Martadiansyah, Abarham
Division Of Maternal Fetal Medicine, Department Of Obstetrics And Gynecology, Faculty Of Medicine, Universitas Sriwijaya / Mohammad Hoesin General Hospital, Palembang, Indonesia

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Placental Factors Affecting Birth Weight of Late Onset Severe Preeclampsia Martadiansyah, A; Pangemanan, W T; Bernolian, N; Maulani, H; Theodorus, Theodorus
Sriwijaya Journal of Medicine Vol. 1 No. 3 (2018): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Objective of the study is to determine the correlation of placenta and birth weight in late onset preeclampsia. A case-control study,analysis prevalence was conducted in Moh Hoesin Hospital Palembang from August 2015 to August 2016. Samples were women who giving birth in Moh Hoesin Hospital Palembang. They were devided into two groups, severe preeclampsia as case group and normotension as control. Data were analyzed by X2, Exact Fisher’s and logistic regression test using SPSS 16.0. There were 180 subjects (90 cases and 90 controls). There was a positive correlation between placental macroscopic and late onset preeclampsia (p=0.009; OR=6.9), in contrast there was only one different placental microvascularisation of 16, between late onset preeclampsia and normotension, the mural or occlusive fibrin thrombi chorion (p=0.005; OR=9.9). Birth weight in late onset preeclampsia tended to be small but still in normal range and it was not statistictly significant (p=0.112; OR=10.4). There was a positive correlation between placental macroscopic and SGA baby on late onset preeclampsia (p=0.026; OR=16.6), but it wasnot proven microscopically. Placenta remains contributed to the pathogenesis of the late onset preeclampsia, but not as dominant as the early one.
Prevalensi Kejadian Preeklampsia dengan Komplikasi dan Faktor Risiko yang Mempengaruhinya di RSUP Dr. Mohammad Hoesin Palembang (Studi Prevalensi Tahun 2015, 2016, 2017) Martadiansyah, Abarham; Qalbi, Anugrah; Santoso, Budi
Sriwijaya Journal of Medicine Vol. 2 No. 1 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Preeklampsia dengan komplikasi merupakan penyakit obstetri dengan prevalensi tertinggi di Indonesia sehingga dapat meningkatkan angka mortalitas dan morbiditas ibu dan bayi. Penyakit ini dikenal sebagai the disease of theorydikarenakan belum terdapatnya teori yang mampu menjelaskan faktor risiko penyakit ini secara jelas. Penelitian ini dilakukan untuk mengetahui prevalensi kejadian preeklampsia dengan komplikasi di RSUP Dr. Mohammad Hoesin periode 1 Januari 2015 - 31 Desember 2017 sekaligus menganalisis faktor risiko yang mempengaruhinya. Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional.Penelitian ini menggunakan data sekunder rekam medik ibu bersalin di RSUP Dr. Mohammad Hoesin Palembang. Sampel penelitian terdiri dari 117 ibu bersalin dengan PDK dan 183 ibu bersalin non-PDK. Data dianalisis menggunakan uji chi-squaredan regresi logistik biner metode Enter pada aplikasi SPSS. Prevalensi kejadian preeklampsia dengan komplikasi di RSUP Dr. Mohammad Hoesin Palembang periode 1 Januari 2015–31 Desember 2017 adalah 14,45%. Hasil analisis bivariat menunjukan usia maternal (p=0,000; PR=2,229; CI 95%: 2,556–7,212), IMT (p=0,000; PR=2,167; CI 95%: 1,525-3,080), riwayat hipertensi dalam kehamilan (p=0,000; PR=3,597; CI 95%: 2.860–4.523), dan jumlah paritas (p=0,007; PR=0,618; risk=1,618; CI 95%: 0.43– 0.883) memiliki hubungan yang signifikan terhadap kejadian preeklampsia dengan komplikasi. Pekerjaan (p=0,065), jarak kehamilan (p=0,458), dan riwayat penyakit maternal (p=0,573) memiliki hubungan yang tidak signifikan terhadap kejadian tersebut. Hasil analisis multivariat menunjukkan usia maternal, pekerjaan, IMT, jarak kehamilan, dan riwayat hipertensi dalam kehamilan memiliki probabilitas sebesar 74,5% terhadap kejadian preeklampsia dengan komplikasi. Prevalensi kejadian preeklampsia dengan komplikasi di RSUP Dr. Mohammad Hoesin masih relatif tinggi, dan faktor risiko yang paling signifikan terhadap kejadian tersebut adalah riwayat hipertensi dalam kehamilan.
Prevalensi dan Faktor Risiko Persalinan Preterm di RSUP Dr. Mohammad Hoesin Palembang Trisa, Yusdela; Martadiansyah, Abarham; Rasyid, Riana Sari Puspita
Sriwijaya Journal of Medicine Vol. 2 No. 2 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Persalinan preterm adalah persalinan kurang dari 37 minggu usia kehamilan. Preterm menyumbang sekitar 50% dari semua kematian neonatal. Indonesia merupakan salah satu negara penyumbang persalinan preterm terbanyak pada tahun 2010. Penyebab persalinan preterm adalah kombinasi dari berbagai macam keadaan, seperti obstetrik, sosiodemografi, dan faktor medik. Penelitian ini bertujuan untuk mengetahui prevalensi dan hubungan faktor risiko dengan persalinan preterm di RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini adalah penelitian analitik observasional. Sebanyak 505 sampel ibu bersalin diambil dengan teknik simple random sampling. Data dicatat dan diobservasi dari rekam medik berupa usia, jarak kehamilan, riwayat persalinan preterm, tingkat pendidikan, kehamilan multipel, ketuban pecah dini, dan riwayat perdarahan antepartum. Lalu data dianalisis dengan uji chi square. Pada penelitian ini dijumpai angka kejadian persalinan preterm sebanyak 497 (20,7%) ditahun 2015, 687 (29,4%) ditahun 2016, dan 578 (26,9%) ditahun 2017. Secara statistik terdapat hubungan yang signifikan antara riwayat persalinan preterm, kehamilan multipel, ketuban pecah dini, dan perdarahan antepartum (p <0,05). Sedangkan variabel usia, jarak kehamilan, dan tingkat pendidikan tidak terdapat hubungan yang signifikan dengan kejadian persalinan preterm. Dari analisis mutivariat didapatkan variabel yang paling berpengaruh adalah kehamilan multipel. Terdapat hubungan yang signifikan antara variabel riwayat persalinan preterm sebelumnya, kehamilan multipel, ketuban pecah dini, dan perdarahan antepartum dengan kejadian persalinan preterm.
RISK FACTORS OF POSTPARTUM HEMORRHAGE IN RSUP DR. MOHAMMAD HOESIN Feisal Moulana; Abarham Martadiansyah; Iche Andriani Liberty
Majalah Kedokteran Sriwijaya Vol 51, No 2 (2019): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v51i2.8534

