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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 16 Documents

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Search results for , issue "Vol 10, No 3 (2020): Pharmaciana" : 16 Documents clear

Antioxidant activity and sun protection factor evaluation for cream formulation of purified roasted corn silk extracts (Zea Mays L. Saccharata) Munifatul Lailiyah; Sony Andika Saputra; Fita Sari
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Free radicals might cause harmful effects on the skin, such as skin irritation, change of skin color, and worst effect. Phenolics play a role as effective sunscreen and antioxidants to prevent UV radiation effects. Corn silk contains flavonoids, which are antioxidants that are potential as sunscreen. Phenolic compounds can be identified by phytochemical screening using the tube method. The study aims to know the antioxidant activity of purified extract of roasted corn silks (Zea Mays L. saccharata) and know the SPF level of the cream preparation. The study was conducted by collecting samples of roasted corn silks waste to make dried simplicial, then extracting it with 70% ethanol as solvent, evaporated till condensed extract is gotten. The obtained extract was then purified with n-hexane solvent. The antioxidant activity test was conducted by using the DPPH method. The cream of the purified extract was made in three formulations: 1%, 5%, and 10% concentration. Its SPF levels were then evaluated. The results showed the purified corn silks extract had an IC50 value of 256.66 Âµg/mL better compared to corn silks ethanol extract having an IC50 value of 356.17 Âµg/mL including the weak antioxidant category. Meanwhile, the SPF level test results for concentration of 1%, 5%, and 10% Â are 1.27 ; 2.41; and 5.94 respectively.

Impact of supplementation with beetroot juice (Beta vulgaris L) on levels of malondialdehyde and antioxidant status in athletes Fajar Apollo Sinaga; Rika Nailuvar Sinaga
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Strenuous physical activity can increase lipid peroxidation, which is characterized by increased levels of malondialdehyde (MDA) and decreased levels of antioxidants. It can drop the athlete's performance and health. It is possible to avoid or reduce lipid peroxidation through supplementation with antioxidants. Beetroot (Beta vulgaris L) produces different forms of natural antioxidants; however, its effectiveness still needs to be investigated. This research aimed to determine the impact of beetroot juice on the malondialdehyde concentration and antioxidant status during strenuous physical activity. The research used experimental (pre-test-post-test) using a control group. The researchers divided a total of 30 students who met the criteria into two groups (Experiment; n = 15; control; n = 15). The experimental group drank 250 mL of the juice 1 hour before training for four weeks. After the strenuous physical activity was carried out with a beep test, the researchers also checked the concentrations of MDA, TAC, and VO2max. The findings indicated a decrease in MDA concentration and an increase in TAC and VO2max to the training group that received 250 ml beet juice (p <0.05). The research concluded that beetroot juice administration during exercise could reduce malondialdehyde concentration and increase total antioxidant capacity and VO2max in athletes.

Antioxidant activity assay of white Turi (Sesbania grandiflora (L.) Pers.) extracts using DPPH radical scavenging method Jamilatur Rohmah; Ida Agustini Saidi; Chylen Setiyo Rini; Zulfida Ainindiyah Putri Purwanto; Karlia Hedit Tiana; Tri Chahyani Rahmawati Putri
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Turi (Sesbania grandiflora (L.) Pers.) is a type of plant belonging to the Fabaceae family that is widespread in Indonesian territory and has the potential as a natural free radical scavenger. The study aims to compare the antioxidant activity from white Turi (Sesbania grandiflora (L.) Pers.) leaf extracts in various extraction solvents. The determination of antioxidant activity was carried out using the DPPH method with a UV-Vis spectrophotometer. The turi plants used were originated from Mojosari, Mojokerto, East Java, Indonesia. Simplicia turi leaves were macerated in various extraction solvents: ethanol, ethyl acetate, and n-hexane for 24 hours. The extraction results are then subjected to phytochemical and antioxidant activity tests. The obtained result shows that the white turi extract has antioxidant activity with strong activity against DPPH radicals; with n-hexane > ethyl acetate extract > ethanol extract. The IC50 values of ethanol, n-hexane, and ethyl acetate extracts of white turi leaves were 33.09 ppm; 26.99 ppm; and 25.33 ppm. Based on these results, the white turi plant (leaves) can be one of the natural sources of antioxidants to prevent diseases caused by free radicals.

