Article Per Year (5 Year)
p-Index From 2019 - 2024
1.151
P-Index
This Author published in this journals
All Journal METAMORFOSA Journal of Biological Sciences Lingkungan dan Kesehatan Kerja Krisna: Kumpulan Riset Akuntansi Jurnal Online Mahasiswa (JOM) Bidang Teknik dan Sains Journal of Bioprocess Chemical and Environmental Engineering Science Jurnal Ekonomi, Bisnis dan Manajemen
Irma Damayanti
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Public Health

Published : 6 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : METAMORFOSA Journal of Biological Sciences

 1 
Mekanisme Kerja Antibiotik Ceftriaxone, Clarithromycin, dan Senyawa Aktif Quercetin pada Streptococcus pneumoniae dengan Metoda Docking In Silico Irma Damayanti; Yan Ramona; Sentot Joko Raharjo
Metamorfosa: Journal of Biological Sciences Vol 9 No 1 (2022)
Publisher : Prodi Magister Ilmu Biologi, Fakultas MIPA, Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/metamorfosa.2022.v09.i01.p01

Abstract

Pneumolysin is a protein that plays an important role in cell death and bacterial colonization of Streptococcus pneumoniae. Ceftriaxone, clarithromycin, dan quercetin has been proven (in vivo and in vitro) to prevent the action of pneumolysin. The purpose of this study was to identify interactions between ceftriaxone, clarithromycin, and quercetin in inhibiting the pneumolysin activity through in silico. The 3D structure of pneumolysin was downloaded via RCSB PDB (PDB ID:PQQA), while 3D structure of ceftriaxone (ID:5479530), clarithromycin (ID:84029), and quercetin (ID:5280343) were downloaded via PubChem. Protein preparations were done with Discovery Studio, while ligands were prepared with OpenBabel. The docking process used HEX 8.0.0 and visualization analysis with Discovery Studio. Pneumolysin-ceftriaxone interaction produces 4 hydrogen bonds, 5 hydrophobic bonds, 1 electrostatic bond, and 2 unfavorable residue bonds with a bond energy value -329.98kJ/mol. Pneumolysin-clarithromycin interaction produces 3 hydrogen bonds, 1 electrostatic bond, and 3 unfavorable residue bonds with a bond energy value -311.12kJ/mol. Pneumolysin-quercetin interaction produces 2 hydrogen bonds, 4 hydrophobic bonds, and 2 electrostatic bonds with a bond energy value -246.52kJ/mol. Keyword: pneumolysin, ceftriaxone, clarithromycin, quercetin, in silico.
Co-Authors Bugi Alifya Devi Puspita Sari Fikri Miftahul Shiddiq Indra Chahaya Indra Purnama Rizki Kurnia Rohman Sentot Joko Raharjo Sri Rezeki Muria Sunarno Sunarno Taufik Ashar Yan Ramona