Abstract

Perdarahan postpartum merupakan salah satu penyebab tingginya angka kematianibu yaitusebanyak 25 - 30% di negara berkembang, salah satunya Indonesia. Hal tersebut dikarenakan banyaknya faktor risiko yang mempunyai hubungan dengan kejadian perdarahan postpartum, maka dari itu penelitian mengenaifaktor risiko terhadap kejadian perdarahan postpartum perlu dilakukan.Penelitian ini adalah penelitian observasional analitik menggunakan desain cross sectional.Sampel analisis dalam penelitian ini ialah pasien melahirkan yang memenuhi kriteria inklusi dan eksklusi sebanyak 200 subjek yang diambil dengan teknik simple random sampling. Penelitian ini menggunakan data sekunder dari rekam medik pasien di bagian Obstetri dan Ginekologi RSUP Dr. Mohammad Hoesin Palembang, lalu dianalisis menggunakan uji statistik chi-square dan regresi logistic biner dengan menggunakan STATA Ver. 15.Kasus perdarahan pospartum di RSUP Dr. Mohammad Hoesin pada periode 1 Januari 2015 – 31 Desember 2017 adalah 27,00%. Faktor risiko yang mempunyai hubungan dengan kejadian perdarahan postpartum adalah status gravida ibu (OR=18,532), status paritas ibu (OR=0,075), berat badan bayi lahir (10,825), dan hamil kembar (OR=0,116).Status gravida ibu, status paritas ibu, berat badan bayi lahir besar, dan hamil kembar merupakan faktor risiko yang mempengaruhi terjadinya perdarahan postpartum di RSUP Dr. Mohammad Hoesin Palembang.
The Safety of Cardioversion in Supra Ventricular Tachycardia Patient with Pregnancy Sugianto Mukmin; Erwin Sukandi; Abarham Martadiansyah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 12 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v5i12.374

