywords: Flocculant, organoclay, bentonite-polyDADMAC, wastewater of TahuDOI: http://dx.doi.org/10.15408/jkv.v0i0.4322

Hasil In Silico Senyawa Z12501572, Z00321025, SCB5631028 dan SCB13970547 dibandingkan Turunan Zerumbon terhadap Human Liver Glycogen Phosphorylase (1l5Q) sebagai Antidiabetes Fitri Kusvila Aziz; Cantika Nukitasari; Fauziyah Ardli Oktavianingrum; Lita Windy Aryati; Broto Santoso
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Abstrak Human Liver Glycogen Phosphorylase (HLGP), suatu katalis glikogen yang mengontrol pelepasan glukosa-1-fosfat glikogen dari hati. Enzim ini mempunyai peran sentral dalam luaran glukosa hati sehingga menjadi target obat antidiabetik. Kajian docking dilakukan pada komputer dengan prosesor Intel Pentium, RAM 1 GB dan Windows 7. Ligan yang digunakan adalah senyawa obat (Z12501572, Z00321025, SCB5631028 dan SCB13970547), dataset pembanding aktif glycogen phosphorylase outer dimer site (PYGL-out) dan decoysdari www.dekois.com dan turunan zerumbon. Protein dipisahkan dari ligan nativ dan semua ligan beserta protein dikonversi menggunakan PyRx. Visualisasi interaksi ligan-protein dihasilkan dengan program Protein-Ligand Interaction Profiler (PLIP) dan PyMOL. Senyawa ZER11 memiliki binding energy terbaik, yaitu -7.11 kkal/mol (untuk metode LGA dan GA) dan -4.08 kkal/mol untuk metode SA. Nilai binding energy tersebut lebih rendah dari pada nilai untuk ligan native dan satu dari keempat senyawa obat, terlebih jika dibandingkan dengan bindingaffinity dari dataset dan decoys. Interaksi ligan-protein pada ketiga metode tersebut ditemukan sangat bervariasi. Hal berbeda terjadi untuk metode Vina, bindingenergy ZER11 (-9.9 kkal/mol) lebih baik dibandingkan dengan ligan native dan keempat senyawa obat. Senyawa ZER11 memiliki residu interaksi yang sama dengan ligan native pada TRP67 dan LYS191 untuk metode Vina. Kata kunci: PDBID-1L5Q, AutoDock, docking molekuler, vina, antidiabetes Abstract Human Liver Glycogen Phosphorylase (HLGP) can catalyze glycogen and control the release of glucose-1-phosphate of glycogen from the liver. This enzyme has a central role in output rule of liver glucose as it can be used as an antidiabetic drug targets. Docking studies were carried out on PC with Intel Pentium, 1 GB RAM, in environment of Windows 7. Ligands used are drug compounds (Z12501572, Z00321025, SCB5631028 and SCB13970547), the active dataset comparator wasglycogenphosphorylase outer dimer site (PYGL-out) and decoys from www.dekois.com andzerumbonederivates. Protein was separated from its native ligand and all ligands including the protein were converted to pdbqt using PyRx. The interaction of protein-ligand was visualized using software of PLIP and PyMOL. Compound of ZER11 had the best binding energy were -7.11 kcal/mol (LGA and GA) and -4.08 kcal/mol (SA). The binding energy value was lower than the ligand native and one of the four drug compounds, especially compared with the binding affinity of dataset and decoys. Vice versa, for Vina method, the value of ligand binding protein for ZER11 (-9.9 kcal/mol) was better than the ligand native and all of the fourth drugcompounds. Vina result showed that ZER11 had the same residual interaction as the ligand native, which are TRP67 and LYS191. Keyword: PDBID-1L5Q, AutoDock, molecular docking, vina, antidiabetic DOI: http://dx.doi.org/10.15408/jkv.v0i0.4170

