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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Mandala Pengabdian Masyarakat
Niluh Puspita Dewi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences

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Optimization and Validation Test of Self Nano-emulsifiying Drug Delivery System Capsule of Ethanol Extract Parang Romang Leaves Magfirah Magfirah; Indah Kurnia Utami; I Dewa Ayu Nurllya K.D; Niluh Puspita Dewi
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 1 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i1.38469

Abstract

Introdiction: Parang romang contains alkaloids, flavonoids, tannins, and saponins. The secondary metabolites of the leaf extract have low solubility in water. The self-nano emulsifying drug delivery system (SNEDDS) is one solution to increase the solubility of the extract. Aims This study aims to obtain the best formula and ensure that the assay analysis method used can provide accurate and reliable results so that they can be trusted. Methods: Parang romang leaf extract was added to the optimum mixture of tween 20/80, propylene glycol, and olive oil and then characterized including% transmittance, drug loading, emulsification time, particle size, index polydispersity, zeta potential, dissolution test, Scanning electron microscopy (SEM ) and validation of the analysis method including linearity, precision, accuracy, LOD, and LOQ. Result: The results showed the ratio of surfactant, co-surfactant, and olive oil which produced the optimum formula for SNEDDS, namely 26 ml; 17.5 ml; and 6.5 ml,% transmittance 85.90, drug loading 45.36, emulsification time for AGF, AIF, and aqua dest was 15-16 seconds, particle size 404.1 nm, index polydispersity 0.840, zeta potential -31.4 mV, dissolution test 92.13%, SEM in the form of spherical chunks, and the result of the validation test of the analytical method with a linearity of r = 0.9902, precision 0.436%, accuracy 103.738%, LOD 1.87 µ / ml and LOQ 5.57 µ / ml. SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant provide optimal nanoemulsion characteristics and validation of the analytical method meets the requirements. Conclusion: Formula 1 SNEDDS parang romang leaf extract using olive oil as the oil phase, Tween 80 as a surfactant, and propylene glycol as a cosurfactant is an optimal formula that provides good nanoemulsion characteristics and validation of analytical methods meets the requirements
The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin: Efektivitas Ekstrak Etanol Biji Kopi Robusta terhadap Kadar Glukosa Darah, Urea, dan Kreatinin Tikus Putih Jantan yang Diinduksi Streptozotocin Joni Tandi; Mimi Marsella; I Made Agus Suarsana; Niluh Puspita Dewi; Magfirah Magfirah; Tien Wahyu Handayani; Maria Kanan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16352

Abstract

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.
Anticancer Activity of Rosella Flowers (Hibiscus Sabdariffa l.) In HepG2 cells Viani Anggi; Recky Patala; Arfiah Arfiah; Niluh Puspita Dewi
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6350

Abstract

The natural ingredients of rosella flowers have the potential as natural anti-cancer and chemopreventive agents, contain secondary metabolite compounds with cancer therapeutic mechanisms with inhibiting and killing cancer cells and their development through inhibition of apoptosis (cell death program) and in vitro inhibited cell flow. The study aims to identification of secondary metabolite compounds and also determine the cytotoxic activity of ethanol extract from the rosemary plant against HepG2 cancer cells. This study used by identification of secondary metabolite compounds of ethanol extract from the rosemary plant (Hibiscus sabdariffa L.) and the cytotoxicity test used with MTT assay on HepG2 liver cancer cells with a test concentration series of 12,5; 25; 50; 100; 200; 250; 500 and 1000 µg/ml. : The results showed the secondary metabolite compounds of rosella flowers have flavonoids, alkaloids, saponins and tannins and data of 50% cell growth inhibition activity, which was showed that rosella flower had IC50 values 629,919 μg/mL. The ethanol extract of rosella flowers have activity on HepG2 cells growth inhibition had considered moderately active anticancer activity
The Edukasi Pemanfaatan Obat Tradisional Untuk Meningkatkan Imunitas Tubuh” di Desa Sejahtera Kecamatan Palolo, Kabupaten Sigi, Sulawesi Tengah Niluh Puspita Dewi; fadilah insani; Ni Wayan Sujati; Nani Astria Polontalo; lidia lidia
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.365

Abstract

The use of traditional medicine in Indonesia is also related to the many types of plants in this country, understanding of traditional medicine is still very lacking so it is necessary to provide education about traditional medicine. The aim of carrying out this service is to provide understanding and skills to the people of Sejahtera Village about the use of traditional medicine to increase body immunity. This activity was attended by 40 people. The result of this activity was increased knowledge about the processing, types and use of traditional medicines. Counseling is provided using an interactive lecture method through distribution of leaflets, traditional medicine books and social service. The effectiveness of the extension was tested by administering a questionnaire on community satisfaction with the activities carried out. The results of service activities have provided increased knowledge and skills of the community regarding how to use traditional plants for body immunity.  
Cegah Stunting Dengan Tanaman Obat Keluarga: Cegah Stunting Dengan Tanaman Obat Keluarga Syafika Alaydrus; Rianto Rianto; Rusliyana Rusliyana; Niluh Puspita Dewi; Wawang Anwarudin
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.369

Abstract

Indonesia has quite a serious nutritional problem which is characterized by many cases of malnutrition. Malnutrition is an impact of nutritional status. 2016 National Health Service data recorded that the prevalence of stunting reached 33.6%, this is an important health problem because the stunting problem is above the 20% threshold. Meanwhile, stunting in children under five is caused by multifactors, such as nutritional consumption during pregnancy, maternal knowledge about nutrition, limited access to services, inadequate access to sanitation and clean water. This counseling aims to help increase public knowledge, about preventing stunting in toddlers and is a form of the Tri Dharma of Higher Education. Counseling is provided using an interactive lecture method through distributing leaflets, health checks, providing nutritious food, providing TOGA books and social service. The effectiveness of the extension was tested by administering a questionnaire on community satisfaction with the activities carried out. The results of this service activity provide the Sejahtera village community with knowledge about what stunting is, the causes of stunting, the dangers of stunting in the long term and how to overcome the impact of stunting so that stunting can be minimized in children.
Co-Authors Arfiah Arfiah fadilah insani I Dewa Ayu Nurllya K.D I Made Agus Suarsana Indah Kurnia Utami Joni Tandi, Joni lidia lidia Magfirah - - Magfirah Magfirah Maria Kanan Mimi Marsella Nani Astria Polontalo Ni Wayan Sujati Patala, Recky Rianto Rianto Rusliyana Rusliyana Syafika Alaydrus Tien Wahyu Handayani Viani Anggi Wawang Anwarudin