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All Journal Jurnal Kefarmasian AKFARINDO DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN Jurnal Stunting Pesisir dan Aplikasinya
Dali
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Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Journal : Jurnal Kefarmasian AKFARINDO

 1 
AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN JARAK MERAH (Jatropha gossypiifolia) ASAL KABUPATEN BANTAENG Wahyuddin, Nurzadrina; Ismail, Ismail; Mashar, Harlyanti Muthma'innah; Dali
Jurnal Kefarmasian Akfarindo Vol 7 No 1 (2022)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.vi0.115

Abstract

Background: In the last few decades there has been an increase in cases of chronic diseases and premature aging which are some of the key factors in influencing public health. This condition is caused by various causes, but the main factor is the number of free radicals that exceed the body's capacity to neutralize them. Antioxidants have an important role as health protective factors because they can neutralize and protect cells from the presence of free radicals. Red castor leaves have been reported to have good activity as an antioxidant. The chemical content of this plant is anthraquinone, flavonoid, saponin, tannin and terpenoid. Objective: This study aimed to evaluate the antioxidant activity of red jatropha leaf extract using the DPPH method. Methods Samples were extracted using 70% ethanol by maceration method. The antioxidant activity test was carried out using the DPPH method (1,1-diphenyl-2-picrylhydrazyl) using a comparison of Vitamin C. Each test used a variation of the concentration of the solution. For red jatropha leaf extract using concentration variations of 20, 40, 60, 80 and 100 g/ml, while for vitamin C using concentration variations of 10, 15, 20, 25, and 30 g/ml. The absorbance of each test solution was measured using a spectrophotometer at a wavelength of 515 nm. The results are reported as IC50 values. Results: The results showed that the IC50 values ​​of red jatropha leaf extract and vitamin C were 47.81 and 14.99 g/ml, respectively. This value indicates that the Chinese jatropha leaf extract has a very strong antioxidant activity (IC50 <50 g/ml). Conclusion: Red jatropha leaf extract showed very strong antioxidant activity with an IC50 value of 47.81 g/ml so it has great potential as an antioxidant that can be used for the development of traditional medicinal raw materials.
ANALISIS KADAR FLAVONOID TOTAL FRAKSI ETIL ASETAT KULIT BATANG SIRSAK (Annona muricata L.) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Mashar, Harlyanti Muthma'innah; Itma Annah; Dali; Teguh Supriyono
Jurnal Kefarmasian Akfarindo Vol 8 No 1 (2023)
Publisher : Akademi Farmasi Indonesia Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37089/jofar.v8i1.161

Abstract

Pendahuluan: Sirsak merupakan tanaman yang memiliki buah dengan kandungan nutrisi dan senyawa kimia yang telah banyak digunakan untuk pengobatan tradisional, dan kaya akan senyawa antioksidan. Aktivitas antioksidan ini dapat menghambat stres oksidatif. Aktivitas antioksidan tersebut terkait dengan kandungan senyawa kimia yang tinggi pada berbagai bagian tubuh tumbuhan ini. Klika sirsak mengandung berbagai senyawa, salah satunya adalah flavonoid. Flavonoid memiliki efek biokimia dan antioksidan yang banyak dimanfaatkan untuk meningkatkan kesehatan. Berbagai penelitian melaporkan bahwa flavonoid memiliki potensi sebagai anti inflamasi, anti alergi, antivirus, antikarsinogenik, serta terapeutik dan sitotoksik. Tujuan: Penelitian ini bertujuan untuk menganalisis kadar flavonoid total ekstrak etil asetat klika sirsak dengan metode spektrofotometri UV-VIS. Metode: Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol, dan dilanjutkan dengan proses partisi dengan pelarut etil asetat sehingga diperoleh ekstrak etil asetat. Analisis kadar flavonoid total dilakukan dengan metode spektrofotometri UV-Vis menggunakan larutan baku rutin pada konsentrasi 10, 20, 30, dan 40 ppm. Absorbansi larutan baku rutin dan ekstrak diukur pada Panjang gelombang 415 nm. Hasil: Hasil ekstraksi dengan pelarut etanol dan dilanjutkan dengan proses partisi dengan pelarut etil asetat diperoleh ekstrak etil asetat sebanyak 1,6 g dan nilai rendemen sebesar 10,67%. Hasil analisis kadar flavonoid total sampel dan didapatkan hasil yaitu kadar flavonoid total dari ekstrak etil asetat klika sirsak adalah 118,266 mg ER/g dengan persentase 11,8266 %. Kesimpulan: Ekstrak etil asetat klika sirsak positif mengandung flavonoid dan sebanyak 1 mg/mL sampel mengandung flavonoid total sebesar 118,266 mg ER/g dengan persentase 11,8266 %.
Co-Authors Annah, Itma Harlyanti Muthma'innah Mashar Ismail Ismail La Banudi Rofiqoh Rosnah, Rosnah Samsuddin Sarita, Sultina Sulupadang, Prishilla Teguh Supriyono Toruntju, Sultan Akbar Wahyuddin, Nurzadrina