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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas (JFSK) JURNAL ILMU KEFARMASIAN INDONESIA Jurnal Jamu Indonesia Cendekia Journal of Pharmacy MEDICINUS
Dewi Setyaningsih
Fakultas Farmasi, Universitas Sanata Dharma
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

 1 
Validasi Metode Kromatografi Lapis Tipis untuk Penentuan Konsentrasi Kurkumin dalam Sampel Disolusi yang Mengandung Ektrak Curcuma longa DEWI SETYANINGSIH; YOSI BAYU MURTI; ACHMAD FUDHOLI; WOUTER L.J. HINRICHS; ROCHMAT MUDJAHID; SUDIBYO MARTONO; TRIANA HERTIANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Curcumin is a lipophilic compound which suffers from the poor bioavailability after oral administration. Increasing its dissolution rate can be a successful strategy to improve the bioavailability. Along with the formulation developments, a rapid and simple analytical method to determine curcumin concentrations in the dissolution medium is required. The aim of this study was to develop and to validate an analytical method based on thin layer chromatography (TLC) to determine curcumin concentrations in a dissolution medium containing 0.5% w/v sodium lauryl sulfate (SLS) and 20 mM sodium phosphate buffer. A polyvinylpyrrolidone K30 based solid dispersion of Curcuma longa extract and its corresponding physical mixture were dissolved in a medium containing 0.5% w/v SLS and 20 mM sodium phosphate buffer (pH 6.0). Dissolution samples were spotted on a normal TLC plate and eluents of various compositions were evaluated. The retardation factor (Rf), resolution (Rs), and asymmetry factor (As0.05) of the optimized method were determined. Using the optimized eluent, proper separation of curcumin peak was achieved with an Rf of 0.50, Rs of 2.62 and As 0.05of 0.87. Linearity (5-30 μg/mL) was demonstrated by r value of 0.9965. The TLC method provided precision with RSD ≤3.50 and accuracy with recovery value of 94-105%.
Co-Authors ACHMAD FUDHOLI Adelsiana Leda Adithya Guntur Agatha Budi Susiana Lestari Agatha Kania Ugahari Dyatmika Anastasia Bella Anastasia Melin Fitria Wulandari Angelina Kinsha Pandhita Arya Pratama Nugraha Pede Benedictus Wisnu Putra Jati Bianca Levie Tania Corina Febrianti Isabel Debby Yunita Debi Kristiananda Desy Natalia Rambu Padji Mahemba Enade Perdana Istyastono Ervan Setyo Nugroho Faustina Evania Ngai Feranita Elsa Papilaya Filisia Putri Rosari Florentinus Dika Octa Riswanto Giovanny Leonarda Istyastono, Enade Perdana Jeanne Magistra Noverita Juvita Lisu Allo Kevin Cahaya Putra Lidvina Niken Yasacaxena Yasacaxena Lintang Adelya Lusiana Lusiana Maria Aurelia Afila Tutonugi Mase Mase Matea Nirmala Defi Maywan Hariono Melania Oktafera Monica Selena Muhammad Radifar Ni Gusti Ayu Diantari Paulina Nadya Feranti Pebby Lorenza Pisga Chrisita Dewi Putri Teresa Rery Weru Radhita Tyastu Puteri Winengku Reynaldo Tiara Rini Dwiastuti ROCHMAT MUDJAHID Sangga Putra Dewa SUDIBYO MARTONO Teresia Kiki Oktavianti Theodora Dominika Gadi Seran Theresia Helena Tokan Titien Siwi Hartayu Triana Hertiani Veronica Arien Widyarahma Vicha Putri Kandari WOUTER L.J. HINRICHS Yohanes Krisna Wisnumurti YOSI BAYU MURTI Yosi Bayu Murti Zerlinda Clara Auw