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Perbandingan efektivitas beberapa pelarut terhadap kelarutan Cerumen Obturans secara In Vitro Syahrijuita, Syahrijuita; Pratiwi Rahardjo, Sutji; I. Djufri, Nani; Djamin, Riskiana
Jurnal Kedokteran YARSI Vol 17, No 3 (2009): SEPTEMBER - DESEMBER 2009
Publisher : Lembaga Penelitian Universitas YARSI

Cerumen obturans merupakan suatu keadaan patologis yang tidak membahayakan jiwa tetapi dapat mengakibatkan perasaan tidak nyaman seperti rasa penuh di telinga, nyeri, gangguan pendengaran dan ketulian serta penurunan kualitas hidup. Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas enam pelarut yaitu aquadest, larutan garam NaCl 0,9%, minyak kelapa, minyak zaitun, karbogliserin 10% dan sodium dokusat 0,5% terhadap cerumen obturans secara in vitro serta untuk mengetahui lama waktu kontak yang paling efektif suatu pelarut terhadap kelarutan serumen. Penelitian ini merupakan eksperimen laboratorium dengan menggunakan 30 spesimen cerumen obturans yang telah dipadatkan dengan berat masingmasing 40 mg. Tingkat kelarutan serumen diukur dengan menggunakan spektrofotometer Spectronic 21. Perbandingan efektifitas pelarut diuji dengan menggunakan uji One Way Anova dengan alfa < 0,05. Didapatkan hasil bahwa efektivitas pelarut yang berbeda bermakna didapatkan pada menit ke 20, 25 dan 30 hanya antara aquadest dan NaCl 0,9% terhadap minyak kelapa dan minyak zaitun menggunakan spektrofotometer.Waktu kontak yang efektif secara in vitro adalah ? 20 menit dan cenderung meningkat sampai batas 30 menit. Pada menit ke 20 dan 25, NaCl 0,9% merupakan pelarut yang paling efektif sedang pada menit ke 30 yang paling efektif adalah aquadest. Minyak zaitun dan minyak kelapa merupakan pelarut yang efektivitasnya paling rendah. Pelarut berbasis air lebih efektif dibanding pelarut berbasis lemak.

Hubungan antara Kadar Anti Streptolisin-O dan Gejala Klinis pada Penderita Tonsilitis Kronis Mindarti, Fadhilah; Pratiwi Rahardjo, Sutji; Kodrat, Linda; Sulaiman, A. Baso
Jurnal Kedokteran YARSI Vol 18, No 2 (2010): MEI - AGUSTUS 2010
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v18i2.187

Anti streptolisin O merupakan antibody terhadap antigen streptolisin O yang dihasilkan oleh bakteri streptokokus ? hemolitikus grup A. Kuman ini sering didapatkan pada tonsillitis kronis. Penelitian ini bertujuan untuk mengetahui ada tidaknya hubungan antara kadar anti streptolisin O (ASO) dengan gejala klinis menurut keriteria Centor modifikasi Mc Isaac. Penelitian dilakukan di rumah sakit pendidikan Bagian Ilmu Kesehatan THT Fakultas Kedokteran Universitas Hasanuddin yang merupakan penelitian analitik cross sectional. Sampel penelitian diperoleh dari semua penderita tonsillitis kronik yang telah memenuhi kriteria inklusi dan eksklusi pada bulan Oktober 2009 sampai Februari 2010. Data dianalisa dengan Chi Square test dengan nilai signifikan 2.

Perbandingan Efektivitas Beberapa Pelarut Terhadap Kelarutan Cerumen Obturans Secara In Vitro Syahrijuita, Syahrijuita; Pratiwi Rahardjo, Sutji; I. Djufri, Nani; Djamin, Riskiana
Majalah Kesehatan Pharmamedika Vol 3, No 1 (2011): JANUARI - JUNI 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i1.438

