Article Per Year (5 Year)
p-Index From 2019 - 2024
0.444
P-Index
This Author published in this journals
All Journal Acta Interna : The Journal of Internal Medicine Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Nina Mulyani
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Comparison of Prognostic Scores in Chronic Myeloid Leukemia (Cml) Patients with Bcr-Abl Mutation Types B3a2 and B2a2 in Dr. Sardjito General Hospital Nina Mulyani; Johan Kurnianda; Mardiah Suci Hardianti
Acta Interna The Journal of Internal Medicine Vol 10, No 1 (2020): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.61296

Abstract

Background. Chronic Myeloid Leukemia (CML) is a myeloproliperative malignancy that is caused byreciprocal translocation between chromosomes 9 and 22 which form the BCR-ABL fusion gene. Most CML patients have a major type of BCR-ABL mutation. There are b3a2 and b2a2 types, which produce different oncoproteins in 25 amino acid elements. The expression of different proteins is thought to cause differences in clinical manifestations, laboratory, and prognosis. In CML, there are several prognostic scoring systems, including Sokal, Hasford, andEUTOS scores which combine clinical and laboratory parameters. The effect of this genomic breakpoint location on clinical and biological characteristics is still controversial.Aims. The aim of this study was to determine the comparison of prognostic scores between CML patients with b3a2 and b2a2 BCR-ABL mutation types in Dr. Sardjito General Hospital.Methods. This study was a cross sectional retrospective study used secondary data from medical records of Dr. Sardjito General Hospital, from March 2014 to April 2016. The prognostic score of Sokal, Hasford, and EUTOS was calculated in the BCR-ABL mutation type groups b3a2 and b2a2. Data were analyzed by Chi Square test.Results. A total of 113 CML patients were analyzed with 74 (65.5%) b3a2 mutation type groups and 39 (34.5%) b2a2 mutation type groups. Hemoglobin levels, leukocytes, platelets, basophils, and eosinophils did not differ significantly between the two groups of mutation types. Meanwhile, the statistical test for the phase of disease when the patient was first diagnosed in both types of mutations showed a significant difference (p = 0.005). More patients with types of b2a2 mutations came in the acceleration and blast crisis phases than b3a2 types. However, Sokal, Hasford, and EUTOS prognostic scores in the b3a2 mutation type group were not significantly different from the b2a2 group (p> 0.05).Conclusions. There was no significant difference in prognostic scores of CML patients with the b3a2 BCRABL mutation type compared with the b2a2 mutation type in Dr. Sardjito General Hospital Yogyakarta.
GAMBARAN KEPATUHAN HAND HYGIENE PADA PESERTA PROGRAM STUDI PROFESI DOKTER DI RSUD ULIN BANJARMASIN Tashya Mutiara Annisa Putri; Rahmiati Rahmiati; Nina Mulyani; Agung Ary Wibowo; Noor Muthmainah
Homeostasis Vol 6, No 1 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i1.8808

Abstract

Pelaksanaan hand hygiene dapat mengurangi peningkatan kejadian Hospital Associated Infections (HAIs). Peserta program studi profesi dokter merupakan salah satu perantara patogen kepada pasien untuk mengurangi kejadian HAIs diperlukan kepatuhan terhadap hand hygiene. Hand hygiene adalah suatu tindakan untuk mengurangi peningkatan angka kejadian. Tujuan dari penelitian ini adalah untuk melihat gambaran kepatuhan hand hygiene pada peserta program studi profesi dokter di RSUD Ulin Banjarmasin berdasarkan jenis kelamin, lama pendidikan, protokol five moments dan cuci tangan 6 langkah. Penelitian ini menggunakan metode observasional deskriptif dengan pengamatan langsung dengan populasi peserta program studi profesi dokter. Penelitian dilakukan pada bulan November – Desember 2022 dengan pengambilan secara consecutive sampling. Hasil penelitian ini menunjukkan angka kepatuhan hand hygiene 33,33% dan melakukan sesuai prosedur 25%. Kepatuhan hand hygiene pada perempuan 35,48% dan laki – laki 31,03%; pada angkatan 31 sebanyak 42,86% dan angkatan 32 sebanyak 25%. Kepatuhan pada tiap momen seelum menyentuh pasien 22,73%, sebelum tindakan aseptis 25%, setelah terpapar cairan tubuh 50%, setelah menyentuh pasien 45,45%, setelah menyentuh lingkungan sekitar pasien 25%. Hasil penelitian kepatuhan hand hygiene ini didapatkan jenis kelamin perempuan dan angkatan 31 lebih patuh. Kepatuhan momen tertinggi saat setelah terpapar cairan tubuh pasien. Subjek penelitian diharapkan dapat meningkatkan kepatuhan hand hygiene.
Co-Authors Agung Ary Wibowo Johan Kurnianda Mardiah Suci Hardianti Noor Muthmainah Rahmiati Rahmiati Tashya Mutiara Annisa Putri