Abstract

Backgrounds. Supraventricular tachycardia is a type of tachyarrhythmia characterized by sudden changes in heart rate and increases rapidly. In supraventricular tachycardia, the abnormalities that occur include components of the conduction system and occur in the upper part of the HIS bundle. This case report describes a case of supraventricular tachycardia suspected of AVNRT in a pregnant woman accompanied by hypokalemia, hypocalcemia and prolonged QT Interval along with cardioversion which was performed as the management of this case.Case presentation. A woman, Mrs Y, 24 years old, a housewife, having her address within the city of Palembang. The patient came to the emergency department of Moh. Hoesin Hospital Palembang with the chief complaint of chest palpitations. On physical examination, there was a grade 2/6 murmur, no shortness of breath, the patient was 7 months pregnant. He had a history of heart disease SVT 8 years ago. ECG examination showed sinus rhythm with low atrial rhythm in leads II, III, AVF. On laboratory examination, the blood calcium level was 8.3 mg/dL. Management of this patient includes pharmacological and non-pharmacological management. On the 14th day of hospitalization, 100 joules of cardioversion was performed and the patient responded well. The patient's condition improved on the 20th day of treatment.Conclusion. The patient experienced a good and effective response to 100 joules of cardioversion which was performed on the 14th day of treatment. Maintenance treatment in the form of drugs in the form of diltiazem due to the condition of the patient who is 27 weeks pregnant. The next management is planning the birth process according to the patient's hemodynamics and preventing the occurrence of SVT in subsequent pregnancies.
Zinc Serum Maternal Levels as a Risk Factor for Preeclampsia Abarham Martadiansyah; Peby Maulina; Putri Mirani; Tia Kaprianti; Theodorus
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 7 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i7.390

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Background. Preeclampsia is defined as gestational hypertension and proteinuria which can be measured by the elevation of liver transaminases to twice normal concentration, and the symptoms of increased intracranial pressure such as dizziness, blurred vision, and seizures. Zinc is an essential mineral for many biological functions and one of the trace elements that is directly involved in the oxidative/antioxidant balance, a pathogenesis process in preeclampsia that is highly dependent on dietary habits and supplements. This study was aimed to assess the association between serum zinc level with preeclampsia (PE). Methods: This observational, case-control study was performed on 90 women with singleton pregnancies at 28 to 42 weeks of gestation which were referred to the Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Palembang, between August 2020 to November 2020. 30 pregnant women with PE were selected as cases and 60 healthy pregnant women were selected as controls. Maternal serum zinc samples were collected. The collected data were entered into the master table. Tabulation, coding, and statistical data analysis were performed using SPSS version 20.0 for Windows. Results: The mean serum zinc levels in the case group and control group were 43,90 ± 15,79 µg/dL (ranged from 15 to 86 µg/dL) and 48,77 ± 10,54 µg/dL (ranged from 22 to 83 µg/dL), respectively. A value of serum zinc levels with the best sensitivity and specificity was 45,5 µg/dL. Conclusion: There was a significant association between maternal serum zinc level with PE. The risk of PE was 3,2 times higher in pregnant women with serum zinc levels of ≤45,5 mcg/dL compared to pregnant women with serum zinc levels of >45,5 mcg/dL. In this case it is necessary to supplement zinc earlier in pregnancy to reduce the risk of preeclampsia.
Multigravid Women with Uterine Rupture: A Case Report Firmansyah Basir; Adnan Abadi; Abarham Martadiansyah; Cindy Kesty; Febi Stevi Aryani; Murwani Emasrissa Latifah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 2 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i2.443

