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All Journal Jurnal Kesehatan Pharmaceutical Sciences and Research (PSR)
Setiadi, Adji Prayitno
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Education Health Professions Medicine & Pharmacology Neuroscience

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KAJIAN PENGGUNAAN MISOPROSTOL ORAL DAN VAGINA SEBAGAI PENGINDUKSI PERSALINAN Setiadi, Adji Prayitno; Wibowo, Yosi Irawati; Anggara, I Gede Yudi; Dhitama, I Made Yogista
Jurnal Kesehatan - STIKes Prima Nusantara Vol 12, No 1 (2021): JURNAL KESEHATAN
Publisher : STIKes Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (170.45 KB) | DOI: 10.35730/jk.v12i1.428

Abstract

Latar belakang: Misoprostol telah digunakan secara luas sebagai penginduksi persalinan, walaupun di beberapa negara masih off-label. Oleh karenanya, pembaharuan data terkait misoprostol perlu dilakukan secara berkelanjutan untuk mendukung praktek berbasis bukti.Tujuan: menyediakan kajian profil misoprostol terkait dengan indikasi, efektivitas dan efek sampingnya.Metode: Kajian naratif dengan penelusuran pada PubMed (Medline), CINAHL, dan Science Direct untuk mendapatkan artikel penelitian acak terkontrol terkait misoprostol oral/vaginal sebagai penginduksi persalinan pada periode 1 Januari 2014 sampai 20 Juni 2020.Hasil: Terdapat 9 artikel yang membandingkan misoprostol vaginal (MV) versus misoprostol oral (MO) (atau placebo atau dinoprostone). Misoprostol terutama digunakan sebagai penginduksi persalinan pada kondisi kehamilan post-datism, atau adanya komplikasi maternal/fetal. MV terlihat lebih efektif terkait ‘kejadian persalinan per-vaginam dalam 24 jam’ dibandingkan MO (1 penelitian menunjukkan perbedaan yang signifikan, p<0,001). Sedangkan terkait dengan ‘tingkat operasi sesar’, masih menunjukkan hasil yang bervariasi. Efek samping maternal terkait hiperstimulasi uterus dan takisistole menunjukkan kecenderungan yang lebih tinggi pada MV. Efek samping pada fetus, seperti meconium-stained liquor dan abnormalitas denyut jantung fetus, cenderung lebih tinggi pada MV, di mana masing-masing terdapat 1 penelitian yang menunjukkan perbedaan yang signifikan (p=0,004 dan p=0,047, secara berurutan).Simpulan: Misoprostol vaginal tampak memberikan profil  efektivitas yang lebih baik, namun terdapat kecenderungan risiko efek samping yang lebih tinggi; sehingga, pemberian oral memiliki potensi sebagai alternatif.
The Development of a Questionnaire on Factors Affecting Non Adherence Behavior among Indonesian Elderly Population Makkulawu, Andi; Setiadi, Adji Prayitno; Rahardjo, Tri Budi Wahyuni; Setiawan, Eko
Pharmaceutical Sciences and Research
Publisher : UI Scholars Hub

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Abstract

Instruments which can be used to identify factors affecting the medication adherence of elderly with diabetes mellitus (DM) have not been discovered in Indonesia. The objective of this study was to develop a questionnaire to identify factors affecting elderly patients’ medication adherence. The development of the questionnaire was conducted based on published references attained through the exploration of research evidence with several keywords and databases. Content validity was conducted using experts’ assessment (two experts). Face validity was conducted in 13 subjects including seven (7) non-elderly subjects and six (6) elderly subjects. Construct validity test was conducted based on calculated R against table R while reliability test was conducted with Cronbach’s Alpha. There were 30 elderly subjects included in the construct validity. Present study produced a valid and reliable questionnaire comprising 35 questions in 14 subcategories from 4 factor domains with the calculated R = 0.357-0.788 and Cronbach’s Alpha = 0.934. The questionnaire can be used for further research throughout Indonesia. Hence, a complete overview of factors affecting elderly DM patients’ medicine consumption adherence can be obtained. The identification of factors related to the usage of DM patients’ medicine is expected to serve as a base for the government, both of state and local government, to produce policies related to health interventions to be implemented.
Co-Authors Abdul Rahem, Abdul Anggara, I Gede Yudi Bobby Presley, Bobby Brata, Cecilia Dhitama, I Made Yogista Eko Setiawan Halim, Steven Victoria Makkulawu, Andi Ningsih, Linda Fidya Susanto, Verlita Evelyn Tri Budi Wahyuni Rahardjo, Tri Budi Wahyuni Wibowo, Yosi Irawati