Cox-2 inhibition activities of creams containing anguilla bicolor and sea cucumbers extract on croton oil induced inflammation in mice Heru Sasongko; Waliyyin Razan Qanit; Raka Sukmabayu W.S; Agung Putu S.P.Kristyawan; Nining Sugihartini; Wisnu Kundarto; Dian Eka Ermawati
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The fatty acids, like EPA and DHA, were known as anti-inflammation. It works on inflammatory tissue, brought by edema plasma, and changed into resolvins, protectins, and maresins by the enzyme reaction. Anguilla bicolor and Sea cucumber fish are known to contain EPA and DHA. This study analyzes the inhibition Cox-2 effect of the combination of Anguilla bicolor oil with Sea cucumber extract as an active ingredient in a cream preparation. This experiment used 7 groups of male BALB/C strain mice: normal control; negative control; positive control; A. bicolor oil cream; H. leucospilota extract cream; a combination of A. bicolor : H. leucospilota (2:1) cream; a combination of A. bicolor : H. leucospilota (1:2) cream. The anti-inflammatory activity was evaluated by the amount of inflammatory cell, the thickness epidermis, and the amount of cell expression COX-2Â on mice's back skin tissue induced by croton oil (0,1 %). After 3 days, histopathological skin tissues were made. The data were analyzed statistically by One Way ANOVA followed by LSD to know each group's differences at a significance level of 0.05. The experiment results showed that the formula with the best anti-inflammatory activities is the combination of A. bicolor and H. leucospilota (2:1) cream.Â The decrease of the amount of inflammatory cell (75.97%), the thickness of the epidermis (43.88%), and the amount of COX-2 cell expressions (60.52%) from the formula did not differ significantly with the positive control (p>0,05). It can be concluded that A. bicolor and H. leucospilota have anti-inflammation activity based on the experiment results.

Antiobesity activity of bambu tali (Gigantochloa apus (Schult.) Kurz) leaves tea in wistar rats Desi Ambarwati; Sapto Yuliani; Arsyannur Pratiwi
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Obesity is an increase in body weight that exceeds normal and the risk of serious illness. Bambu Tali leaves (Gigantochloa apus (Schult.) Kurz) contain flavonoids, tannins, and saponins, which can inhibit the absorption of fatty acids in the digestive tract and excrete them through feces to lose weight. This study examines the tea activity of the Bambu Tali leaves in inhibiting weight gain, total cholesterol, and triglyceride levels of obese Wistar rats fed with a high-fat diet (HFD). A total of 30 Wistar rats were divided into 6 groups: normal control (standard feed), negative control (HFD), positive control (HFD + Orlistat), and 3 groups of tea doses of Bambu Tali leaves (HFD + 360, HFD + 720, HFD + 1440 mg/kg BW). HFD was given together with the Bambu Tali leaf tea for 35 days. On the 36th day, the blood sample was taken to measure cholesterol and triglyceride levels. The weighing was conducted weekly. The results showed that giving HFDincreased body weight significantly, total cholesterol, and triglyceride levels (p <0.05). Bambu Tali leaf tea at doses of 720 and 1440 mg/kg BW could significantly inhibit weight gain (p <0.05). Bambu Tali leaf tea with doses of 360, 720, and 1440 mg/kg BW can also inhibit the increase in total cholesterol levels (p<0.05). Meanwhile, the inhibition of a significant increase in triglyceride levels (p <0.05) only occurs at a dose of 1440 mg/kg BW. This study concludes that Bambu Tali leaf tea has antiobesity activity by inhibiting weight gain, total cholesterol levels, and plasma triglycerides of Wistar rats.

Physical evaluation of lipstick contains encapsulated beet (Beta vulgaris linn.) root water extract in maltodextrin Hilda Srivaliana Ilham; Anita Sukmawati
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The natural dyes from beet (Beta vulgaris Linn) (BV) roots can be used as coloring agents in lipsticks. However, the dye has low stability in high temperature and light and can be oxidized by air. The dye was encapsulated into a microparticle (MP) using maltodextrin (MD) as a matrix to improve color stability. The research's objective was to evaluate the effect of various MD concentrations in encapsulated BV root extract towards physical characterizations of MP and lipsticks, including pH, lipstick hardness, melting point, and color stability. The BV roots water extract was obtained by grinding BV root into a juice and then dried using a freeze dryer. The encapsulation of the BV root extract was using MD as a matrix with a ratio of 1:5 BV dried extract to MD. The MD solution concentrations used in this experiment were 25%, 50%, and 75% (w/v). The result showed that the morphology of MPs resulting from the encapsulation is amorphous. Lipsticks were characterized by pink color and had shape according to the lipstick mold. The lipstick color changed to brown on the seventh day and faded on the 28th day. The variation of MD concentrations during MP preparation did not significantly influence the lipstick's pH value, hardness and melting point.

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Muhammad Syahrir

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA