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All Journal Journal of Tropical Pharmacy and Chemistry Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmako Bahari Jurnal Sains dan Kesehatan Pharmaceutical Sciences and Research (PSR) RISTEC : Research in Information Systems and Technology
Suwandi, Deden Winda
Universitas Garut
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Studi Pendahuluan Fitokimia Tanaman Koleksi Arboretum Legok Pulus Garut Retty Handayani; Ardi Rustamsyah; Farid Perdana; Setiady Ihsan; Deden Winda Suwandi
Journal of Tropical Pharmacy and Chemistry Vol. 4 No. 2 (2017): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.42 KB) | DOI: 10.25026/jtpc.v4i2.136

Abstract

Arboretrum is a botanical garden which is an open place where there are plants that have been labeled. The purpose of this research is the preliminary study on phytochemical content of secondary metabolite compounds on the leaves of the Legok Pulus Garut arboretum collection plant. the results of the study known twenty-two types of plants contained in Arboretum Garut contain various phytochemical compounds and can be used as collection and research base of medicinal plants. Keywords : arboretum, phytochemicals, secondary metabolites.
Aktivitas Analgetika dan Antiinflamasi Ekstrak Etanol dan Fraksi Daun Jambu Mawar (Syzygium jambos L.) Secara In Vivo: Analgetic and Anti-inflammatory Activity of Ethanol Extract and Fraction of Guava Leaf (Syzygium jambos L.) In Vivo Deden Winda Suwandi; Tita Puspita; Doni Anshar Nuari; Syifa Hamdani
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (219.985 KB) | DOI: 10.25026/jsk.v3i2.279

Abstract

Syzygium jambos is a plant that has traditionally been used to treat several diseases, especially the leaves as a medicine for rheumatism. In this study, the ethanol extract, fraction of n-hexane, ethyl acetate, and water from its leaves were tested for analgesic and anti-inflammatory activity using the writhing method (Siegmund), hot plate, and the formation of swelling of the soles induced by carrageenan lamda. The results showed that the ethanol extract at doses of 100 and 200 mg/kg BW and fractions of n-hexane, ethyl acetate and water at doses of 50 and 100 mg/kg BW had analgesic and anti-inflammatory activities. The ethanol extract at doses of 100 and 200 mg/kg BW can reduce the amount of writhing every 5 minutes for 60 minutes of observation by 84 and 98 times with percent protection of 58.0 and 52.0%. The Ethyl acetate, n-hexane, and water fractions of 50 and 100 mg/kg BW can reduce the amount of animal writhing by 93 and 35 times, 75 and 100 times, as well as 84 and 124 times with the percent of protection is 54.45 and 82.85, 63.0 and 50.9, as well as 58.47 and 38.02%. The analgesic activity of the hot plate method, ethanol extract can increase the survival time of animals in the hot plate by 154.0 and 95.02%, while the animal survival time of the n-hexane fraction is 95.86 and 105.5, ethyl acetate by 143, 7 and 105.7, and the water fraction of 34.1 and 99.5%. The anti-inflammatory activity of ethanol extract at doses of 100 and 200 mg/kg BW was indicated by a decrease in the volume of rat leg edema at the time of observation for 6 hours with the percent inhibition of edema of 59.2 and 41.12%. The n-hexane, ethyl acetate, and water fractions have relatively the same ability, indicated by the edema inhibition value of the n-hexane fraction of 68.24 and 68.56%, the ethyl acetate fraction of 57.08 and 67.32% and the fraction water of 64.02 and 67.46%. The effective dose of extracts and fractions of n-hexane, ethyl acetate, and water as analgesics and anti-inflammatory is 100 mg/kg BW.
AKTIVITAS PENGHAMBATAN XANTIN OKSIDASE EKSTRAK ETANOL DAUN ALPUKAT (Persea americana MILL) SECARA IN VITRO Deden Winda Suwandi; Farid Perdana
Jurnal Ilmiah Farmako Bahari Vol 8, No 2 (2017): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v8i2.784

