Harahap, Asro Hayani
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Genetic variant of TGF-ß associated with decreased renal function in type II diabetes mellitus patient: single center pilot study in Indonesia Anggelia Puspasari; Elfiani Elfiani; Susan Tarawifa; Rina Nofri Enis; Asro Hayani
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202101

Abstract

The interaction between genetic factors, blood glucose and hypertension plays a role in the onset of diabetic kidney disease (DKD) in type II diabetes mellitus (T2DM). Genetic variation of TGF-ß1 is associated with renal complication in T2DM with varying results between ethnicities. The Jambi Malay ethnic, which is the majority ethnic in Jambi Province, is an area that reports an increased prevalence of T2DM with DKD as the most frequent microvascular complications. In addition, previous study reported controlling blood glucose not associated with DKD indicating genetic may have play a role in DKD in this population. Studies related to genetic variation and decreased kidney function in T2DM patients has never been performed in this ethnic group. This study aimed to investigate the role of TGF-ß genetic variation as risk factor for decreased renal function in T2DM patients from Jambi Malay ethnicity. We conducted a cross sectional study involving 70 patients with T2DM. The inclusion criteria for renal complication based on a decrease in the glomerular filtration rate (GFR) of less than 60 mL/min/1.73. The genotyping method used was amplification refractory mutation system polymerase chain reaction (ARMS-PCR) for TGF-β1 rs1800470 T/C. Bivariate and multivariate analysis was performed to analyze phenotype and genotype association. The result of bivariate analysis showed T2DM patients with genotype CT (p:0.006; OR:0.125; 95% CI:0.027-0.575) and CC (p:0.007; OR:0.104; 95% CI:0.020-0.546) or C allele carrier (p:0.003; OR:0.117; 95% CI:0.027-0.500) had lower risk for decreased renal function than TT genotype. Multivariate analysis that included blood pressure and age variables showed the same finding for CT (p:0.007; OR:0.086; 95% CI:0.014-0.508) and CC genotype (p:0.022; OR:0.115; 95% CI:0.018-0.731). It is concluded from this study that T2DM patients with genotype CT, CC and carrier allele C have a lower risk for suffering kidney complications than genotype TT.
GAMBARAN NEUTROPHIL LYMPHOCYTE RATIO (NLR) PADA EARLY ONSET PREECLAMPSIA (EOP) DAN LATE ONSET PREECLAMPSIA (LOP) Nofrienis, Rina; Shafira, Nyimas Natasha Ayu; Herlambang, Herlambang; Elfiani, Elfiani; Puspasari, Anggelia; Fitri, Amelia Dwi; Kusdiyah, Erny; Harahap, Asro Hayani
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 9 No. 3 (2021): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

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ABSTRACTBackground: Preeclampsia is a syndrome characterized by hypertension at gestational age above 20 weeks. Basedon the onset, preeclampsia is divided into EOP and LOP with a different time limit is 34 weeks gestation.Method: This study is a retrospective analytic using secondary data from medical record, the sampling method ispurposive sampling.Result: The results of the study, there were 175 cases of preeclampsia was obtained at Raden Mattaher Jambi Hospitalfrom the period 2014 - 2019. There were 31 patients with EOP and 146 patients with LOP, with the mean age of thestudy subjects 32.29 years for EOP and 31.68 years for LOP. The mean gestational age was 31 weeks for EOP andthe mean gestational age was 37 weeks for LOP. There were more multiparas for EOP and in LOP found morenulliparas and p value of 0.035. The median value of neutrophils was higher at EOP (10.20), while the value oflymphocytes was higher at LOP (2.00) but not statistically significant. The higher NLR frequency was found in the LOPgroup, which was 79.5% compared to the EOP group, which was 77.4% and not statistically significant.Conclusion: Descriptively, it was found that higher NLR values and higher NLR frequencies than the cut off point werefound in LOP, but they did not show statistically significant differences.Keywords: Preeclampsia, NLR, early onset, late onsetABSTRAKPendahuluan: Preeklampsia merupakan sindroma yang ditandai dengan hipertensi pada usia kehamilan diatas 20minggu. Berdasarkan onset, preeklampsia dibagi menjadi EOP dan LOP dengan batas waktu yang membedakanadalah 34 minggu gestasi.Metode: Penelitian ini merupakan analitik retrospektif dengan menggunakan data sekunder dari data rekam medis,metode pengambilan sampel adalah purposive sampling.Hasil: Dari hasil penelitian didapatkan sampel 175 kasus preeklampsia di RSUD Raden Mattaher Jambi dari periodetahun 2014 - tahun 2019. Terdapat 31 pasien dengan EOP dan 146 pasien dengan LOP dengan rerata usia subjekpenelitian 32.29 tahun untuk EOP dan 31.68 tahun untuk LOP. Untuk usia gestasi didapatkan rata-rata 31 mingguuntuk EOP dan rata-rata usia gestasi adalah 37 minggu untuk LOP. Dari status paritas, didaptkan lebih banyakmultipara untuk EOP dan pada LOP lebih banyak ditemukan nullipara dan nilai p 0,035. Nilai median neutrofil lebihtinggi pada EOP yaitu 10.20 sedangkan nilai limfosit lebih tinggi pada LOP yaitu 2.00 akan tetapi tidak berbedabermakna secara statistik.Kesimpulan: Frekuensi NLR yang lebih tinggi dijumpai pada kelompok LOP yaitu sebanyak 79.5% dibandingkan EOPyaitu 77.4% dan tidak bermakna secara statistik. Secara deskriptif didapatkan bahwa nilai NLR yang lebih tinggi danfrekuensi NLR yang lebih tinggi dari cut off point dijumpai pada LOP, akan tetapi tidak menunjukkan berbeda bermaknasecara statistik.Kata Kunci: Preeklampsia, NLR, early onset, late onse
KONTRIBUSI HIGIENITAS BOTOL SUSU DAN SUMBER AIR TERHADAP KEJADIAN DIARE PADA BALITA 6-24 BULAN DI PUSKESMAS KENALI BESAR KOTA JAMBI Darmawan, Armaidi; Kusdiyah, Erny; Mulyadi, Deri; Herlambang, Herlambang; Aurora, Wahyu Indah Dewi; Harahap, Asro Hayani; Moniga, Agra Farellio
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 10 No. 2 (2022): Special Issues: Jambi Medical And Health Sciences International Conference (JA
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

