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Potensi Antibakteri Ekstrak Etanol dan Etil Asetat Daun Benalu Dendrophtoe pentandra terhadap Klebsiella pneumoniae Penghasil ESBL Ardy Prian Nirwana; Indah Tri Susilowati
Biomedika Vol 10 No 1 (2017): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Antibiotik yang diberikan berlebihan, tidak adekuat dan monoton, dapat mengurangi efektifitas antibiotik, sehingga menimbulkan resistensi terutama pada bakteri. Resitensi Klebsiela sp terhadap antibiotik disebabkan salah satunya karena mampu menghasilkan enzim extended spectrum β-lactamase (ESBL). ESBL merupakan enzim yang dapat menghidrolisis penicillin, cephalosporin generasi I, II, III dan aztreonam. Dendropthoe pentandra mengandung senyawa metabolit sekunder yang bersifat bakterisida. Penelitian ini bertujuan mengetahui potensi antibakteri ekstrak etanol dan etil asetat daun D.pentandra terhadap K.pneumoniae penghasil ESBL. Daun D. pentandra diekstraksi menggunakan metode maserasi dengan pelarut etanol 96% dan etil asetat. Kandungan antibakteri diidentifikasi secara kualitatif dengan uji skrining fitokimia. Desain penelitian adalah deskriptif eksperimental dengan mengukur zona hambat radikal. Uji pendahuluan dan daya hambat bakteri dilakukan dengan metode difusi cakram dikomparasikan dengan kontrol antibiotik cefotaxim, ceftazidim, ceftriaxone dan ciprofloxacin. Hasil skrining fitokimia menunjukkan bahwa ekstrak etanol dan etil asetat D.pentandra, keduanya mengandung senyawa antibakteri seperti flavonoid, alkaloid, terpenoid, tanin, dan saponin. Konsentrasi hambat tumbuh minimum untuk ekstrak etanol dan etil asetat adalah 50% dengan rata-rata diameter zona hambat radikal secara berturut-turut adalah 7,25 mm dan 7,38 mm. Uji sensibilitas menunjukkan bahwa bakteri resisten terhadap antibiotik cefotaxim, ceftazidim, dan ceftriaxone tetapi sensitif terhadap ciprofloxacin. Ekstrak etanol dan etil asetat D.pentandra pada konsentrasi 100% memiliki potensi antibakteri terhadap K.pneumonia lebih baik dibanding kontrol antibiotik beta-laktam dengan zona penghambatan radikal secara berturut-turut adalah 13,55 mm dan 15,38 mm.

The Measurement of Antioxidant Activity of Velvet Beans (Mucuna pruriens) and Velvet Beans (Mucuna pruriens) in Coffee Preparations Indah Tri Susilowati; Purwati Purwati
Biomedika Vol 13 No 2 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i2.900

Antioxidant activity tests of methanol extracts of velvet beans (Mucuna pruriens) and velvet beans (Mucuna pruriens) in coffee preparations have been previously carried out by several researchers. This present study aims to examine the phytochemical and antioxidant activities of methanol extracts of Mucuna pruriens and Mucuna pruriens in coffee preparations. The methanol extract was tested for the phytochemical and antioxidant activities by applying DPPH (1,1-Dhiphenyl-2-picrylhydrazil) method. The results of the phytochemical test showed that the methanol extracts of the Mucuna pruriens and Mucuna pruriens in coffee preparations contained secondary metabolites of flavonoids, alkaloids, saponins, terpenoids, and tannins. The outcomes of the antioxidant activity test revealed that the methanol extracts of the Mucuna pruriens and Mucuna pruriens in coffee preparations had antioxidant activities, as indicated by the IC50 values of 42.09 ppm and 37.23 ppm. It was also revealed that the antioxidant content of Mucuna pruriens in coffee preparations was stronger than the content in the velvet beans alone.

