Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

2.332

P-Index

This Author published in this journals

All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik Indonesian Journal of Chemistry Cendekia Journal of Pharmacy Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat MEDICINUS JURNAL JAMU KUSUMA Journal of Food and Pharmaceutical Sciences

Florentinus Dika Octa Riswanto

Faculty Of Pharmacy, Sanata Dharma University, Yogyakarta 55282

Author-ID : 361816

Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 23 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3

Computer-aided Design of Chalcone Derivatives as Lead Compounds Targeting Acetylcholinesterase Riswanto, Florentinus D. Octa; Hariono, Maywan; Yuliani, Sri Hartati; Istyastono, Enade Perdana
INDONESIAN JOURNAL OF PHARMACY Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

One of well-established biological activities for chalcone derivatives is as acetylcholinesterase inhibitors, which can be developed for the therapy of Alzheimerâs disease. Assisted byretrospectively validated structure-based virtual screening (SBVS) protocol to identify potent acetylcholinesterase inhibitors, 80chalcone derivatives were designed and virtually screened. The F-measure value as the parameter of the predictive ability of the SBVS protocol developed in the research presented in this article was 0.413, which was considerably better than the original SBVS protocol (F-measure = 0.226). Among the screened chalcone derivatives two were selected as potential lead compounds to designpotent inhibitors for acetylcholinesterase: 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one(3k) and 3-[4-(benzyloxy)-3-methoxyphenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one (4k).

Analytical method validation and determination of dexamethasone in divided powder using reverse phase HPLC Riswanto, Florentinus Dika Octa; Virginia, Dita Maria; Putri, Dina Christin Ayuning; Yuliani, Sri Hartati
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dexamethasone as glucocorticoids has been widely used to reduce inflammation and tissue damage in a variety of conditions. It was commonly prescribed in combination with the other compounds such as chlorpheniramine maleate for the relief of asthma. It was important to observe the quality and safety of the combination dosage form, called pulveres or puyer in order to serve the patient oriented medication. This research aimed to develop analytical method validation and determine the content uniformity of the divided powder containing dexamethasone compounded by pharmacy in Yogyakarta and hospital in Central Java, Indonesia. A validated high performance liquid chromatography (HPLC) method was chosen to determine dexamethasone in the samples. The column of ACE 5 C18 (250 x 4.6 mm) was used in this research and the methanol:water (65:35) was used as the mobile phase at the flow rate of 1 mL/min. The UV detection was performed at 239 nm. Analytical method validation was performed on the parameters of system suitability, limit of detection, limit of quantification, accuracy, precision, and linearity. The results showed that dexamethasone contains in divided powder compounded by pharmacy in Yogyakarta and hospital in Central Java were met the acceptance requirement.Â Â

EFFECTS OF PARTICLE SIZE, EXTRACTION TIME, AND SOLVENT ON DAIDZEIN YIELD EXTRACTED FROM TEMPEH Sri Hartati Yuliani; Petrus Damiani Tosan Aji; Arini Safti Sandrapitaloka; Fransiska Revana Restiana; Michael Raharja Gani; Florentinus Dika Octa Riswanto
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Daidzein, one of the isoflavone aglycones contained in tempeh, has several biological activities such as anti-inflammatory, anti-oxidant, anti-breast cancer, and suppression of expression of matrix metalloprotease-9. As a fermented product from soybeans, daidzein content in tempeh was found in higher concentration compared to the soybean raw material. It was important to optimize several factors affecting extraction process such as particle size of tempeh simplicia, extraction time, and solvent in order to develop an effective method for the daidzein isolation from the tempeh or other natural products. Evaluation of extraction factors was conducted by applying variations for each factor followed by quantitative analysis using HPLC methods. The optimization condition was performed by daidzein standard and achieved with the particle size of tempeh simplicia of 1.2 mm, extraction time of 360 minutes, and 70% ethanol was used as solvent. Furthermore, the optimized condition was applied for the daidzein isolation from tempeh, a soybean fermented product.