Cerumen obturans is a pahtological condition with no harmfull to the patients but can caused ear tumbness sensation, earache, hearing impairment, deafness and decreasing the quality of life.The objections of the study are to compare the effectivity of six solvents, that are aquadest, NaCl 0,9%, coconut oil, olive oil, carboglycerin 10% and sodium docusate 0,5% againts cerumen obturans by means of in vitro study and to know the most effective duration contact of a solvent to cerumen osmolarity. The study is a laboratory experimental by using 30 specimen of solid cerumen with weight of 40 mg for each. The cerumen osmolarity is established by Spectronic 21 spectrophotometer. The effectivity comparison of solvents are tested with One Way Anova with alfa 0,05.The effectivity of solvents have a significant differentiation especially inÃ‚Â 20th , 25th and 30th minutes. The spectrophotometer that used to established the osmolarity of cerumen have revelead a significant results only in aquadest and NaCl 0,9% againts coconut oil dan olive oil,Ã‚Â The effective duration of contact by in vitro study is Ã¢â€°Â¥ 20 minutes and tends to increased to 30 minutes. In 20th and 25th minutes, NaCl 0,9 % is the most effective solvent, while aquadest is most effective in 30th minutes. Olive oil and coconut oil are less effective solvents. Water-based solvents are more effective than lipid-based solvents.

HUBUNGAN PAJANAN DEBU TERIGU TERHADAP KUALITAS HIDUP PENDERITA RINITIS AKIBAT KERJA Carolina Manuputty, Anita; Pratiwi Rahardjo, Sutji; Djamin, Riskiana; Perkasa, Fadjar
Jurnal Kedokteran YARSI Vol 18, No 1 (2010): JANUARI - APRIL 2010
Publisher : Lembaga Penelitian Universitas YARSI

Rinitis akibat kerja dapat mempengaruhi kualitas hidup pekerja, menghilangkan banyak waktu kerja yang dapat menurunkan produktivitas namun masih sedikit informasi yang dimiliki mengenai epidemiologi pada industri terigu. Penelitian ini bertujuan untuk menganalisis hubungan antara lama pajanan debu terigu dan kejadian rinitis akibat kerja (RAK) terhadap kualitas hidup penderita rinitis akibat kerja pada pekerja pabrik terigu X diMakassar. Penelitian ini menggunakan kajian potong lintang (cross sectional study). Penelitian dilakukan di pabrik terigu X, yakni di bagian produksi dan pengepakan. Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara lama pajanan debu terigu dan kejadian rinitis akibat kerja (RAK) dengan nilai p 0.05). Akan tetapi tidak terdapat hubungan bermakna antara lama pajanan debu terigu dan penurunan kualitas hiduppenderita RAK. Hubungan antara merokok dan kejadian RAK belum dapat dibuktikan, namun didapatkan bahwa merokok tanpa RAK lebih dominan dibandingkan RAK tanpa merokok dalam menyebabkan pemanjangan waktu transpor mukosiliar. Hubungan penggunaan masker dengan kualitas hidup pada kejadian RAK belum dapat dibuktikan, namun didapati bahwa pada pekerja yang tidak secara rutin menggunakan masker terkenaRAK dengan risiko yang lebih tinggi dan dapat menurunkan kualitas hidupnya. Hasil penelitian menunjukkan bahwa terdapat hubungan yang bermakna antara lama pajanan debu terigu dan kejadian rinitis akibat kerja (RAK) dengan nilai p 0.05). Akan tetapi tidak terdapat hubungan bermakna antara lama pajanan debu terigu dan penurunan kualitas hiduppenderita RAK.

Dynamics of Interleukin-10 Levels in Chronic Rhinosinusitis with/without Allergy Abdul Qadar Punagi; Sutji Pratiwi Rahardjo
The Indonesian Biomedical Journal Vol 7, No 3 (2015)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v7i3.182

BACKGROUND: Rhinosinusitis occurs when the lining of the nasal and sinuses gets inflamed, infected or irritated, become swollen, and create extra mucus, the swollen lining may also interfere with drainage of mucus. Chronic rhinosinusitis (CRS) is a more persistent problem that requires a specific treatment approach. Aim of this study was to determine changes in interleukin (IL)-10 as an anti-inflammatory cytokines in allergic and non-allergic CRS at Makassar. METHODS: A prospective cohort study was designed to assess the level of IL-10 for three times during two weeks of therapy. Medication of Cefadroxil 500 mg 2x1, Pseudoephedrine 30 mg 2x1, Terfenadine 40 mg 2x1 and Methylprednisolone 4 mg 3x1, was conducted during two weeks for 13 subjects in allergic CRS group and 12 subjects in non-allergic CRS group. Results were statistically analyzed with student t-test and paired t-test.RESULTS: The changes in levels of IL-10 in allergic CRS group were increased, but not significant (5.293 to 5.769, p=0.058), and in non-allergic CRS group were decreased, but not significant (6.125 to 5.475, p=0.103). CONCLUSION: The serum levels of IL-10 were not significant increased in allergic CRS group and not significant decreased in non-allergic CRS group. KEYWORDS: interleukin-10, chronic rhinosinusitis, allergy, cefadroxil, pseudoephedrine, terfenadine, methylprednisolone