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Introduction: Uterine rupture is the discontinuation of the uterine scar that creates connection between uterine and peritoneal cavity. The most common etiology for uterine rupture is dehiscence of uterine scar tissue from previous cesarean section. In patient with uterine rupture and fetal expulsion to the peritoneal cavity, fetal survival becomes extremely poor. Therefore, it is important for clinician to understand the uterine rupture and be able to give prompt treatment in order to prevent maternal and fetal morbidity and mortality. Case Presentation: A 34-year-old woman, G3P2A0 38 weeks of gestation complained that she had abdominal pain, couldn’t feel her baby movement, watery discharge since 10 hours before admission. Bloody discharge and trauma were all denied. Patient underwent twice cesarean section before. Patient only had four times antenatal care with obstetrician at 24, 28, 32, and 36 weeks of gestation. She was scheduled for caesarean section at 38 weeks of gestation. Patient looked alert with low blood pressure and tachycardia. On physical examination, we found that she was pale, fundal height could not be determined, and there was no fetal heart rate detected. Speculum examination showed livide portio, closed external orifice of uterus, and inactive blood. There was positive slinger sign and Douglas cavity was bulging. Ultrasound examination showed intrauterine fetal demise, complete uterine rupture on lower segment, and positive sign of free fluid on abdominal cavity. Patient underwent operation and we found the died male neonate was in the peritoneal cavity and the placenta was still attached in the uterine cavity. We delivered the baby and placenta completely. There was uterine rupture on the previous CS scar, the edge of the uterine wound was regular with no necrosis and extended to the right side of uterus. Then, we performed hysterorrhaphy in order to stop the bleeding and repair the uterus, and we also performed tubal ligation. The died neonate had maceration grade I. Conclusion: Uterine rupture causes poor fetal and maternal prognosis. Early diagnosis and prompt treatment is really important in uterine rupture. Prevention of uterine rupture could be done by meticulous antenatal care, especially visiting to obstetrician in order to review maternal and fetal condition and determine mode of delivery.
Cardiac Disease in Pregnancy: Maternal and Perinatal Outcomes in RSUP Dr. Mohammad Hoesin Palembang Ni Made Dyah Gayatri; Peby Maulina Lestari; Abarham Martadiansyah; Nuswil Bernolian; Hadrians Kesuma Putra; Rizky Agustria; Muwarni Emasrissa Latifah
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 2 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i2.448

