Article Per Year (5 Year)
p-Index From 2019 - 2024
1.259
P-Index
This Author published in this journals
All Journal Nusantara of Research : Jurnal Hasil-hasil penelitian Universitas Nusantara PGRI Kediri (e-journal) Jurnal Ketahanan Nasional Jurnal Ilmu Kesehatan JURNAL EDUCATION AND DEVELOPMENT JURNAL ILKES (Jurnal Ilmu Kesehatan) Adi Husada Nursing Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal Tarombo Usadha
Puguh Santoso
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 9 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Usadha

 1 
Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K: Studi Bioinformatika Kandungan Curzerene Pada Daun Dewandaru (Eugenia uniflora Linn.) Sebagai Antikanker Prostate Melalui Pensinyalan PI3K Ni Putu Sri Ayu Sevilla Andriese Andriese; Puguh Santoso; Agung Ari Candra; I Wayan Surya Rahadi
Usadha Vol 2 No 2 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i2.6733

Abstract

One of the original Indonesian plants that has medicinal properties is Dewandaru (Eugenia uniflora Linn.). Dewandaru shows cytotoxic activity against cancer cells so it has the potential to be used as a drug preparation. The potential compound from the leaves of Dewandaru is Curzerene. This research was conducted to identify the interaction between the compounds of dewadaru leaves and PI3K receptors in prostate cancer. This study uses a computational method known as molecular docking. Bond energies, visualization of bonds, and types of bonds between compounds and receptors were observed. The PI3K receptor has fulfilled the method validation test requirements. The results showed that compounds from the dewadaru plant could inhibit one target protein from prostate cancer which was expressed with the lowest ∆Gbinding value, namely Curzerene compound (-7.65 kcal/mol) in PI3K protein. The interaction between Curzerene compounds has a lower binding energy value when compared to the original ligands at the PI3K receptor. Thus, it can be concluded that the Curzerene compound in the dewadaru plant used in the study has a good interaction with the PI3K receptor in prostate cancer. This compound has the potential to be developed as an anticancer drug. It is necessary to carry out in vivo testing and modification of the structure of the compound so that it can be used as an effective anticancer therapy in prostate cancer. Keywords: Prostate cancer, Curzerene, Dewandaru leaves, In silico
Co-Authors Agung Ari Candra Anang Puji Utama Andi Muhammad Arief Malleleang Dwi rahayu Erna Susilowati Fauziyah Aulia Rishanti Hengky Irawan Herlina Juni Risma Saragih I Gede Sumertha KY I Wayan Surya Rahadi Moch. Yuwono Ni Nyoman Wahyu Udayani Ni Putu Sri Ayu Sevilla Andriese Andriese Putra, I Made Agus Sunadi