Correlation of Rhinomanometry Measurement and True Lateral Radiography towards the Degree of Upper Airway Obstruction in Patients with Adenoid Hypertrophy Nanda Mayasari; Sutji Pratiwi Rahardjo; Abdul Kadir; Muhammad Fajar Perkasa; Abdul Qadar Punagi
Nusantara Medical Science Journal Volume 6 Issue 2, July - December 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i2.18869

Background: Adenoid hypertrophy is one of the most common disorders in children which may lead to upper airway obstruction. Various modalities to measure airway obstruction in patients with adenoid hypertrophy, including true lateral radiographs, nasoendoscopy, and rhinomanometry are available; however, the results from different studies are still controversial. This study aimed to determine the relationship between the results of rhinomanometry and the true lateral radiographs to the degree of upper airway obstruction in patients with adenoid hypertrophy. Methods: This cross-sectional study included a total of 33 patients with adenoid hypertrophy aged 5-18 years using a purposive sampling technique. Patients diagnosed with adenoid hypertrophy were subjected to a true lateral examination using lateral neck radiographs to measure the degree of airway obstruction. Subsequently, an active anterior rhinomanometry was performed by measuring resistance and nasal airflow and then measuring the degree of airway obstruction. Data analysis was done using Chi-Square test. Results: The rhinomanometric nasal resistance in the inspiratory phase was 0.4159 ± 0.15201 Pa/cm3/s and 0.3694 ± 0.13717 Pa/cm3/s in the expiration phase. The results showed a significant relationship between the true lateral radiographs and both nasal inspiratory (p=0.005) and expiratory resistance (p=0.004). Similarly, the relationship between the true lateral radiographs and nasal airflow on both inspiratory and expiratory rhinomanometry was significant (p<0.05). Conclusion: Rhinomanometric measurements can be used as an additional objective examination in assessing the degree of upper airway obstruction in patients with adenoid hypertrophy prior to surgery.

Microbial Pattern and Sensitivity Analysis of Otitis Externa Patients in Makassar, Indonesia Joy Tobing; Riskiana Djamin; Sutji Pratiwi Rahardjo
Nusantara Medical Science Journal Volume 7 Issue 1, January - June 2022
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v7i1.18910

Introduction: Globally, the cases of otitis externa were increased, followed by the incidence of antimicrobial resistance. Several factors, such as untrained medical health personnel and unprescribed antibiotics, are thought to play a major role in this phenomenon. This study aims to determine the bacterial patterns and antimicrobial sensitivity in otitis externa patients in Makassar, South Sulawesi, Indonesia. Methods: This cross-sectional study was conducted from November 2020 to February 2021 at Dr. Wahidin Sudirohusodo and Health Laboratory Center, Makassar, South Sulawesi, Indonesia. There were in total 33 subjects with otitis externa participating in this study. The secretion from the outer ear canal was taken and cultured using Mac Conkey agar for bacteriological examination and Vitek 2 for antimicrobial sensitivity. This study assessed age, sex, and type of otitis externa. All data analyses used SPSS version 26.00 (IBM Corp., Armonk, New York). Bacteria patterns and otitis externa were analyzed using the Fisher test. Results: Fourteen cases (42.4%) were caused by Pseudomonas Aeruginosa. Most Gram-negative bacteria were sensitive to ciprofloxacin, gentamicin, amikacin, and meropenem. Staphylococcus haemolyticus, Staphylococcus capitis, and Staphylococcus epidermidis were the most resistant Gram-positive bacteria. Aerobic bacteria in otitis externa were sensitive to antimicrobials (p<0.023). Conclusion: Gram-negative aerobic bacteria were common causes of otitis externa, with Pseudomonas aeruginosa being the most common isolated bacteria. Ciprofloxacin, gentamicin, amikacin, and meropenem were sensitive antimicrobials for otitis externa.

