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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 10 Documents
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Search results for , issue "Vol 27, No 1 (2022)" : 10 Documents clear
The Spectometric Quantification of Total Content of Flavonoid, Phenol, and Alkaloid in Kesum leaf (Polygonum minus Huds) from West Borneo with Methanol and Ethanol Solvent Dian Kartikasari; Ika Ristia Rahman; Heni Puspasari; Abduh Ridha
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68497

Abstract

Kesum (Polygonum minus Huds) is one of the typical plants that grow in West Borneo. The Kesum leaves are the part which is mostly used. Kesum leaves contain a lot of phytochemical compounds. This study quantitatively determined the total phenolic, flavonoid, and alkaloid contents in methanol and ethanolic extract of Polygonum minus Huds leaves using a spectrophotometric method. The samples were extracted by maceration. The content was determined by using a UV-Vis spectrophotometer. Based on the assay result, the methanol extract contained a total of phenolic 49.351±0.430 ppmEAG (equivalent to gallic acid); total of flavonoids 44.128±0.116ppmEQ (quercetin equivalent); total of alkaloids 356,798±1,004ppmEP (piperine equivalent). The 96% ethanol extract contained total of phenol 46,196±0.329ppmEAG; total of flavonoids 34,969±0.116ppmEQ; total of alkaloids 183.525±0.766ppmEP. The 70% ethanol extract contained total of phenol 64.189+0.215ppmEAG; total of flavonoids 27.834±0.158ppmEQ; total of alkaloids 432,947±1,533ppmEP. The ethanol extract 50% contained total of phenol 67,343±0.164ppmEAG; total of flavonoids 26.063±0.158ppmEQ; total of alkaloids 679,142±2,525ppmEP. All of the results are preliminary data for further research, especially for the isolation of compounds with specific targets or for utilization as main ingredients for traditional medicine.
Accelerated Stability Test of Snakehead Fish Extract (Channa striata) and Kelulut Honey (Heterotrigona itama) Ointment Combination with BHT as an Antioxidant Mohamad Andrie; Wintari Taurina; Dyah Ayuningtias
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68861

Abstract

The oil phase of adeps lanae was used as a basis in the ointment formulation with snakehead fish extract and kelulut honey, which influences wound healing. Adeps lanae has the potential to become rancid due to the high water content in it (25-30%). The use of oil-soluble antioxidants such as Butyl Hydroxy Toluene (BHT) can overcome the rancidity in oil. This study aimed to see how adding BHT as an antioxidant affects the ointment's stability. The ointment is prepared in three different BHT concentrations: F1 (0.0075%), F2 (0.05%), F3 (0.1%), and a control for comparison. Organoleptic tests, homogeneity, spreadability, adhesion, protection power, and acid number were used to evaluate the stability of the preparation over 28 days at 40 ± 2°C / RH 75 ± 5%. The data obtained were analyzed statistically using One Way ANOVA. The addition of BHT affected the preparation's spreadability, adhesion, and acid number but did not affect the organoleptic, homogeneity, or protective power. At F3, there is a significant difference in spreadability (5.57 ± 0.21 cm) and adhesion (89.00±2.00 seconds) based on statistical analysis. F3 is the best ointment based on the physical characteristics test results and the minimum increase in acid number (8.83 mg KOH/g).
Serum Biochemical Changes in Alloxan-induced Diabetic Rats and Ameliorative Effects of Moringa oleifera and Morinda lucida Leaf Extracts Amadi Anthonia Nnenna Chuks; Chinedu-Ndukwe Peace Amarachi; Ijioma Solomon Nnah; Robert Ikechukwu Uroko; Madubike Kelechi Gideon
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.69945

