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All Journal Jurnal Sistem Komputer & Kecerdasan Buatan Law Research Review Quarterly Asian Australasian Neuro and Health Science Journal (AANHS-J) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Sains Medisina
Ramadhan, Hafiz
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Social Sciences

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Journal : Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

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DAUN Alphitonia incana (Roxb.) Teijsm. & Binn. ex Kurz SEBAGAI ANTI-Escherichia coli: STUDI IN SILICO DAN IN VITRO Ramadhan, Hafiz; Forestryana, Dyera; Jamaludin, Wahyudin Bin; Hadi, Ahmad Nur; Raudatunnisa
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 2023: Webinar Nasional & Call For Paper
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i3.1701

Abstract

This research was conducted to determine the potential of phytochemical contents in producing antibacterial activity from 70% ethanol extract of Balik Angin leaves  (Alphitonia incana (Roxb.) Teijsm . & Binn. ex Kurz) against Escherichia coli bacteria in silico and in vitro. In silico assay of 20 compounds contained in Alphitonia species against the DNA gyrase receptor using PLANTs. Anti-E.coli activity assay of Balik Angin leaves macerated with 70% ethanol solvent using the Well diffusion method. In silico studies show that β-Sitosterol, Stigmasterol, Rutin, Kaempferol 3-O-rutinoside, and Zizyphoiside C have binding energies with DNA gyrase that can exceed Ciprofloxacin. The antibacterial assay results at a highest concentration of 26.56 mg/ml can provide an average inhibitory zone diameter of 12.75 ± 0.2 mm with a minimum inhibitory concentration (MIC) of 1.66 mg/ml (5.87 ± 1.5 mm). The 70% ethanol extract of Balik Angin leaves has the potential as an anti-Escherichia coli, supported by the content of phytochemical compounds that can act as DNA gyrase inhibitors.
Co-Authors Adinda Syafitri, Adinda Arsyad, Zyrzasya Sofia Nara Forestryana, Dyera Hadi, Ahmad Nur Ibrahim, Sabri Irsyad, Muhammad Ari Jamaludin, Wahyudin Bin Nasution, Muhammad Deni Pangestu, Rico Alfian Rahmi Muthia Raudatunnisa Ridwan Arifin Saefudin, Yusuf Rizky Wicaksono, Andri Aditya Zailani, Achmad Udin