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All Journal HAYATI Journal of Biosciences Chimica et Natura Acta Meditory : The Journal of Medical Laboratory Bioma Jurnal Sains Natural Biota Jurnal Kesehatan Islam : Islamic Health Journal Jurnal Mitra Kesehatan JURNAL BIOSHELL International Islamic Medical Journal Jurnal Mitra Masyarakat (JMM) Jurnal Masyarakat Religius dan Berwawasan
Inggraini, Maulin
STIKes Mitra Keluarga
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : HAYATI Journal of Biosciences

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Genetic Background of β-Lactamase Genes in Extraintestinal Pathogenic Escherichia coli ST131 in Indonesia Based on Whole-Genome Sequencing (WGS) Sequences Noor Andryan Ilsan; Sipriyadi Sipriyadi; Melda Yunita; Siti Nurfajriah; Maulin Inggraini
HAYATI Journal of Biosciences Vol. 29 No. 4 (2022): July 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.4.540-548

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) is a group of pathogens that can colonize the outside of the intestine, such as the kidney, urinary tract, or bloodstream. This study analyzed more about the genetic background of β-lactamase genes among Indonesian ExPEC ST131. Whole-genome sequencing (WGS) sequences from the National Center for Biotechnology Information (NCBI) of Indonesian ExPEC ST131 were taken, then analyzed. Circular genomic mapping and genomic comparison of surrounding genes of β-lactamase in these isolates were generated. blaOXA-1 and blaDHA-1 were analyzed deeply due to their presence in a relatively long contig, making them available for analysis. Indonesian ExPEC ST131 isolates had blaOXA-1 with an identical genetic background of E. coli originating from China and Austria with aac (6’)-1b-cr5 in the downstream and cab83 in the upstream. The blaOXA-1 was also detected in other species, including Klebsiella pneumoniae INF142 originating from Australia and Salmonella enterica S146 from China. While, blaDHA-1 in EC_0406 had an identical genetic background to E. coli 142 and other species such as Shigella sonei FC1428 from India and S. flexneri M2901 from Australia, with Globulin-encoded gene in the upstream and lysR in the downstream. Our findings demonstrate the global spread of β-lactamase genes detected in Indonesian ExPEC ST131. These genes were identical to those isolated from some countries around the world.
Co-Authors Agustin, Yola Violita Dianita Apriyanti Elfira Maya Sari Euodia Naomi Septiana Siburian Ika Nurfitrianti Ilsan, Noor Andryan Intan Kurniawati Pramitaningrum Nathalia, Dede Dwi Noor Adrya Ilsan Noor Andryan Ilsan Nurfitrianti, Ika Pangeran Andareas Prasetia, Dinar Ikhwal Reza Anindita Ria Amelia Rosa Ihza Arlinda Salma Lailatul Amwia Sipriyadi Siti Nur Fajriah Siti Nurfajriah Vincentia Donalda Petra Lerrick Widana, I Putu Eka Yola Violita Agustin Yundari, Yundari Yunita, Melda