Kemangi (Ocimum basilicum L.): Kandungan Kimia, Teknik Ekstraksi, dan Uji Aktivitas Antibakteri Adithya Guntur; Monica Selena; Anastasia Bella; Giovanny Leonarda; Adelsiana Leda; Dewi Setyaningsih; Florentinus Dika Octa Riswanto
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.3376

Resistensi terhadap beberapa antibiotik disebabkan oleh adanya penggunaan antibiotik yang rasional masih sering diabaikan. Kemangi (Ocimum basilicum L.) merupakan salah satu tanaman yang memiliki aktivitas antibakteri. Salah satu kandungan kemangi yang diduga memiliki aktivitas antibakteri yaitu minyak atsiri. Penelitian terkait aktivitas antibakteri pada kemangi sebagian besar dilakukan dengan menggunakan sampel segar maupun simplisia dari daun kemangi yang kemudian diekstraksi, namun ada beberapa uji yang menggunakan bagian batang. Metode uji aktivitas antibakteri kemangi terhadap beberapa bakteri gram positif dan gram negatif dilakukan dengan metode difusi cakram agar, difusi cakram kertas, mikrodilusi broth, mikrodilusi dalam microtiter plates, difusi sumuran agar, dan macro-dilusi. Hasil uji aktivitas antibakteri menunjukkan bahwa kandungan minyak atsiri yang terdapat dalam kemangi memiliki aktivitas penghambat aktivitas bakteri.

Analytical method validation and determination of dexamethasone in divided powder using reverse phase HPLC Florentinus Dika Octa Riswanto; Dita Maria Virginia; Dina Christin Ayuning Putri; Sri Hartati Yuliani
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Review: Pemanfaatan Teknik Kemometrika Pengenalan Pola Pada Analisis Kuantitatif Senyawa Obat Kombinasi Tanpa Tahap Pemisahan Paulina Nadya Feranti Pebby Lorenza; Angelina Kinsha Pandhita; Desy Natalia Rambu Padji Mahemba; Arya Pratama Nugraha Pede; Theodora Dominika Gadi Seran; Dewi Setyaningsih; Florentinus Dika Octa Riswanto
MPI (Media Pharmaceutica Indonesiana) Vol. 3 No. 4 (2021): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v3i4.4719

Penjaminan mutu produk obat kombinasi salah satunya dilakukan melalui analisis kuantitatif. Teknik kemometrika menjadi salah satu alternatif pilihan pengenalan pola pada analisis kuantitatif senyawa obat kombinasi tanpa tahap pemisahan yang mudah diterapkan, sensitif, dan cukup terjangkau. Keunggulan teknik kemometrika seperti ini telah dibuktikan pada berbagai penelitian yang relevan. Tujuan artikel review ini adalah untuk mengetahui lebih lanjut pemanfaatan teknik kemometrika pengenalan pola pada analisis kuantitatif senyawa obat kombinasi tanpa tahap pemisahan. Penyusunan artikel review ini menggunakan metode penelusuran literatur ilmiah primer terbitan sepuluh tahun terakhir pada rentang 2011 hingga 2021. Hasilnya menunjukkan bahwa teknik kemometrika yang paling banyak diaplikasikan adalah PLS 78,95% dengan instrumen tanpa tahap pemisahan yang paling banyak digunakan sebagai kombinasinya adalah spektrofotometer UV-Vis 84,21%. Selain itu, campuran obat dari dua senyawa 71,05% pada berbagai golongan obat menjadi jumlah campuran yang paling banyak dianalisa dengan kombinasi teknik kemometrika dan instrumen analisis.