Perbandingan efektivitas beberapa pelarut terhadap serumen obturans secara in vitro di Makassar Syahrijuita s; Sutji Pratiwi Rahardjo; Nani Iriani Djufri; Riskiana Djamin
Oto Rhino Laryngologica Indonesiana Vol 42, No 1 (2012): Volume 42, No. 1 January - June 2012
Publisher : PERHATI-KL

Background: Cerumen obturans is a pahtological condition which is not harmful to the patients but could cause ear numbness sensation, earache, hearing impairment, deafness and decreasing the quality of life. Purpose: The objective of the study was to compare the effectiveness of six solvents, which were aquadest, NaCl 0,9%, coconut oil, olive oil, carboglycerin 10% and sodium docusate 0,5% againts cerumen obturans by means of in vitro study and to know the most effective contact duration of a solvent to liquefy cerumen. Method: The study is a laboratory experimental by using 30 specimens of solid cerumen, each weight 40 mg. The cerumen liquefaction was measured by Spectronic 21 spectrophotometer. The effectiveness of the solvents were tested with One Way Anova with alfa <0,05. Result: The spectrophotometer showed significant differentiations of effectiveness of the solvents in the 20th , 25th and 30th minutes, only in aquadest and NaCl 0,9% againts coconut oil dan olive oil. The effective duration of contact by in vitro study was = 20 minutes and tend to increase up till 30 minutes. In the 20th and 25 minutes, NaCl 0,9 % was the most effective solvent, while aquadest was most effective in the 30ththPerbandingan efektivitas beberapa pelarut minutes. Olive oil and coconut oil are less effective solvents. Conclusion: Water-based solvents were found more effective than lipid-based solvents. Key words: cerumen solvents, cerumen obturans, in vitro Abstrak : Latar belakang: Serumen obturans merupakan suatu keadaan patologis yang tidak membahayakan jiwa tetapi dapat mengakibatkan rasa penuh di telinga, nyeri, gangguan pendengaran dan ketulian serta penurunan kualitas hidup. Tujuan: Penelitian ini bertujuan untuk mengetahui perbandingan efektivitas enam pelarut yaitu aquadest, NaCl 0,9%, minyak kelapa, minyak zaitun, karbogliserin 10% dan sodium dokusat 0,5% terhadap serumen obturans secara in vitro serta untuk mengetahui lama waktu kontak yang paling efektif suatu pelarut terhadap kelarutan serumen. Metode: Penelitian ini merupakan eksperimental laboratorium dengan menggunakan 30 spesimen serumen obturans yang telah dipadatkan dengan berat masing-masing 40mg. Kelarutan serumen diukur menggunakan spektofotometer Spectronic 21. Perbandingan efektifitas pelarut diuji dengan menggunakan uji One Way Anova dengan alfa <0,05. Hasil: Didapatkan hasil bahwa efektivitas pelarut yang berbeda bermakna didapatkan pada menit ke-20, ke-25 dan ke-30 hanya antara aquadest dan NaCl 0,9 % terhadap minyak kelapa dan minyak zaitun menggunakan spektofotometer. Waktu kontak yang efektif secara in vitro adalah = 20 menit dan cenderung meningkat sampai batas 30 menit. Pada menit ke-20 dan ke-25, NaCl 0,9% merupakan pelarut paling efektif sedang pada menit ke-30 paling efektif adalah aquadest. Minyak zaitun dan minyak kelapa merupakan pelarut yang efektivitasnya paling rendah. Kesimpulan: Pelarut berbasis air lebih efektif dibanding pelarut berbasis lemak. Kata kunci: Pelarut serumen, serumen obturans, in vitro

Aritenoidektomi intralaring pada paralisis abduktor bilateral Sutji Pratiwi Rahardjo
Oto Rhino Laryngologica Indonesiana Vol 40, No 2 (2010): Volume 40, No. 2 July - December 2010
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v40i2.10

