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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas (JFSK) JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Cendekia Journal of Pharmacy MEDICINUS
Dewi Setyaningsih
Fakultas Farmasi, Universitas Sanata Dharma
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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Journal : Jurnal Farmasi Sains dan Komunitas (JFSK)

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THE EFFECTIVENESS OF CLOPIDOGREL AS AN ANTITHROMBOTIC COMPARED TO TICLOPIDINE AND ASPIRIN (META-ANALYSIS) Titien Siwi Hartayu; Dewi Setyaningsih
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 14, No 1 (2017)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (422.247 KB) | DOI: 10.24071/jpsc.00565

Abstract

Clopidogrel, an antithrombotic drug, has been proven by FDA as Plavix was initially used for the prevention of vascular occlusive that cause of myocardial infarction, stroke, and vascular death in patients with atherosclerosis and then it is used to treat Acute Coronary Syndrome (ACS). Aim of the study is to compare the effectiveness of Clopidogrel to aspirin and ticlopidine by meta-analysis of CLASSICS (The Clopidogrel Aspirin Stent International Cooperative Study), MATCH trial dan CAPRIE trial. Results of the study show that the effectiveness of Clopidogrel is significantly higher, however the risk of ischemic and bleeding is lower than aspirin and ticlopidine. Cost-effectiveness of Clopidogrel in avoiding secondary stroke in one episode is approximately US $ 33,000, and aspirin is only US $ 1400. In Indonesia the price of Clopidogrel is ranged from US $1.5 to US $3 each tablet, while the price of aspirin ranged from US $ 0.35 to US $ 0.72. However, in Indonesia Clopidogrel is now in the list of National Formulary, this fact might have contributed to the increasing use of Clopidogrel, which has reached around 1000 tablets per day in each hospital while aspirin has reached almost 1500 tablets per day.
Co-Authors ACHMAD FUDHOLI Adelsiana Leda Adithya Guntur Agatha Budi Susiana Lestari Agatha Kania Ugahari Dyatmika Anastasia Bella Anastasia Melin Fitria Wulandari Angelina Kinsha Pandhita Arya Pratama Nugraha Pede Benedictus Wisnu Putra Jati Bianca Levie Tania Corina Febrianti Isabel Debby Yunita Debi Kristiananda Desy Natalia Rambu Padji Mahemba Enade Perdana Istyastono Ervan Setyo Nugroho Faustina Evania Ngai Feranita Elsa Papilaya Filisia Putri Rosari Florentinus Dika Octa Riswanto Giovanny Leonarda Istyastono, Enade Perdana Jeanne Magistra Noverita Juvita Lisu Allo Kevin Cahaya Putra Lidvina Niken Yasacaxena Yasacaxena Lintang Adelya Lusiana Lusiana Maria Aurelia Afila Tutonugi Mase Mase Matea Nirmala Defi Maywan Hariono Melania Oktafera Monica Selena Muhammad Radifar Ni Gusti Ayu Diantari Paulina Nadya Feranti Pebby Lorenza Pisga Chrisita Dewi Putri Teresa Rery Weru Radhita Tyastu Puteri Winengku Reynaldo Tiara Rini Dwiastuti ROCHMAT MUDJAHID Sangga Putra Dewa SUDIBYO MARTONO Teresia Kiki Oktavianti Theodora Dominika Gadi Seran Theresia Helena Tokan Titien Siwi Hartayu Triana Hertiani Veronica Arien Widyarahma Vicha Putri Kandari WOUTER L.J. HINRICHS Yohanes Krisna Wisnumurti YOSI BAYU MURTI Yosi Bayu Murti Zerlinda Clara Auw