Abstract

Background: Impaired maternal and uteroplacental perfusion can occur in pregnancy with cardiac disease leading to maternal and perinatal mortality and morbidity due to increased cardiac load and ventricular dysfunction. This research aims to determine maternal and perinatal outcomes of pregnancies with cardiac disease. Method: This research was a descriptive observational study conducted by total sampling method and cross-sectional design. This research used medical records of pregnant women with cardiac disease who gave birth in RSUP Dr. Mohammad Hoesin Palembang in January 2018-December 2020 as study samples. Result: Among 68 pregnancies with cardiac disease, there were 6 cases (0.87%) found in 2018, 38 cases (2.47%) found in 2019, and 24 cases (1.48%) found in 2020. The highest distribution of pregnancies with cardiac disease was found at 64.7% in the range of 20-35 years old age group; 57.4% in the multiparity group; 38.2% in the range of ≥34 – <37 weeks gestational age group; 86.8% in the high school educational level group; 66.2% in the high-risk cardiac functional status group; 54.4% in the peripartum cardiomyopathy group; and 36.8% with preeclampsia/eclampsia as a comorbid. In this study, maternal outcomes found were maternal mortality at 11.8%; cardiac failure at 70.6%; arrhythmia at 1.5%; and stroke at 1.5%, while perinatal outcomes found were prematurity at 60.3%; low birth weight at 64.4%; IUGR at 37.0%; IUFD at 1.4%; stillbirth at 6.8%; neonatal death at 9.6%; and perinatal asphyxia at 42.5%. Conclusion: The prevalence rate of pregnancies with cardiac disease in RSUP Dr. Mohammad Hoesin Palembang was 0.87% in 2018, 2.47% in 2019, and 1.48% in 2020. The most common maternal outcome in this study was cardiac failure, with most in the peripartum cardiomyopathy group, while the most common perinatal outcome was low birth weight, with most in the hypertensive heart disease group.
Kehamilan pada Skar Seksio Sesaria Nuswil Bernolian; Win T. Pangemanan; A. Kurdi Syamsuri; M. Hatta Ansyori; Putri Mirani; Peby Maulina Lestari; Abraham Martadiansyah; Cindy Kesty
Indonesian Journal of Obstetrics & Gynecology Science Volume 3 Nomor 2 September 2020
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v3n2.198

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Tujuan: Memaparkan klasifikasi, faktor risiko, epidemiologi, cara diagnosis, tatalaksana, dan komplikasi kehamilan pada skar seksio sesareaMetode: Tinjauan pustakaKesimpulan: Kehamilan pada skar SC merupakan kehamilan yang kantung kehamilannya terdapat pada miometrium yang menipis akibat SC sebelumnya. Secara umum, kehamilan pada skar Caesarean Scar Pregnancy (CSP) dapat dibedakan menjadi 2 tipe, yaitu tipe 1 (endogenik) dan tipe 2 (eksogenik). Kejadiannya berkisar antara 1 per 8.000 dan 1 per 2.500 SC dengan risiko rekurensi 3,2-5,0% pada wanita dengan riwayat SC 1 kali yang ditatalaksana dengan dilatasi dan kuretase dengan atau tanpa embolisasi arteri uterina. Adapun faktor risiko CSP adalah tebal Segmen Bawah Rahim (SBR) <5 mm, kantong kehamilan menonjol ke plika vesikouterina, SC di rumah sakit umum daerah, dan riwayat perdarahan melalui vagina ireguler dan nyeri abdomen selama CSP sebelumnya. Pengobatan CSP dapat secara konservatif dengan metotreksat (MTX) maupun operatif termasuk eksisi jaringan kehamilan dengan laparoskopi, histerotomi, atau histerektomi. Pilihan pengobatan lain termasuk dilatasi dan kuretase, reseksi transervikal (TCR) dengan histeroskopi, embolisasi arteri uterina (UEA), kemoembolisasi arteri uterina, atau penempatan kateter balon ganda.Caesarean Scar PregnancyAbstractObjective: To explain about classification, risk factors, epidemiology, diagnostic methods, management, and complications of Caesarean Scar Pregnancy (CSP).Method: Literature review Conclusion: CSP is a pregnancy where the gestational sac is found in the thin myometrium due to previous CS. In general, Caesarean Scar Pregnancy (CSP) can be divided into 2 types, namely type 1 (endogenic) and type 2 (exogenic). Its incidence ranges from 1 per 8,000 and 1 per 2,500 SC with a recurrence risk of 3.2-5.0% in women with a history of 1 time CS who are treated with dilatation and curettage with or without uterine artery embolization. The risk factors for CSP are lower uterine segment thickness <5 mm, gestational sac pouches protruding into the vesicouterine fold, CS in regional public hospitals, and a history of irregular vaginal bleeding and abdominal pain during previous CSP. Caesarean scar pregnancy treatment can be conservative with methotrexate (MTX) or operatively including excision of pregnancy tissue with laparoscopy, hysterotomy, or hysterectomy. Other treatment options include dilatation and curettage, transcervical resection (TCR) with hysteroscopy, uterine artery embolization (UAE), chemoembolization of the uterine arteries, or placement of a double-balloon catheter.Key words: Caesarean scar pregnancy
Preeklamsia Pascasalin Nuswil Bernolian; Wim T. Pangemanan; A. Kurdi Syamsuri; M. Hatta Ansyori; Putri Mirani; Peby Maulina Lestari; Abarham Martadiansyah; Cindy Kesty
Indonesian Journal of Obstetrics & Gynecology Science Special Issue: Article Review
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n2s.196