Background: Bilateral abductor paralysis is a condition caused by recurrent laryngeal nerve injuryso that the abductor muscles innervated by the nerve are paralyzed and narrowing the rima glottis. Thiscondition is very rare, but could be fatal from asphyxia. Clinical features included dyspnoea, inspiratorystridor and hoarseness. The diagnosis is based on anamnesis, physical examinations, indirect anddirect laryngoscopy, neurology, serology examinations, and radiological imaging. Purpose: To showthat bilateral abductor paralysis needs a management which provides good airway passage withoutphonation dysfunction. Case: A patient complained of dyspnea since three month after undergoingstrumectomy and thyroid ablation in 2006. Flexible endoscopy revealed bilateral abductor paralysis.Case management: The patient underwent tracheostomy with right arytenoidectomy and right posteriorintralaryngeal cordectomy by microlaryngeal surgery approach. Conclusion: Optimal treatment willprovide adequate function of the airway and restore the function of voice. Key words: bilateral abductor paralysis, recurrens laryngeal nerve, arytenoidectomy. Abstrak : Latar belakang: Paralisis abduktor bilateral adalah keadaan yang ditimbulkan oleh cedera nervuslaringis rekuren, sehingga otot-otot abduktor yang dipersarafinya tidak dapat berkontraksi dan rimaglotis menyempit. Kelainan ini jarang dijumpai, namun dapat menimbulkan akibat yang fatal berupaasfiksia. Gejala yang sering timbul pada paralisis abduktor bilateral adalah keluhan sesak napas disertaidengan stridor inspiratoir dan suara serak. Diagnosis paralisis abduktor bilateral ini dapat ditegakkandengan anamnesis, pemeriksaan fisik, laringoskopi indirek maupun laringoskopi direk, pemeriksaanneurologi, serologi, dan pemeriksaan radiologi. Tujuan: Untuk mempresentasikan penatalaksanaanyang baik pada paralisis abduktor bilateral untuk mendapatkan jalan napas yang baik dan juga tidakterlalu mengganggu fungsi bicara. Kasus: Pasien datang dengan keluhan sesak napas sejak tiga bulansetelah dilakukan operasi strumektomi dan ablasi tiroid pada tahun 2006. Pada pemeriksaan endoskopifleksibel didapatkan hasil paralisis abduktor bilateral. Penatalaksanaan: Dilakukan trakeostomi danaritenoidektomi dekstra dan kordektomi posterior dekstra intralaring dengan pendekatan bedah laringmikroskopik. Kesimpulan: Dengan penatalaksanaan yang baik didapatkan hasil fungsi pernapasanadekuat dan fungsi bicara cukup baik.Kata kunci: paralisis abduktor bilateral, saraf laringeal rekuren, aritenoidektomi.

Risiko terjadinya rinitis akibat kerja pada pekerja yang terpajan debu terigu Emanuel Quadarusman; Sutji Pratiwi Rahardjo; Abdul Qadar Punagi; Riskiana Djamin
Oto Rhino Laryngologica Indonesiana Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011
Publisher : PERHATI-KL

Background: Occupational rhinitis (OR) may decrease quality of life and productivity, but there is still little information about occupational rhinitis in flour industries. Purpose: To know the influence of atopic history, working duration, work placement and face-mask use in the incidence of occupational rhinitis in wheat flour workers of PT. X in Makassar. Methods: A cross-sectional study on workers in production and packing sections of flour factory X had been conducted. Result: Prevalence of occupational rhinitis in that factory was about 50.7%, and there was a significant relationship between atopic history and work placement with OR incidence (p<0.05). Conclusion: There was a significant relationship between atopic history and work placement with OR incidence, but relationship between OR with working duration and face-mask use could not be established. It was shown that in atopic workers, longer working duration and un-routine use of face-mask increased the risk of OR incidence twice higher. Keywords: occupational rhinitis, flour dust, face mask Abstrak : Latar belakang: Rinitis akibat kerja (RAK) dapat mempengaruhi kualitas hidup pekerja, menghilangkan banyak waktu kerja dan dapat menurunkan produktivitas, namun masih sedikit informasi yang dimiliki mengenai epidemiologi pada industri terigu. Tujuan: Untuk mengetahui pengaruh riwayat atopi, lama bekerja, bagian kerja dan penggunaan masker terhadap kejadian rinitis akibat kerja pada pekerja pabrik terigu X di Makassar. Metode: Suatu studi potong lintang pada pekerja bagian produksi dan pengepakan di pabrik terigu X. Hasil: Didapatkan angka kejadian RAK pada pekerja pabrik adalah 50,7%, dan terdapat hubungan yang bermakna antara atopi dan tempat kerja dengan kejadian RAK (p<0,05). Kesimpulan: Faktor atopi dan tempat kerja dapat mempengaruhi angka kejadian RAK, sedangkan hubungan antara RAK dengan lama kerja dan penggunaan masker belum dapat dibuktikan. Didapati bahwa pada pekerja dengan riwayat penyakit atopi semakin lama masa kerja dan dengan penggunaan masker tidak rutin dapat meningkatkan risiko dua kali lebih tinggi untuk terkena RAK. Kata kunci: rinitis akibat kerja, debu terigu, masker

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