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All Journal IJOEP : International Journal of Ecophysiology Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Ririe Fachrina Malisie
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Agriculture, Biological Sciences & Forestry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : IJOEP : International Journal of Ecophysiology

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Plasma Sirt-1 Level in Various Frailty Degree in Elderly Outpatients at Prof. Chairudin P. Lubis Hospital, Medan Fadhilah Hayati; Dedi Ardinata; Nuraiza Meutia; Ririe Fachrina Malisie; Muhammad Ichwan
International Journal of Ecophysiology Vol. 5 No. 2 (2023): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v5i2.13681

Abstract

Frailty is a physical aging syndrome characterized by health vulnerability. Diagnosis is established incorrectly based on three or more of the five criteria: weakness, decreased walking speed, fatigue, decreased physical activity, and weight loss. Sirtuin 1 plays a role in weakness, particularly in the elderly, acting as a protective factor during weakness, and its activation could provide a novel therapeutic approach. However, research in this area is still very limited. A cross-sectional method with observation or measurement of study subjects was employed in this research, involving a total of 118 elderly subjects selected through non-probability sampling. Pearson correlation test indicates a relationship between the polymorphism genotype (rs2273773) in the SIRT1 gene and the frailty scale (p-value < 0.05), while no relationship was found between plasma SIRT1 levels and the frailty scale (p-value > 0.05). Furthermore, the F-test reveals a significant simultaneous relationship between the polymorphism genotype (rs2273773) and plasma SIRT1 levels with frailty (p-value < 0.05).
Co-Authors Ahmad Yapiz Hasby Chairiza Muttaqien Dea Ayunda Dedi Ardinata Dina Keumala Sari Fadhilah Hayati Hemma Yulfi M. Ichwan Muhammad Ichwan Nuraiza Meutia Putri Chairani Eyanoer, Putri Chairani Yulia Putri Yunita Sari Pane