METODE REDUKSI TAHU BERFORMALIN MENGGUNAKAN VARIASI KONSENTRASI AIR GARAM YANG DITAMBAHKAN DENGAN EKSTRAK BAWANG PUTIH (ALLIUM SATIVUM L.) Tri Harningsih; Indah Tri Susilowati
Jurnal Kesehatan Kusuma Husada Vol. 6 No. 2, Juli 2015
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.412 KB)

ABSTRAKTahu merupakan makanan dengan kadar air mencapai 85% sehingga tahu tidak dapat bertahan lama.Beberapa produsen tahu diketahui menggunakan formalin sebagai bahan pengawet tahu. Salah satu carauntuk menurunkan kadar formalin adalah menggunakan air garam dan ekstrak bawang putih (Alliumsativum L.). Tujuan penelitian untuk mengetahui pengaruh variasi konsentrasi air garam terhadap aktivitasekstrak bawang putih (Allium sativum L.) sebagai pereduksi tahu berformalin. Metode penelitian adalahmetode eksperimental dengan pendekatan pre post test without control. Pemeriksaan kadar formalinmenggunakan metode spektrofotometri UV-Vis (Spectronic 200). Uji hipotesis menggunakan uji regresilinier sederhana. Penelitian menggunakan enam sampel tahu berformalin dengan penambahan ekstrakbawang putih (Allium sativum L.) 20% dan air garam dalam berbagai variasi konsentrasi yaitu 0%,2%, 4%, 6%, 8% dan 10%. Penurunan kadar formalin tertinggi diperoleh pada konsentrasi 10% yaitu405,0441 ppm dan penurunan kadar formalin terendah diperoleh pada konsentrasi 0% yaitu 312,2371ppm. Kesimpulan terdapat hubungan yang sangat signifi kan (r = 0,997, sig= 0,000) antara variasikonsentrasi air garam terhadap aktivitas ekstrak bawang putih (Allium sativum L.) sebagai pereduksitahu berformalin.Kata kunci : tahu, formalin, ekstrak bawang putih, air garam ABSTRACTTofu is a food with a moisture content reaches 85% so that it tofu as perishable food. Some manufacturerstofu to be using formaldehyde as a preservative. One way to reduce levels of formaldehyde is to use saltwater and extract of garlic (Allium sativum L.). The aim of research to determine the effect of variationsin the concentration of salt water on the activity of the extract of garlic (Allium sativum L.) as a reducingformalin of tofu. The research method is experimental method with pre post test approach withoutcontrol. The level of formaldehyde using UV-Vis spectrophotometry (Spectronic 200). The hypothesistesting using simple linear regression test. The study used six samples tofu of formalin with addition ofgarlic extract (Allium sativum L.) 20% and salt water in various concentrations as 0%, 2%, 4%, 6%,8% and 10%. 10% The salt concentration 10% decreased the highest levels of formaldehyde is 405.0441ppm whereas the control without the addition of salt decreased the lowest levels of formaldehyde is is312.2371 ppm. There is a very signifi cant correlation (r = 0.997, sig = 0.000) between the variation ofthe concentration of salt water on the activity of the extract of garlic (Allium sativum L.) as a reducingformalin of tofu.Keywords: tofu, formalin, extracts of garlic, salt water

PENAMBAHAN BAWANG PUTIH (ALLIUM SATIVUM) TERHADAP KUALITAS VIRGIN COCONUT OIL (VCO) SEBAGAI MINYAK GORENG Indah Tri Susilowati; Tri Harningsih
Jurnal Kesehatan Kusuma Husada Vol. 6 No. 2, Juli 2015
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.61 KB)

ABSTRAKProses ketengikan yang mengakibatkan merosotnya kualitas minyak goreng kelapa terjadi pada minyakselama penyimpanan dan pemanasan. Proses yang merugikan ini dapat dihambat dengan penambahanantioksidan. Dalam penelitian ini digunakan antioksidan bawang putih (Allium sativum) yangmengandung fl avonoid untuk mencegah proses ketengikan pada VCO yang diolah dengan metodepemanasan. Tujuan penelitian untuk mengetahui penambahan bawang putih(Allium sativum) akanmeningkatkan kualitas Virgin Coconut Oil (VCO) yang dibuat pada metode pemanasan bertahap sebagaiminyak goring serta perbandingan kualitasnnya dengan VCO tanpa penambahan bawang putih (Alliumsativum). Parameter kualitas yang diuji meliputi kadar air; bobot jenis VCO sebelum penyimpanan danpemanasan; kadar asam lemak bebas, dan bilangan peroksida setelah pemanasan 160oC selama 10 menitpada hari ke 0, 5, dan 10. Hasil penelitian menunjukkan VCO dengan penambahan bawang putih 10%memiliki kualitas yang lebih baik dibandingkan dengan VCO tanpa penambahan bawang putih, danmemenuhi standar APCC (Asian and Pacifi c Coconut Community).Kata kunci : bawang putih, kualitas, VCO, minyak goreng ABSTRACTRancidity process which resulted in the decline of the quality of cooking oil in the oil palm occurs duringstorage and heating. This harmful process can be inhibited by the addition of antioxidants. This studyused an antioxidant garlic (Allium sativum) which contains fl avonoids to prevent rancidity process onVCO is processed by the method of heating. The aim of research to determine the addition of garlic(Allium sativum) will increase the quality of Virgin Coconut Oil (VCO) which is made on the method ofgradual warming as cooking oil as well as comparison quality of VCO without the addition of garlic(Allium sativum). Quality parameters tested include water content; VCO specifi c gravity before storageand heating; levels of free fatty acids and peroxide value after heating 160oC for 10 minutes on days 0,5, and 10. The results showed VCO with the addition of garlic 10% have a better quality than the VCOwithout the addition of garlic and according to the standards of APCC (Asian and Pacifi c CoconutCommunity).Keywords: garlic, quality, VCO, cooking oil

