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Journal of Clinical Pharmacy and Pharmaceutical Science
Published by Politeknik Katolik Mangunwijaya
ISSN : 28293452     EISSN : 28293460     DOI : 10.61740
Core Subject : Health,
Medicine & Pharmacology
spek ilmu Farmasi Sains dan Klinis meliputi: Ilmu Farmasi, Farmasi-Biologi, Farmasi-Kimia, Farmasi-Fisika, Farmakognosi, Mikrobiologi Farmasi,
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 33 Documents
 1   2   3   4 
EVALUASI BIAYA KEMOTERAPI PASIEN EARLY BREAST CANCER DI RSUD TUGUREJO SEMARANG PERIODE JULI-DESEMBER 2018 Wilis Rakhmadhanti; Fef Rukminingsih
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.1

Abstract

Early breast cancer (EBC) is defined as with or without in a breast cancer, but it has not metastasized to wider tissue. Chemotherapy expense  has 59% portion of the total cost of cander patients at the hospital. There were 137 EBC patients visit during January-March 2018 conducted at Tugurejo Regional Hospital Semarang. Therefore, research is needed to evaluate the cost of chemotherapy in EBC patient in Tugurejo  Hospital Semarang. This study was an observational descriptive study with a cross sectional study design. Data sources were gained from Medical Record (MR) data and billing / billing data for National Health Insurance (JKN) participant patients with an EBC diagnosis undergoing chemotherapy at Tugurejo Hospital Semarang in the period July-December 2018. The inclusion criteria for this study was JKN patients with EBC diagnosis age 17 -65 years who did chemotherapy at Tugurejo General Hospital Semarang in the period July-December 2018. Data was processed qualitatively and quantitatively. The results of evaluation of  the cost of chemotherapy for EBC patients at Tugurejo Hospital Semarang in the period July-December 2018 were done with the regimen Doxorubicin-Doxetacel-Fluorouracil (AT-F) Rp 3.683.388,00 ± 193.960, Doxetacel-Epirubicin-Fluorouracil (TE-F) Rp 4.342.914 00 ± 37.614, Fluorouracil-Epirubicin-Cyclofosphamid (FEC) Rp 2.929.464,00 ± 193.960, Fluorouracil-Doxorubicin-Cyclofosphamid (FAC) amounting to Rp2.471.671,00 ± 193.960.  
ANALISIS CEMARAN LOGAM BERAT KADMIUM (Cd) DALAM JAMU PEGAL LINU DENGAN METODE SPEKTROFOTOMETRI SERAPAN ATOM (SSA) Gabriel Lauranita Geovanny Devi; Maria Mita Susanti
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.2

Abstract

Pegal linu traditional medicine is one of tradisional medicine that are in great demand by the community, such as in the district of Mranggen, Demak, as much as 66,50% of the people consume pegal linu traditional medicine. One of the security aspects that need to be considered in traditional medicine is the presence of heavy metal contamination. The research aims to determine the levels of Cd heavy metals in pegal linu traditional medicine with capsule dosage forms that are based on the district of Mranggen, Demak are in accordance with the regulation of BPOM RI in 2014 regrading heavy metal contamination in traditional medicines, ≤ 0,3 mg/kg. This research use explorative experimental, including : sampling, sample preparation used wet closed destruction method with HNO3 and H2SO4 (3:1)  of the destruction solution in the Kjeldhal flask, qualitative analysis of Cd with color test and Cd quantitative analysis using Atomic Absorption Spectroscopy (AAS). The results of the quantitative analysis in this study did not show the metal content of Cd, this was due the small Cd content in the sample. Quantitative analysis shows that the Cd level in 12 sampels of pegal linu traditional medicine circulating in the distric of Mranggen, Demak exceeded the threshold of heavy metal contamination determined by BPOM RI in 2014 with the highest average levels of 18,86 mg/kg and the lower average levels of 7,38 mg/kg.  
HIPERTENSI EMERGENSI DI INTENSIVE CARE UNIT (ICU) RUMAH SAKIT UMUM DAERAH (RSUD) TUGUREJO SEMARANG Setyoningrum Pujiastuti; Fef Rukminingsih
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.3

