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All Journal Jurnal Medik Veteriner JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH
Vita, Angelica Diana
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Veterinary

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Efek Antidiabetik Ekstrak Daun Gendola (Basella rubra L.) Terhadap Kadar Gula Darah Tikus Putih Vita, Angelica Diana; Fatimah, Nurmawati; Murtiwi, Sri
Jurnal Medik Veteriner Vol. 2 No. 2 (2019): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.853 KB) | DOI: 10.20473/jmv.vol2.iss2.2019.127-132

Abstract

Penelitian bertujuan untuk menguji efek antidiabetik ekstrak daun gondola (Basella rubra L.) pada kadar gula darah tikus putih (Rattus norvegicus) yang diinduksi Alloxan. Penelitian ini merupakan penelitian eksperimen dengan menggunakan 35 ekor tikus putih. Tikus tersebut dibagi menjadi lima kelompok perlakuan, yakni: P1; P2; P3; kontrol negatif (K-); dan kontrol positif (K+). Masing-masing kelompok diinduksi menggunakan Alloxan untuk meningkatakan kadar gula darah. Kelompok P1; P2; P3 diberi ekstrak daun gendola dengan dosis 200; 300; 400 mg/kgBB/hari. Kelompok K+ diberi obat glimepirid 0.1 mg/kgBB/hari. Kelompok P1 mengalami penurunan kadar gula darah yang tidak signifikan sebesar 30.14 mg/dL (p-value=0.128); kelompok P2 mengalami penurunan kadar gula darah tidak signifikan sebesar 25.80 mg/dL (p-value=0.159); kelompok P3 mengalami penurunan kadar gula darah yang signifikan sebesar 42.80 mg/dL (p-value=0.043). Kelompok kontrol negatif mengalami peningkatan kadar gula darah sebesar 116.00 mg/dL (p-value=0.084). Kelompok kontrol positif mengalami penurunan kadar gula darah yang signifikan sebesar 21.60 mg/dL (p-value=0.011). Ekstrak daun gendola 400 mg/kgBB/hari dapat menurunkan kadar gula darah tikus dengan perbedaan tidak signifikan apabila dibandingkan dengan obat antidiabetes glimepirid 0.1 mg/kgBB/hari.
COMPARISON OF MORTALITY BETWEEN THE COMBINATION OF STANDARD THERAPY AND CONVALESCENT PLASMA THERAPY AND STANDARD THERAPY ONLY IN COVID-19 PATIENTS : SYSTEMATIC REVIEW AND META-ANALYSIS Klarin, Felicia; Vita, Angelica Diana; Siahaan, Cynthia Elvira Sari; Rifdah, Salsabila Nabilah; Putri, Ayu Rahmanita; Kusuma, Indriasti Putri; Prayitno, Subur
Journal of Community Medicine and Public Health Research Vol. 2 No. 2 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.579 KB) | DOI: 10.20473/jcmphr.v2i2.27432

Abstract

Coronavirus Disease-19 (COVID-19) is an infectious disease caused by a newly discovered type of coronavirus. Comprehensive management for COVID-19 patients includes infection control, hemodynamic stability maintenance, oxygenation monitoring, ventilation, and pharmacotherapy administration. Convalescent plasma is one of the COVID-19 therapy choices, proven to provide relief for Ebola, SARS, and MERS patients. Therefore, the authors believed in searching data on whether convalescent plasma therapy also improves COVID-19 patients, specifically in terms of mortality. This study aims to compare the comparison in mortality between standard therapy and convalescent plasma therapy with standard therapy only in COVID-19 patients. This study used a systematic review and meta-analysis method according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This study used ten studies that met the inclusion criteria to evaluate the comparison in mortality between the combination therapy with standard therapy only in COVID-19 patients. There was a significant difference in mortality between the combination of standard therapy and convalescent plasma therapy with standard therapy only in COVID-19 patients, and mortality in the combination therapy groups being lower than standard therapy only.
Co-Authors Fatimah, Nurmawati Klarin, Felicia Kusuma, Indriasti Putri Murtiwi, Sri Prayitno, Subur Putri, Ayu Rahmanita Rifdah, Salsabila Nabilah Siahaan, Cynthia Elvira Sari