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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Dentika Dental Journal Medical Journal of Indonesia Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Indonesian Dental Association Majalah Anestesia dan Critical Care
Elza Ibrahim Auerkari
Faculty Of Dentistry, University Of Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Journal : Journal of Indonesian Dental Association

 1 
Human Beta-defensin-1 and Periodontal Disease: The Past, Present, and Future Benso Sulijaya; Sri Lelyati C Masulili; Elza Ibrahim Auerkari
Journal of Indonesian Dental Association Vol 4 No 1 (2021): April
Publisher : Indonesian Dental Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32793/jida.v4i1.624

Abstract

Human beta-defensin-1 (HBD-1), a peptide released by the immune system, has been investigated for its association with periodontal disease. Several studies have found positive findings of its expression related to disease progression, whereas others have reported some tendencies. This review highlights studies associated with HBD-1 and periodontal disease in both primary and clinical investigations, as well as the underlying mechanism and discusses further research possibilities for HBD-1. HBD-1 acts as an innate immune apparatus and mediating the adaptive immune system; therefore, its role in the pathogenesis of a periodontal disease is indisputable. HBD-1 is mainly expressed in the oral stratified epithelium and sulcular epithelium, where the barrier junction properties (e.g., E-cadherin and β-catenin in the adherent junction) of the gingival epithelial cells serve as the first line of defense against periodontal infection. The HBD-1-reinforced epithelium therefore provides both a mechanical and a chemical barrier action. Critical issues that arise in the gingival epithelium can therefore be alleviated by modulation of HBD-1 production to enhance its protective function. The antimicrobial, anti-inflammatory, and wound healing properties of HBD-1 support its use as a promising clinical treatment strategy.
Co-Authors Andi Izham Antonius Winoto Suhartono Astrid Dinda Hutabarat Benny M. Soegiharto Benny Sjariefsjah Latief Benso Sulijaya Christopher Talbot Dewi Nurul Mustaqimah Dewi Nurul Mustaqimah Fadli Jazaldi Firdaus, Riyadh Januarrifianto, Desy Ken Sekar Langit Lies Zubardiah Lies Zubardiah Lilies Dwi Sulistyani Mustaqimah Dewi Nurul Mustaqimah Dewi Nurul Niniarty Zeiroeddin Djamal Noertami Soedarsono Rarasih Kiranahayu Sri Lelyati C Masulili Tienneke Riana Septiwidyati