Kajian Kualitas Briket Biomassa dari Sekam Padi dan Tempurung Kelapa Idzni Qistina; Dede Sukandar; Trilaksono Trilaksono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Abstrak Biomassa seperti sekam padi dan tempurung kelapa dapat menjadi sumber bahan baku briket sebagai salah satu energi alternatif pengganti bahan bakar fosil (minyak bumi).Penelitian ini bertujuan untuk mengkaji kualitas briket sekam padi dan tempurung kelapa melalui proses semi-karbonisasi pada temperatur antara 50-125 0C dengan durasi waktu proses 50-120 menit. Proses pembuatan briket meliputiproses semi-karbonisasi, pencampuran biomassa dengan perekat, pencetakan, pengeringan, dan uji kualitas briket. Pengujian kualitas briket meliputi analisis briket yaitu nilai kalor, kadar air, fixed carbon, volatile matter, abu, dan analisis ultimat. Disamping itu juga dilakukan uji kuat tekan, pengukuran emisi gas, dan uji termal briket yang dihasilkan.Hasilnya menunjukkan penurunan kadar air bahan baku briket sekam padi dan tempurung kelapa membutuhkan energi masing-masing 8.54% dan 4.97% dari proses karbonisasi murni yang menghasilkan semi arang. Nilai kalor briket sekam padi maupun tempurung kelapa mengalami penurunan masing-masing 9.72% dan 7.21% jika dibandingkan dengan bahan bakunya.Gas emisi dari briket sekam padi dan tempurung kelapa yaitu gas NOx, SOx, CO, dan hidrokarbon (HC) masih di bawah baku mutu yang dipersyaratkan. Hasil uji termal briket menunjukkan efisiensi termal briket sekam lebih baik dibandingkan briket tempurung kelapa dengan nilai efisiensi masing-masing sebesar 31.13% dan 22.28%. Kata kunci: Briket sekam padi, briket tempurung kelapa, semi karbonisasi, emisi gas, efisiensi termal. Abstract Biomass energy, among others, rice husk and coconut shell can be an alternative energy source to replace fossil fuels (petroleum). This study aims to assess the quality briquettes rice husk and coconut shell with raw materials through semi-carbonization process at a temperature between 50-125 0C with a duration of 50-120 minutes of processing time. Briquetting process meliputu semi-carbonization, refining raw materials and sieving made passes restrained 30 mesh and 30 detained 50 mesh. Then do the mixing biomass with adhesive, printed, dried and tested briquette quality test. Briquette quality testing consists of the analysis of the characteristics of briquettes are calorific value, moisture content, fixed carbon, volatile matter, ash, and the ultimate analysis. Besides, it also conducted compressive strength test, the measurement of gas emission, and thermal test briquettes were produced. The results show a decrease in raw material briquettes moisture content of rice husk and coconut shell on semi karbonization process requiring respectively 8.54% and 4.97% of the energy of pure carbonization process which produces semi charcoal. Calorific value briquettes rice husk and coconut shell fell respectively 9.72% and 7.21% when compared to the raw material. The quality of biomass briquettes is based on the results of the analysis of the characteristics and compressive strength test briquettes showed that coconut shell briquettes better quality than the rice husk briquettes. Briquettes gas emissions from rice husks and coconut shells are gas NOx, SOx, CO and hydrocarbons (HC) is still below the quality standards required. The test results demonstrate the thermal efficiency of thermal briquettes rice husk briquettes for 31.13% and better than coconut shell briquettes by 22.28%. Keywords: Briquette rice husk, coconut shell briquettes, semi-carbonization, gases,thermal efficiency DOI: http://dx.doi.org/10.15408/jkv.v0i0.4054

