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All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J The Journal of Society Medicine (JSOCMED)
Gani, Azhari
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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HUBUNGAN LAMA PENGGUNAAN KONTRASEPSI DEPO MEDROKSIPROGESTERON ASETAT (DMPA) DENGAN OBESITAS Suciana, Suciana; Rajuddin, Rajuddin; Gani, Azhari
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 3: No. 1 (Mei, 2017)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.006 KB) | DOI: 10.29103/averrous.v3i1.448

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan lama penggunaan kontrasepsi DMPA dengan obesitas. Penelitian dilakukan dengan menggunakan metode analitik cross sectional  terhadap 78 responden. Untuk mengukur lamanya penggunaan kontrasepsi DMPA digunakan kuesioner dan untuk mengukur obesitas dilakukan pengukuran BMI. Analisis data menggunakan uji Chi-Square dengan CI 95% dan ? = 0,05. Sebanyak 20,5% akseptor kontrasepsi DMPA dengan lama penggunaan DMPA 3-18 bulan mengalami obesitas, sedangkan akseptor yang menggunakan kontrasepsi DMPA >18 bulan sebanyak 59% mengalami obesitas dengan p value 0,001. Terdapat hubungan antara lama penggunaan kontrasepsi DMPA dengan obesitas.
Thyroid Heart Disease in Young Male, a Case Report Sihite, Perdana Liansyah; Hambali, Abdullah; Kamil, Muhammad Firdaus; Muhsin, Muhsin; Gani, Azhari; Diah, Muhammad
Journal of Society Medicine Vol. 2 No. 1 (2023): January
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.182 KB) | DOI: 10.47353/jsocmed.v2i1.20

Abstract

Introduction: The thyroid gland produces thyroid hormones that affect all tissue's metabolic processes, including the heart. Disorders of thyroid hormones, both increasing and decreasing thyroid hormones, can cause similar symptoms to primary heart disease. Thyroid heart disease (THD) is a heart disease that occurs due to increasing (hyperthyroid) or decreasing (hypothyroid) thyroid hormones in the circulation. Hyperthyroidism can cause several types of heart disease, including mitral regurgitation, tricuspid regurgitation, cardiomyopathy, heart failure, mitral valve prolapses, atrial fibrillation or sinus tachycardia. Method: This was a retrospective case report, after analysis of patient clinical data. The patient provided written informed consent to publish their case details and any accompanying images. Results: Almost all cases of THD occur in middle-aged women. Here we presented a 32-year-old male patient diagnosed with THD caused by graves' disease. Patient was admitted to emergency department due to shortness of breath. Medical and non-medical treatments were administered to the patients, and patients experienced improvement after several days of hospitalization. Conclusion: In fact, the progression of hyperthyroidism is characterized by remission and long-term exacerbations. Although some patients can remain euthyroid for a long time after therapy, many eventually get into hypothyroidism. Therefore, lifetime follow-up is an indication for all patients with hyperthyroidism.
Antibacterial and anti-inflammatory activities of Nothopanax scutellarium, Moringa oleifera and Piper betle extracts on staphylococcal mastitis animal model Cut Sriyanti; Siregar, Tongku N.; Mudatsir, Mudatsir; Gani, Azhari; Hasan, Denny I.; Sutriana, Amalia
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.176

Abstract

Inappropriate and prolonged administration of antibiotics in mastitis could cause antibiotic resistance and herbal treatment might could be one alternative treatment. Nothopanax scutellarium, Moringa oleifera, and Piper betle are medicinal plants that contain various active compounds, including antibacterial and anti-inflammatory agents, but their potentials in treating mastitis are not well understood. The aim of this study was to assess the effectiveness of those plants against mastitis in rabbit model induced by Staphylococcus aureus. A total of 25 lactating rabbits (Oryctolagus cuniculus) weighing 3.0±0.4 kg were grouped into five groups: healthy control; mastitis control, and three treatment groups (Nothopanax scutellarium, Moringa oleifera, and Piper betle). Except the healthy control group, all animals were inoculated with 0.15 mL of Staphylococcus aureus containing 1.5x107colony forming unit (CFU)/mL on eight days after giving birth. The extract was administered orally after four hours Staphylococcus aureus inoculation at a dose of 50 mg/kg body weight, twice a day for five consecutive days. The number of bacteria in the milk and the level of serum interleukin 6 (IL-6) were measured and histopathological examination of mammary gland tissues were analyzed. The log number of total plate count of Staphylococcus aureus indicated that all extract groups had significant lower of bacterial logs compared to mastitis control (all comparisons had p<0.05) with the lowest was found in Piper betle group, followed by Nothopanax scutellarium and Moringa oleifera. The enzyme-linked immunosorbent assay (ELISA) results showed that all ethanolic extract groups had significantly lower levels of IL-6 compared to the mastitis control (all comparisons had p<0.05). The histopathologyassessment suggested that extract groups had lower infiltration of inflammatory cells such as lymphocytes and macrophages in alveoli compared to the mastitis control group. In conclusion, all three extracts contained antibacterial and anti-inflammatory activities and Piper betle had the most effective in reducing bacterial growth and IL-6 level compared to others.
Co-Authors Amalia Sutriana Cut Sriyanti Diah, Muhammad Hambali, Abdullah Hasan, Denny I. Kamil, Muhammad Firdaus Mudatsir Mudatsir Muhsin Muhsin Rajuddin Rajuddin Sihite, Perdana Liansyah Siregar, Tongku N. Suciana, Suciana