Abstract

Hiperurisemia merupakan keadaan berlebihnya kadar asam urat dalam darah disebabkan oleh ketidak seimbangan antara produksi dan ekskresi asam urat dalam tubuh. Kondisi ini dapat menimbulkan penyakit gout yang ditandai pengendapan kristal monosodium urat. Salah satu obat yang digunakan untuk menurunkan kadar asam urat adalah allopurinol dengan cara menghambat aktivitas xantine oxidase sebagai enzim pembentuk asam urat. Penggunaan obat tradisional seperti tumbuhan alpukat yang mengandung flavonoid diduga memiliki aktivitas antihiperurisemia karena dilaporkan bahwa senyawa flavonoid dapat menurunkan kadar asam urat darah dengan cara menghambat aktivitas xantin oksidase. Telah dilakukan penelitian terhadap ekstrak etanol daun alpukat dalam menghambat aktivitas xantin oksidase sehingga bisa digunakan sebagai obat penyakit gout. Aktivitas penghambatan enzim xantin oksidase oleh ekstrak etanol daun alpukat secara invitro ditentukan melalui penurunan produksi asam urat yang diukur dengan alat spektrofotometer pada (λ) 293 nm dengan xantin sebagai substrat. Ekstrak etanol daun alpukat dapat menghambat enzim xantin oksidase pada pada konsentrasi 40; 60; 80; 100 dan 120 ppm dengan persen penghambatan sebesar 27,97; 51,98; 64,07; 71,15 dan 77,54 %. Aktivitas penghambatan xantin oksidase ekstrak daun alpukat ditentukan dengan nilai IC50, dimana hasilnya menunjukkan ekstrak etanol daun alpukat mampu menghambat aktivitas xantin oksidase dengan IC50 65,55 ppm yang lebih lemah bila dibandingkan dengan IC50 allopurinol yaitu sebesar 0,59 ppm. Kata kunci: Hiperurisemia, daun alpukat, penghambatan xantin oksidase.
ANTIHYPERURICEMIA ACTIVITY OF ETHANOL EXTRACT AND FRACTIONS OF AZADIRACHTA INDICA LEAF IN VIVO AND MECHANISM OF ACTION OF ACTIVE FRACTIONS IN VITRO Deden Winda Suwandi; Anas Subarnas; Sri Adi Sumiwi
Jurnal Ilmiah Farmako Bahari Vol 12, No 2 (2021): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v12i2.1207

Abstract

Azadirachta indica, A.,Juss is a medicinal plant that is used traditionally for some disease, especially its leaves to treat a rheumatic diseases and lower blood uric acid levels. This study was carried out to examine antihyperuricemia activity of ethanol extract, water fraction, ethyl acetat fraction and n-hexane fraction of the A. Indica leaves in male mice of Swiss-Webster strain. Extract and fraction doses used were 250 and 500 mg/kg of body weight and the doses of allopurinol as a standard drug was 13 mg/kg of body weight. The tests were conducted on mice suffering from hyperuricemia induced by potassium oxonat at adose of 300 mg/kg of body weight intraperitoneally and chicken liver juice orally. Measurement of blood uric acid levels were performed using an Easy Touch® every hour for 4 hours after being given test preparations. The results showed that the ethanol extract and the fractions lowered blood uric acid levels in the same way as allopurinol did. The n-hexane fractions at the all doses showed the highest activity, followed by ethanol fraction, and water fraction at the dose of 250 mg/kg at the 4th hour. These results illustrated that the A. Indica leaves might be potential to be used as antihyperuricemia. The active compounds which possibly reduce blood uric acid levels in mice are believed to be flavonoid or polyphenolic compounds because they are reported to be able to inhibit the action of the xanthine oxidase enzyme that converts purines into uric acid. Then, the most active fraction, n-hexane fraction, was tested for its inhibitory activity on xanthine oxidase enzyme to determine its mechanism of action. The results showed that the n-hexane fraction, like allopurinol, inhibited uric acid biosynthesis through inhibiting the activity of xanthine oxidase enzyme with the IC50 value of 132 μg/mL lower than that of allopurinol IC50 58.35 μg/mL. Key words: A. indica leaves, antihyperuricemia, chicken liver juice, potassium oxonat, xanthine oxidase.
UJI TOKSISITAS AKUT EKSTRAK ETANOL AKAR PAKIS TANGKUR (Polypodium Feei MEET) DARI GUNUNG TALAGA BODAS PADA MENCIT SWISS WEBSTER Dani Sujana; Deden Winda Suwandi; Taofik Rusdiana; Anas Subarnas
Jurnal Ilmiah Farmako Bahari Vol 11, No 2 (2020): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v11i2.856

Abstract

Meningkatnya minat masyarakat terhadap penggunaan bahan alam dari tanaman terjadi karena ketersediaan bahan yang mudah didapat. Cara tersebut terus dilakukan oleh masyarakat, serta diwariskan secara turuntemurun mengingat penggunaannya dianggap relatif aman serta efek samping yang minimal. Bagian akar dari pakis tangkur digunakan oleh masyarakat setempat untuk mengobati berbagai jenis penyakit, antara lain rematik, hipertensi dan sebagai afrodisiaka. Menurut United States of Food and Drug Administration (FDA) meskipun bahan alam dianggap relatif aman oleh sebagian kelompok penggunanya, tetap harus dilakukan skrining toksikologi terhadap senyawa yang berpotensi obat untuk melihat serta menggambarkan efek toksik sehingga diperoleh nilai Dosis letal (LD50). Dari hasil penelitian toksisitas akut ini nilai LD50 yang diperoleh yaitu lebih dari 5000 mg/kgBB. Dikarenakan pada dosis paling tinggi pada penelitian yaitu 5000 mg/kgBB tidak terdapat hewan yang mati, sehingga dapat disimpulkan bahwa ekstrak akar pakis tangkur termasuk kedalam kategori praktis tidak toksik. Kata kunci: Ekstrak Akar Pakis Tangkur, Toksisitas Akut
Aktivitas Mukolitik Kombinasi Ekstrak Etanol Daun Kemangi dan Ekstrak Etanol Daun Sirih Merah Kurniati, Neng Fisheri; Suwandi, Deden Winda; Yuniati, Safira
Pharmaceutical Sciences and Research Vol. 5, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