The employment of UV-spectroscopy combined with multivariate calibration for analysis of paracetamol, Propyphenazone and caffeine Abdul Rohman; Arief Dzulfianto; Florentinus Dika Octa Riswanto
Indonesian Journal of Pharmacy Vol 28 No 4, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The reference method for simultaneous analysis of drugs is chromatography, however, this technique is expensive, complex, and needs excessive sample preparation; therefore, some simple methods like UV spectroscopy is proposed. Assisted with multivariate calibration, it is possible to analyze drugs using UV spectroscopy without prior separation. This study is intended to use UV spectroscopy coupled with multivariate calibration of partial least square (PLS) for simultaneous analysis of paracetamol (PCT), propyphenazone (PROPI), and caffeine (CAFF) in tablet dosage form. The calibration model is prepared by developing a series 20 mixture of PCT, PROPI and CAFF with certain composition randomly and its absorbance is measured at wavelength of 220-313 nm with an interval of 3 nm. The performance of calibration model was assessed by coefficient of determination (R2), root mean square error of calibration (RMSEC) and root mean square error of cross validation (RMSECV). The R2 values for the correlation between actual values of PCT, PROPI and CAFF and predicted values using UV-spectroscopy combined with PLS are 0.9994; 0.9878; and 0.9919, respectively. The calibration errors expressed with RMSEC are 0.027%, 0.082% and 0.043% for PCT, PROPI and CAFF, respectively. While, during cross validation using “leave one out” technique, RMSECV values obtained are 0.062%, 0.095% and 0.982%, respectively for PCT, PROPI and CAFF. The level of drugs obtained are 226.76 ± 14.49 mg/tablet (equivalent to 90.70% from labeled claim) for PCT, 135.74 ± 11.23 mg/tablet (equivalent to 90.49% from labeled claim) for PROPI and 51.69 ± 2.35 mg/tablet (equivalent to 103.38% from labeled claim) for CAFF.

EDUKASI KESEHATAN ALAT REPRODUKSI MENGGUNAKAN MEDIA PAKEM BRAILLE DI MTS YAKETUNIS YOGYAKARTA Novia Indah Permatasari Putri Mahenu; Birgita Elsia Setiarini; Familia Putri Wulandari; Fransisca Wahyu Indriastuti Indriastuti; Klemen Wahyu Kurniadi; Florentinus Dika Octa Riswanto
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 1, No 2 (2018): Oktober 2018
Publisher : Universitas Sanata Dharma

The limitations of science and students' awareness of reproductive health causes such students susceptible to various diseases caused by viruses, fungi, or bacteria. This program aims to provide education about "Reproductive Health for Students in Yaketunis Yogyakarta through the media “Pakem Braille", and examples of diseases that can be caused due to lack of maintaining health and hygiene of reproductive organs. The program is expected to increase interest in learning, especially science and awareness of students of MTs Yaketunis in maintaining reproductive health, producing the media "Pakem Braille" and learning modules, and also an article publication. The method used in educational activities consisted of a lecture with and without the media "Pakem Braille", where the media will be used as props in the educational process. Overall the students' understanding regarding the material of reproductive health in humans increased by 77.78%. Students’ interest also increased, it is seen from the increase in the number of questions asked by students amounted to 61.11%. Knowledge and awareness of reproductive health-related students increased to 73% and the result obtained was 55.6% of students categorized as having sufficient awareness and 38.9% of students considered to have good awareness of the importance of maintaining reproductive health.

Computer-Aided Drug Repurposing: A Cyclooxygenase-2 Inhibitor Celecoxib as a Ligand for Estrogen Receptor Alpha Enade Perdana Istyastono; Florentinus Dika Octa Riswanto; Sri Hartati Yuliani
Indonesian Journal of Chemistry Vol 15, No 3 (2015)
Publisher : Universitas Gadjah Mada

A cyclooxygenase-2 (COX-2) inhibitor celecoxib has been previously reported to have cytotoxic activities towards gastric, prostate, ovarian, colon and breast cancer cell lines. This article reports that the cytotoxic activities of celecoxib could be resulted from its activity as a potent ligand for estrogen receptor alpha (ERα). Aided by molecular docking simulations, an in silico test to examine whether celecoxib is a ligand for estrogen receptor alpha (ERα) was performed followed by in vitro test employing cytotoxic assay using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method. The compound was extracted from Celebrex®. Measured by using UV spectrophotometric method at 255.5 nm, it was identified that the content of celecoxib was 102.15 mg/271.48 mg capsule content. The in silico test indicated that celecoxib is a potent ligand for ERα. This finding was confirmed experimentally by an in vitro test that celecoxib has a comparable activity as an ERα ligand to tamoxifen, a drug of choice for breast cancer treatment.

