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All Journal Jurnal Ilmiah Manuntung Jurnal Ilmu Kesehatan Jurnal Kedokteran Mulawarman Jurnal Sains dan Kesehatan
Siagian, Loly Rotua Dharmanita
Universitas Mulawarman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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SKRINING THALASEMIA-BETA MINOR PADA MAHASISWA FAKULTAS KEDOKTERAN Sihotang, Fransiska Anggreni; Siagian, Loly Rotua Dharmanita; Ngo, Novia Fransiska; Kalalo, Lily Pertiwi
Jurnal Ilmiah Manuntung Vol 5 No 1 (2019): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (713.562 KB)

Abstract

Thalassemia is a group of congenital hemoglobinopathy characterized by deficiency or absence of one (or more) of the globin chains that constitute hemoglobin. Thalassemia major is inherited through autosomal recessive pattern by marriage between carriers of the thalassemia gene known as thalassemia minor. Beta-thalassemia is the most common type of thalassemia. It is estimated that 10% of Indonesia's population carries the beta-thalassemia gene. However, there has been no routine screening for thalassemia gene carriers. Several recognized methods of thalassemia screening are available. One of them is screening of prospective brides using several hematology parameters such as Mentzer index and red blood cells fragility; both are relatively straightforward and inexpensive compared to hemoglobin analysis or genetic testing. This study aimed to determine the frequency of beta-thalassemia minor suspects among students in the Medical Faculty of Mulawarman University. This study was a descriptive quantitative study with cross sectional approach that involved 160 participants. Participant's blood sample was collected for complete blood count and one tube osmotic fragility test (OTOFT). Mentzer index is calculated by dividing MCV values ??with erythrocyte count. Participants were determined as beta-thalassemia minor suspects if they met following criterias: (1) MCV < 80 fL; (2) Mentzer index < 13; and (3) positive OTOFT result. This study demonstrated that 1.25% (n=2) of 160 participants were beta-thalassemia minor suspect. Further examination of hemoglobin electrophoresis or genetic testing is needed to further confirm this finding.
Hubungan Kadar Natrium Serum dengan Outcome Klinis pada Pasien Cedera Kepala Berat di RSUD Abdul Wahab Sjahranie Samarinda Rivaldi, Achmad; Ibrahim, Arie; Siagian, Loly Rotua Dharmanita
Jurnal Ilmiah Manuntung Vol 6 No 1 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (267.125 KB) | DOI: 10.51352/jim.v6i1.296

Abstract

Recently, Traumatic Brain Injury (TBI) has high mortality in the world. In severe TBI, secondary brain injury can occur. ElectrSolyte disorders are the most common in secondary brain insult especially sodium disorders. It remains unclear whether hyponatremia or hypernatremia can cause worse clinical outcome in TBI patients. This study aimed to determine association between serum sodium level with clinical outcome in severe TBI patients at RSUD Abdul Wahab Sjahranie Samarinda. A cross sectional analytical study by taking samples to the patients with diagnosed severe TBI (GCS ≤ 8) which were hospitalized at RSUD Abdul Wahab Sjahranie Samarinda in the period of January-December 2018 that complied inclusion and exclusion criteria. Research variables are sodium serum level and clinical outcome that was assessed by structured interviews for Glasgow Outcome Scale (GOS). The relationship between variables was done using the Fisher's Exact test. A total of 41 severe TBI patients were administered. The characteristics of the sample were the most patients in 20s-40s (46.3%), patients were dominated by male (82.9%) and the most common CT scan characteristic were epidural hematoma (29.3%). The most of patients showed normonatremia in 25 patients (61%), 9 patients (22%) had hypernatremia and 7 patients (17.1%) had hyponatremia. The most clinical outcome on severe TBI patients were worse outcome with 70.7% while good outcome with 29.3%. Statistical result showed there’s no association between serum sodium level (hyponatremia and hypernatremia) with clinical outcome in severe TBI patients with p values, 1.000 and 0.225, respectively. There’s no association between serum sodium level with clinical outcome in severe TBI patients.
GAMBARAN PROFIL LIPID DAN RASIO LIPID PADA PASIEN STROKE ISKEMIK BERULANG DI RSUD ABDUL WAHAB SJAHRANIE SAMARINDA Muhammad Fadlan Adam; Yetty Octavia Hutahaean; Loly Rotua Dharmanita Siagian
Jurnal Kedokteran Mulawarman Vol 7, No 2 (2020): Jurnal Kedokteran Mulawarman
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/j.ked.mulawarman.v7i2.4293