Delignification of Sawdust White Teak (Gmelina arborea Roxb.) by Fungi Phanerochaete chrysosporium Irradiated Gamma Ray Nurhasni Nurhasni; Tri Retno Dyah Larasati; Afinanisa Iksan
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Abstrak Biomassa lignoselulosa yang merupakan limbah pemanenan kayu harus dilakukan proses untuk memisahkan selulosa, hemiselulosa dan lignin sehingga dapat termanfaatkan. Penelitian ini bertujuan untuk mengetahui efektivitas inokulan fungi Phanerochaete chrysosporium iradiasi gamma dan pretreatment kimia terhadap percepatan delignifikasi serbuk kayu jati putih (Gmelina arborea Roxb.) sehingga dapat dimanfaatkan dalam proses pulping. Pada penelitian ini dilakukan pretreatment substrat kayu jati putih (Gmelina arborea Roxb.) menggunakan larutan NaOH 1% dan H2SO4 1% serta iradiasi gamma Co-60, yang mempunyai daya ionisasi kecil, daya tembus yang tinggi serta Co-60 dapat memancarkan sinar gamma dengan waktu paruh pendek. Penelitian ini dilakukan dalam dua tahap, tahap pertama penentuan dosis optimum iradiasi gamma terhadap fungi Phanerochaete chrysosporium (0 Gy, 200 Gy, 400 Gy, 600 Gy, 800 Gy, dan 1000 Gy) dan tahap kedua analisis karakteristik substrat kayu jati putih yang telah di pretreatment dengan metode Solid State Fermentation (SSF) selama 21 hari. Hasil penelitian menunjukkan bahwa dosis optimum pemberian iradiasi gamma pada fungi Phanerochaete chrysosporium yaitu pada dosis 600 Gy yang dapat meningkatkan aktivitas enzim lignin peroksidase (LiP) sebesar 22.18 U/mL. Proses pretreatment kimia dengan menggunakan H2SO4 1% dapat mempercepat proses biodelignifikasi yang menghasilkan efisiensi degradasi lignin tertinggi yaitu sebesar 25.65%. Kata kunci: Lignoselulosa, delignifikasi, Solid State Fermentation (SSF), Phanerochaete chrysosporium,iradiasi gamma. Abstract Lignocellulose biomass is waste wood harvesting should be a process for separating cellulose, hemicellulose and lignin that can be utilized. This study aims to determine the effectiveness of the inoculant fungi Phanerochaete chrysosphorium gamma irradiation and chemical pretreatment to accelerate delignification powder white teak (Gmelina arborea Roxb.). In this research, pretreatment of substrate wood white teak (Gmelina arborea Roxb.) Using a solution of NaOH 1% and H2SO4 1% and gamma-ray irradiation Co-60, have the power of ionization is small, high penetrating power, and Co-60 which can emit gamma rays a short half-life time. This research was conducted in two stages, the first stage of determining the optimum dose gamma irradiation for fungi Phanerochaete chrysosphorium (0 Gy, 200 Gy, 400 Gy, 600 Gy, 800 Gy, and 1000 Gy) and the second stage of the analysis of the characteristics of the substrate wood white teak has been in pretreatment by methode Solid State Fermentation (SSF) for 21 days. The results showed that the optimum dose administration of gamma irradiation on fungi Phanerochaete chrysosphorium is a dose of 600 Gy which can increase the activity of enzymes lignin peroxidase (LiP) amounted to 22.18 U / mL. Chemical pretreatment process using H2SO4 1% biodelignification can accelerate the process of lignin degradation that produces the highest efficiency of 25.65%. Keywords: Lignocellulose, delignification, Solid State Fermentation (SSF), Phanerochaete chrysosporium, gamma irradiation. DOI: http://dx.doi.org/10.15408/jkv.v0i0.3079

