Putri Chairani Eyanoer, Putri Chairani
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Korelasi ekspresi Cyclooxygenase-2 (COX-2) dan TNF-α sebagai mediator cancer-related inflammation pada karsinoma nasofaring Nurdiansah, Firman; Pardede, Sujahn Anto; Farhat, Farhat; Munir, Delfitri; Asnir, Rizalina Arwinati; Hasibuan, Mangain; Eyanoer, Putri Chairani
Oto Rhino Laryngologica Indonesiana Vol 43, No 2 (2013): Volume 43, No. 2 July - December 2013
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.692 KB) | DOI: 10.32637/orli.v43i2.66

Abstract

Latar belakang: Karsinoma nasofaring (KNF) adalah suatu karsinoma sel skuamosa yang berasal dari sel epitel nasofaring. Cyclooxygenase (COX) merupakan enzim pada jalur biosintetik dari prostaglandin, tromboksan dan prostasiklin dari asam arakhidonat. Ekspresi seluler COX-2 meningkat di atas normal pada stadium awal karsinogenesis dan selama perkembangan serta pertumbuhan invasif tumor. TNF-α diperlukan untuk proliferasi dan fungsi yang normal dari NK cells, sel T, sel B, makrofag dan sel dendrit. Akan tetapi bukti yang terbarumenunjukkan bahwa TNF-α merupakan suatu mediator utama pada cancer-related inflammation dan juga berperan sebagai tumour-promoting factor.Tujuan: Untuk mengetahui ekspresi COX-2 dan TNF-α sebagai mediator cancer-related inflammation pada KNF. Metode: Penelitian ini bersifat deskriptif secara cross sectional design dengan 30 sampel dilakukan di RSUP. H. Adam Malik Medan. Ekspresi COX-2 dan TNF-α pada KNF diperiksa dengan immunohistokimia. Hasil: Dengan menggunakan Fisher’s exact test tidak ditemukan hubungan yang signifikan antara ukuran tumor primer, ukuran kelenjar getah bening serta stadium klinis dengan ekspresi COX-2 (p > 0,05). Ditemukan hubungan yang signifikan antara ukuran tumor primer dan ekspresi TNF-α (p < 0,05). Tidak ditemukan adanya hubungan antara ukuran kelenjar getah bening dan stadium klinis dengan ekspresi TNF-α (p >0,05). Dengan uji Spearman’s rho didapatkan bahwa COX-2 berkorelasi signifikan dengan TNF-α pada KNF (p <0,05). Kesimpulan: Terdapat korelasi signifikan ekspresi COX-2 dan TNF-α pada KNF.Kata kunci: Karsinoma nasofaring, cyclooxygenase-2, TNF-α.
Hubungan rinitis alergi dan disfungsi tuba Eustachius dengan menggunakan timpanometri Rambe, Andrina Yunita Murni; -, Fadhlia; Munir, Delfitri; Haryuna, Tengku Siti Hajar; Eyanoer, Putri Chairani
Oto Rhino Laryngologica Indonesiana Vol 43, No 1 (2013): Volume 43, No. 1 January - June 2013
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (213.294 KB) | DOI: 10.32637/orli.v43i1.20