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AbstrakTujuan: Memaparkan etiologi dan faktor risiko, diagnosis banding, patofisiologi, pemantauan, terapi, komplikasi, rekurensi dan tindakan preventif pada kasus preeklamsia pascasalin.Metode: Tinjauan pustaka dengan berbagai referensi yang diakses melalui mesin pencarian seperti Pubmed dan Sci-Hub dengan menggunakan kata kunci preeclampsia, hypertension, postpartum, management. Sumber referensi yang digunakan yaitu guidelines, jurnal, dan buku teks yang diterbitkan dalam 15 tahun terakhir.Kesimpulan: Insiden preeklamsia di Indonesia yaitu 128.273/tahun atau sekitar 5,3%. Sebanyak 0,3 – 27,5% kasus yang dilaporkan mengalami preeklamsia atau hipertensi pascasalin. Gejala-gejala preeklamsia pascasalin muncul setelah melahirkan. Mayoritas kasus berkembang dalam 48 jam setelah persalinan, walaupun sindrom dapat muncul hingga 6 minggu setelah persalinan. Periode pascasalin merupakan waktu kritis bagi spesialis obstetri dan ginekologi untuk menjamin wanita dengan riwayat preeklamsia untuk dipantau dalam jangka waktu pendek dan panjang. Akan tetapi, pemantauan pascasalin sangatlah rendah, berkisar antara 20-60%. Pemilihan antihipertensi pasca salin yaitu berikatan kuat dengan protein dan solubilitas lipid yang rendah sehingga lebih sedikit yang masuk ke ASI. Selain itu, dipengaruhi juga oleh ionisasi, berat molekul dan konstituen ASI (kandungan lemak, protein, dan air). Agen lini pertama untuk preeklamsia pascasalin adalah labetalol dan hidralazin intravena serta nifedipin. Wanita dengan hipertensi gestasional ataupun preeklamsia biasanya dapat menghentikan antihipertensi dalam 6 minggu pasca salin.Postpartum PreeclampsiaAbstractObjective: To explain about etiologies and risk factors, differential diagnosis, pathophysiology, follow up, treatment, complications, recurrence, and prevention of preeclampsia post delivery discharged.Method: Literature review with several references accessed through search engines such as Pubmed and Sci-Hub by using keywords preeclampsia, hypertension, postpartum, management. Reference sources used are guidelines, journals, and textbooks published in the last 15 years.Conclusion: The incidence of preeclampsia in Indonesia is 128,273/year or around 5.3%. As many as 0.3-27.5% of cases reported postpartum preeclampsia or hypertension. Symptoms of postpartum preeclampsia appear after delivery. The majority of cases develop within 48 hours after delivery, although the syndrome can appear up to 6 weeks after delivery. The postpartum period is a critical time for obstetricians and gynecologists to ensure women with a history of preeclampsia are monitored in the short and long term. However, postpartum monitoring is very low, ranging from 20-60%. The choice of antihypertensive postpartum is that it is strongly bound to protein with low lipid solubility so that fewer enter breast milk. In addition, it is also influenced by ionization, molecular weight and constituents of breast milk (fat content, protein, and water). The first line agent for postpartum preeclampsia is intravenous labetolol and hydralazine and also nifedipine. Women with gestational hypertension or preeclampsia can usually stop antihypertension within 6 weeks postpartum.Key word: postpartum preeclampsia, antihypertension