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All Journal Majalah Obat Tradisional Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) CERATA Jurnal Ilmu Farmasi HERBAPHARMA : Journal of Herb Farmacological Medical Sains : Jurnal Ilmiah Kefarmasian JURNAL BESEMAH CERATA
Marini Marini
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Journal : Majalah Obat Tradisional

 1 
Comparative Effects of Yellow Root (Arcangelisia flava (L.) Merr.) Decoctions with Water and Brackish Water on Kidneys and Uterus in Wistar Rats Suwijiyo Pramono; Risqika Y.T. Paramidhita; Marini Marini; Moch. Saiful Bachri
Majalah Obat Tradisional Vol 25, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.55178

Abstract

Yellow root (Arcangelisia flava (L.) Merr.) is a medicinal plant used traditionally in Borneo, Indonesia, for several diseases. Nevertheless, it contains berberine alkaloids that are considered harmful. Empirically, based on local wisdom people do not boil yellow roots with water but with brackish water. This study aimed to determine the effects of yellow root decoctions made using water and brackish water on blood biochemical and histopathological profile of kidneys and uterus in Wistar rats after subchronic treatment. Overall, 70 Wistar female rats were divided into seven groups of which three groups were given yellow root water decoctions and three groups were given yellow root brackish water decoctions with doses equivalent to 1.25 g/kg BW, 2.5 g/kg BW and 5 g/kg BW of dried yellow root, whereas the control group was only given Aquadest. After 28 days of treatments, blood samples were obtained for biochemical examination followed by a surgical examination to observe the histological features of the organs. The results revealed significant differences in the blood urea nitrogen (BUN) levels between group that was given water decoction of the yellow root and the control group. On the other hand, the groups that were given brackish water decoction revealed no significant changes, except at  the highest dose. Furthermore, histopathological features of rats treated using all doses of the yellow root water decoctions revealed organ damage compared with the normal group, manifested as hemorrhage, degeneration, and necrosis of the kidneys, as well as epithelial damage and inflammatory infiltration of the uterus.
Co-Authors Aas Mugi Lestari Ai A’yunin Syam Amalia Sumiar Astri Pratiwi Azis Sugarna Azmi Darotulmutmainnah Cici Sri Nurjanah Daniar Pratiwi Dea Safitri Diana Fitri Dama Yanti Egy Nurnabhilah Ersih - Saphira Fany Lesmana Haty Latifah Priatni Ii Carsita Maesaroh, Imas Mirna Mirna Moch. Saiful Bachri Nova Oktavia Nufa Abriana Rina Nurhayatina Risqika Y.T. Paramidhita Rosyida, Anis Ryan Farhan Pebrian Sinta Partiwi Suwijiyo Pramono wilda yuniar