Abstract

This study evaluated the antidiabetic properties and biochemical changes in alloxan-induced diabetic rats treated with Moringa oleifera and Morinda lucida leaf extracts. The acute toxicity values of the extracts were determined before evaluating their antidiabetic effects in 7 groups of 4 rats each. Rats in groups 1-6 were made diabetic via a single injection of alloxan monohydrate (160 mg/kg i.p). Animals whose blood glucose levels rose to 200 mg/dl and above were considered diabetic and used for the study, but group 7 was the normal control. Groups 1 and 2 received 500 and 250 mg/kg of M. oleifera extract, respectively, while groups 3 and 4 received 500 and 250 mg/kg of M. lucida extract, respectively. Group 5 received 3 mg/kg of the standard drug (Daonil), while groups 6 and 7 were the diabetic and normal control groups, respectively. Treatment lasted for 21 days and was administered orally. The phytochemical screening results showed that each of the extracts was rich in phytochemical agents. Higher amounts of flavonoids and terpenoids were found in M. oleifera, while M. lucida had higher phenols and saponins. LD50 value obtained for each extract was above 5000 mg/kg. Results of the antidiabetic study indicated that the extracts significantly brought down glucose levels in the test rats (p<0.05) when compared with the diabetic control. Treatment also restored elevated lipids values, liver function, and renal function parameters in the diabetic rats. The decreased glutathione, catalase, and superoxide dismutase activities and increased lipid peroxidations resulting from diabetes mellitus induction were also significantly corrected following extracts administration when compared with the diabetic control (p<0.05). Our findings show that Moringa oleifera and Morinda lucida extracts may be safe for use in the management of diabetes mellitus and its associated biochemical complications.
Prediction of Anti-SARS CoV-2 Activity from Green Tea Catechin (Camellia sinensis L. Kuntze) Compound Against To Receptors Non-structural Protein 3 (6W6Y) And Non-structural Protein 5 (6M2N) Roihatul Mutiah; Chamlah Ayatillah; Yen yen Ari Indrawijaya; Arief Suryadinata
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.70124

Abstract

Green tea catechin compounds (Camellia sinensis L. Kuntze) have an antiviral activity such as influenza, hepatitis B, hepatitis C, herpes simplex virus, HIV, and proven in vitro antiviral influenza against NSP5 in SARS CoV. These considerations are used in this study using Non-structural Protein (NSP), namely NSP3 and NSP5 in SARS CoV-2, which have a role in viral replication and transcription. This study aims to predict the physicochemical properties according to the five rules of Lipinski's using swissADME. Prediction of toxicity with LD50 classification using the Protox II online tool. Catechin compound activity based on ligand interaction with NSP3 (PDB ID: 6W6Y) and NSP5 (PDB ID: 6M2N) receptors using Molegro Virtual Docker (MVD) 6.0. The results showed the predictions of physicochemical properties of the (-)-epigallocatechin (EGC), (-)-epicatechin-3-gallate (ECG), and (-)-epicatechin (EC) compounds fulfilled the five rules of Lipinski's. Catechin compounds have toxicity at levels 4 and 6. The activity of catechin compounds on NSP3 (PDB ID: 6W6Y) and NSP5 (PDB ID: 6M2N) receptors indicated that all catechin compounds had inhibitory activity. The best potential activity compound is (-)-epigallocatechin-3-gallate (EGCG) with a rerank score of -102.8200 and -134.1800 Kcal/mol so that EGCG can be recommended as a candidate for the SARS CoV-2 antiviral compound.
Antioxidant Activity of TEMON (Clitoria ternatea and Citrus sp.) as an Infused Herbal Tea Wahyu Widowati; Teresa Liliana Wargasetia; Teddy Markus Zakaria; Meganita Marthania; Ria Aprilia Tri Puteri Permata Akbar; Michael Sebastian Gunadi; Nathanael Halim; Sherly Santiadi
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.71628