Abstract

Stroke iskemik merupakan tipe stroke yang paling sering terjadi pada serangan berulang. Subtipe yang paling sering terjadi adalah aterosklerosis arteri besar yang menyebabkan oklusi arteri pada otak. Abnormalitas lipid plasma merupakan penyebab utama terjadinya aterosklerosis. Rasio lipid dapat menginformasikan risiko aterosklerosis yang sulit diukur dengan pemeriksaan rutin dan peningkatan rasio lipid menggambarkan ketidakseimbangan antara fraksi lipid aterogenik dan antiaterogenik. Penelitian ini bertujuan untuk mengetahui gambaran profil lipid dan rasio lipid pada pasien stroke iskemik berulang di RSUD Abdul Wahab Sjahranie Samarinda. Penelitian ini bersifat deskriptif dengan desain studi cross sectional. Pengambilan sampel secara purposive sampling pada pasien stroke iskemik yang mempunyai riwayat stroke iskemik sebelumnya sebanyak 71 sampel. Pengambilan data profil lipid menggunakan data sekunder dari rekam medik dan rasio lipid didasarkan pada perbandingan kolesterol total (K-Total)/kolesterol high density lipoprotein (K-HDL), kolesterol low density lipoprotein (K-LDL)/K-HDL, dan trigliserida (TG)/K-HDL. Pada penelitian ini didapatkan hasil pasien stroke iskemik berulang paling banyak dengan K-Total yang optimal sebesar 49,3%, K-LDL mendekati optimal 42,2%, K-HDL rendah 71,8%, TG optimal 62,0%, rasio K-Total/K-HDL di atas nilai risiko 76,1%, rasio K-LDL/K-HDL di atas nilai risiko 63,4%, dan rasio TG/K-HDL di atas nilai risiko 52,1%. Berdasarkan hasil ini dapat disimpulkan bahwa profil lipid pasien stroke iskemik berulang di RSUD Abdul Wahab Sjahranie Samarinda paling banyak ditemukan dengan kadar K-Total dan TG yang optimal, K-LDL yang mendekati optimal, dan kadar K-HDL yang rendah. Rasio lipid yang terdiri dari rasio K-Total/K-HDL, rasio K-LDL/K-HDL dan rasio TG/K-HDL masing-masing ditemukan paling banyak dengan rasio di atas nilai risiko.
Hubungan Jenis Plasmodium falciparum dan Plasmodium vivax dengan Kejadian Anemia pada Pasien Malaria di RSUD Ratu Aji Putri Botung Penajam Paser Utara: Relationship between Plasmodium falciparum and Plasmodium vivax Types with the Incidence of Anemia in Malaria Patients at Ratu Aji Putri Botung Hospital, Penajam Paser Utara Doni Suryadi; Vera Madonna Lumban Toruan; Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian
Jurnal Sains dan Kesehatan Vol. 3 No. 2 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.761 KB) | DOI: 10.25026/jsk.v3i2.283

Abstract

Malaria is a disease caused by Plasmodium infection that is still a health problem in the tropical area including Indonesia. Penajam Paser Utara is the only district with a high level of malaria endemicity outside eastern of Indonesia which is located at the Province of East Kalimantan. Malaria can cause various complications including haematological abnormalities. Haematological abnormalities that are often found in both falciparum malaria and vivax malaria is anaemia. The purpose of this study was to determine the relationship between the types of Plasmodium falciparum and Plasmodium vivax with the incidence of anaemia in malaria patients at Ratu Aji Putri Botung, Penajam Paser Utara hospital. This research is an observational analytic study with cross sectional method. The data was obtained from medical records of hospitalized malaria patients at Ratu Aji Putri Botung Penajam Paser Utara hospital in the period of January 2013 – August 2018 by purposive sampling method. The data were analyzed using the Chi-square test. The subjects of the study were 310 malaria patients consisting of 60,3% (n=187) patients infected with Plasmodium falciparum and 39,7% (n=123) patients infected with Plasmodium vivax. The majority of research subjects were male (95,8%) and were in the 26 – 40 years age group (56,5%). Anaemia was found in 49% of malaria patients dominated by vivax malaria patients (52%). Statistical test result between types of Plasmodium with the incidence of anaemia was p = 0,391. It was concluded that there was no association between the types of Plasmodium falciparum and Plasmodium vivax with the incidence of anaemia in malaria patients.
The RELATIONSHIP BETWEEN TYPES OF PLASMODIUM FALCIPARUM AND PLASMODIUM VIVAX WITH THE DEGREE OF THROMBOCYTOPENIA IN MALARIA PATIENTS AT RSUD RATU AJI PUTRI BOTUNG PENAJAM PASER UTARA Doni Suryadi; Vera Madonna Lumban Toruan; Fransiska Anggreni Sihotang; Loly Rotua Dharmanita Siagian
Jurnal Ilmu Kesehatan Vol 9 No 1 (2021): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v9i1.2218

Abstract

Malaria is a tropical infectious disease with high morbidity and mortality rates. In malaria, various kinds of haematological complications can arise, one of which is thrombocytopenia. Thrombocytopenia is most commonly encountered during acute malaria infection with varying degrees observed in both Plasmodium falciparum and Plasmodium vivax infections. The purpose of this study was to determine the relationship between the types of Plasmodium falciparum and Plasmodium vivax with the degree of thrombocytopenia in malaria patients at the Ratu Aji Putri Botung Penajam Paser Utara Hospital. This research is an observasional analytic study with cross sectional method. The data was taken by using purposive sampling method from the medical records of malaria patients hospitalized in Ratu Aji Putri Botung Penajam Paser Utara Hospital in the period of January 2013 - August 2018. Data analysis used the Chi-square test. Of the 310 malaria patients who were study subjects, 60,3% (n = 187) were infected with Plasmodium falciparum and 39,7% (n = 123) were infected with Plasmodium vivax. Most of the research subjects were male (95,8%) who were dominated by adults (56,5%). As many as 90% of malaria patients experienced thrombocytopenia with mild, moderate, and severe thrombocytopenia respectively 29,4% ; 56,6% ; 14,0%. Severe thrombocytopenia was more common in falciparum malaria patients (16,4%). The statistical test result for the type of Plasmodium with the degree of thrombocytopenia were p = 0,139. It was concluded that there was no relationship between the types of Plasmodium falciparum and Plasmodium vivax with the degree of thrombocytopenia in malaria patients.
Co-Authors Doni Suryadi Doni Suryadi Fransiska Anggreni Sihotang Ibrahim, Arie Kalalo, Lily Pertiwi Muhammad Fadlan Adam Novia Fransiska Ngo Rivaldi, Achmad Vera Madonna Lumban Toruan Yetty Octavia Hutahaean