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UJI SENYAWA FLAVONOID TOTAL DARI EKSTRAK ETANOL HERBA BINARA (ARTEMISIA ANNUA) MENGGUNAKAN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) TAHUN 2019 Purba, Novandi; Sinurat, Jhon Patar; Marbun, Romauli Anna Teresia
Jurnal FARMASIMED (JFM) Vol 2 No 1 (2019): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

ABSTRAK Herba binara (Artemisia Annua) is one of the plants that contains flavonoids which are efficacious as antioxidants and anticancer. The purpose of this study was to determine the total flavonoid compounds contained in ethanol extract of binara herbs (Artemisia Annua). Compounds in ethanol extract of binara herbs were identified by phytochemical screening. The results showed that the ethanol extract of binara herbs contained alkaloids, flavonoids, saponins, and tannins. Extraction was carried out in two stages, namely maceration stage with 96% ethanol and fat removal stage by hydrolysis using distilled water solvent. The extract was partitioned with ethyl acetate and n-hexane solvents, then the partitions were examined by TLC using the mobile phase of chloroform and ethyl acetate (7: 3). Ribbon patches that have the same Rf and color prices as the initial detection are taken and searched. Then analyzed using High Performance Liquid Chromatography (HPLC). Based on the wavelength as well as the TLC test, a partial structure which was strongly suspected of total flavonoids was 0.93 g. Kata Kunci :Herba Binara (Artemisia Annua), flavonoid, KLT, High Performance Liquid Chromatography(HPLC).

SKRINING FITOKIMIA EKSTRAK ETANOL UMBI BAWANG MERAH (Allium cepa L.) Hasibuan, Ahmad Syukur; Edrianto, Vicky; Purba, Novandi
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Bawang merah (Allium cepa L) diketahui banyak mengandung senyawa yang memiliki aktivitas farmakologi. Etanol merupakan pelarut yang bersifat universal yang mampu melarutkan senyawa polar dan non polar serta memiliki sifat netral, absorbsi baik, tidak beracun dan stabil sehingga dapat digunakan untuk ekstraksi umbi bawang merah. Skrining fitokimia dilakukan untuk mengetahui golongan senyawa yang terkandung dalam ekstrak umbi bawang merah. Penelitian ini menggunakan ekstraksi dengan metode maserasi selama 5 hari dan dilanjutkan dengan remaserasi selama 2 hari. Kemudian ekstrak yang didapat dilakukan skrining fitokimia. Hasil skrining fitokimia umbi bawang merah menggunakan pelarut etanol menunjukkan adanya kandungan senyawa flavonoid, tanin, saponin, alkaloid dan steroid/terpenoid.

EFEKTIFITAS IMUNOSTIMULLAN DARI EKSTRAK ETANOL DAUN BENALU KOPI (Loranthus ferrugineus Roxb) PADA TIKUS JANTAN DENGAN METODE TITER ANTIBODI Purba, Novandi; Sari, Lasma Novita; Ginting, Radika
Jurnal FARMASIMED (JFM) Vol 2 No 2 (2020): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v2i2.372

The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB.

TEST OF ANTIBACTERIAL ACTIVITY FROM THE COMBINATION OF ETHANOL EXTRACT OF WARU (HIBUSCUSTILIACEUS L.) LEAVES AND LEAF RED PUCUK (SYZYGIUM OLEANA) AGAINST SALMONELLA THYPI ON 2021 Purba, Novandi; Putri, Nabila
Jurnal FARMASIMED (JFM) Vol 4 No 2 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v4i2.1009

The research in this paper aims to determine the effectiveness of immunostimulants from ethanol extract of coffee parasite leaves (Loranthus ferrugineus Roxb) with four variants of doses of 50mg / kgBB, 100mg / kgBB, 200mg / kgBB, 400mg / kgBB. This study used 18 male white rats with 200 gram BB which were divided into 6 treatment groups. Rats were injected with 0.1ml SDMS 1% for 7 consecutive days intraperitoneal, then on the 7th day each blood sample was taken through veins in the tail, CMC Na 0.5% suspension, and Levamisole suspension 50mg / kgBB as a positive control was administered orally on the 8th day. Then blood samples were collected in a micro tube and then 1900rpm was centrifuged at a temperature of 4oC for 10 minutes. The results of the study of ethanol extract of coffee parasite leaves proved effective as immunostimulants because they have a value close to positive control, starting from a dose of 200mg / kgBB to 400mg / kgBB.