Abstract

A sudden increase in blood pressure reaching> 180/120 mmHg accompanied by involvement of organ damage is called hypertensive emergencies. Nationwide Emergency Department recorded visits of hypertensive emergency cases as much as 3309 million in 2006 and 6178 million in 2013. The Hospital data information system (SIMRS) in Tugurejo Regional Hospital Semarang in 2017 found that the number of patients diagnosed with hypertension reached 1,125 patients. The aim of this study was to evaluate the use of antihypertension in hypertensive emergency patients in the Intensive Care Unit (ICU) of Tugurejo Hospital Semarang in the period January - December 2018. This study is a descriptive observational study using retrospective data. Data retrieval was done by looking at the medical record data of patients with hypertensive emergencies who received hypertension therapy in the ICU Tugurejo Hospital in the period January - December 2018. Data were analyzed based on patient characteristics, antihypertensive use patterns and evaluation of antihypertensive use. The number of patients who fulfilled the inclusion and exclusion criteria were 58 patients. The results of this study indicate that the suitability of antihypertensive use in decreasing systolic blood pressure at 1 hour, 2 – 6 hours, 24 – 48 hours in a row is 81.03%; 24.14%; 20.93%. Whereas for a decrease in diastolic blood pressure at 1 hour, 2 – 6 hours, 24 – 48 hours respectively 77.59%; 43.10%; 74.42% according to the ACC / AHA guidelines (2018).     
PENGARUH VARIASI KONSENTRASI CROSCARMELLOSE SODIUM SEBAGAI SUPERDISINTEGRANT TERHADAP KARAKTERISTIK FISIK FAST DISSOLVING TABLET (FDT) GLIBENKLAMID Sendy Fitriani; Monica Kristiani
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.4

Abstract

   Glibenclamide is a second generation DM drug sulfonylurea group with the properties of lowering blood sugar levels. Most glibenklamid preparations are available in conventional tablet form and can be developed into pharmaceutical preparations that are more practical and accelerate the therapeutic effect of Fast Dissolving Tablet (FDT). The physical characteristics of the FDT are faster wetting and disintegration times compared to conventional tablets. Superdisintegrant is an important component in FDT preparations because it affects the time of wettability and disintegration time of FDT. The purpose of this study was to determine the effect of variations in the concentration of croscarmellose sodium as a superdisintegrant on the physical characteristics of FDT glibenclamide preparations of croscarmellose sodium concentration which gave the best characteristics.The type of research used is experimental research. Used study design a completely randomized pattern design in line with one factor. The manufacture of glibenclamide FDT uses the direct press method. The croscarmellose sodium concentration used is 3%, 4%, and 5%. The testing of FDT physical characteristics includes organoleptic, uniformity of weight, dimensions, hardness, friability, wettability time and FDT disintegration time.The results of statistical analysis showed that variations in the concentration of croscarmellose sodium as a superdisintegrant had an effect on the physical characteristics of FDT glibenclamide which included hardness, wettability and disintegration time, but had no effect on organoleptic, uniform weight, dimensions, and fragility. Based on the results of the characteristics and statistics, the formula III is the formula that provides the best physical characteristics.  
EVALUASI KADAR GLUKOSA DARAH PASIEN DIABETES MELITUS TIPE 2 DENGAN HIPERTENSI DI RUANG CEMPAKA RUMAH SAKIT PANTI WILASA CITARUM SEMARANG Wisma Supriatining Krestiana; Paulina Maya Octasari
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 1 (2022): April: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i1.5

