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All Journal Jurnal Kedokteran MNJ (Malang Neurology Journal)
Sahly, Aliza Raudatin
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Health Professions Medicine & Pharmacology Neuroscience

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PENGARUH EKSPRESI RESEPTOR INSULIN PANKREAS TERHADAP EKSPRESI GLUT4 NEURON HIPOKAMPUS PADA TIKUS MODEL DIABETES Sahly, Aliza Raudatin; Hunaifi, Ilsa; Lestari, Rizka Vidya; Wardani, Indah Sapta; Padauleng, Novrita; Nurhidayati; Harahap, Herpan Syafii
Jurnal Kedokteran Vol 9 No 4 (2020): Jurnal Kedokteran volume 9 no 4 2020
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v9i4.441

Abstract

Background: Diabetes Melitus (DM) is a degenerative diseases characterized by hyperglycemia condition. Basic Health Research data for 2018, shows an increase in prevalence of DM in Indonesia over last 5 years with 6,9% in 2013 to 8,5% in 2018. Pancreatic insulin receptor expression can be a marker for assessing presence of ? cells, production and secretion of insulin. Insulin could cause GLUT4 to be translocated to cell membrane of hippocampal neurons. In DM conditions, there may be changes in expression of pancreatic insulin receptors accompanied by changes in expression of GLUT4 hippocampal neurons. Methods: This experimental research used 16 white rats (Rattus Novergicus) which divided randomly into 4 groups, namely 2 control grups (A0 and A1) and 2 treatment groups (B0 and B1). Treatment group were induced by diabetes with a single dose of nicotinamide 110 mg/kgBB and streptozotocin 70 mg/kgBB intraperitoneally. The research data were obtained from immunohistochemical analysis of pancreatic and hippocampal tissue. Result: The mean expression of pancreatic insulin receptor in diabetic rat group was higher but not significant on the 14th day observation compared to the 0th day (p>0,05), while the mean GLUT4 expression of hippocampal neurons was significantly higher on 14th day of observation compared to the 0th day (p<0,05). The result of correlation test did not show a significant results in each group both at the 0th and 14th day observation (p>0,05). Conclusion: There was no significant effect of pancreatic insulin receptor expression on hippocampal neuron GLUT4 expression in diabetic model rats.
THE EFFECT OF GLUT4 EXPRESSION IN HIPPOCAMPAL NEURONS TO SPATIAL MEMORY OF DIABETES-INDUCED RATTUS NOVERGICUS Harahap, Herpan Syafii; Padauleng, Novrita; Lestari, Rizka Vidya; Nurhidayati, Nurhidayati; Wedayani, Anak Agung Ayu Niti; Sari, Putu Suwita; Muliyana, Hifdzil Haq; Laksmana, Ngakan Putu Proudy; Sahly, Aliza Raudatin
Malang Neurology Journal Vol 7, No 2 (2021): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2021.007.02.6

Abstract

Background: Identification of appropriate biomarker involved in the pathophysiology of diabetes-associated cognitive decline in animal model is necessary. Glucose transporter 4 (GLUT4) is the component of insulin-dependent neuronal signaling pathway needed for maintaining cognitive function. It is highly expressed in hippocampal neurons.Objective: To investigate the effect of GLUT4 expression in hippocampal neurons on the spatial memory of diabetes-induced Rattus novergicus.Methods: This experimental study used 24 male Rattus novergicus divided into control groups terminated on day-0 (C0), 14 (C1) and 28 (C2) and diabetic groups terminated on day-0 (D0), 14 (D1) and 28 (D2). Diabetes was induced using streptozotocin injections intraperitoneally. Spatial memory (travel time) of rats was assessed on day-14 and 28. Brain tissue sampling was performed for assessment of GLUT4 expression using immunohistochemical methods. Significant differences in means of GLUT4 expression and travel time between groups on day-0, 14 and 28 as well as correlation between means of GLUT4 expression and travel time in D1 and D2 were analyzed statistically.Results: The mean of GLUT4 expression in diabetic group was significantly higher compared to control on day-14, but not on day-0 and 28. The immunohistochemical examination confirmed this results. There were no significant differences in mean of travel time between control and diabetic groups on day-14 and 28. There were no significant correlation between means of GLUT4 expression and travel time in diabetic groups on day-14 and 28.Conclusion: The GLUT4 expression of hippocampal neurons did not significantly affect spatial memory of diabetes-induced Rattus novergicus.
Co-Authors Anak Agung Ayu Niti Wedayani Herpan Syafii Harahap Ilsa Hunaifi Indah Sapta Wardani Laksmana, Ngakan Putu Proudy Lestari, Rizka Vidya Muliyana, Hifdzil Haq Nurhidayati Nurhidayati Nurhidayati Padauleng, Novrita Sari, Putu Suwita