Abstract

Many people around the world believed that herbal tea had a lot of antioxidants contained in it, thus it was widely drunk all over the world. However, the antioxidant capacities of herbal tea may be various because it is affected by the usage of different plants as its primary ingredient. As a result, this study examines the antioxidant activity of herbal tea made from dried Citrus sp. and Clitoria ternatea flower petals. The antioxidant potential was assessed by performing a DPPH and H2O2 scavenging activity assay on 2,2-diphenyl-1picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) scavenging activity assay, total phenolic, and flavonoid content assay, ABTS reduction, and FRAP assay. This study showed that pure telang (Clitoria ternatea) herbal tea has antioxidant properties. Dried Telang (Clitoria ternatea) tea had the highest activity of antioxidants as we refer to the results of it had the highest activity value in DPPH, ABTS, and FRAP assay and also had the lowest IC-50 value. Followed by TEMON infusion which showed the second-highest antioxidant activity after pure telang infusion. The decrease in antioxidant activity in the mixture of telang and lemon was due to the mixture of lemons which tended to have the lowest antioxidant activity among the three types of infusions tested. The addition of dried lemon has the aim of enhancing the flavor of the tea infusion.
Ethnomedical Study of Plants as a Traditional Medicine on Respiratory System Disease in Cilongok, Banyumas, Indonesia Retno Wahyuningrum; Dondi Pangestu; Arif Budiman
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.72168

Abstract

Indonesia is one of the most geologically complex regions globally and makes it one of the greatest of the world's biodiversity centers. But the primary data on medicinal plants in Indonesia is still lacking. Cilongok is a district in Banyumas located on the slope of Slamet mountain. It is one of the biodiversity areas in Java, Indonesia. Respiratory System Disease has become one of the top ten diseases in Banyumas Indonesia. This study aimed to explore information about the type of medicinal plants used for respiratory system disease and how to process it in Cilongok District, Banyumas Regency, Central Java. This study was descriptive survey research with semi-structured interviews of 68 informants. Data were qualitatively analyzed by interpreting the interview transcript and quantitatively to calculate the Species Use Value of those medicinal plants. The result showed that in Cilongok District, there were 40 medicinal plant species from 25 families used as traditional medicine in respiratory system disease and pounded as the most used method of preparation. Citrus aurantiifolia (Christm.) Swingle is the most used medicinal plant with SUV were 0.235, followed by Amomum compactum Sol. ex Maton (SUV 0.206), Zingiber officinale Roscoe (SUV 0.176), Kaempferia galanga L (SUV 0.176), and Zingiber officinale var Rubrum (SUV 0.147).
Evaluation of Total Flavonoid, Total Phenolic, and Antioxidant Activity of Etlingera elatior (Jack) R.M.Sm Flower, Fruit, and Leaf Ulya Safrina; Wardiyah Wardiyah; Harpolia Cartika
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.72210

Abstract

Etlingera elatior (E. elatior) plant has long been used as a kitchen spice and daily food. E. elatior has potential as an antioxidant because it contains polyphenol and flavonoid compounds widely found in the leaves, fruit, and flowers. This study measures the total flavonoid content, total phenol content, and antioxidant activity using the ABTS method. Total phenol content was determined by the Follin-Ciocalteu method and total flavonoid content was determined by the Aluminium Chloride method. The results showed that the total flavonoid content from the highest to the lowest value from E. elatior was fruit extract, leaf extract, and flower extract, respectively. The value of total flavonoid content was 8.38 ± 0.15; 4.86 ± 0.10; and 2.60 ± 0.04 % w/w Catechin Equivalent (CE). The total phenol content from the highest to the lowest value from E. elatior was fruit extract, leaf extract, and flower extract, respectively. The total phenolic content values were 54.48 ± 1.89, 46.20 ± 0.83, and 4.80 ± 0.53 % w/w Gallic Acid Equivalent (GAE). The highest to lowest antioxidant activity values (IC50) were leaf extract at 58.82 ppm (strong activity), fruit extract at 103.05 ppm (moderate activity), and flower extract at 251.40 (weak activity), respectively.
The Effectiveness of Red Fruit Oil (Pandanus conideus Lamk.) Emulgel on the Acceleration of the Incision Wound Healing Process Fidia Rizkiah Inayatilah; Abdul Malik Guhir; Ria Ramadhani Dwi Atmaja
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.73135