Abstract

Latar belakang: Rinitis alergi merupakan masalah kesehatan global dengan prevalensi yang terusmeningkat serta dapat berdampak pada penurunan kualitas hidup penderitanya. Ko-morbiditas rinitis alergi salahsatunya adalah otitis media yang sangat erat hubungannya dengan gangguan fungsi tuba Eustachius yangberkaitan dengan tekanan telinga tengah. Tujuan: Mengetahui hubungan rinitis alergi dengan disfungsi tubaEustachius dengan menggunakan timpanometri. Metode: Satu studi kasus-kontrol. Disfungsi tuba ditentukandengan pemeriksaan timpanometri (MEP negatif/<-25 daPa) dan hasil tes fungsi tuba (ETF) yang tidak baik.Analisis hasil dengan uji Chi-square dan regresi logistik. Hasil: Penelitian ini melibatkan 60 sampel. Tipetimpanogram terbanyak pada kedua kelompok yaitu tipe A, dimana kelompok RA tipe A sebesar 73,3% (rerataMEP -40,8 daPa), tipe As 10%, tipe Ad dan tipe B masing-masing 3,3%, tipe C 10%. Kelompok kontrol tipe Asejumlah 93,3% dan tipe As 6,7%. Pada kelompok kasus 83,3% hasil tes fungsi tuba abnormal dan 16,7%normal, sedangkan kelompok kontrol yaitu 93,3% normal dan 6,7% abnormal. Uji chi-square menunjukkanperbedaan yang signifikan antara klasifikasi RA dan disfungsi tuba Eustachius (p=0,006) dan perbedaan yangsignifikan antara jenis alergen dan disfungsi tuba Eustachius (p=0,041). Hasil uji multivariat terdapat bahwa tiperinitis alergi berpengaruh tiga kali lebih besar terhadap disfungsi tuba Eustachius (OR 2,9; 95% IK: 1,52-241,90dan nilai p=0,022) sedangkan jenis alergen dua kali lebih berpengaruh terhadap disfungsi tuba dengan OR 2,2;95% IK: 0,01-7,31 dan nilai p=0,295. Kesimpulan: Rinitis alergi memiliki kemungkinan 3 kali lebih seringmengalami disfungsi tuba Eustachius dari pada kelompok kontrol OR:2,5 (95% CI 2,36-2,99) P=0,000.Kata kunci: rinitis alergi, disfungsi tuba Eustachius, rerata tekanan telinga.ABSTRACTBackground: Allergic rhinitis is a global health problem with increasing prevalence and can have impacton the quality of life of sufferers. One of co-morbidity of allergic rhinitis is otitis media which is closely relatedto Eustachian tube dysfunction, associated with middle ear pressure. Purpose: To determine the relationshipbetween allergic rhinitis and Eustachian tube dysfunction, using tympanometry. Methods: A case-control study.Tubal dysfunction was determined with tympanometry (MEP negative / <-25 Dapa) and tubal function test resultwas not good (≤15 daPa). Chi-square test and logistic regression analysis used for data analysis. Results: Therewere 60 samples. The most common tympanogram type in both groups were type A, which AR group was 73.3%(mean -40.8 daPa MEP), type As 10%, type ad and type B respectively 3.3%, type C 10.0% and control groupstype A 93.3%, type As 6.7%. In AR group, 83.3% showed abnormal tubal function and 16.7% was normal. As incontrol group, 93.3% was normal and 6.7% was abnormal. Chi-square test showed a significant differencebetween AR classification and Eustachian tube dysfunction (p = 0.006), and also between type of allergens andEustachian tube dysfunction (p= 0.0041). Multivariate test revealed AR classification contributed to Eustachiantube dysfunction OR:2.9 (95% CI 1.52-241.90) p=0.022, not between type of allergens and Eustachian tubedysfunction OR:2.2 (95% CI 0.01-7.31) p=0.295. Conclusion: Allergic rhinitis contributes three times higher toEustachian tube dysfunction than the control group. OR: 2.5 (95% CI 2.36-2.99) p= 0.000.Keywords: allergic rhinitis, Eustachian tube dysfunction, Mean Ear Pressure.
Relationship between Body Mass Index, Age, and Muscular Endurance among Soccer Players in Medan, North Sumatra Sarah, Dewi Maya; Siregar, Yahwardiah; Eyanoer, Putri Chairani
Indonesian Journal of Medicine Vol 4, No 1 (2019)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.874 KB)