Abstract

Diabetes mellitus is a degenerative disease that increases every year in the world. The most common case of DM is a case of type 2 DM (90%). Type 2 DM with hypertension is one of the ten biggest diseases in Panti Wilasa Citarum Hospital Semarang. The purpose of this study was to evaluate and calculate the value of decreasing blood glucose levels. The type of research conducted was descriptive observational using a prospective method. The study was conducted in Cempaka Room at Panti Wilasa Citarum Hospital Semarang in the period March-April 2019. The research subjects were patients aged 18-60 years with National Health Insurance who met the inclusion-exclusion criteria who were willing to be respondents in this study. Data is processed and analyzed qualitatively and quantitatively. The results showed that the target blood glucose level of type 2 DM patients with hypertension at Panti Wilasa Citarum Hospital Semarang was achieved. Patients experienced a decrease in GD2JPP and GDP levels in single antidiabetic therapy of 73.68%, two combinations of antidiabetic 95%, three combinations of antidiabetic 100%.
Evaluasi Kelengkapan Administratif dan Farmasetis Resep di Poliklinik Anak Rumah Sakit Karanggede Sisma Medika Boyolali Paulina Maya Octasari; Patriana Agustin Windasari
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 2 (2022): Oktober: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i2.8

Abstract

Prescription screening is one of the pharmaceutical services carried out by reviewing prescriptions according to administrative, pharmaceutical and clinical requirements. Administrative and pharmaceutical requirements ensure the legality of prescriptions, correct identification and successful treatment of patients. The purpose of this study was to evaluate the administrative and pharmaceutical completeness of prescriptions at the Children's Polyclinic Karanggede Sisma Medika Hospital Boyolali. This research was carried out in an observational descriptive manner with retrospective data from prescriptions at the Children's Polyclinic at Karanggede Sisma Medika Boyolali Hospital for the period July – September 2021, with a total sample of 215 prescription sheets. The complete administrative prescription data includes the patient's name, medical record number, gender, date of birth, doctor's name, doctor's initials and date of prescription. Complete prescription pharmaceutical data include the name of the drug, the dosage form, the strength of the preparation, the dosage unit, the amount of the drug, the rules for use and how to use it. The data were analyzed quantitatively to determine the percentage of administrative completeness, pharmaceutical completeness, and both. The study was conducted with 215 prescriptions. The results of this study showed that 43.72% of prescriptions were administratively complete which consisted of 100% of the patient's names. As many as 60% are complete pharmaceutically consisting of the name of the drug, the form of the drug and the amount of the drug by 100%, and 28.37% complete both.
Uji Daya Antiinflamasi Ekstrak Etanolik Daun Mengkudu (Morinda Citrifolia (L.)) Terhadap Mencit Putih (Mus Musculus) Jantan Galur Swiss Yang Diinduksi Karagenin Paulina Maya Octasari; Andreas Napoleon
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 2 (2022): Oktober: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i2.9

Abstract

Inflammation is the body's response to protect it self from chemicals, infectious agents, and damage to body tissues caused by injury. Flavonoid compounds can be used as anti-inflammatory by inhibiting the activity of cyclooxygenase (COX) and lipoxygenase enzymes. The amount of flavonoid content in noni leaves was 15.97 mg QE/g extract. The difference between this study and the previous research conducted by Rifaldy, et al (2019) lies in the test animals, the method of measuring inflammation, and the dose of extract used. This study aims to determine the anti-inflammatory power and dosage of the ethanolic extract of noni (Morinda citrifolia (L.)) leaves. This study is an experimental study, using a completely randomized design with one-way pattern with one treatment factor, namely variations in the dose of Noni Leaf Ethanolic Extract (EEDM), namely 42 mg/20gBW mice, 56 mg/20gBW mice, and 70 mg/20gBW mice. The anti- inflammatory test method uses artificial edema formation with carrageenin. The research data was in the form of percentage of anti-inflammatory power (%DAI), thenstatistically analyzed using SPSS with 95% confidence level. The results of the anti-inflammatory power of EEDM from the smallest to the largest doses produced anti-inflammatory properties, namely 55.30%, 62.28%, and 69.41%, this means that the larger the dose, the higher the percentage of anti-inflammatory power (p<0.05). The percentage of anti-inflammatory power of EEDM at a dose of 70 mg/20gBW mice had an anti-inflammatory effect that was not significantly different from the positive control (p>0.05).
PEMBUATAN BIOETANOL DARI TANDAN PISANG AMBON MENGGUNAKAN METODE FERMENTASI DENGAN BANTUAN MIKROORGANISME DAN DESTILASI AIR Itsna Diah Kusumaningrum; Melani Dewi
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 2 (2022): Oktober: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i2.10