Abstract

Incision wounds have a fairly high prevalence in Indonesia. Chemical treatment of incision wounds has adverse side effects, therefore alternative treatment with natural ingredients is needed, namely using red fruit oil as the basic ingredient. The purpose of this study is to determine the effectiveness of red fruit oil (Pandanus conoideus­­ Lamk.) gel emulsion on the healing process of incision wounds in males both macroscopically and microscopically. This is an experimental laboratory study. The study design used was true experimental with a post-test-only control group design approach. The population consisted of 25 male mice which were divided into 5 groups, namely: (1) K- was a control group where the incision wound on the back was given a gel emulsion base; (2) K+ was the control group where the incision wound on the back was given Iodine Povidone ; (3) P1 is the treatment group where the incision wound on the back is given a 5% red fruit oil gel emulsion (F1); (4) P2 is the treatment group where the incision wound on the back is given a red fruit oil gel emulsion 10% (F2); (5) P3 was the treatment group where the incision on the back was given a 15% red fruit oil gel emulsion (F3). The treatment was given for 14 days. The data were then analyzed using the ANOVA test. The result showed that the administration of red fruit oil emulgel had a significant effect on the size of the incision wound on the 7th day (p=0.035) and the 14th day (p=0.005). Giving red fruit oil emulgel also had a significant effect on the thickness of the epithelium (p=0.000) and the number of fibroblasts (p=0.000). It can be concluded that the administration of red fruit oil emulgel affects the healing process of the incision wound both macroscopically and microscopically.
Phytochemical Screening and Antidengue Activity of Jatropha Multifida Extract against DENV-2 Mia Munawaroh Yuniyanti; Dwi Aris Agung Nugrahaningsih; Mae Sri Hartati Wahyuningsih
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.73368

Abstract

Cases of dengue infection are still high in various parts of the world and no antiviral has been found to treat dengue infection. Jatropha multifida is one of the herbs used by the community to treat dengue infection, but pre-clinical and clinical scientific evidence has not been carried out. Phytochemical screening of ethanol extract of Jatropha multifida leaves was carried out using thin layer chromatography. Cytotoxic assay was performed on Vero cells using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide). The cytotoxic concentration 50 (CC50) was determined using probit analysis. Anti-dengue test on dengue  virus serotype 2 (DENV-2) was performed on Vero cells and the RNA (ribonucleic acid) copy number was quantified using quantitative polymerase chain reactions ((qPCR). Phytochemical screening results showed that the ethanol extract of Jatropha multifida leaves contains flavonoid and terpenoid compounds. CC50 of the extract was found to be 651.8 µg/mL. The RNA copy number of the treated group was lower than the control group and the difference was significant. The ethanol extract of Jatropha multifida leaves has anti-dengue activity against DENV-2.
Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer Elsa Fitria Apriani; Mardiyanto Mardiyanto; Rika Destiana
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.73513

Abstract

Pegagan is a plant that plays an important role in health because of its secondary metabolite. However, many secondary metabolites tend to be unstable when exposed to UV light and oxygen such as flavonoid and terpenoid. The purpose of this study was to formulate the ethanolic extract of pegagan leaves into nanoparticle preparations to increase the stability of the extract. Nanoparticle preparations were made using the emulsion solvent evaporation method using Poly-Lactic-Co-Glycolic Acid (PLGA) and polyvinyl alcohol (PVA). PLGA acts as a polymer that will coat the extract and PVA as a stabilizer. Variations in the concentration of PLGA used were 50 mg, 75 mg, and 100 mg, while the concentration of PVA used was 40 mg and the extract concentration was 158 mg. Determination of the best formula is done by looking at the results of the percent encapsulation efficiency obtained from the three formulas, namely 93.68%, 85.35%, and 88.76%, respectively. Based on these results, formula 1 was determined as the best formula. The particle size obtained in the best formula was 288.1667±3.4195 nm, the polydispersity index (PDI) was 0.371±0.0045 and the zeta potential value was -10.6333±0.1154. A physical stability test (cycling test method) of the best formula found a decrease in pH of 0.54 and no organoleptic changes or precipitate formed.

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