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All Journal Jurnal Integrasi Kesehatan dan Sains Bandung Conference Series : Medical Science
Gunantara, Tito
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Humanities Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Faktor-Faktor yang Memengaruhi Kualitas Hidup Penderita Talasemia Anak di RSUD Al-Ihsan Kabupaten Bandung Tahun 2019 Jamaluddin Kamil; Tito Gunantara; Yani Dewi Suryani
Jurnal Integrasi Kesehatan dan Sains Vol 2, No 2 (2020): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v2i2.5848

Abstract

Talasemia merupakan penyakit genetik dan kronis yang dapat menyebabkan anemia berat sehingga mengganggu kualitas hidup. Penelitian ini bertujuan untuk mengetahui gambaran dan faktor apa saja yang memengaruhi kualitas hidup penderita talasemia anak di RSUD Al- Ihsan Kabupaten Bandung tahun 2019. Subjek penelitian adalah pasien talasemia anak di RSUD Al-Ihsan Kabupaten Bandung yang memenuhi kriteria inklusi. Data diambil menggunakan teknik total sampling dengan jumlah subjek 65 orang. Desain penelitian bersifat analitik dengan rancangan potong lintang. Penelitian menggunakan alat berupa kuesioner pediatric quality of life (PedsQL) yang berisi 23 pertanyaan. Hasil analisis univariat didapatkan kualitas hidup total subjek penelitian adalah buruk dengan rerata skor 68,9. Fungsi fisik, emosi, dan sekolah buruk dengan nilai rerata skor <80. Analisis bivariat dengan chi square test didapatkan hubungan bermakna antara faktor-faktor dengan kualitas hidup dengan nilai p≤0,05. Analisis multivariat dengan multiple logistic regression test didapatkan faktor yang paling dominan memengaruhi kualitas hidup yaitu fungsi sosial dengan koefisien beta 1,823 dan nilai p=0,039. Simpulan, rerata kualitas hidup penderita talasemia anak di RSUD Al-Ihsan Kabupaten Bandung adalah buruk. Fungsi yang terganggu yaitu fungsi fisik, emosi, dan sekolah. Faktor yang paling dominan memengaruhi kualitas hidup dengan nilai tertinggi yaitu fungsi sosial. FACTORS THAT INFLUENCE THE QUALITY OF LIFE OF CHILDREN WITH THALASSEMIA IN RSUD AL-IHSAN BANDUNG IN 2019Thalassemia is a genetic and chronic disease that can cause severe anemia that disrupts the quality of life. The purpose of this study was to determine the description and factors that influence the quality of life of children with thalassemia in RSUD Al-Ihsan Bandung in 2019. The subjects were pediatric thalassemia patients in RSUD Al-Ihsan Bandung who met the inclusion criteria. Data were taken using a total sampling technique with a total 65 subjects. This study design was analytic with cross sectional design. This study used a tool of a Pediatric Quality of Life (PedsQL) questionnaire containing 23 questions. Univariate analysis results found that the total quality of life of the study subjects was poor with a mean score of 68.9. Physical, emotional, and school functions were poor with an average score of <80. Bivariate analysis with chi square test found a significant relationship between factors with quality of life with a p value ≤0.05. Multivariate analysis with multiple logistic regression test found that the most dominant factor affecting the quality of life was social function with a beta coefficient of 1.823 (p=0.039). Conclusions, the average quality of life of children with thalassemia in RSUD Al-Ihsan in Bandung is poor. Functions that are disrupted are physical, emotional, and school functions. The most dominant factor influencing the quality of life with the highest value is social function.
Kepatuhan Konsumsi Obat Kelasi Besi dan Kadar Feritin Serum Pasien Talasemia Beta-Mayor di RSUD Al-Ihsan Bandung Hutari Gustiana; Tito Gunantara; Hilmi Sulaiman Rathomi
Jurnal Integrasi Kesehatan dan Sains Vol 2, No 1 (2020): Jurnal Integrasi Kesehatan dan Sains
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiks.v2i1.5572

