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Biology, Medicine, & Natural Product Chemistry

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Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta

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Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.

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Articles 196 Documents

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A Stability Mathematical Model of Nasopharyngeal Carcinoma on Cellular Level Sugiyanto Sugiyanto; Fajar Adi Kusumo; Lina Aryati; Mardiah Suci Hardianti
Biology, Medicine, & Natural Product Chemistry Vol 5, No 2 (2016)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

This paper discussed the stability of “Tumorigenesis Models” to link between EBV and carcinoma of the nasopharyngeal from normal cell to invasive carcinoma. The review on this case accomplished the previous theorem of equilibrium point on “Tumorigenesis Models”.

Modified Alizarin Red S-Alcian Blue Staining for Reptilian Skeleton Muhammad Ja’far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 5, No 1 (2016)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Skeletal staining is an important method in anatomical study. The aim of the research was to develop staining and clearing method of Reptilian skeleton using Alizarin Red S-Alcian Blue. The specimen were eviscerated, fixed, stained, cleared, and keep in glycerine solution. This modified double-staining has successfully stain bone and cartilage of Reptilian.

Clustering of 18 Local Black Rice Base on Total Anthocyanin Kristamtini Kristamtini; Endang Wisnu Wiranti
Biology, Medicine, & Natural Product Chemistry Vol 6, No 2 (2017)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Black rice has a high anthocyanin content in the pericarp layer, which provides a dark purple color. Anthocyanin serve as an antioxidant that control cholesterol level in the blood, prevent anemia, potentially improve the body's resistance to disease, improve damage to liver cells (hepatitis and chirrosis), prevent impaired kidney function, prevent cancer/tumors, slows down antiaging, and prevent atherosclerosis and cardiovascular disease. Exploration results at AIAT Yogyakarta, Indonesia from 2011 to 2014 obtained 18 cultivar of local black rice Indonesia. The names of the rice are related to the color (black, red or purple) formed by anthocyanin deposits in the pericarp layer, seed coat or aleuron. The objective of the study was to classify several types of local black rice from explorations based on the total anthocyanin content. The study was conducted by clustering analyzing the total anthocyanin content of 18 local black rice cultivars in Indonesia. Cluster analysis of total anthocyanin content were done using SAS ver. 9.2. Clustering dendogram shows that there were 4 groups of black rice cultivars based on the total anthocyanin content. Group I consists of Melik black rice, Patalan black rice, Yunianto black rice, Muharjo black rice, Ngatijo black rice, short life of Tugiyo black rice, Andel hitam 1, Jlitheng, and Sragen black rice. Group II consists of Pari ireng, Magelang black hairy rice, Banjarnegara-Wonosobo black rice, and Banjarnegara black rice. Group III consists of NTT black rice, Magelang non hairy black rice, Sembada hitam, and longevity Tugiyo black rice. Group IV consist only one type of black rice namely Cempo ireng. The grouping result indicate the existence of duplicate names among the black rice namely Patalan with Yunianto black rice, and short life Tugiyo with Andel hitam 1 black rice.

Antioxidant Capacity Comparison of Ethanolic Extract of Soursop (Annona muricata Linn.) Leaves and Seeds as Cancer Prevention Candidate Dyah Ayu Widyastuti; Praptining Rahayu
Biology, Medicine, & Natural Product Chemistry Vol 6, No 1 (2017)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Annona muricata Linn. (soursop) is one of tropical plants which have relatively complete chemical compounds. It has flavonoid, tannin, phytosterol, alkaloid, etc. The high antioxidant compound in soursop is believed as cancer prevention so the cancer threat in the world can be minimized. The antioxidant compound in soursop can be found not only in its fruit, but also in other parts like leaves, seeds, etc. Based on that potency, this study aimed to compare antioxidant capacity of soursop leaves and seeds, also to study about the utilization of soursop parts which is usually not used. This research began with maceration to extract leaves and seeds with 96% ethanol. Ethanolic extract of soursop leaves and seeds were then tested for antioxidant capacity with DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The result showed that antioxidant capacity of soursop leaves and seeds are 85,66875% and 39,0166, respectively. The antioxidant capacity of leaves is higher than seeds due to seed’s extraction difficulty so its antioxidant compound could not be extracted optimally. However, either leaves or seeds extract in this study are potential as antioxidant resources because there are no significant differences between antioxidant capacity of both extract.