Analytical Method Validation and Determination of Pyridoxine, Nicotinamide, and Caffeine in Energy Drinks Using Thin Layer Chromatography-Densitometry Florentinus Dika Octa Riswanto; RR. Endang Lukitaningsih; Sudibyo Martono
Indonesian Journal of Chemistry Vol 15, No 1 (2015)
Publisher : Universitas Gadjah Mada

Food supplement which contains vitamins and stimulants such as caffeine were classified as energy drink. TLC-densitometry method was chosen to determine the pyridoxine, nicotinamide, and caffeine in the energy drink sample. TLC plates of silica gel 60 F254 was used as the stationary phase and methanol : ethyl acetate : ammonia 25% (134:77:10) was used as the mobile phase. The correlation coefficient for each pyridoxine, nicotinamide, and caffeine were 0.9982, 0.9997, and 0.9966, respectively. Detection and quantitation limits of from the three analytes were 4.05 and 13.51 µg/mL; 13.15 and 43.83 µg/mL; 5.43 and 18.11 µg/mL, respectively. The recovery of pyridoxine, nicotinamide, and caffeine were within the required limit range of 95-105%. The percent of RSD were below the limit value of 5.7% for caffeine and nicotinamide and 8% for pyridoxine. The content amount of pyridoxine in the sample 1 and 2 were 33.59 ± 0.981 and 30.29 ± 2.061 µg/mL, respectively. The content amount of nicotinamide in the sample 1 and 2 were 106.53 ± 3.521 and 98.20 ± 3.648 µg/mL, respectively. The content amount of caffeine in the sample 1 and 2 were 249.50 ± 5.080 and 252.80 ± 2.640 µg/mL, respectively. Robustness test results showed that the most optimal method conditions should be applied for the analysis.

Co-Authors Abdul Rohman Abdul Rohman Adelsiana Leda Adithya Guntur Agatha Kania Ugahari Dyatmika Agnes Margaretta Sihombing Agustina Setiawati Alni Desra Anandha Nabila Prjanaparamita Anastasia Bella Anastasia Melin Fitria Wulandari Angelina Kinsha Pandhita Arief Dzulfianto Arini Safti Sandrapitaloka Arya Pratama Nugraha Pede Birgita Elsia Setiarini Christofori Maria Ratna Rini Nastiti Corina Febrianti Isabel Debby Yunita Debi Kristiananda Debi Kristiananda Desy Natalia Rambu Padji Mahemba Dewi Setyaningsih DEWI SETYANINGSIH Dina Christin Ayuning Putri Dita Maria Virginia Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Familia Putri Wulandari Faustina Evania Ngai Febrina Dameria Marbun Filisia Putri Rosari Florentina Yohana Ngelu Fransisca Wahyu Indriastuti Indriastuti Fransiska Revana Restiana Giovanny Leonarda Indriastuti, Fransisca Wahyu Indriastuti Indriastuti, Fransisca Wahyu Indriastuti Jeanne Magistra Noverita Jeanne Magistra Noverita Jullius Ivan Mahadhika Juvita Lisu Allo Juvita Lisu Allo Katharina Floransia Walburga Resmianto Katrina Imaculata Tema Pedha Klemen Wahyu Kurniadi Kurniadi, Klemen Wahyu Kurniadi, Klemen Wahyu Lintang Adelya Lusiana Lusiana Lusiana Lusiana Mahenu, Novia Indah Permatasari Putri Mahenu, Novia Indah Permatasari Putri Marchaban Marchaban Maria Aurelia Afila Tutonugi Maria Theresia Mawarni Mase Mase Maywan Hariono Michael Raharja Gani Monica Selena Ni Gusti Ayu Diantari Novia Indah Permatasari Putri Mahenu Noviayanti Chandra Paulina Nadya Feranti Pebby Lorenza Petrus Damiani Tosan Aji Pisga Chrisita Dewi Putri Natasya Br Siregar Radhita Tyastu Puteri Winengku Rini Dwiastuti Rinjani Mustika Sari RR. Endang Lukitaningsih Setiarini, Birgita Elsia Setiarini, Birgita Elsia Sri Hartati Yuliani Sudibyo Martono Sudibyo Martono Suwidjiyo Pramono Teresia Kiki Oktavianti Theodora Dominika Gadi Seran Theresia Helena Tokan Valentino Thomas Vania Rambu Kaha Milla Ate Veronica Arien Widyarahma Veronica Arien Widyarahma Vinsensia Nalita Maharani Wulandari, Familia Putri Wulandari, Familia Putri Yoanes Fransiskus Regis Widyo Utomo Yohana Manalu Yohana Maria Bina Zerlinda Clara Auw

Title

Found 23 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 23 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 23 Documents
Search