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All Journal The Indonesian Biomedical Journal Nusantara Medical Science Journal Oto Rhino Laryngologica Indonesiana YARSI Medical Journal Majalah Kesehatan Pharmamedika International Journal of Nasopharyngeal Carcinoma
Pratiwi Rahardjo, Sutji
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Biochemistry, Genetics & Molecular Biology Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : The Indonesian Biomedical Journal

 1 
Dynamics of Interleukin-10 Levels in Chronic Rhinosinusitis with/without Allergy Abdul Qadar Punagi; Sutji Pratiwi Rahardjo
The Indonesian Biomedical Journal Vol 7, No 3 (2015)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v7i3.182

Abstract

BACKGROUND: Rhinosinusitis occurs when the lining of the nasal and sinuses gets inflamed, infected or irritated, become swollen, and create extra mucus, the swollen lining may also interfere with drainage of mucus. Chronic rhinosinusitis (CRS) is a more persistent problem that requires a specific treatment approach. Aim of this study was to determine changes in interleukin (IL)-10 as an anti-inflammatory cytokines in allergic and non-allergic CRS at Makassar. METHODS: A prospective cohort study was designed to assess the level of IL-10 for three times during two weeks of therapy. Medication of Cefadroxil 500 mg 2x1, Pseudoephedrine 30 mg 2x1, Terfenadine 40 mg 2x1 and Methylprednisolone 4 mg 3x1, was conducted during two weeks for 13 subjects in allergic CRS group and 12 subjects in non-allergic CRS group. Results were statistically analyzed with student t-test and paired t-test.RESULTS: The changes in levels of IL-10 in allergic CRS group were increased, but not significant (5.293 to 5.769, p=0.058), and in non-allergic CRS group were decreased, but not significant (6.125 to 5.475, p=0.103). CONCLUSION: The serum levels of IL-10 were not significant increased in allergic CRS group and not significant decreased in non-allergic CRS group. KEYWORDS: interleukin-10, chronic rhinosinusitis, allergy, cefadroxil, pseudoephedrine, terfenadine, methylprednisolone
Co-Authors Abdul Kadir Abdul Qadar Punagi Carolina Manuputty, Anita Emanuel Quadarusman Fadjar Perkasa I. Djufri, Nani Indo Sakka Irawan Yusuf Joy Tobing Kodrat, Linda Linda Kodrat Mindarti, Fadhilah Muhammad Fajar Perkasa Nanda Mayasari Nani Iriani Djufri Nani Iriani Djufri Raden Sedjawidada Riskiana Djamin Sulaiman, A. Baso Syahrijuita s Syahrijuita, Syahrijuita