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All Journal JURNAL WIDYA MEDIKA Folia Medica Indonesiana Journal Of Widya Medika Junior
Silvia Sutandhio
Departemen Mikrobiologi Dan Parasitologi, Fakultas Kedokteran, Universitas Katolik Widya Mandala Surabaya
Medicine & Pharmacology Public Health Other

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Journal : Journal Of Widya Medika Junior

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Antibacterial Effect Of Curcuma Domestica Ethanolic Extract On Group A Streptococcus Î’ Hemoyticus Halim, Stefan W; Wihanto, Laura; Sutandhio, Silvia
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 1, No 3 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.081 KB) | DOI: 10.33508/jwmj.v1i3.2098

Abstract

Introduction : Pharyngitis is one of the most common infection that general practitioners handled. It is estimated in one year there are 15 million people with pharyngitis will come to the doctor. American Society of Microbiology said that 94,3 % from 402 patient who were suspected pharyngitis received antibiotic therapy even without indication of antibiotic therapy. Antibiotic resistance is becoming a great threat for the world today. World Health Organization state that one of the plan to fight antibiotic resistance is to research and develop new drugs. Curcuma domestica is a plant that is widely used in Indonesia and some research said that it has anti-inflammatory, antioxidant, and antimicrobial effect. Aim: The aim of this study is to find the antibacterial effect of Curcuma domestica ethanolic extract on Group A Streptococcus ? hemolyticus and find the Minimum Bactericidal Concentration (MBC) value. Methods : This was in vitro experimental study with broth microdilution method and inoculation on agar blood media to find the MBC. Treatment group consisting of, media (Mueller Hinton Blood Broth), Group A Streptococcus ? hemolyticus bacteria, and 5 concentrations (312.5 ?g/ml, 625 ?g/ml, 1250 ?g/ml, 2500 ?g/ml, 5000 ?g/ml) of Curcuma domestica extract. Result : There is no bacterial growth at 5000 ?g/ml concentration on solid media, but there are less bacterial growth at 2500 ?g/ml than at concentration 312.5 ?g/ml, 625 ?g/ml, 1250 ?g/ml. Conclusion: There is an antibacterial effect of Curcuma domestica ethanolic extract on Group A Streptococcus ? hemolyticus with MBC value in range 2500 ? 5000 ?g/ml.
The Comparison Of Antibacterial Effects On Cinnamomum Burmannii Water Extract With Penicillin Against Staphylococcus Aureus In Vitro Halim, Felicia; Dewi, Bernadette Dian Novita; Sutandhio, Silvia
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 1 (2020): January
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1112.866 KB) | DOI: 10.33508/jwmj.v2i1.2335

Abstract

Introduction: Along with the development of science, many varieties of microorganisms are resistant to antibiotics. To avoid cases of resistance grew severe, researchers developed alternative medicines as a substitute for antibiotics. One of the ingredients of herbs researched that has antibacterial activity is Cinnamon (Cinnamomum burmannii). Aim: This study aimed to compare antibacterial effects water extract of Cinnamomum burmannii with penicillin against Staphylococcus aureus Methods: This an experimental studies witd non-equivalent control group design. Research using the bacteria S. aureus are divided into two groups, the control group and experimental group. The concentration of Cinnamomum burmannii and penicillin are used that is 80- 150mg/L. Antibacterial test used dilution method and a microplate reader for reading absorbance. This research conducted in the laboratory of Microbiology, Faculty of Pharmacy Widya Mandala Catholic University Surabaya for 2 weeks. Result: Based on visual observations, Cinnamomum burmannii’s MIC is located at concentration 320- 600 mg/L while penicillin’s MIC is located at concentration 160- 300 mg/L. Based on the results of microdilution test, Cinnamomum burmannii’s MIC is located at concentration 160- 300 mg/L while penicillin’s MIC is located at concentration 640- 1200 mg/L. Conclusion: The conclusion of this research is giving Cinnamomum burmannii water extract in Staphylococcus aureus has efficacy or inhibitory that is not significantly different with penicillin.
Co-Authors Agung Dwi Wahyu Widodo Alimsardjono, Lindawati Bernadette Dian Novita Budiono Budiono Deby Kusumaningrum Dewi, Bernadette Dian Novita Eddy Bagus Wasito Eko Budi Koendhori, Eko Budi Halim, Felicia Halim, Stefan W Hardiono Hardiono Kuntaman Kuntaman Laura Wihanto Lindawati Alimsardjono ManikRetno Wahyunitisari Maria Inge Lusida Maria Inge Lusida Ni Made Mertaniasih Pepy Dwi Endraswari, Pepy Dwi Rebekah Setiabudi, Rebekah Titiek Sulistyowati