Abstract

Background: Maintaining body mass index is one of the social problems, especially for young athletes. This study aimed to determine the relationship of body mass index (BMI) and age to muscular endurance in soccer athletes in Medan.Subjects and Method: This was a cross-sectional study soccer clubs in Medan, North Sumatera, Indonesia, in April 2018. A sample of 96 soccer players was selected for this study. The dependent variable was muscular endurance. The independent variables were BMI and age. Body weight was measured by weight scale. Body height was measured by microtoise. The other data were collected by questionnaire. Muscle endurance was assessed by 1 minute push up test. The data were analyzed by Person product moment.Results: BMI was positively correlated with muscle endurance but it was not statistically significant (r = 0.09; p = 0.390). Age was positively correlated with muscle endurance and it was statistically significant (r= 0.62; p= 0.001).Conclusion: BMI and age are positively correlated with muscle endurance among soccer players.Keywords: BMI, muscle endurance, soccer athleteCorrespondence: Dewi Maya Sarah. Masters Program in Biomedics, Faculty of Medicine, Universitas Sumatera Utara. Jl. Dokter Mansur, Medan, Sumatera Utara, Indonesia. Email: dewidewi­maya­sarah­@ymail.com. Mobile: 081295583909.Indonesian Journal of Medicine, (2019), 4(1): 21-27https://doi.org/10.26911/theijmed.2019.04.01.04
Correlation between Hemoglobin Levels and Muscular Endurance in Soccer Athletes Octavia, Nur Afni Heryanti; Ichwan, Muhammad; Eyanoer, Putri Chairani
Indonesian Journal of Medicine Vol 3, No 3 (2018)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Muscular endurance is one of the important components of physical fitness in the sport of soccer player. Soccer athletes are required to contracting the muscle explosively as maximum as possible and must have high aerobic capability. This study aimed to determine the correlation between hemoglobin levels with muscular endurance in soccer athletes.Subjects and Method: This was an analytic observational study with a cross-sectional design. The population was soccer player athlete who was incorporated in soccer clubs and soccer schools at Medan, North Sumatera, Indonesia. A sample of 96 soccer athletes was selected for this study. The dependent variable was muscular endurance. The independent variables were hemoglobin levels. Hemoglobin level was measured by the cyanmethemoglobin method, and muscular endurance was measured by the push-up test. The data was analyzed using a Spearman test.Results: Hemoglobin levels were positively correlated with muscular endurance levels and it was statistically significant (r = 0.226; p<0.05).Conclusion: This study showed hemoglobin levels correlates with muscular endurance.Keywords: hemoglobin, muscular endurance, soccer  athletesCorrespondence: Nur Afni Heryanti Octavia. Masters Program in Biomedics, Faculty of Medicine, Universitas  Sumatera Utara. Email: nurafniheryantioctavia@gmail.com.Indonesian Journal of Medicine (2018), 3(3): 168-172https://doi.org/10.26911/theijmed.2018.03.03.07
Diagnostic Accuracy of Gene X-pert MTB/RIF for Tuberculous Pleural Effusion Compared to Adenosine Deaminase (ADA) at Haji Adam Malik General Hospital Medan Muhammad Zainul A; Fajrinur Syahrani; Siagian, Parluhutan; Eyanoer, Putri Chairani
Sumatera Medical Journal Vol. 2 No. 2 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (309.146 KB) | DOI: 10.32734/sumej.v2i2.1067

