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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue " Vol 28, No 03 (1996)" : 8 Documents clear
AccomodaUve esotropia combined-type. A case report Wasisdi Gunawan, Wasisdi Gunawan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A 10 year old girl suffering from esotropia for distant vision since she was 4 years old has been reported. Distant correction of S+3 to S + 4 dioptries resulted in orthophoric eye whereas esotropia still developed during the close work. By adding S+3 dioptries for close work this esotropia disappeared. Until now the patient has been using bifocals with comfort. Accommodative esotropia is a type of esotropia accommodative factor. This condition can be caused by hypermetropic refractive anomaly alone so that it is called refractive accommodative esotropia. Consequently corrective measure of underlying refractive errors will correct the eye deviation. Meanwhile esotropia that manifests during the accommodation alone, such as In close work and not due to refractive error is called non refractive accommodative esotropia. This type of esotropla is due to a higher AC/A ratio. Accommodative esotropia combined type is a combination of these two types of esotropia mentioned above. In this type, esotropia still occurs in close work (accommodation) although its refractive anomaly has been corrected. In this case, addition of positive lens 2-3 dioptries for close work (near vision) will cure this accommodative esotropia. The patient needs a bifocals.Key words : accommodative esotropia - non accommodative esotropia - AC/A ratio - distant correction - addition for close work.
Model terapi gen menggunakan sel fibroblas rekombinan yang dibungkus mikrokapsul. Suatu Kajian In Vivo M. Mansyur Romi, M. Mansyur Romi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

Current approaches to human gene therapy focus on insertion of a desired gene into autologous cells such as fibroblasts. hepatocytes, bone marrow stem cells or lymphocytes. An alternate strategy to gene therapy through genetic modification of the patients own cells is to implant into different recipients the same engineered cell line under immunologically isolated conditions. This in vivo study shows that human growth hormone (hGH) as a novel reporter gene product from microencapsulated genetically modified mouse cells is detectable in the circulation of allogenic recipient mice. On day 3 of post implantation no hGH was detected, 3 ng/ml of hGH was detected on day 12 and increased during the next 9 days up to 10-fold. The high level of hGH was maintained during days 21 - 33 post implantation and went down afterward to the baseline on day 45. No hGH was detected in the control mouse implanted with the same amount of free recombinant cells.Key Words: Gene therapy - autologous cells - genetic modification - recombinant cells - lymphocytes
Dipstik leukosit esterase untuk diagnosis servisitis mukopurulenta Kajian pada wanita pekerja seks Meita Dewayani, Meita Dewayani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

Mucopurulent cervicitis (MPC) is an endocervical inflammation that causes a variety of complications, including infertility. The diagnosis of MPC is usually confirmed by counting the number of leucocytes using a Gram stain of an endocervical swab. This method requires trained personnel, microscopic equipment and time to read the result, so the detection of MPC in primary health care setting is often difficult. The leucocyte esterase dipstick (LED) is an easy and rapid method designed for detecting leucocytes, although its role for diagnosing MPC needs to be clarified. In order to test whether LED could be used as Gram stain substitute for diagnosing MPC, a diagnostic study was conducted among 145 female sex workers seeking reproductive health care from Griya Lentera STD clinic, managed by the Indonesia Planned Parenthood Association in Yogyakarta. Endocervical swabs were taken from each subject for Gram staining, a gonorhoeae culture and LED examination. The result showed that compared to Gram staining, the LED had 96.7% sensitivity, 64.81% specificity, a Positive Predictive Value (PPV) of 82.2% and a Negative Predictive Value (NPV) of 92.1 %. Compared to the gonorrhoeae culture, the LED had 100% sensitivity, 32.2% specificity, a PPV of 25.23% and a NPV of 100%. This study concluded that among women at high risk for STD infection the LED could be used as a Gram stain replacement in the diagnose of MPC and as an initial screening method to eliminate MPC caused by gonorrhoeae.Key words : mucopurulent cervicitis - gram stain - leukocyte esterase dipstick - gonococcal microculture -female sex workers.
Ketepatan MESS (mangled extremity severity score) pada penentuan amputasi dini fraktur terbuka tibia tipe III sesuai klasifikasi Gustilo Armis, Armis
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

The amputation and reconstructive procedure of the management of open tibial fracture type III is still of interest and controversy because the amputation effort is considered as a punishment of primary treatment but a reconstructive method in massive lower extremity trauma is difficult. The MESS is a scoring system that can be applied to mangled extremity and help one determines which mangled limb will eventually come to amputation. The record of 28 open tibial fracture type III patients had been reviewed at the SARDJITO hospital 1990-1995. All seven open tibial fracture type Ill C patients with MESS of greater than seven were amputated. According to four tables of blind comparison analyzing MESS value those patients of more than seven was found to have a positive predictive of 100 % that may be best treated by primary amputation. In conclusion the MESS is an early and accurate predictor for identifying the extremity that may be best treated by amputation or reconstruction.Key words : open fracture - MESS - tibial fracture - amputation - mangled extremity
Positive effect of magnetism on cerebral malaria (A hypothesis) Sugeng Juwono Mardihusodo, Sugeng Juwono Mardihusodo
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