Checklist of Macroalgae in Waisai Coast, Raja Ampat Retno Suryandari; Widodo Widodo
Biology, Medicine, & Natural Product Chemistry Vol 5, No 1 (2016)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Macroalgae are very abundant organisms in Indonesian coastal zone. They comprise 8.6% of the total marine organisms.The aim of the research was to identify macroalgae in Waisai Coast Raja Ampat. The results showed that 38 macroalgae were found in Waisai Coast Raja Ampat but only 29 species of macroalgae can be identified. Macroalgae found in Waisai Coast Raja Ampat are green algae, red algae and brown algae. Green algae found and identified are Caulerpa macra (Weber-van Bosse) Draisma & Prud’homme, Caulerpa racemosa var. macrophysa (Sonder wx Kutzing) W.R.Taylor, Caulerpa sertularoides (S. Gmelin) Howe f. brevipes (J. Agardh Svedilus), Caulerpa cupressoides (Vahl) C. Agardh, Halimeda discoidea Decaisne, Halimeda Opuntia (Linnaeus) J.V. Lamoroux, Halimeda tuna (J. Ellis & Solander) J.V. Lamoroux, Halimeda cylindraceae Decaisne, Halimeda macroloba Decaisne, Avrainvillea erecta (Berkeley) A. Gepp & E.S. Gepp, Codium geppiorum O.C.Schmidt, Boergesenia forbesii (Hardvey) Feldmann, Valonia ventricosa J. Agardh, Dictyosphaeria cavernosa (Forsskål) Børgesen, Chaetomorpha spiralisOkamura, Anadyomene wrightii Harvey ex. J. E. Gray, Neomeris annulata Dickie. Red algae species found and successfully identified areAcanthophora spicifera (M. Vahl) Børgesen, Laurencia papilosa (C. Agardh) Greville, Gracilaria salicornia (C. Agardh) E.Y. Dawson, Amphiora fragilissima (Linnaeus) J.V. Lamoroux, Hypnea pannosa J. Agardh. Brown algae species found and identified are Hormophysa cuneiformis (J.F. Gmelin) P.C. Silva, Sargassum aquifolium (Turner) C. Agardh, Sargassum polycystum C. Agardh, Turbinaria ornata (Turner) J. Agardh, Padina australis Hauck, Canistrocarpus cervicornis (Kutzing) De Paula & De Clerck Hydroclathrus clatratus (C. Agardh ) M. Howe. The only species found in Indonesia is Sargassum aquifolium.

Vitamin C and Total Sugar Content Characterization on 31 Accessions of Banana Collection of Banana Germplasm Plants of Yogyakarta Indrasari, Siti Dewi; Kristamtini, Kristamtini; Wiranti, Endang Wisnu
Biology, Medicine, & Natural Product Chemistry Vol 6, No 2 (2017)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Banana is one of the tropical fruits that people like because it tastes good and contains good nutritional value that beneficial for health.Ã‚Â The content of vitamin C and total sugar are an important character to complete the morphological characterization of banana accession that can be utilized by breeders in choosing accession as parent. The study aimed to determine the content of vitamin C and total sugar on 31 accessions of banana collection of Banana Germplasm Plants of Yogyakarta. The research was conducted at Banana Germplasm Plantation and Laboratory of Agricultural Technology Production of Gadjah Mada University, Yogyakarta from January to December 2016. The results indicated that 31 banana accessions showed their susceptibility to vitamin C content 60.42 + 39.22 mg / 100 g and total sugar 22.06 + 16.01%. High standard deviation values indicate the large diversity of banana accessions that were characterized, indicating that the accessions of each characterized banana were separate accessions of one another.

Analysis of Bull Sperm DNA Abnormalities Due to Cadmium Accumulation Fuad Fitriawan
Biology, Medicine, & Natural Product Chemistry Vol 6, No 1 (2017)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Sperm abnormalities can occur by various causes. Abnormality of sperm is usually characterized by abnormal sperm motility and viability. This was caused by the inability of mitochondria on ATP-ase in producing ATP and ecto-enzyme Cik role in keeping the movement so that movement of sperm motility declines. Research that leads to total abnormal sperm DNA analysis is still rare. The purpose of this research was to get the results of the molecular characteristic picture of the overall characteristics of DNA loci that have abnormalities in bull sperm and get a picture of differences in overall DNA loci of abnormal and normal sperm. This research was conducted in October-December 2016. With the results of Group I consists of D, E with a percent similarity of 92.308%, group II consists of C and Group I with a percentage similarity of 50.125%, group II consists of A and B with a percent similarity of 100%, group II and group III with a percentage similarity of 0%. Based on the above data it can be concluded that the treatment A and B is not suspected to cause DNA damage compared to treatment C, D and E.