Abstract

Indonesia is one of the few countries in the world with very high burden of tuberculosis (TB). Tubercular pleural effusion (Pleural TB) is the most common form of extra-pulmonary TB, however the remains a common clinical challenge. This research from May 2017 through September 2017 a total of 42 patients with exudative lymphocytic pleural effusions suspected to pleural tuberculosis were enrolled in this study. Adenosine deaminase (ADA) and Gene X-pert were examined from pleural fluid. Diagnosis was made clinically or based from sputum/pleural fluid culture. The result of this research showed out of all participants, 64,3% (27/42) had ADA in positive level (>40 IU/L) and 31% (13/24) had Gene X-pert positive Mycobacterium Tb. The Gene X-pert sensitivity was 40.7% with specificity 86.6%, PPV and NPV were 44.8% and 57.1% respectively. Kappa Compatibility study show that Gene X-pert point was 0.227 (p 0.066). The usefulness of Gene X-pert to diagnose pleural TB is limited by its poor sensitivity. Gene X-pert cannot be used as single diagnostic tool for tuberculous pleural effusion
Factors Related to Depression Level among Malaysian Students Batch 2015-2018 in Universitas Sumatera Utara Amaiappan, Jesvinder; Eyanoer, Putri Chairani
Journal of Epidemiology and Public Health Vol 5, No 2 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Depression is the most common psychological disorder encountered and is a disorder that is mainly characterized by sad and depressed emotional conditions and is associa­ted with cognitive, physical, and interpersonal symptoms. Depression has several things such as loss of energy, changes in appetite, lack of sleep, restlessness, decreased concentration, doubt, anxiety, feelings of worthlessness, guilt or despair, and thoughts of self-harm or sui­cidal ideation. This study aimed to investigate the factors related to depression in Malaysian students in Universitas Sumatera Utara.Subjects and Method: This was a cross-sectional study conducted at the Universitas Sumatera Utara, Indonesia, from September to October 2019. A total of 100 2nd and 3rd semes­ter Malaysian students from Faculty of Medi­cine, Faculty of Dentistry, and Faculty of Phar­macy, in Universitas Sumatera Utara, who live in Medan were selected by consecutive sam­pling. The dependent variable was depres­sion. The independent variables were social adap­ta­tion, academic achievement, loneliness/ home­sickness, culture shock, and study pres­sure. Depression level was measured by the Korean version of the Center for Epidemiologic Studies Depression Scale (CES-D) question­naire that was validated using the Mini Inter­national Neuropsychiatric Interview (MINI).Results: From 100 students, the average age of 22 years (Mean= 22; SD= 1.58). Social adaptation, academic achievement, loneliness, culture shock, and study pressure were posi­tively associated with depression in Malaysian students batch 2015-2018, Universitas Suma­tera Utara.Conclusion: Social adaptation, academic achievement, loneliness, culture shock, and study pressure are posi­tively associated with depression in Malaysian students.Keywords: depression, social adaptation, culture shock, Malaysian studentsCorrespondence: Putri Chairani Eyanoer. Department of Com­munity and Preventive Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Email:putrieyanoer@usu.ac.id. Mobile: +62-813 7023-2513.Journal of Epidemiology and Public Health (2020), 05(02): 207-217https://doi.org/10.26911/jepublichealth.2020.05.02.08
Premature Rupture of Membrane Outcome Determinants in Reproductive Age Women Zakirah, Sarah Chairani; Eyanoer, Putri Chairani; Azali, Chairul Nurdin; Wiweko, Budi
Journal of Maternal and Child Health Vol 5, No 4 (2020)
Publisher : Journal of Maternal and Child Health

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Abstract

Background:  Premature Rupture of Membrane (PROM) may cause maternal and neonatal mor­bi­dity and mortality. This study aimed to in­ves­ti­ga­te the risk factors related to PROM in pregnant wo­men below <35 years old.Subjects and Method: This cross-sectional stu­dy was conducted in Kertha Usada General Hos­­­pital, North Bali, Indonesia. We collected 224 repoductive women using consecutive sampling. The dependent variable was premature rupture of membrane. The inde­pen­­dent variables were gra­vidity status, ges­ta­tio­nal age, body mass index (BMI), history of cae­sa­rean section, miscarriage, infection, and anemia. Data of infection was obtained from examination, such as neutro­phil, lymphocyte, platelet, neutrophil-to-lympho­cyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). We also obtained Hb, MCV, and MCH as laboratory parameter of ane­mia. The data were analyzed by a multiple logistic regress­ion.Results: Multigravida (or= 0.04; 95% CI= 0.01 to 0.27; p= 0.001) and MCH >34 pg (OR= 0.10; 95% CI= 0.01 to 0.86; p= 0.036) decreased the risk of premature of rupture membrane in women of reproductive age.Conclusion: Multigravida and MCH >34 pg decrease the risk of premature of rupture mem­brane in women of reproductive age.Keywords: premature rupture membraneCorrespondence: Putri Chairani Eyanoer. Department Community and Preventive Medicine, Faculty of Medicine, Uni­­versitas Sumatera Utara, Medan, Indonesia. Email: putrieyanoer@usu.ac.id. Mobile: +62-813 7023-2513Journal of Maternal and Child Health (2020), 5(4): 576-586https://doi.org/10.26911/thejmch.2020.05.04.04