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All Journal MEDISAINS Science and Technology Indonesia SRIWIJAYA JOURNAL OF MEDICINE
Rasyid, Riana Sari Puspita
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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A Cytotoxic Activity of Tahongai (Kleinhovia hospita Linn.) Leaves Extracts Using Brine Shrimp Lethality Test Solihah, Indah; Herlina, Herlina; Rasyid, Riana Sari Puspita; Suciati, Tri; Khairunnisa, Khairunnisa
Science and Technology Indonesia Vol 4 No 3 (2019): July
Publisher : ARTS Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1489.712 KB) | DOI: 10.26554/sti.2019.4.3.60-63

Abstract

Tahongai (Kleinhovia hospita Linn.) leaves had been known contain alkaloids, flavonoids, saponins, steroids, and tannins. At Komering, South Sumatera tribe, tahongai leaves had been known to treat tumor, cancer, polyps, acne, and dysmenorrhea. The study of cytotoxic activity of tahongai bark and stem were done. This study aims to determine the cytotoxic activity of tahongai leaves extracts using BSLT method. Tahongai leaves were extracted using gradual maceration with n-hexane, ethyl acetate, and ethanol 96%. Each extract was tested cytotoxic activity towards Artemia salina L. larvae. The yield of n-hexane, ethyl acetate, and ethanol extracts are 2,686%, 7,033%, and 7,933% respectively. Ethanol extract of tahongai leaves had the best cytotoxic activity with lethality value 76,667% at 500ppm. Statistical analysis with two way ANOVA showed extract and concentration had a significant (p<0,05) effect on larvae lethality percentage.
Prevalensi dan Faktor Risiko Persalinan Preterm di RSUP Dr. Mohammad Hoesin Palembang Trisa, Yusdela; Martadiansyah, Abarham; Rasyid, Riana Sari Puspita
Sriwijaya Journal of Medicine Vol. 2 No. 2 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (388.081 KB)

Abstract

Persalinan preterm adalah persalinan kurang dari 37 minggu usia kehamilan. Preterm menyumbang sekitar 50% dari semua kematian neonatal. Indonesia merupakan salah satu negara penyumbang persalinan preterm terbanyak pada tahun 2010. Penyebab persalinan preterm adalah kombinasi dari berbagai macam keadaan, seperti obstetrik, sosiodemografi, dan faktor medik. Penelitian ini bertujuan untuk mengetahui prevalensi dan hubungan faktor risiko dengan persalinan preterm di RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini adalah penelitian analitik observasional. Sebanyak 505 sampel ibu bersalin diambil dengan teknik simple random sampling. Data dicatat dan diobservasi dari rekam medik berupa usia, jarak kehamilan, riwayat persalinan preterm, tingkat pendidikan, kehamilan multipel, ketuban pecah dini, dan riwayat perdarahan antepartum. Lalu data dianalisis dengan uji chi square. Pada penelitian ini dijumpai angka kejadian persalinan preterm sebanyak 497 (20,7%) ditahun 2015, 687 (29,4%) ditahun 2016, dan 578 (26,9%) ditahun 2017. Secara statistik terdapat hubungan yang signifikan antara riwayat persalinan preterm, kehamilan multipel, ketuban pecah dini, dan perdarahan antepartum (p <0,05). Sedangkan variabel usia, jarak kehamilan, dan tingkat pendidikan tidak terdapat hubungan yang signifikan dengan kejadian persalinan preterm. Dari analisis mutivariat didapatkan variabel yang paling berpengaruh adalah kehamilan multipel. Terdapat hubungan yang signifikan antara variabel riwayat persalinan preterm sebelumnya, kehamilan multipel, ketuban pecah dini, dan perdarahan antepartum dengan kejadian persalinan preterm.
In vivo study of the antioxidant test of ethanolic extract of Chromolaena odorata Linn. leaves Solihah, Indah; Herlina, Herlina; Munawwaroh, Inayatul; Rasyid, Riana Sari Puspita
MEDISAINS Vol 18, No 3 (2020)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v18i3.8307

Abstract

Background: Chromolaena odorata L. leaf was reported to contain phenolic group compounds, such as flavonoids. Flavonoid compounds have been reported to have antioxidant activity. Based on in vitro study, Chromolaena odorata L. leaves have potent antioxidant activity. However, in vivo, studies with dose variations have not been reported.Purpose: This study evaluates the antioxidant activity with various doses of ethanolic extract of Chromolaena odorata L. leaves against male Wistar rats induced by paracetamol.Methods: Flavonoid contents were measured spectrophotometrically based on the formation of a complex flavonoid-aluminum. Quercetin was used to make a calibration curve. In vivo test was used TBARS method carried out by measured malondialdehyde (MDA) level in male Wistar rats induced by paracetamol 2g/Kg BW. The test was carried out on extracts with doses of 125, 250, and 500 mg/Kg BW. Vitamin C with dose 6,5mg/Kg BW used as a positive control, and 1% of Na CMC used as the negative control. Histopathology assessment of liver used Hema-toxylin Eosin Stain.Results: Ethanolic extract of Chromolaena odorata L. leaves contain flavonoid 126.459±0.163 mg/g extract as quercetin equivalent. Intoxication paracetamol on rats increased MDA serum level significantly different (p-value < 0.005) with normal control. Treatment of ascorbic acid and extracts decreased MDA serum level significantly different (p-value < 0.005) with control negative and improved the histological structure of hepatocytes.Conclusion: Ethanolic extract of Chromolaena odorata Linn. dose 500 mg/Kg BW was the best treatment with exhibited 58.974% reduction of MDA serum level and better improve the histological structure hepatocytes than other doses
Co-Authors Chodijah, Nyimas Herlina Herlina Khairunnisa Khairunnisa Krisna Murti Martadiansyah, Abarham Munawwaroh, Inayatul Solihah, Indah Tri Suciati Trisa, Yusdela