ANTI-INFLAMMATORY ACTIVITY TEST OF LIME LEAF (CITRUS AURANTIIFOLIA) ETHANOL EXTRACT IN MALE MICE (MUS MUSCULUS) INDUCED CARRAGEENAN ON 2022 Purba, Novandi; Andriani Harianja, Bulan; Akbar, Khairil; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 5 No 1 (2022): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i1.1233

Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun jeruk nipis (Citrus aurantiifolia) sebagai antiinflamasi. Metode yang digunakan adalah udema buatan telapak kaki mencit putih jantan dengan induksi karagenan 1%. Pengujian aktivitas antiinflamasi ekstrak etanol daun jeruk nipis menggunakan 25 hewan uji, dengan 5 kelompok perlakuan. Kelompok terdiri atas kontrol positif yang diberikan na.diklofenak dengan dosis 6,5 mg/kgBB, kontrol negatif yang diberi perlakuan CMC Na 0,5%, dan 3 kelompok ekstrak yang dimana kelopok ektrak dosis 100 mg/kgBB, kelompok ekstrak dosis 200 mg/kgBB, dan kelompok ekstrak dosis 300 mg/kgBB. persen radang pada kelima kelompok uji mengalami penurunan secara terus menerus mulai dari menit ke-60 sampai menit ke-360 setelah induksi karagenan. persen radang terbesar terjadi pada menit ke-120 pada suspensi Na.cmc dan diikuti oleh 100 mg/kgBB, 200 mg/kgBB, 300 mg/kgBB dan Na.diklofenak. nilai persen inhibisi radang terbesar dimiliki oleh kelompok Na.diklofenak dan diikuti oleh 300 mg/kgBB, 200 mg/kgBB dan 100 mg/kgBB. Hal ini berarti, persen hambatan yang baik terdapat pada EEDJN 300 mg/kgBB setelah Na.diklofenak, kemudian diikuti EEDJN 200 dan 100 mg/kgBB dan hal ini menunjukan bahwa kelompok Na.diklofenak, 100, 200 dan 300 mg/kgBB memiliki potensi sebagai agen antiinflamasi sedangkan kelompok Na.Cmc tidak.

ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT BROCOLI (BRASSICA OLERACEA VAR. ITALICA) IN WHITE MALE RATS Purba, Novandi; Handayani, Diah Tri; Cahayani Zebua, Kristian; Harefa, Karnirius
Jurnal FARMASIMED (JFM) Vol 5 No 2 (2023): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v5i2.1587

Diabetes is a chronic disease characterized by excessive blood glucose levels caused by absolute and relative insulin deficiency. The stages in this study were sampling, identification of samples/plants, simplification, simplification screening, and preparation of extracts by maceration. The method used in the diabetes activity test uses a glucometer to induce alloxan in rats at a dose of 150 mg/kg body weight. The test animals were 25 rats which were divided into 5 treatment groups namely CMC Na 0.5% (negative control), glibenclamide (positive control) 0.45 mg/kg body weight and EEB dose 200 mg/kg body weight, 400 mg/kg body weight and 600. mg/kg body weight. kg B.W. kg body weight as a test material given orally. Measurement of blood glucose values ??according to Allox and on days 3, 5, and 7 after administration of the test substance, namely EEB. The test results data were analyzed statistically using one-way ANOVA at a 95% confidence level followed by Tukey's post hoc test. The results of the phytochemical screening showed that EEB contains alkaloids, flavonoids, tannins, saponins, and glycosides. The results of the diabetes efficacy test showed that EEB doses of 200, 400, and 600 mg/kg BW had an anti-diabetic effect on male white rats. The EEB dose of 600 mg/kg is the most effective. Post hoc Tukey test results showed that EEB doses of 200 mg/kg, 400 mg/kg, and 600 mg/kg were not significantly different from the positive control glibenclamide 0.45 mg/kg (p>0.05) and 200,400 ug. and 600 mg/kg BW were significantly different from the negative control CMC Na 0.5% (p<0.05).

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