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Penghambatan aktivitas proliferasi sel dan perubahan histopatologik epitel mukosa nasofaring mencit C3H dengan pemberian ekstrak benalu teh Tjahjono; Hidayat Sulistyo; Awal Prasetyo
Majalah Patologi Indonesia Vol 19 No 1 (2010): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.128 KB)

Abstract

ABSTRAKLatar belakangEfek scurrulla atropurpurea (SA) sebagai anti kanker telah banyak dibuktikan hingga tingkat molekuler, namunsebagaian besar dilakukan secara in vitro. Penelitian ini bertujuan untuk membuktikan inhibisi aktivitas proliferasisel dan perubahan histopatologik epitel mukosa nasofaring mencit C3H dengan pemberian ekstrak SA.MetodePenelitian eksperimental menggunakan 15 mencit C3H, dibagi menjadi tiga kelompok: kelompok kontrol (K)diinduksi dengan uap larutan formalin 10%, diberi diet standar AIN-93M mengandung 54 mg/kg BB formalinselama 9 minggu; kelompok P1 diinduksi uap formalin dan diet standar berformalin selama 6 minggu, lalu diberi1,5 g/kgBB ekstrak SA selama 3 minggu; kelompok P2 diberi ekstrak SA selama 3 minggu, kemudian diinduksiuap formalin dan diet standar mengandung formalin selama 6 minggu. Di akhir penelitian dilakukan pemeriksaanhistopatologik dan hitung AgNOR.HasilSkor perubahan histopatologik epitel nasofaring kelompok K (3,72±0,46), P1 (2,07±0,62), dan P2 (1,69±0,48).Rerata hitung AgNOR kelompok K (3±0,15), P1 (1,72±0,07), dan P2 (1,76±0,08). Uji Mann-Whitney terhadapvariabel perubahan histopatologik antara P1 vs P2, K vs P2, dan P2 vs P3 bermakna. Uji Mann-Whitneyterhadap variabel hitung AgNOR antara K vs P1 dan K vs P2 bermakna, namun antara P1 vs P2 tidakbermakna.KesimpulanEkstrak SA sebelum dan sesudah induksi formalin menimbulkan pengaruh berbeda bermakna pada perbaikanskor histopatologik dan aktivitas proliferasi sel epitel mukosa nasofaring mencit C3H
The Development of Collaborative Learning in The Frame work of Learning Developmnet HE 4.0 Tjahjono; Susanto; Yulhendri
International Journal of Science, Technology & Management Vol. 1 No. 4 (2020): November
Publisher : International Journal of Science, Technology & Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v1i4.95

Abstract

This study reports the development of an adaptive collaborative learning framework in the industrial era 4.0. The development of learning models in schools is determined by the ability of teachers in pedagogy and the ability of the technology used. The purpose of this study is to develop a collaborative learning model in terms of student-centered learning in addition to interactive learning that will determine the success of the learning management system. Respondents of this study were 310 primary school teachers in West Jakarta, DKI Jakarta Province. The research methodology used the Structured Equation Model (SEM), Obtained by using the fit model testing 72.01% and 66.45% and r square as much as 110.86% and 94.16% for the parameters of Collaborative Learning and Learning Management System. This study uses a standard loadings factor of 0.7. The results showed that all loadings factor values for each indicator were> 0.7. Research findings indicate an influence between interactive learning, collaborative, user-centered learning, and learning management systems.