Pembentukan Hidrogen dari Air Secara Fotokatalitik oleh Serbuk TiO2 yang Didoping Nitrogen Febrina Arfi; Hermansyah Aziz; Admin Alif
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Abstrak Kesadaran terhadap ancaman krisis energi karena kebutuhan yang sangat besar dan pencemaran lingkungan yang terjadi, maka perlu dilakukan penelitian untuk menghasilkan sumber energi alternatif. Hidrogen merupakan energi alternatif yang dapat digunakan sebagai bahan bakar, ramah lingkungan, dan dihasilkan dari sumber yang melimpah di bumi yaitu air. Salah satu metode yang dipakai untuk memproduksi gas hidrogen adalah metode fotolisis. Katalis yang digunakan adalah TiO2 yang didoping N, tujuannya mempelajari pengaruh variasi perbandingan TiO2/N terhadap aktifitas fotokatalitik pembentukan hidrogen. Hasil penelitian memperlihatkan produksi gas menggunakan TiO2/N pada kondisi optimum terjadi pada perbandingan 4:6 yang menghasilkan gas 2.2 mL. Dari hasil penelitian dapat disimpulkan bahwa TiO2 doping N dapat membantu pembentukan gas secara fotokatalitik. Kata kunci : Fotolisis, katalis, doping, fotokatalitik Abstract The awareness about energy crisis is rising quickly. Consider to the very fast growing need of energy and the environmental impact caused by the conventional energy, so that the research about renewable energy as an alternative energy resource is very urgent. Therefore, the research to produce hydrogen as an alternative energy resourse was conducted. Hydrogen can be used as a green fuel which can be extracted from water, a huge amount of resource on the earth. In this research, the photolysis method was used. Nitrogen-doped TiO2 catalyst was used in order to analyse the influence of variational ratio of TiO2/N to the photocatalytic process of hydrogen production. The result shows that the optimum condition in producing gas using TiO2/N occured at the ratio 4:3 which produced as much as 2.2 ml gas. From this result can be concluded that Nitrogen-doped TiO2 supports the extraction of gas in photocatalytic process. Keywords: Photolysis, catalys, doped, photocatalytic DOI: http://dx.doi.org/10.15408/jkv.v0i0.3077

Anti-bacterial Activity of Prenylated Xanthone from The Bark of Garcinia lowa Darwati Darwati; Elisabeth Krismayanti; Supriyatna Supriyatna; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Bioactivity-guided fractionation of a ethyl acetate extract of Garcinia lowa bark has led to the isolation and identification of a known prenylated xanthone, mangosharin, (2,6-dihydroxy-8-methoxy-5-(3-methylbut-2-enyl)-xanthone (1, 15.4 mg) The structure of the compound was identified from analysis of their spectroscopic data and by comparison with previous studies.Compound 1 showed anti-bacterial activity against Sreptococcus mutans with MIC value of 7.25 mg/mL. DOI : http://dx.doi.org/10.15408/jkv.v0i0.4057

Analisis Karaterisasi Konsentrasi dan Komposisi Partikulat Udara (Studi Case : Surabaya) Eka Fithriani Ahmad; Muhayatun Santoso
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Abstrak Pencemaran udara merupakan dampak yang sangat merugikan, tidak hanya bagi manusia tetapi juga akan berdampak buruk bagi ekosistem hewan dan tumbuhan. Pada penelitian ini akan mengkaji pencemaran udara dari Oktober 2012 hingga Februari 2014 melalui penelitian konsentrasi dan komposisi dari partikulat udara dengan ukuran PM 2.5. Penelitian ini bertujuan untuk menentuan sumber asal pencemaran di Surabaya sehingga dapat dijadikan referensi berbasis ilmiah sebagai langkah untuk membuat keputusan dan kebijakan yang tepat dalam menanggulangi dampak pencemaran. Metode pengolahan data dalam penelitian ini adalah dengan menggunakan analisis reseptor modeling yaitu Positif Matrix Factorization (PMF) untuk mengetahui sumber asal pencemaran. Hasil pengukuran yang diperoleh pada konsentrasi PM 2,5 adalah 15.05 μg/m3 sehingga telah melebihi baku mutu tahunan yang telah ditetapkan PP 41 tahun 1999, USEPA, maupun WHO. Dalam partikulat terdapat konsentrasi black carbon (BC) sebesar 3.20 μg/m3 dan unsur Pb dengan konsentrasi 0.28 μg/m3 yang telah melebihi nilai baku mutu USEPA. Sedangkan hasil analisis reseptor modeling di dapatkan sumber asal polutan berasal dari biomass, vehicle, soil, industri Pb, industri Zn dan indutri Fe. Kata kunci: Partikulat mater 2.5, black carbon, Pb, positive matrix factorization, Surabaya Abstract Air pollution is a very adverse impact, not only for humans but also the ecosystem of plants and animals. This research examine air pollution from October 2012 until February 2014 through the research of concentration and composition of airborne particulates with a size of PM 2.5 μm. This study aims to determine the origin and location of pollution sources in Surabaya so that it can be used as scientific reference as a step to make the right decisions and policies in tackling the impact of pollution. Data processing method in this research used analysis of receptor modeling that is Positive Matrix Factorization (PMF) to determine the source of the pollution. Results obtained at a concentration of PM 2.5 was 15.05 μg/m3 so PM 2.5 has exceeded the quality standard yearly, based on PP 41 1999, USEPA and WHO. There are 3.20 μg/m3 concentration of black carbon (BC), element Pb in particulate matter with a concentration of 0.28 μg/m3 which has exceeded the value of the quality standard USEPA. The source of the pollutants come from biomass, vehicle, soil, industrial Pb, Zn and industries Fe industry. Keywords: Particulate matter 2.5, black carbon, Pb, positive matrix factorization, Surabaya DOI: http://dx.doi.org/10.15408/jkv.v0i0.3602