Starch-Glycerol Based Edible Film and Effect of Rosella (Hibiscus Sabdariffa Linn) Extract and Surimi Dumbo Catfish (Clarias gariepinus) Addition on Its Mechanical Properties Endaruji Sedyadi; Syafiana Khusna Aini; Dewi Anggraini; Dian Prihatiningtias Ekawati
Biology, Medicine, & Natural Product Chemistry Vol 5, No 2 (2016)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Effect of Rosella (Hibiscus Sabdariffa Linn) Extract and Surimi Dumbo catfish (Clarias gariepinus) addition on Starch-Based Edible Film-Glycerol Mechanical Properties has been done. The purpose of this study is to create an active environment-friendly packaging material. Surimi additions are intended to improve the mechanical properties of bioplastics and additions of Rosella extract intended as a bio-indicator of acidity. The method used was Solvent Casting. An amount of surimi and rosella extract varied to obtain the best mechanical properties. The results shows that the addition of surimi and rosella flower extract significantly effect the elongation of Edible films produced up to 27%.

Alliin as a Natural Bioactive from Single Bulb Garlic (Allium sativum) for Nitric Oxide (NO) Increasing in Atherosclerotic Process Based on Insilico Screening Riza Rahayu Ilmawati; Ahya Zhilalikbar Amin; Mohamad Amin
Biology, Medicine, & Natural Product Chemistry Vol 6, No 2 (2017)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Atherosclerosis is a chronic inflammatory disease in the arterial wall mediated by proinflammatory factor. Atherosclerosis cause heart disease and stroke is generally believed to be preventable. The single bulb garlic is one of the local plants known as the medicinal plant in Indonesia. Garlic contains alliin compounds as antiatherosclerotic agent. This study aimed to determine the potential of active compound of single bulb garlic as an antioxidant that improve endothelial function by increasing nitric oxide (NO) to increase vasodilation. The bioinformatics webserver used in this study are: Pubchem, Pharmmapper, Swiss Target Prediction, Superpred, Uniprot, and Protein Data Bank. Docking software using PyRx, PyMOL and Discovery Studio. Based on these steps, it was found that alliin interacts with nitric oxide synthase (NOS) through hydrogen and alkyl bonds. Alliin is effective as an inhibitor of NOS based on binding afinity (-5.4 kcal / mol) although no more negative than an aspirin inhibitor based on binding afinity (-6.5 kcal / mol). Based on the docking results, it is found that alliin is effective as a potential drug to decreased atherosclerosis.

Leukocytes Description of Mudskipper (Periophthalmodon schlosseri) of Barito River Estuary, Desa Tanipah, Kalimantan Selatan Heri Budi Santoso; Hidayaturrahmah Hidayaturrahmah; Muhamat Muhamat
Biology, Medicine, & Natural Product Chemistry Vol 7, No 1 (2018)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Leukocytes have an important role in driving away infections from pathogen microorganism by phagocytosis together with macrophages. The aim of this research was to analyze the leukocytes’ differentiation (eosinophil, basophil, neutrophil, lymphocytes, and monocytes) of mudskipper‘s blood (Periophthalmodon schlosseri). Samples were taken from desa Tanipah Kalimantan Selatan. The sampling locations were decided by purposive or taking the data intentionally according to the consideration of mudskipper‘s location which is not homogenous. The data collection were conducted using Line Transect which means the sample was taken according to how many encounters can be taken. There were 15 mudskippers taken from Desa Tanipah used in this research. The parameter observed wasthe differentiation of leukocytes which consists of the percentages of monocytes, lymphocytes, eosinophil, basophil, and heterophil. The result showed that the percentage of lymphocytes in mudskippers is 62+4,1% and monocytes 24,7+0,8%, and the neutrophil is 0,5+0,1% and eosinophil 0,6+0,1% and no basophils were found. According to the result, it can be concluded that lymphocytesis the most dominant one amongst others.

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