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All Journal HAYATI Journal of Biosciences Jurnal Prima Medika Sains Buletin Kedokteran dan Kesehatan Prima
Nardi, Leo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Medicine & Pharmacology Nursing Public Health

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Perilaku dengan penggunaan asam formiat dan kejadian penyakit kulit pada pekerja bagian produksi pengolahan karet PT. X Fitriani, Dini Dwi; Nardi, Leo; Hanjaya, Hanjaya; Angie, Evelyn; Fransisca, Silvia; Leslie, William; Yani, Herlina
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 1 (2022): Maret
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (307.633 KB)

Abstract

Keluhan penyakit kulit yang dialami oleh pekerja di tempat kerja biasanyan disebabkan oleh bahan kimia dan bahan lain. Salah satu perusahaan yang menggunakan bahan kimia dalam proses reproduksinya adalah perusahan pengolahan karet. PT.X adalah salah perusahaan yang bergerak dalam proses pengolahan karet dengan menggunakan bahan kimia asam formiat dalam oengolahan nya. Diketahui bahwa dari survey awal yang dilakukan bahwa dari 7 orang yang di wawancarai 4 di antaranya mengalami keluhan gangguan kulit .Tujuan penelitian ini adalah untuk mengetahui hubungan pengetahuan, sikap, dan tindakan dengan penggunaan asam formiat terhadap kejadian penyakit kulit di bagian produksi Pabrik Pengolahan Karet PT.X. Penelitian ini bersifat deskriptif analitik, dengan rancangan penelitian cross-sectional. Populasi dalam penelitian ini adalah seluruh pekerja yang bekerja di PT X. Sampel dalam penelitian ini adalah seluruh karyawan yang bekerja di bagian produksi sebanyak 42 karyawan, dengan teknik pengambilan sample secara purposive sampling. Teknik pengumpulan data dengan cara observasi dan kuesioner. Analisis data yang digunakan dalam penelitian ini adalah uji Chi-Square dengan derajat kepercayaan 95%. Berdasarkan hasil uji Chi-Square didapatkan hasil bahwa ada hubungan pengetahuan (0,014), sikap (0,006), dan tindakan (0,000) dengan penggunaan asam formiat terhadap kejadian penyakit kulit.
Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.15 KB) | DOI: 10.34012/bkkp.v1i2.2689

Abstract

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.
Effectiveness of durian peel ethanol extract for lowering blood sugar levels in alloxan diabetic wistar rats Budi, Andre; Nababan, Samuel Maringan Tua; Nardi, Leo
Jurnal Prima Medika Sains Vol. 5 No. 2 (2023): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i2.4523

Abstract

High blood sugar levels can be influenced by several factors, including high-carbohydrate food consumption and a lack of physical activity. To minimize the side effects of hyperglycemic treatment, efforts have been made to explore anti-hyperglycemic compounds from other sources, such as durian peel (Durio zibetthinus Murr.). This study aimed to determine the effectiveness of ethanol extract from durian peel in lowering alloxan-induced blood sugar levels in Wistar rats (Rattus novergicus). The study is an experimental research employing an alloxan-induced diabetic rat model. The rats were divided into five different groups: Group I (negative control), Group II (positive control), Group III (dose 25 × 10–30/gBW), Group IV (dose 50 × 10–30/gBW), and Group V (dose 100 × 10–30/gBW). The durian peel used in this study was extracted using the maceration method with ethanol as the solvent. The results of this study indicate that ethanol extract from durian peel significantly reduced blood sugar levels after 10 to 15 days of durian peel extract administration (p < 0.05).
Effect of moringa flower extract on liver function and histopathology appearance of obesity model rat's liver Wahyuniasri, Nuri Rahma; Nardi, Leo; Sopacua, Erwin
Jurnal Prima Medika Sains Vol. 6 No. 1 (2024): June
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i1.5005

Abstract

This study aims to test and analyze the effectiveness of moringa flower extract on the liver function of male wistar strain white rats obesity model and how the histopathological picture. This research is a type of experimental quantitative research using post-test only group design. This study used test animals in the form of male white wistar rats with a body weight of 200-300 gr aged 2-3 months. The test animals were divided into 4 groups, the control group was only given regular food and distilled water, the treatment group was given high-fat food and Moringa flower extract at different doses, namely 200 mg / kgBB, 400 mg / kgBB, and 600 mg / kgBB. The results of the phytochemical test showed that moringa flower extract contains secondary metabolites in the form of saponins, tannins, flavonoids, alkaloids, and steroids. The administration of moringa flower extract at a dose of 600 mg/KgBB is effective in improving liver function in obese Wistar white rats. This improvement can be seen through the levels of ALT, AST, and histological structure of the liver that has improved. The results of histopathological observations of liver tissue in treatment group 3, namely moringa flower extract at a dose of 600 mg/KgBB, experienced the most significant improvement and approached the control group compared to other groups.
Topical Application of Paraboea leuserensis on Excision Wound with Angiogenesis and Vascular Endothelial Growth Factor Analysis Heryani, Dyah Wijiana; Maya Wardhani, Fiska; Yensuari; Nazimuddin Putri, Nadya; Nardi, Leo; Ikhtiari, Refi
HAYATI Journal of Biosciences Vol. 31 No. 2 (2024): March 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.2.300-316

Abstract

Gagatan harimau or Paraboea leuserensis B.L. Burtt is an endemic plant that grows in limestone areas, natively found in Leuser Mountain Area, North Sumatra Province, Indonesia. This study determines the wound healing potential of P. leuserensis gel-based ethanolic extract (PGEE) on full-thickness excision wounds based on the angiogenesis and VEGF expression. Here, we reported 67 compounds detected by LC-MS/MS from the ethanolic extract. The antibacterial activity regarding pathogenic wound infection was also investigated. The experimental study used 30 Rattus novergicus, randomly divided into five treatment groups: base gel as a negative control, Bioplacenton as a positive control, PGEE 2.5%, 5%, and 10%. Experimental data showed that PGEE indicated a significant effect on bacterial inhibition (p = 0.02), where the greatest inhibitory was found against S. epidermidis. Topical application of PGEE showed significant differences in the number of blood vessels of PGEE 2.5% and 10% (p = 0.007) and expression of VEGF (p<0.05). The correlation between the number of blood vessels and VEGF was also described with the number of macrophages, fibroblasts, collagen, and wound diameter. Overall, this study demonstrates the pharmacological potential of PGEE for wound healing applications regarding angiogenesis and VEGF expression.
Co-Authors Angie, Evelyn Binarwan Halim Budi, Andre Fioni, Fioni Fitriani, Dini Dwi Fransisca, Silvia Hanjaya, Hanjaya Heryani, Dyah Wijiana IKHTIARI, REFI Leslie, William Maya Wardhani, Fiska Meutia, Rena Nababan, Samuel Maringan Tua Nasution, Chairul Radjab Nazimuddin Putri, Nadya Razoki, Razoki Sopacua, Erwin Tarigan, Antje Irmella Wahyuniasri, Nuri Rahma Yani, Herlina Yensuari