Abstract

Kadar feritin serum yang tinggi pada pasien talasemia menimbulkan berbagai komplikasi yang menurunkan kualitas hidup pasien. Kadar tersebut dipengaruhi oleh berbagai hal, salah satunya kepatuhan pasien dalam mengonsumsi obat kelasi besi. Penelitian ini bertujuan mengetahui tingkat kepatuhan konsumsi obat kelasi besi dan kadar feritin serum pada penderita talasemia beta-mayor di RSUD Al-Ihsan Bandung serta hubungan antara keduanya. Penelitian ini merupakan studi cross sectional dengan melibatkan 50 pasien talasemia di RSUD Al-Ihsan Bandung yang dipilih secara consecutive. Data tingkat kepatuhan diukur dengan kuesioner Morisky Medication Adherence Scale-8 (MMAS-8) yang diisi dipandu oleh peneliti, sedangkan data kadar feritin serum didapatkan dari rekam medis pasien. Pengambilan data dilakukan pada bulan Juli–September 2019, data dianalisis menggunakan uji chi square dengan bantuan piranti lunak STATA versi 13. Hasil penelitian menunjukkan mayoritas penderita talasemia beta-mayor di RSUD Al-Ihsan Bandung (60%, IK 45,4–72,9%) memiliki tingkat kepatuhan rendah dalam konsumsi obat kelasi besi dan sebagian besar memiliki kadar feritin serum >2.500 ng/mL (58%, IK 43,5–71,2%). Terdapat hubungan bermakna secara statistik antara tingkat kepatuhan konsumsi obat kelasi besi dan kadar feritin serum pada penderita talasemia beta-mayor di RSUD Al-Ihsan Bandung (p=0,00). DRUG ADHERENCE OF IRON-CHELATING AGENT AND SERUM FERRITIN LEVELS OF BETA-MAJOR THALASSEMIA PATIENTS IN AL-IHSAN HOSPITAL BANDUNG High serum ferritin levels in thalassemia patients cause various complications that reduce the quality of life of patients. These levels are influenced by various things, one of which is patient compliance in consuming iron chelation. This study aims to determine the level of compliance with iron chelation drug consumption and serum ferritin levels in patients with beta-major thalassemia in Al-Ihsan Regional Hospital Bandung and the relationship between the two. This was a cross-sectional study involving 50 thalassemia patients at Al-Ihsan Regional Hospital Bandung, which was chosen consecutively. We measure the adherence by the Morisky Medication Adherence Scale-8 (MMAS-8) questionnaire, filled out with the researcher’s guidance, while ferritin level data was obtained from the patient’s medical record. Data was collected in July–September 2019, and data were analyzed using chi-square test with the help of STATA software version 13. The results showed the majority of patients with beta-major thalassemia in Al-Ihsan Regional Hospital Bandung (60%, 45.4–72.9% CI) have a low level of compliance in the consumption of iron chelation drugs and most have serum ferritin levels >2.500 ng/mL (58%, 43.5–71.2 CI). There was a statistically significant relationship between the level of compliance with iron chelation drug consumption with serum ferritin levels in patients with beta-major thalassemia in Al-Ihsan Regional Hospital Bandung (p=0.00).
Analisis Varian Histopatologis dan Lokasi Tumor pada Pasien Adenocarcinoma Colorectal di RSUP Dr. Hasan Sadikin Bandung Tahun 2016 Dzikru Rahmah Robbika Az-Zahra; Meike Rachmawati; Tito Gunantara
Bandung Conference Series: Medical Science Vol. 2 No. 1 (2022): Bandung Conference Series: Medical Science
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsms.v2i1.1841

Abstract

Abstract. Colorectal Adenocarcinoma is the third most common type of cancer and the most frequently diagnosed after lung cancer and breast cancer. Colorectal Adenocarcinoma is a malignant tumor of the colon epithelium with genetic mutations. The number of colorectal adenocarcinoma cases in 2020 were 17,368 or around 4.4% of the total cancer cases in Indonesia. This study aims to determine the characteristics of Colorectal Adenocarcinoma patients based on histopathological variants at RSUP Dr. Hasan Sadikin Bandung period of January 1, 2016—December 31, 2016. This research is an analytical observational study with a cross sectional approach. The data used is secondary data in the form of medical record data. The sampling technique used is total sampling. From this study, it was found that Colorectal Adenocarcinoma patients had histopathological variants in the form of Adenocarcinoma NOS (ratio: 0.906, proportion: 90.6%, 95% CI: 0.835; 0.977), Mucinous Adenocarcinoma (ratio: 0.063, proportion: 6.3%, 95% CI: 0.003; 0.123), and Signet Ring Cell Carcinoma (ratio: 0.031, proportion: 3.1%, 95% CI: -0.011; 0.073). Colorectal adenocarcinoma patients in this study had tumors located in the right colon (ratio: 0.344, proportion: 34.4%, 95%CI: 0.288; 0.46) and tumors located in the left colon (ratio: 0.655, proportion: 65.5%, 95% CI 0.54; 0.772). The conclusion of this study is that colorectal adenocarcinoma patients tend to have histopathological variants in the form of adenocarcinoma NOS and have tumors located in the left colon. Abstrak. Adenocarcinoma Colorectal merupakan jenis kanker paling umum ketiga dan paling sering didiagnosis setelah kanker paru-paru dan kanker payudara. Adenocarcinoma Colorectal merupakan tumor epitel ganas usus besar yang mengalami serangkaian mutasi genetik. Jumlah kasus Adenocarcinoma Colorectal di tahun 2020 adalah sebesar 17.368 atau sekitar 4,4% dari total seluruh kasus kanker di Indonesia. Penelitian ini bertujuan untuk mengetahui karakteristik penderita Adenocarcinoma Colorectal berdasarkan varian histopatologis dan lokasi tumor di Rumah Sakit Dr. Hasan Sadikin Bandung periode 1 Januari 2016—31 Desember 2016. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan potong lintang. Teknik pengambilan sampel yang digunakan adalah total sampling. Dari penelitian ini diperoleh pasien Adenocarcinoma Colorectal memiliki varian histopatologis berupa Adenocarcinoma NOS (rasio: 0,906, proporsi: 90,6%, 95% CI: 0,835; 0,977), Mucinous Adenocarcinoma (rasio: 0,063, proporsi: 6,3%, 95% CI: 0,003; 0,123), dan Signet Ring Cell Carcinoma (rasio: 0,031, proporsi: 3,1%, 95% CI: -0,011; 0,073). Pasien Adenocarcinoma Colorectal pada penelitian ini memiliki tumor yang berlokasi di kolon kanan (rasio: 0,344, proporsi: 34,4%, 95%CI: 0,288; 0,46) dan tumor yang berlokasi pada kolon kiri (rasio : 0,655, proporsi : 65 ,5%, 95% CI 0,54; 0,772). Kesimpulan dari penelitian ini adalah pasien Adenocarcinoma Colorectal cenderung memiliki varian histopatologis berupa Adenocarcinoma NOS dan memiliki tumor yang berlokasi di kolon bagian kiri.
Co-Authors Dzikru Rahmah Robbika Az-Zahra Hilmi Sulaiman Rathomi Hutari Gustiana Jamaluddin Kamil Meike Rachmawati Yani Dewi Suryani