Sintesis Komposit TiO2-Bentonit dan Aplikasinya untuk Penurunan BOD dan COD Air Embung UNNES Navela Rahma Aji; Emas Agus Prastyo Wibowo; Resti Ujiningtyas; Hestin Wirasti; Nuni Widiarti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v2i2.3620

Abstrak Telah disintesis komposit TiO2-bentonit untuk penurunan BOD dan COD. Penelitian ini bertujuan untuk mengetahui proses pembentukan komposit TiO2-Bentonit serta mengetahui katalis terbaik dalam proses fotodegradasi air embung. Penelitian diawali dengan preparasi TiO2-Bentonit. Hasil pembentukan komposit dikarakterisasi dengan menggunakan X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) dan Scanning Electron Microscope (SEM). Katalis yang diuji adalah TiO2, bentonit, TiO2-bentonit yang diaplikasikan ke air embung dengan waktu penyinaran selama 30 menit.Terbentuknya komposit TiO2-Bentonit ditunjukkan dengan refleksi TiO2 pada 2 25. Hasil analisis menggunakan FTIR yakni Ti-O antara range 400-700 cm -1 dalam hal ini ditunjukkan dalam peak 478.35 dan 594.08. Puncak serapan-serapan utama pada bentonit beradi di bilangan gelombang 3626.17 cm-1, 3448.72 cm-1 dan 1635.64 cm-1. Spektra TiO2-Bentonit tidak menunjukkan adanya pergeseran serapan pada bilangan gelombang 3448.72 cm-1 yang belum menunjukkan ikatan O-H yang semakin lemah karena adanya TiO2 di dalam antar lapis bentonit.Penurunan nilai BOD dan COD terbesar diperoleh dengan menggunakan TiO2-Bentonit yakni untuk BOD 18.40 ppm dan COD 10.05ppm. Kemampuan komposit TiO2-Bentonit lebih besar dibandingkan katalis TiO2 dan bentonit. Kata kunci: air embung, fotodegradasi, TiO2-bentonit Abstract Have done synthesized composite TiO2-bentonite to decrease BOD and COD. This study aims to determine the process of form he composite TiO2-bentonite and determine the best catalyst in the process of photodegradation water reservoir. The study begins with the preparation of TiO2-bentonite. Results composite formation characterized using X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR) and Scanning Electron Microscopy (SEM). The catalyst is tested TiO2, bentonite, TiO2-bentonite which is applied to the water reservoir with the exposure time for 30 menit.Terbentuknya composite TiO2-bentonite indicated by TiO2 reflection on the 2θ ≥ 25. FTIR analysis results using the Ti-O between the range 400-700 cm-1 in this case is shown in peak 478.35 and 594.08. The main absorption peak-absorption on bentonite beradi at wavenumber 3626.17 cm-1, 3448.72 and 1635.64 cm-1. TiO2-bentonite spectra did not indicate any shift in absorption at wavenumber 3448.72 cm-1 which has not shown the OH bond is weakened by the existence of TiO2 in between layers of bentonite. Impairment The BOD and COD obtained using the TiO2-bentonite for BOD 18.40 ppm and 10.05 ppm COD. TiO2-bentonite composite capability greater than TiO2 catalyst and bentonite. Keyword: air embung, photodegradation, TiO2-bentonite DOI: http://dx.doi.org/10.15408/jkv.v0i0.3620