Abstract

Dalam tandan pisang diduga ada kandungan glukosa sebagai salah satu bahan baku untuk menghasilkan bioetanol. Tujuan penelitian yaitu peneliti ingin membuktikan bahwa tandan pisang Ambon (Musa paradisiaca var. Sapientum (L.) Kunt) menghasilkan bioetanol dengan menggunakan metode fermentasi dengan bantuan mikroorganisme Saccharomyces cerevisiae dan destilasi air. Metode fermentasi yang digunakan dengan bantuan mikroorganisme Saccharomyces cerevisiae, ragi tape NKL 15%. Sedangkan metode destilasi yang digunakan destilasi sederhana atau destilasi air labu alas bulat leher tiga. Desain penelitian yang digunakan adalah rancangan pra Eksperimen berupa posttest only Design / The One Shot Case Study perilakuan intervensi telah dilakukan (X), kemudian dilakukan pengukuran atau posttes. Hasil destilat yang didapatkan 0,44 mL. Evaluasi hasil destilat tandan pisang Ambon dilakukan dengan cara menambahkan asam salisilat, asam sulfat pekat, lalu dipanaskan tecium bau metil salisilat (gondopuro), yang berarti hasil destilat mengandung bioetanol.
Persepsi Orang Tua Terhadap Pentingnya Pemberian Penambah Nafsu Makan Di Posyandu Desa Pamriyan Dra. Metta Dewi, M.Si.,Apt.; Itsna Diah Kusumaningrum
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 2 (2022): Oktober: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i2.11

Abstract

Pemberian nafsu makan dianggap penting ketika anak mulai diberikan asupan makanan selain ASI yaitu pada usia 6 bulan pada saat usia tersebut anak mulai diberikan makanan yang mudah dicerna. Persepsi tehadap penambah nafsu makan merupakan faktor utama yang diteliti pada orang tua yang mengikuti Posyandu di Desa Pamriyan. Penelitian ini bertujuan untuk mengetahui persepsi orang tua terhadap pentingnya penambah nafsu makan anak di Desa Pamriyan. Penelitian ini menggunakan metode deskriptif dengan membagikan kuesioner secara langsung pada subyek peneliti sebanyak 50 responden. Hasil penelitian menunjukkan bahwa sebagian besar orang tua (68%) menjawab kandungan penambah nafsu makan adalah vitamin, dan tidak ada hubungan antara berat badan anak, frekuensi makan anak, usia pemberian MPASI, makanan anak telah memenuhi PGS terhadap pentingnya p
GAMBARAN TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN (KIE) OBAT OLEH APOTEKER DI UPTD PUSKESMAS PATEBON I Y. B. Heru Dwi Purnomo, M.Sc., Apt.; Itsna Diah Kusumaningrum; Dra. Metta Dewi, M.Si.,Apt.
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 1 No. 2 (2022): Oktober: Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v1i2.12

Abstract

Kepuasan adalah tingkat perasaan seseorang setelah membandingkan kinerja atau hasil yang dirasakan sesuai dengan harapannya. Kepuasan pasien menjadi salah satu satu faktor penentu dalam pelayanan KIE obat di UPTD Puskesmas Patebon I Kabupaten Kendal. Penelitian ini bertujuan untuk mengetahui gambaran tingkat kepuasan pasien terhadap pelayanan komunikasi, informasi, dan edukasi (KIE) obat oleh apoteker di UPTD Puskesmas Patebon I Kabupaten Kendal. Penelitian ini menggunakan metode deskriptif dengan membagikan kuesioner secara langsung pada subyek peneliti sebanyak 97 responden. Hasil penelitian menunjukkan bahwa pasien sangat puas pada poin 1 (petugas menanggapi pasien dengan ramah dan tersenyum) sebanyak 52 (53,6%), dan pasien yang cukup puas pada poin 6 (petugas menyampaikan peringatan atau efek samping obat) sebanyak 47 (48,45%). Bagi UPTD Puskesmas Patebon I hendaknya petugas pelayanan obat menyampaikan efek samping dari obat, karena salah penggunaan obat juga berdampak buruk bagi pasien.

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