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Mistika Zakiah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Tanjungpura
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Pemanfaatan bakteri endofit daun cengkodok (Melastoma malabathricum L.) sebagai anti Shigella flexneri Mahyarudin Mahyarudin; Anggita Serli Verdian; Mistika Zakiah
Jurnal Pendidikan Informatika dan Sains Vol 10, No 2 (2021): Jurnal Pendidikan Informatika dan Sains
Publisher : IKIP PGRI Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31571/saintek.v10i2.3380

Abstract

Shigellosis atau disentri basiler merupakan penyebab diare paling umum yang disebabkan oleh Shigella flexneri. Masyarakat suku Dayak Iban di Kabupaten Sintang, Kalimantan Barat telah memanfaatkan daun cengkodok sebagai obat diare. Penelitian terdahulu melaporkan bahwa bakteri endofit memiliki kemampan menghasilkan metabolit sekunder seperti tanaman inangnya yang berpotensi menghambat pertumbuhan bakteri patogen. Penelitian ini bertujuan untuk mendeterminasi efek antibakteri dan karakter bakteri endofit potensial dari daun cengkodok (M. malabathricum L.) terhadap S. flexneri. Penelitian ini menggunakan desain studi  eksploratif – deksriptif. Isolasi bakteri endofit dari daun cengkodok menggunakan metode tanam langsung dan purifikasi isolate bakteri endofit menggunakan metode cawan gores. Uji aktivitas bakteri endofit terhadap S. flexneri menggunakan metode difusi cakram. Identifikasi isolat potensial berdasarkan morfologi sel, morfologi koloni dan karakteristik biokimia sel. Sebanyak 14 dari 35 isolat memiliki aktivitas terhadap S. flexneri berkisar antara 2,2 - 15,2 mm. 4 isolat yang memiliki aktivitas tertinggi yaitu isolate 21, 10, 30, dan 12. Hasil identifikasi menunjukkan isolate 21, 10, dan 30 memiliki kemiripan dengan genus Acetobacter, isolate 12 memiliki kemiripan dengan genus Citrobacter. Bakteri endofit daun cengkodok memiliki aktivitas penghambatan pertumbuhan S. flexneri.
EFEK HEPATOPROTEKTOR ANDROGRAPHOLIDE TERHADAP AKTIVITAS ALANIN AMINOTRANSFERASE DALAM SERUM Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA Dewinta Putri Utami; Andriani Andriani; Mardhia Mardhia; Virhan Novianry; Mistika Zakiah
Jurnal Fitofarmaka Indonesia Vol 8, No 1 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i1.582

Abstract

Background: Andrographolide is a diterpenoid bioethanol that effectively prevent liver injury by reducing liver oxidative stress response. Method :  The research was randomized experimental design with pretest-posttest design. Thirty male wistar rats was randomly divided into 6 groups, normal control, negative control (0,2 ml CCl4), and positive control (500 mg/kgBW curcumin), dose I (50 mg/kgBW), dose II (100 mg/kgBW), dose III (200 mg/kgBW) given for 8 days and induced by 0,2 ml CCl4 on the first day. Data was analyzed by One-Way Anova test, LSD  Post-Hoc test and paired T test. Results :All groups induced by CCl4 shows elevated of ALT activity. The posttest results shows significant differences of ALT activity between groups (p<0,05). Conclusion :  Andrographolide shows hepatoprotector effect by decrease the activity of ALT in male wistar rats induced by CCl4. The effective dose of andrographolide is 200 mg/kgBW.
Efektivitas ekstrak metanol akar pandan wangi (Pandanus amaryllifolius Roxb.) Sebagai antimalaria terhadap jumlah limfosit dalam darah mencit (Mus musculus) yang diinfeksi Plasmodium berghei Danang Mustofa; Muhammad Ibnu Kahtan; Diana Natalia; Mistika Zakiah; Ari Widiyantoro
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.562 KB) | DOI: 10.15562/ism.v10i2.366

Abstract

Malaria is a infectious disease cause by protozoa with genus Plasmodium that is transmitted by female Anopheles mosquito. Our immune system which is role by lymphocyte works specifically when body infected by Plasmodium. The secondary metabolites of Pandan Wangi roots (Pandanus amaryllifolius Roxb.)  possess as antimalaria. The purpose of this research to know the activity of methanol exctract from roots of Pandan Wangi (Pandanus amaryllifolius Roxb.) as antimalaria on white male mice (Mus muscullus) lymphocyte count infected by Plasmodium berghei. This is a true experimental in vivo with completely randomized design. Antimalaria effect test used methanol extract from roots of Pandan Wangi with concentration 6.5%, 13% and 26%. Positive control group was given 3.74 mg/mL DHP (Dihydroartremisinin-Piperaquin), normal control group was not given any intervention, negative control group was given aquadest. Results of this research show extract with concentration 6.5%, 13% and 26% have the antimalaria effect show by the decrease of parasitemia percentage. In addition, concentration of 26% extract can increase the number of lymphocytes significantly. Extract of Pandan Wangi Roots have antimalaria effect and can increase the number of lymphocytes with the best concentration of 26%. The decreasing number of parasitemia level is not directly related to the increasing of lymphocyte
Analisis Kandungan Metabolit Sekunder, Antioksidan dan Uji Aktivitas Antibakteri Minuman Tradisional Serbat Khas Kalimantan Barat dengan Variasi Komposisi dan Lama Perendaman Syarifah NYRS Asseggaf; Mistika Zakiah; Ridha Ulfah
Jurnal Kesehatan Andalas Vol 11, No 2 (2022): Online July 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.1925