Cerebral malaria (CM) is one of serious complications of falciparum malaria that may cause high mortality rate in a malaria endemic area where Plasmodium falciparum is predominant. Based on a lot of histopathological findings, pathogenesis of CM is thought to be mainly caused by the blockade of cerebral vessels by parasitized red blood cells (PRBC), that could be aggravated by secondary factors such as depositions of immune complexes in brain capillaries, reduced humoral or cell-mediated immune responses, action of endotoxin, and the action of tumor necrosis factor (TNF). Biological effects of magnetism have been extensively and intensively studied in the past five decades including their applications to the treatment of common diseases. Among other conclusions reached by scientists after innumerable experimentations in the field of biomagnetism are (1) living systems are very sensitive to magnetic fields and magnetic effect reaches every cells in the body on account of the highly pervasive character of magnetism; (2) as the entire body is infused with electrical energy and magnetic fields exist in every part of it, magnets, if properly applied exercise a positive effect on the electrical response behaviour pattern; (3) effects on the blood picture and on erythrocyte sedimentation rate result, from exposure of the organism to a constant magnetic field which initiate biochemical changes; (4) a magnetic field can exert direct influence on the diencephalon and the forebrain. Studies on the effect of magnetism on blood revealed the activation of the iron content in the blood and a weak current was discerned to have been generated, the process of ionisation was hastened which freed the blood from danger of clotting and stimulated easier and more spontaneous flow of blood through the blood vessels and capillaries. It is hypothesized, therefore, that magnetism exerts a positive effect on CM.Key Words : magnetotherapy - biomagnetism - biomagnetics - malaria - biomagnetology
Pengaruh penutupan arteri renalis terhadap kadar ion-ion Na, K, Ca dan jumlah eritrosit, trombosit serta hematokrit pada anjing Bambang Soejatno, Bambang Soejatno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Universitas Gadjah Mada

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Abstract

The effect of renal artery occlusion on the blood concentrations of sodium, potassium and calcium as well as on the amount of red blood cells, blood platelets and hematocrite were studied in dogs. Twenty dogs, both sexes, were used in this experiment. The dogs were anesthetized with ketalar and chloralose. The systemic blood pressure was continously monitored during the experiment. The experiment was done under normal systemic blood, left renal artery occlusion,, and on both renal arteries occlusion. The dogs were divided into four groups according to both sexes and body weight. The results showed that during the occlusion of renal artery the blood pressure increased (6.27 - 18.28%). The increase of systemic blood pressure was followed by the increase of the amount of red blood cells, blood platelets and hematocrite. The serum electrolytes concentration of sodium of both increased or decreased. The concentration of potasium and calcium decreased and increased respectively. The concentrations of sodium, potassium and calcium in the urine decreased during the occlusion of the renal artery.Key Words: renal artery occlusion - erythrocytes - blood platelets - urine electrocytes - blood electrolytes
Sensitivitas rapid test untuk mendeteksi hepatitis surface antigen (HBsAg) pada penderita hepatitis-B Suwarso, Suwarso
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

A new rapid-test, sandwich immunochromatography assay technique has been recently introduced for the routine, rapid, qualitative detection of the presence hepatitis-B surface antigen (HBsAgl. To evaluate the sensitivity of rapid test, we studied 39 sera positive and one sera negative for HBsAg with conventional ELISA method. The study found that the minimal detectable level of HBsAg with rapid test was 4.03 ng/ml (range 3,25-4,03 ng/ml), it was 8 times less sensitive than conventional ELISA method (4,03 vs 0,47 ng/m1)• Many factors such as "eddy diffusion" and structure of HBsAg, humidity, direct contact with sunlight and sera of borderline-low level of HBsAg with conventional ELISA had a potency for lower sensitivity of rapid test; conversely, technical factors such as adhesion, migration and viscosity of the samples do not.Key words : rapid test - dry chemistry hepatitis surface antigen (HBsAg) - sensitivity - ELISA.
Epilepsi refrakter Harsono, Harsono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 28, No 03 (1996)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

In most patients with epilepsy the prognosis for seizure control is very good. However, about 10-20% of patients develop chronic or refractory epilepsy despite the advent of new antiepileptic drugs and intensive monitoring. Meanwhile, the definition of refractory or intractable epilepsy may vary, and a correct diagnostic work-up is of the utmost importance for the choice of treatment. Refractory epilepsy represents a challenge for both experimental and clinical research to obtain knowledge about why and how it develops and whether the condition can be prevented by early and adequate treatment. Definitions and epidemiology, experimental models, diagnostic evaluation, consequences, risk and costs, medical management, neurosurgery, and vagus stimulation are all important elements in managing refractory epilepsy. When dealing with therapy-resistant patients, a systemic step-by-step evaluation is essential. This includes: diagnosis, seizure/syndrome classification, aetiological considerations, review of drug treatment hitherto given, and evaluation of significant learning and psychosocial problems.Key words : refractory epilepsy - seizure - diagnostic evaluation - medical management - aetiological consideration

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