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All Journal International Journal of Public Health Science (IJPHS) Global Medical and Health Communication MNJ (Malang Neurology Journal) Jurnal Keperawatan Padjadjaran Smart Medical Journal Indonesian Journal of Medicine Callosum Neurology Journal : Jurnal Berkala Neurologi Bali Majalah Kedokteran Neurosains Abdimas Universal SEMAR (Jurnal Ilmu Pengetahuan, Teknologi, dan Seni bagi Masyarakat) Smart Society Empowerment Journal Neurona
Stefanus Erdana Putra
Universitas Sebelas Maret
Humanities Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Callosum Neurology Journal : Jurnal Berkala Neurologi Bali

 1 
ASSOCIATION OF LIPID PROFILES AND COGNITIVE FUNCTION DETERIORATION OF GERIATRIC OUTPATIENTS AT NEUROLOGY CLINIC GUNUNGSITOLI REGIONAL GENERAL HOSPITAL Stefanus Erdana Putra; Berkat Hia; Muhammad Hafizhan; Astrida Fesky Febrianty; Fauzi Novia Isnaening Tyas
Callosum Neurology Vol 4 No 1 (2021): Callosum Neurology Journal
Publisher : The Indonesia Neurological Association Branch of Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29342/cnj.v4i1.135

Abstract

Background: The increase of life expectancy in Indonesia causes increasing numbers of dementia, mostly caused by Alzheimer's disease (AD). High serum cholesterol level has been suggested as a risk factor for AD. The strongest evidence linking lipid profile with AD provided by previous experimental studies where adding or reducing cholesterol altered amyloid precursor protein (APP) and amyloid ?-protein (A?) levels is the basic of this research. Objective: To determine whether lipid profile is associated with cognitive function deterioration of geriatric outpatients at Neurology Clinic Gunungsitoli Regional General Hospital. Methods: Participants of this cross-sectional study were outpatient geriatric patients at Neurology Clinic Gunungsitoli Regional General Hospital (n=85; mean age, 62.46±5.49 years old). The cognitive state was evaluated using Montreal Cognitive Assessment Indonesian Version (MoCA-INA) and those with MoCA-INA score <24 were considered cognitively declined. Concentrations of serum lipid profile were measured and correlated with cognitive state using Pearson’s correlation. Multiple logistic regression analysis was used to calculate odds ratios (ORs) for cognitive decline. Results: Based on Pearson’s correlation test, high-density lipoprotein (HDL) level had significant strong positive correlation with MoCA-INA score (r=0.876;p=0.000) and triglyceride level had significant strong negative correlation with MoCA-INA score (r=-0.726;p=0.000). Relatively to cognitive decline, ORs for decreased HDL level was 3.19 (95%CI 2.02-4.36) and increased triglyceride level was 2.59 (95%CI 1.29-3.91). Conclusion: There was a significant relationship between decreased HDL-cholesterol level and increased triglyceride level with cognitive decline in geriatric outpatients.
Co-Authors Astrida Fesky Febrianty Astrida Fesky Febrianty Astrida Fesky Febrianty Atik Maftuhah Berkat Hia Berkat Hia Budianto, Pepi Cynthia Hanny Lestari Damayanti, Elok Dewi Hayu Kirana Diah Kurnia Mirawati Diah Kurnia Mirawati Diah Kurnia Mirawati Diah Kurnia Mirawati Dian Nugroho Ervina Arta Jayanti Hutabarat Eti Poncorini Pamungkasari Faizal Muhammad Fauzi Novia Fauzi Novia Isnaening Tyas Fauzi Novia Isnaening Tyas Fauzi Novia Isnaening Tyas Hafizhan, Muhammad Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindya Riani Prabaningtyas Hillary Hillary Ira Ristinawati Isnaening Tyas Lestari Handayani Maria Sekar Cahyaningrum Muhammad Hafidzan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Novian Anindito Santosa Prabaningtyas, Hanindya Riani Raden Ajeng Hanindia Riani Prabaningtyas Raden Ajeng Hanindia Riani Prabaningtyas Raden Andi Ario Tedjo Raden Andi Ario Tedjo Rakhma, Titian Rivan Danuaji Rivan Danuaji Rivan Danuaji Siti Munawaroh Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Susilo, Wahyu Agung Veronika Ika Budiastuti Vivienne Tjung Wahyu Agung Susilo Wahyu Gusti Randa Widhianingsih, Nella Lusti Wilson Arpin Yeremia Suryo Pratama