Article Per Year (5 Year)
p-Index From 2019 - 2024
0.61
P-Index
This Author published in this journals
All Journal ad-Dawaa : Journal of Pharmaceutical Sciences AMMA : Jurnal Pengabdian Masyarakat
Indah Kurnia Utami
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : ad-Dawaa : Journal of Pharmaceutical Sciences

 1 
Effectiveness Of Cassia alata L Leaf Extract Decrease Blood Glucose Level On Streptozotocin-Induced Male White Rats Niluh Puspita Dewi; Febry Grasela Aula; Indah Kurnia Utami; Ayu Wulandari; Rezky Yanuarty; Wayan Wirawan
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38400

Abstract

Introduction: Diabetes mellitus (DM) is a condition in which the body either fails to produce enough insulin at the right time or fails to use it properly. Aims: The goal of this study is to show how Cassia alata L. leaf extract affects blood glucose levels in streptozotocin-induced diabetic rats. Methods: Cassia alata L. leaves therapy is an alternative treatment for DM. In this investigation, laboratory techniques were employed. Streptozotocin was administered intraperitoneally to mice at a dose of 40 mg/kg body weight initially. Except that they produce normal controls. Six groups of 30 rats each received treatment with Cassia alata L. leaf extract at doses of 500 mg/kg body weight, 600 mg/kg body weight, and 700 mg/kg body weight in addition to the usual control group. Trial outcome data were first examined using one-way ANOVA to confirm differences between treatments and then put through the DUNCAN trial. Result: As a result, it was discovered that secondary metabolites of alkaloids, flavonoids, saponins, and tannins were present in the ethanol extract of Cassia alata L. leaves. A dose of 700 mg/kg body weight is an effective blood sugar-lowering dose, with an average reduction of 121 mg/dl. Conclusion: Ethanol extract from Cassia alata L. leaves has this effect.
Optimization and Validation Test of Self Nano-emulsifiying Drug Delivery System Capsule of Ethanol Extract Parang Romang Leaves Magfirah Magfirah; Indah Kurnia Utami; I Dewa Ayu Nurllya K.D; Niluh Puspita Dewi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38469

Abstract

Introdiction: Parang romang contains alkaloids, flavonoids, tannins, and saponins. The secondary metabolites of the leaf extract have low solubility in water. The self-nano emulsifying drug delivery system (SNEDDS) is one solution to increase the solubility of the extract. Aims This study aims to obtain the best formula and ensure that the assay analysis method used can provide accurate and reliable results so that they can be trusted. Methods: Parang romang leaf extract was added to the optimum mixture of tween 20/80, propylene glycol, and olive oil and then characterized including% transmittance, drug loading, emulsification time, particle size, index polydispersity, zeta potential, dissolution test, Scanning electron microscopy (SEM ) and validation of the analysis method including linearity, precision, accuracy, LOD, and LOQ. Result: The results showed the ratio of surfactant, co-surfactant, and olive oil which produced the optimum formula for SNEDDS, namely 26 ml; 17.5 ml; and 6.5 ml,% transmittance 85.90, drug loading 45.36, emulsification time for AGF, AIF, and aqua dest was 15-16 seconds, particle size 404.1 nm, index polydispersity 0.840, zeta potential -31.4 mV, dissolution test 92.13%, SEM in the form of spherical chunks, and the result of the validation test of the analytical method with a linearity of r = 0.9902, precision 0.436%, accuracy 103.738%, LOD 1.87 µ / ml and LOQ 5.57 µ / ml. SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant provide optimal nanoemulsion characteristics and validation of the analytical method meets the requirements. Conclusion: Formula 1 SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant is an optimal formula that provides good nanoemulsion characteristics and validation of analytical methods meets the requirements
Co-Authors Ayu Wulandari Febry Grasela Aula I Dewa Ayu Nurllya K.D Magfirah - - Niluh Puspita Dewi Niluh Puspita Dewi Niluh Puspita Dewi Ratna Ika Yususf Rezky Yanuarty Syafika Alaydrus Wayan Wirawan