A cough is a protective physiological mechanism that is useful for removing and clearing the respiratory tract from sputum and foreign particles that can cause infection. Treatments for cough disorders using medicinal plants were conducted because medicinal plants were widely known to have less side effects than synthetic drugs. Basil leaves (Ocimum sanctum L.) and red betel leaves (Piper crocatum Ruiz and Pav) have been used traditionally to treat a cough. The purpose of this study was to determine the mucolytic activity, and the effective concentration of the combination of basil and red betel leaves ethanol extract. The mucolytic activity was performed by measuring the decrease of viscosity of mucous from the cow intestinal mucosa. Mucolytic activity was evaluated upon treatment by each extract (concentration 0.1%, 0.5%, and 1%) and the combination of both. Results showed that ethanol extract of basil leaves or ethanol extract of red betel leaves could reduce viscosity of artificial sputum at the dose of 0.5% each. Moreover, the combination of these extracts synergistically decreases the viscosity. Combination of ethanol extract of basil leaves and red betel can be an alternative medicine for cough treatment.
SIMULASI IN SILICO SENYAWA AKTIF DAUN JAMBU MAWAR (Syzygium jambos L. Alston) SEBAGAI OBAT ANTIINFLAMASI Deden Winda Suwandi; Nindi Wahyuni; Selvira Anandia Intan M
Jurnal Farmamedika (Pharmamedika Journal) Vol 8 No 1 (2023): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v8i1.205

Abstract

Inflamasi merupakan salah satu respon imun bawaan yang berperan dalam sistem pertahanan terhadap senyawa asing. Dalam penelitian terdahulu telah diketahui bahwa ekstrak daun jambu mawar memiliki aktivitas antiinflamasi. Tujuan penelitian ini adalah untuk mengetahui senyawa kandidat dari daun jambu mawar yang memiliki aktivitas antiinflamasi melalui interaksi terhadap reseptor TNF-α dan enzim iNOS. Penelitian ini menggunakan metode in silico yaitu penambatan molekul untuk memprediksi afinitas senyawa-senyawa daun jambu mawar terhadap iNOS dengan kode: 1NSI dan TNF-α dengan kode: 3EWJ. Hasil penambatan molekul menunjukkan senyawa methyl (4R,9R,10R,15R)-4-(cyanomethyl)-4,9,10–trimethyl-3-[2-methyl-1-oxo-1-(1,3-thiazol-2-ylamino)propan-2-yl]-15-prop-1-en-2-yl-2,3,5,6,7,8,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-13-carboxylate memiliki afinitas lebih baik dari ligan alaminya dengan nilai ΔG -13,65 kkal/mol pada residu asam amino GLY346 dan LEU348 reseptor TNF-α, dan menunjukkan senyawa alpha-Tocopherol-beta-D-mannoside memiliki afinitas terbaik dengan nilai ΔG -10,53 kkal/mol pada residu asam amino TRP372 reseptor enzim iNOS. Dapat disimpulkan bahwa kedua senyawa ini merupakan kandidat yang paling potensial sebagai antiinflamasi.
Design of an Internal Quality Assurance System Based on Smart System to Improve the Quality of Higher Education at Universitas Garut Dendi Ramdani; Deden Winda Suwandi; Yasya Fauzan Wakila; Riyad Sabilul Muminin
RISTEC : Research in Information Systems and Technology Vol. 4 No. 2 (2023): RISTEC : Research in Information Systems and Technology
Publisher : RISTEC : Research in Information Systems and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Garut University has a Quality Assurance Institute (LPM) responsible for overseeing the quality assurance cycle, but it still uses manual archiving, leading to data accumulation and slow performance. This research aims to develop an internal quality assurance system based on a smart system to improve the quality of higher education. The research method uses a waterfall approach with stages of data collection, system analysis, application design, and implementation. The system is designed to effectively distribute and store LPM data and information. The research results show that this information system can help improve the quality of higher education by providing quick and accurate information related to data standards and audits.
Co-Authors Anas Subarnas Ardi Rustamsyah Dani Sujana Dendi Ramdani Neng Fisheri Kurniati Nindi Wahyuni Nuari, Doni Anshar Perdana, Farid Retty Handayani Riyad Sabilul Muminin Selvira Anandia Intan M Setiady Ihsan Sri Adi Sumiwi Syifa Hamdani Taofik Rusdiana Tita Puspita Yasya Fauzan Wakila Yuniati, Safira