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ABSTRACT Background: Diarrhea contributed to 8.8% of the average death per 1000 births as a cause of child mortality in children under 5 years old in the Southeast Asian region in 2016. This disease is influenced by many factors, including hygiene and sanitation of eating and drinking utensils. As many as 75% of infants in developing countries are bottle fed, but the contribution of hygiene and water sources is unknown. Objective: This study aims to determine the relationship between feeding bottle hygiene and water sources with the incidence of diarrhea in children aged 6-24 months in the work area of Puskesmas Kenali Besar Kota Jambi on 2020. Methods: This study is an analytical observation survey with a Case Control approach. This study uses the help of a questionnaire that has been tested for validity and reliability. A total of 80 samples were involved in this study. Results: Factors that influence the relationship between feeding bottle hygiene and diarrhea are how to wash bottles, use of soap, use of special brushes, sterilization of milk bottles, storage of milk bottles and based on the use of water sources where more respondents used water that was not refilled as many as 55 people (68.8 %). The physical quality of the water used by the respondents was cloudy as many as 18 samples (22.5%) and smelly as many as 4 samples (5.0%). The bacteriological quality of the water used by the respondents was positive for Lactose Broth (LB) as many as 33 samples (41.3%) and the positive for Brilliant Green Lactose Bile Broth (BGLBB) were 29 samples (36.3%). Conclusion: The researcher concluded that the use of soap and how to store milk bottles and water sources were the causes of diarrhea in toddlers. It is hoped that this research can be a recommendation for regional policy makers to pay attention, especially to the water sources used. Keywords: diarrhea, toddlers, feeding bottle hygiene, water sources ABSTRAK Latar belakang: Diare berkontribusi terhadap 8,8 % dari rata-rata kematian per 1000 kelahiran sebagai penyebab kematian anak pada balita dibawah 5 tahun di wilayah Asia Tenggara pada tahun 2016. Penyakit ini dipengaruhi banyak faktor, termasuk higienitas dan sanitasi alat makan-minum. Sebanyak 75% bayi di negara berkembang mendapatkan susu botol, namun kontribusi higienitas dan sumber air belum diketahui. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan higienitas botol susu dan sumber air dengan kejadian diare pada anak usia 6-24 bulan di wilayah kerja Puskesmas Kenali Besar Kota Jambi tahun 2020. Metode: Penelitian ini adalah survei yang bersifat observasi analitik dengan pendekatan Case Control. Penelitian ini menggunakan bantuan kuesioner yang telah di uji validitas dan realibilitas. Sebanyak 80 sampel terlibat dalam penelitian ini. Hasil: Faktor yang mempengaruhi hubungan higienitas botol susu dengan kejadian diare yaitu berupa cara mencuci botol, penggunaan sabun, penggunaan sikat khusus, cara sterilisasi botol susu, penyimpanan botol susu, serta berdasarkan penggunaan sumber air dimana lebih banyak responden menggunakan air yang bukan isi ulang yaitu sebanyak 55 orang (68,8 %). Kualitas fisik air yang digunakan responden yaitu keruh sebanyak 18 sampel (22,5 %) dan berbau sebanyak 4 sampel (5,0 %). Kualitas bakteriologis air yang digunakan responden bersifat positif Lactose Broth (LB) sebanyak 33 sampel (41,3 %) dan yang positif Brilliant Green Lactose Bile Broth (BGLBB) sebanyak 29 sampel (36,3 %). Kesimpulan: Peneliti menyimpulkan bahwa terdapat bahwa pengunaan sabun dan cara penyimpanan botol susu serta sumber air merupakan penyebab diare pada balita. Diharapkan penelitian ini dapat menjadi rekomendasi pengambilan kebijakan daerah untuk memperhatikan terutama sumber air yang digunakan. Kata kunci: diare, balita, higienitas botol susu, sumber air