Solid-phase Synthesis of Tetrapeptide on 2-Chlorotrityl Chloride Resin by Using Benzotriazol-1-yl-oxytripyrrolidinophosphonium Hexafluorophosphate as Coupling Reagent Rani Maharani; Nuruzzahra Ammatillah; Gunawan Gunawan; Ace Tatang Hidayat
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v2i2.4055

Tetrapeptide, OH-Pro-Ala-Gly-Tyr-NH2, was successfully synthesised on 2-chlorotrityl chloride resin by taking advantage of PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) as coupling reagent. The selection of the peptide as the target of synthesis was due to its interesting bioactivity as antioxidant. The synthesis was undertaken with Fmoc strategy, where Fmoc-proline was added onto the resin at the first place. It is known from the literature that proline can resist from rasemisation when it was attached on the resin at the first time. Fmoc deprotection step was carried out by employing 20% piperidine in DMF and the reaction mixture was shaken for 30 minutes. Once the proline attached, the next step was to attach amino acids, alanine (Ala), glycine (Gly) and tyrosine(Tyr), subsequently onto the resin until tetrapeptidyl resin was constructed on the resin. Hydroxyl group of Tyr was protected with t-butyl, which is TFA-labiled. Coupling reaction was undertaken by mixing the amino acid and PyBOP in a mixture of dichloromethane and DMF (1:1) and in the presence of basic DIPEA. Resin cleavage step was carried out by using 95% TFA in water, where t-butyl protecting group on the side chain of Tyr was cleaved at the same time. The analytical RP-HPLC of the final product showed a single peak at 21.9 minutes (20-90% of acetonitrile in water with 0.1% of TFA during 30 minutes), indicating that each coupling has given a good coupling performance and resulting in a pure product. The desired product showed the correct molecular weight with m/z 407.2 [M+H]+ and 429.2 [M+Na]. DOI: http://dx.doi.org/10.15408/jkv.v0i0.4055

Synthesis, Spectral, Anticancer Studies on Cu (II) Complex of 2,4,5-Triphenyl-1H-Imidazole Fahimah Martak; Iin Candrawati; Ayu Widyasari
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 2, No. 2, November 2016
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v2i2.3328

Schiff bases of 2,4,5-triphenyl-1H-imidazole ligand and Cu(II) complex has been synthesized and characterized by 1H and 13C NMR, elemental analyses, molar conductance, thermal analysis (TGA), magnetic moment measurement, IR and UV-Vis. On the basis spectral studied and analytical data, it is evident that the Schiff base acts as monodentat ligand coordinating via nitrogen atom. The result showed that Cu(II) complex has octrahedral geometry. The studied complex was tested for anticancer activity. The anticancer activity of Cu(II) complex is evaluated against liver Carninoma (HEPG2) cell lines. These compound exhibites a moderate and weak activity against HCT 116 cell line with IC50 19.8 mM. DOI: http://dx.doi.org/10.15408/jkv.v0i0.3328

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Dr. Sandra Hermanto, M.Si

Contact Email
hermantokimia@uinjkt.ac.id

Phone
+6285220042401

Journal Mail Official
kimia@uinjkt.ac.id

Editorial Address
Program Studi Kimia, Fakultas Sains dan Teknologi, UIN Syarif Hidayatullah Jakarta

Location
Kota tangerang selatan,

Banten

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Dr. Sandra Hermanto, M.Si

Contact Email hermantokimia@uinjkt.ac.id

Phone +6285220042401

Journal Mail Official kimia@uinjkt.ac.id

Editorial Address Program Studi Kimia, Fakultas Sains dan Teknologi, UIN Syarif Hidayatullah Jakarta

Location Kota tangerang selatan, Banten INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Dr. Sandra Hermanto, M.Si

Contact Email
hermantokimia@uinjkt.ac.id

Phone
+6285220042401

Journal Mail Official
kimia@uinjkt.ac.id

Editorial Address
Program Studi Kimia, Fakultas Sains dan Teknologi, UIN Syarif Hidayatullah Jakarta

Location
Kota tangerang selatan,

Banten

INDONESIA