Edukasi Bahaya Timbal pada Sekolah Rentan Polusi terhadap Prestasi Akademik dan Kesehatan Siswa Indah Tri Susilowati; Noviana Dewi; Endang Widhiyastuti
Jurnal Surya Masyarakat Vol 5, No 2 (2023): Mei 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.5.2.2023.201-207

This community service project is a promotive and preventive activity that aims to educate students about the danger of lead exposure accumulation in students, delivered to teaching staff throughout Central Java. This activity was conducted as counseling using the webinar method through zoom meetings. Participants were enthusiastic, as seen from the questions asked during the discussion and question-answer sessions. The ability of participants to answer pretest and posttest questions showed an increase in participants’ knowledge between before and after the counseling. The average score of the pretest was 7.00 with a standard deviation of 3.428, while the average score of the posttest was 14.06 with a standard deviation of 1.983. A paired t-test was then used to determine whether the scores from the pretest and posttest differed. Given that the p-value for the difference between the pretest and posttest scores was 0.000, it can be said that the difference is statistically significant. It can be determined that the partner satisfaction questionnaire's answers were valid because they ranged from 0.549 to 0.905 when it was previously assessed for validity using the Pearson product-moment method. The instrument passed the reliability test with a Cronbach Alpha rating of 0.925, indicating that it was trustworthy. According to the results of the partner satisfaction survey, the typical score was 4.09. Thus, it can be concluded that the activity satisfies the participants. Based on the results of data analysis, it can be said that the counseling activities can increase participants’ knowledge about the danger of lead exposure accumulation on students’ achievement.

Edukasi Bahaya Timbal pada Sekolah Rentan Polusi terhadap Prestasi Akademik dan Kesehatan Siswa Indah Tri Susilowati; Noviana Dewi; Endang Widhiyastuti
Jurnal Surya Masyarakat Vol 5, No 2 (2023): Mei 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.5.2.2023.201-207

This community service project is a promotive and preventive activity that aims to educate students about the danger of lead exposure accumulation in students, delivered to teaching staff throughout Central Java. This activity was conducted as counseling using the webinar method through zoom meetings. Participants were enthusiastic, as seen from the questions asked during the discussion and question-answer sessions. The ability of participants to answer pretest and posttest questions showed an increase in participants’ knowledge between before and after the counseling. The average score of the pretest was 7.00 with a standard deviation of 3.428, while the average score of the posttest was 14.06 with a standard deviation of 1.983. A paired t-test was then used to determine whether the scores from the pretest and posttest differed. Given that the p-value for the difference between the pretest and posttest scores was 0.000, it can be said that the difference is statistically significant. It can be determined that the partner satisfaction questionnaire's answers were valid because they ranged from 0.549 to 0.905 when it was previously assessed for validity using the Pearson product-moment method. The instrument passed the reliability test with a Cronbach Alpha rating of 0.925, indicating that it was trustworthy. According to the results of the partner satisfaction survey, the typical score was 4.09. Thus, it can be concluded that the activity satisfies the participants. Based on the results of data analysis, it can be said that the counseling activities can increase participants’ knowledge about the danger of lead exposure accumulation on students’ achievement.

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