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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Oto Rhino Laryngologica Indonesiana Sumatera Medical Journal
Ashri Yudhistira
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Health Professions Immunology & microbiology Medicine & Pharmacology

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PROFILE OF SINONASAL TUMOR PATIENT IN ADAM MALIK GENERAL HOSPITAL 2016-2018 Ulya, Ulfatul; Ashri Yudhistira; Rambe, Andrina Y.M; Yetty Machrina
Sumatera Medical Journal Vol. 3 No. 3 (2020): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v3i3.3682

Abstract

Abstract. Sinonasal tumor is a neoplasm that arises from nasal and paranasal sinus tissue. It is rarely found, only <3% of all malignancy in head and neck, and 1% of all malignancy in the body. Although it is rarely found, it can cause serious complication in adult. Unspecific sign and symptoms of sinonasal tumor often make the patients ignore the disease. It leads to the diagnosis of this disease becomes late and the patients come to the doctor in advanced stage. This research was conducted to know about the profile of sinonasal tumor patients in H. Adam Malik Medan Hospital on 2016-2018. The study was a descriptive study with retrospective approach. The data used are secondary data taken from medical records. The data were analyzed using a statistical application programs. Sinonasal tumor patients in RSUP HAM Medan are 158 patients, where 95 patients met the inclusion criteria, consisting of 24 benign tumors (25,3%) and 71 malignant tumors (74,7%). The majority of patients are male (71,6%), and the highest age group in in 51-60 years old (31,6%). The main complaints felt by the patients were nasal symptoms (64,2%), the location of tumors mostly found in nasal cavity (50,5%), the most histopathological type is NKSCC (43,2%), the most occupation is self-employment (26%), and the treatment of the patients are surgery (29,5%). Keyword: Sinonasal Tumor, Profile, Sinonasal Cancer
Korelasi positif ekspresi cyclooxygenase-2 dengan microvessel density pada karsinoma nasofaring Nova Rahma Hasibuan; Farhat Farhat; Tengku Siti Hajar Haryuna; Ashri Yudhistira
Oto Rhino Laryngologica Indonesiana Vol 44, No 1 (2014): Volume 44, No. 1 January - June 2014
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1335.1 KB) | DOI: 10.32637/orli.v44i1.81

Abstract

Pendahuluan: Tumor memerlukan proses pembentukan pembuluh darah baru untuk tumbuh dan bermetastasis yang dikenal sebagai proses angiogenesis. Angiogenesis dapat dinilai secara imunohistokimia dengan Microvessel Density (MVD). Proses angiogenesis dapat dipicu oleh berbagai faktor angiogenik. Beberapa penelitian menemukan ekspresi Cyclooxygenase-2 (COX-2) meningkat pada kanker. COX-2 dapat merangsang pengeluaran faktor-faktor angiogenik. Pada penelitian ini akan dilihat apakah angiogenesis, yang dinilai dengan MVD, pada karsinoma nasofaring memiliki korelasi dengan COX-2. Tujuan: Mengetahui korelasi ekspresi COX-2 dengan MVD pada penderita karsinoma nasofaring di RSUP H. Adam Malik Medan. Metode: Penelitian ini bersifat analitik dengan studi potonglintang. Dua puluh empat sampel diperiksa secara imunohistokimia untuk ekspresi COX-2 dan MVD. Kemudian hasil dianalisa dengan uji Spearman. Hasil: Ekspresi COX-2 positif ditemukan pada 17 (70,83%) subyek dan dijumpai negatif pada 7 (29,17%). Ditemukan 17 (70,83%) jaringan karsinoma nasofaring dengan MVD tinggi dan 7 (29,17%) dengan MVD rendah. Ditemukan adanya korelasi positif sedang antara ekspresi COX-2 dengan MVD (r=0,559; p=0,005). Kesimpulan: Ditemukan ada korelasi positif sedang antara ekspresi COX-2 dan MVD pada karsinoma nasofaring. Kata kunci : Karsinoma nasofaring, Cyclooxygenase-2, Microvessel density ABSTRACTIntroduction: Tumor needs new blood vessel formation to grow and metastasize. New blood vessel formation is known as angiogenesis. Angiogenesis is determined by Microvessel Density (MVD) using immunohistochemical examination. Angiogenesis was affected by various angiogenic factors. Recent studies found elevated COX-2 expression in cancers. COX-2 can stimulate angiogenic factors. This research assessed the correlation between COX-2 and angiogenesis, determined by MVD. Purpose: To find out the correlation between COX-2 and MVD in nasopharyngeal carcinoma in H. Adam Malik Hospital. Method: This is a cross sectional analytical research. Twenty four samples was observed by immunohistochemical examination for COX-2 expression and MVD. The results then were analyzed using Spearman correlation test. Result: Positive COX-2 expression was found in 17 (70.83%) subjects and negative in 7 (29,17%) subjects. High MVD was found in 17 (70.83%) subjects and low MVD was found in 7 (29.17%) subjects. There was moderate positive correlation between COX-2 expression and MVD (r=0,559; p=0,005). Conclusion: COX-2 is moderate positively correlated with MVD in nasopharyngeal carcinoma.Keywords :Nasopharyngeal carcinoma, Microvessel density, Cyclooxygenase-2.
Karakteristik penderita benda asing di esofagus di Rumah Sakit Umum Pusat H. Adam Malik Medan Januari 2006-Desember 2011 Suri Anita; Abdul Rachman Saragih; Linda Irwani Adenin; Ashri Yudhistira
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 2 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (165.326 KB)

Abstract

Introduction : Foreign body ingestion and impaction in the esophagus constitutes an important cause of morbidity and mortality at any groups of age in worldwide.Objective : To determine the characteristic of esophageal foreign bodies in H. Adam Malik General Hospital Medan from January 2006 – December 2011.Methods : A descriptive study applying medical records of patients who were hospitalized for foreign body ingestion from January 2006 – December 2011.Result : One hundred and thirteen medical records was collected (71 males and 42 females) aged of 4 month – 75 years old, with mean 16.8 years old, were admitted with the diagnosis of esophageal foreign body. The most clinical symptoms was dysphagia 43.3% and odynophagia 28.2% from total symptoms. Anorganic was the most common foreign bodies 92% and organic 8%. The most common site of impaction were upper third 92.9%. The duration of impaction 44.2% was 6-24 hours. 92.9% with >24 hours length of time from diagnosed to the esophagoscopy procedure. Complication were noted in 5.4%. There was significant relation between age and type of foreign body and between age and location of impaction (P <0.05). Conclusion : The characteristic of esophageal foreign body were collected and found that there was significant relation between type of foreign body and age, site of impaction also.Keywords: foreign bodies; esophagus; esophagoscopy; characteristic
Co-Authors Abdul Rachman Saragih Farhat Farhat Haryuna, Tengku Siti Hajar Linda Irwani Adenin Nova Rahma Hasibuan Rambe, Andrina Y.M Suri Anita Ulya, Ulfatul Yetty Machrina