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All Journal Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima International Journal of Health and Pharmaceutical (IJHP)
Budi, Andre
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Buletin Kedokteran dan Kesehatan Prima

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Detection of glibenclamide adulteration in herbal remedies for diabetes mellitus using TLC Budi, Andre; Razoki, Razoki; Harahap, Halimah; Amansyah, Adek; Edlin, Edlin; Tarigan, Susiani
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5287

Abstract

The widespread use of jamu, a traditional Indonesian herbal medicine, has been accompanied by a surge in adulteration with synthetic drugs to enhance efficacy and sales. This study aimed to detect the presence of glibenclamide, a common adulterant, in antidiabetic jamu product using TLC. This study employed three herbal medicine samples marketed for lowering blood glucose levels, with glibenclamide BPFI serving as a reference standard. Thin-layer chromatography, employing a mobile phase consisting of chloroform, cyclohexane, ethanol, and glacial acetic acid (9:9:1:1), was utilized for the analysis. Thin-layer chromatography (TLC) analysis revealed a standard Rf value of 0.4 for glibenclamide, producing a distinct blue-violet spot when visualized with 10% sulfuric acid. The results indicated that the tested herbal medicine samples did not contain the pharmaceutical substance glibenclamide. This conclusion was drawn from the absence of a corresponding Rf value for glibenclamide in the herbal samples when compared to the reference standard.
Screening of polypharmacy prescriptions in hypertensive patients at Royal Prima Hospital Nasution, Nanda Rahma Dewi; Budi, Andre; Lubis, Razoki; Sari, Nila
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5288

Abstract

Hypertension occurs when a person's blood pressure exceeds the normal limits. This results in increased morbidity and mortality. The method in this study is descriptive, with the use of retrospective research, where the study was conducted by reviewing information or retrieving data that had existed before. Data were collected through polypharmacy prescriptions for patients with high blood pressure at the Royal Prima Medan Hospital between September and November 2023, with 650 prescriptions collected. From the results of this study, the prescriptions that met the inclusion criteria were 100% in accordance with the symptoms, drug doses, mechanisms, procedures, and duration of drug use. A total of 26 prescriptions contained five drugs with 63.41% interaction out of a total of 41 prescriptions. A total of 34 prescriptions contained 6 drugs, with 65.11% of the total 49 prescriptions. A total of 19 prescriptions contained seven drugs, with 82.61% of the total 23 prescriptions. A total of 13 prescriptions containing 8 drugs with a percentage of interactions of 86.67% of the total 15 prescriptions. Most interactions occurred in six prescriptions containing nine drugs, with 100% interaction from a total of six drugs. Most interactions also occurred in four prescriptions containing 10 drugs, with 100% interaction from a total of four drugs.
Co-Authors Adek Amansyah Ananda, Dara Edlin Edlin, Edlin Harahap, Halimah Jaya, Risnaldo Lubis, Razoki Nababan, Samuel Maringan Tua Nardi, Leo Nasution, Nanda Rahma Dewi Nila Sari Pratama Zendrato Razoki, Razoki Sihombing, Bungaran Tarigan, Susiani