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All Journal Jurnal Farmasi Indonesia Jurnal Kefarmasian Indonesia Jurnal Insan Farmasi Indonesia
Lukito Mindi Cahyo
Program Studi Farmasi, Fakultas Farmasi, Universitas Setia Budi, Surakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Medicine & Pharmacology Physics

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Aktivitas Antioksidan Ekstrak dan Fraksi Daun Manggis (Garcinia mangostana) terhadap DPPH (1,1-Difenil-2-Pikrilhidrazil) Ghani Nurfiana; Lukito Mindi; Masyitah Novia
Jurnal Farmasi Indonesia Vol 14 No 1 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.407 KB) | DOI: 10.31001/jfi.v14i1.358

Abstract

Antioxidant is very important to keep human’s health because it can scavenge free radical. Garcinia mangostanaL. which is used by people as traditional herbal medicine and it has traditional name mangosteen is known contain of flavonoid, tannin and saponin. The aim of the experiment was to find out the antioxidant activity of extracts and fractions of mangosteen folium against the DPPH radicals (1,1-diphenyl-2-picrylhydrazyl) to determine the IC50 and classes of compounds that play a role in antioxidant activity assay.Mangosteen leaves were extracted by maceration method using 96% ethanol. Extract was partitionedwith water and n-hexane, and then with ethyl acetate. The antioxidant activity of fraction was tested against DPPH radicals. The test was conducted in 5 series of concentrations by adding 4.0 ml test solutions with 1.0 mlDPPH 0.45 mM. The radicals scavenging activity was measured with spectrophotometer at 517 nm wavelength anddetermined the IC50 value. The experiment used Rutin as positive control.The identification of the class of compounds can be carried out using the Thin Layer Chromatography (TLC) method whose results can be identified by spray reagents or compared with the standard standard. The result of the experiment showed that Mangosteen folium had antioxidant activity with IC50 of ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction: 17.64 μg / ml, 45.36 μg / ml, 13.71 μg / ml, 12.10 μg / ml respectively. The water fraction has the strongest activity compare to the other with the IC50 is almost near often Rutin’s IC50 is 15.24 μg as the positive control. Extracts and fractions of TLC with various spotting agents contain a class of compounds: flavonoids, saponins and steroids
Studi Inkompatibilitas Parenteral dan Penggunaan Antibiotika Pada Pasien Rawat Inap Di Rumah Sakit Surakarta Avianti Dewi Purwaningsih; Lukito Mindi Cahyo
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.158 KB) | DOI: 10.31001/jfi.v15i2.452

Abstract

Intravenous admixtures is a process of admixtures sterile drugs with sterile intravenous solutions to produce a sterile preparation aimed at intravenous use. The scope of intravenous admixtures is to dissolve or reconstitute sterile powders, prepare simple intravenous injections, and prepare complex intravenous injections. Identification and evaluation of incompatibility events in the drug dispensing stage in the hospital aims to determine incompatibility events, know the prescription patterns of intravenous preparations, know the process of drug dispensing, determine the effect of pharmacist ability on incompatibility events, find out the incompatibility with outcome therapy, and incidence of incompatibility on antibiotic use. This research needs to be done because incompatibility is a high risk problem in a hospital. The study used experimental studies, namely to provide an understanding of the effect of quantitative incompatibility and observational studies to determine the incidence of antibiotic incompatibility. The samples used were inpatients in the hospital, excluding hemodialysis patients and labor patients. Data retrieval is done retrospectively, to obtain qualitative data and prospectively, to obtain quantitative data. The results of this study obtained the greatest antibiotic use was Ceftriaxone with NaCl solvents. Incompatibility occurring at 19.5% includes chemical and physics incompatibility. This study concluded that there was no significant relationship between the use of antibiotics and the incidence of incompatibility.
Evaluasi Penggunaan Ramipril dan Candesartan pada Pasien Rawat Inap COVID-19 dengan Komorbid Hipertensi di RSUD Dr. Moewardi Deva Yolanda Dwi Nur Azizah; Tri Wijayanti; Lukito Mindi Cahyo
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Kebijakan Sistem Ketahanan Kesehatan dan Sumber Daya Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6064

Abstract

Hypertension is the most common comorbid in patients infected by COVID-19. Drugs often given for the treatment of hypertension, namely ramipril, and candesartan, are thought to increase the development of COVID-19 because the angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) increase the expression of ACE-2, which is the binding site of SARS-CoV-2. This study aims to analyze the effect of using ramipril and candesartan on healing in hospitalized patients with COVID-19 with hypertension at RSUD dr. Moewardi in 2020. This study was conducted retrospectively. The results were presented descriptively and used medical record data of hospitalized patients with COVID-19 with comorbid hypertension at RSUD dr. Moewardi in 2020. Using ramipril and candesartan affects patient recovery in terms of length of stay (LOS), symptom relief, and RT-PCR test results. Analysis of the research data using SPSS with Spearman correlation test. The Spearman correlation test showed that there was a fairly strong relationship between the use of ramipril and candesartan in patients with COVID-19 with comorbid hypertension on LOS, symptom relief, and RT-PCR test results. The study results show that using ramipril and candesartan can improve the recovery of patients with COVID-19 with comorbid hypertension. ACEI and ARB drugs have not been proven to worsen the patient's condition so their use can be continued.
ISOLASI DAN IDENTIFIKASI BAKTERI PENGHASIL PROTEASE EKSTRASELULER DARI LIMBAH CAIR INDUSTRI TAHU Wiwi Kusumasari; Ana Indrayati; Lukito Mindi Cahyo
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1266

Abstract

Tofu waste that is discharged into the aquatic environment has a negative impact on the quality of the water around the tofu liquid waste disposal site. Industrial enzyme production is currently dominated by proteases. Proteases in the pharmaceutical field support the absorption of proteins in the digestive tract, as active cosmetic ingredients. This study aims to isolate, identify protease-producing bacteria from tofu wastewater, determine the total protein content and enzyme activity index of 5 isolates of protease-producing bacteria. Tofu wastewater bacteria were isolated with Skim Milk Agar medium. 5 bacterial isolates were selected which produced the widest clear zones, different colony characters, identified by morphological tests, gram staining tests, and biochemical tests. Five isolates were made into a bacterial suspension isolated from crude protease extract and the protease level was determined using the Bicinchoninic Acid method, and the protease activity was tested. Five bacterial colonies showed that colony 1 and colony 2 included Gram positive bacteria, colonies 3, 4 and 5 included Gram negative bacteria. The value of total protein content in the tofu industrial wastewater from the five colonies respectively: 219.93; 833,267; 421,267; 81,267; and 38.6 µg/µL. The highest proteolytic activity test was in sample 2 of 2.13.
Co-Authors Ana Indrayati Avianti Dewi Purwaningsih Deva Yolanda Dwi Nur Azizah Ghani Nurfiana Fadma Sari Masyitah Novia Tri Wijayanti Wiwi Kusumasari