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All Journal Indian Journal of Forensic Medicine & Toxicology Surabaya Biomedical Journal
Indri Ngesti Rahayu
Physiology Department FK UHT
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Environmental Conditions and Sincerity affects Cortisol and ?-Endorphins Plasma Levels in Young Healthy Subjects Undergoing Dawood’s Fast Indri Ngesti Rahayu; Bambang Purwanto; Moh. Ali Azis; M. Yogiarto; Aryati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14761

Abstract

Background: Prevention of Coronary Heart Disease by identifying risk factors facilitates the planning ofprevention interventions. The prevalence of non-communicable disease (NCD) increases with one of therisk factors for NCD being an unbalanced diet. Dawood’s fasting is one of the sunnah fastings that can bedone at any time except at times that are forbidden to fast. This fast is a combination model of TRF and ADF(modified ADF = MADF).Objective: To prove that MADF for six consecutive weeks can increase levels of the hormone ?-endorphinsand reduce levels of the hormone cortisol in peripheral blood circulation.Materials and Methods: Quasi-experimental research with a comparative design of a non-equivalentcontrol group with a population of PP students. Hidayatullah Surabaya with the purposive sampling methoduntil the number of samples required was met as many as 34 people and divided into two groups, namelycontrol and MADF treatment for six consecutive weeks. Sampling was carried out at the pre-test, at the endof the third week for the middle and at the post-test. All subjects in both groups received the same nutritiontwice a day for 42 days. The subject gets spiritual motivation from competent resource persons to givespiritual spark twice.Result: Dawood’s fasting (MADF) for six consecutive weeks did not cause significant differences comparedto control on cortisol and ?-endorphins (p> 0.05). However, Dawood’s fasting (MADF) for six consecutiveweeks decreased the mean values of cortisol levels due to the effect of fasting, although there was also asignificant difference in the control group. Meanwhile the ?-endorphins mean values was increased at themiddle of study, and then decreased at the end of the study, with a significant difference in the both groupbefore and after treatment.Conclusion: There was no difference in cortisol and ?-endorphins levels in healthy young adult subjectsundergoing Dawood’s fast due to the influence of the same environmental conditions and a change in thesincerity of the subjects.
PENURUNAN KADAR MDA TIKUS PUTIH JANTAN DENGAN PEMBERIAN DIET TINGGI LEMAK DAN EKSTRAK BIJI MAHONI Indri Ngesti Rahayu; Asami Rieta Kumala
Surabaya Biomedical Journal Vol 1 No 1 (2021): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v1i1.7

Abstract

Masyarakat modern saat ini mengalami perubahan gaya hidup yang mengakibatkan perubahan pada pola konsumsi makanan menjadi pola makanan yang tinggi lemak jenuh, tinggi gula dan rendah serat. Hal tersebut sering berakibat tingginya asupan makanan yang berkolesterol tunggi kemudian ditambah dengan seringnya frekuensi makan serta konsumsi sayur dan buah yang rendah, akan berpotensi menyebabkan kegemukan. stroke, aterosklerosis dan penyakit jantung koroner (PJK) memiliki faktor risiko paling besar menjadi penyakit serius di masyarakat yaitu hiperlipidemia sehingga diduga menjadi penyebab kesakitan dan kematian di negara adidaya dan berkembang. Membuktikan pengaruh ekstrak biji mahoni terhadap kadar MDA plasma tikus putih jantan galur wistar yang diberikan diet tinggi lemak. 32 ekor tikus dikelompokkan dalam kelompok kontrol negatif yang diberikan diet standart, kontrol positif yang diberikan diet tinggi lemak dan perlakuan yang mendapatkan diet tinggi lemak bersama ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB. Diet tinggi lemak dikonsumsi tikus selama 14 hari dan pada hari ke 15 pada kelompok perlakuan ditambahkan ekstrak biji mahoni dengan dosis 100 mg/ kgBB dan 200 mg/kgBB Derajat stres oksidatif diukur dengan menggunakan indikator malondialdehyde (MDA). Kelompok kontrol negatif menunjukkan kadar MDA 78,5±16,92 µg/ml. Kelompok kontrol positif menunjukkan kadar MDA 97,17±26,559 µg/ml. Kelompok perlakuan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dengan dosis 100 mg/kgBB, kadar MDAnya 65,25±24,126 µg/ml dan yang mendapatkan diet tinggi lemak dan ekstrak biji mahoni dosis 200 mg/kgBB 82±22,836 µg/ml. Uji ANOVA tidak mendapatkan hasil dengan perbedaan yang bermakna (p=0,151).
PENGARUH PUASA INTERMITEN MENGGUNAKAN METODE PUASA DAUD TERHADAP KADAR SGOT TIKUS PUTIH (Rattus norvegicus) ALIRAN WISTAR YANG DIINDUKSI PARACETAMOL Eric Mayo Dagradi; Judya Sukmana; Indri Ngesti Rahayu
Surabaya Biomedical Journal Vol 2 No 1 (2022): September
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v2i1.43

Abstract

Background: Intermittent fasting is done with one day of fasting and one day of eating as usual so that it can reduce oxidative stress, inhibit apoptosis and tissue damage which will reduce degenerative diseases. Fasting can activate SIRT1 and SIRT3 to prevent apoptosis by decreasing reactive oxygen species and inhibiting the mitochondrial permeability transition pore component. The accumulation of free radicals is one of the mechanisms that play a role in liver damage so that the SGOT enzyme present in the liver cells will leave and enter the blood circulation, so that the number of these enzymes in the blood increases. Objective : To prove that there was a decrease in the levels of SGOT (Serum Glutamic Oxaloacetic Transaminase) in male white rats (Ratus norvegicus) of the wistar strain which were fasted intermittently by the Daud fasting method after being induced by Paracetamol. Method : The research design used is a laboratory experimental research type where the method used is randomized the post only control group design. The experimental animals used were white rats (Rattus norvegicus) wistar strain 2-3 months old with an initial body weight of 150-200gr as many as 32 tails. During the fasting treatment, the research subjects were not given diet and drinking, while the non-fasting subjects were given a standard diet and drank regularly were divided into four groups, namely negative control with a water probe that was filtered for 10 days and 1ml of 1% CMC-Na, positive control with a probe. filtered water for 10 days and induction of paracetamol 400mg/kgBW, treatment 1 with standard diet and induction of paracetamol and treatment 2 with intermittent fasting and induction of paracetamol. Results: The results of this study indicate that One-Way ANOVA test obtained p value = 0.384. (p > 0.05) then H0 was accepted, there was no significant difference between the SGOT levels of the experimental animal group that was given a standard diet, the experimental animal group that was given intermittent fasting, the experimental animal group that was given a standard diet and paracetamol and the experimental animal group that was given intermittent fasting and paracetamol treatment. Conclusion: There is no effect of intermittent fasting with the Dawood fasting method on decreasing SGOT levels in male white rats (Rattus norvegicus) Wistar strain induced by paracetamol. Keywords: intermittent fasting, SGOT, paracetamol
Co-Authors Aryati Asami Rieta Kumala Bambang Purwanto Eric Mayo Dagradi Judya Sukmana M. Yogiarto Moh. Ali Azis