Abstract

Serbat drink is a traditional drink typical of the Malay of West Kalimantan made from plant spices usually served in the Saprahan tradition. Serbat drinks are widely circulated among the public because, empirically, they are useful for health problems, one of which is to treat diarrhea. Objectives: To analyzed the content of secondary metabolites, antioxidant activity, and antibacterial activity of serbat drink on the growth of Escherichia coli bacteria which were known from the presence or absence and measurement of the length of the inhibition zone (the clear area around the disc) with the positive control, namely ciprofloxacin, and negative control, namely distilled water. Methods: The plant spices used in this research include cardamom, cloves, star anise, cinnamon, pandan leaves, sappan wood, anise, and ginger. Serbat drink was made in 3 variations, namely composition A, composition B, and composition C. The three composition variations were carried out for two soaking times, namely 15 minutes and 540 minutes. This study used the thin-layer chromatography (TLC) method for phytochemical screening, the DPPH (2,2-diphenyl-1-pikrilhidrazil) method for examination of antioxidant activity, and Escherichia coli bacteria cultured in 3 agar and tested using the disc diffusion method (Kirby-Bauer) to determine its antibacterial activity.  Results: The secondary metabolites contained in each serbat water sample, antioxidant activity from strongest to weakest among the serbat samples, and the absence of visible inhibition zones. Conclusion: Serbat drink does not have antibacterial activity against Escherichia coli.Keywords:  secondary metabolites, serbat drink, variations in composition, variations in the soaking time
Pengaruh Penyakit Penyerta terhadap Toksisitas Obat Metamizole Athira Syafika; Syarifah NYRS Asseggaf; Mistika Zakiah
Jurnal Pharmascience Vol 10, No 1 (2023): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13920

Abstract

Metamizole merupakan obat yang memiliki efek analgesik, antipiretik, dan spasmolitik. Metamizole diketahui memiliki toksisitas yang dipengaruhi oleh penyakit penyerta, dosis dan interaksi obat. Hal ini yang menjadi salah satu latar belakang bagi peneliti untuk membahas lebih lanjut terkait pengaruh penyakit penyerta terhadap toksisitas metamizole. Penelitian ini bertujuan untuk mengkaji pengaruh penyakit penyerta terhadap toksisitas obat metamizole. Desain penelitian yang digunakan adalah literature review dan data yang digunakan berasal dari Google Schoolar, PubMed, dan Science Direct. Hasil dari review sepuluh jurnal menunjukkan bahwa adanya pengaruh penyakit penyerta seperti kardiovaskular, autoimun, infeksi virus, acute liver injury, kanker dan asma terhadap toksisitas obat metamizole. Pengaruh ini sering kali diperberat oleh interaksi obat seperti obat aspirin, antibiotik, antikonvulsan, dan cDMARD (methotrexate). Kesimpulan review ini adalah adanya pengaruh penyakit penyerta terhadap toksisitas obat metamizole. Penyakit penyerta tersebut antara lain adalah kardiovaskular yang dapat menyebabkan MACCE (P<0,001), autoimun yang dapat meningkatkan resiko agranulositosis dengan OR 2,28 (CI 95%: 1,294,04), infeksi virus, acute liver injury, kanker dan asma. Kata Kunci: Penyakit Penyerta, Toksisitas, Metamizole, Interaksi Obat, Efek Samping Obat Metamizole is a drug that has analgesic, antipyretic, and spasmolytic effects. Metamizole is known to have a toxicity that is influenced by comorbidities, dosage, and drug interactions. This is one of the backgrounds for researchers to discuss further regarding the effect of co-morbidities on metamizole toxicity. This study aims to examine the effect of comorbidities on the toxicity of the metamizole. The research design used was a literature review and the data used came from Google Schoolar, PubMed, and Science Direct. The results of a review of ten journals showed that there was an influence of comorbidities such as cardiovascular, autoimmune, viral infections, acute liver injury, cancer, and asthma on the toxicity of the metamizole. This effect is often exacerbated by drug interactions such as aspirin, antibiotics, anticonvulsants, and cDMARD (methotrexate). The conclusion of this study is that there is an effect of comorbidities on the toxicity of the metamizole. These comorbidities include cardiovascular disease that can cause MACCE (P < 0.001), autoimmune which can increase the risk of agranulocytosis with an OR of 2.28 (95% CI: 1.29 4.04), viral infections, acute liver injury, cancer and asthma.
PENGARUH EDUKASI KESEHATAN TERHADAP PENINGKATAN PENGETAHUAN IBU DENGAN BALITA TERKAIT MP-ASI Puji Astuti; Syarifah Nurul Yanti; Mistika Zakiah; Sari Rahmayanti
Pontianak Nutrition Journal (PNJ) Vol 6, No 2 (2023): September 2023
Publisher : Poltekkes Kemenkes Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/pnj.v6i2.1243

Abstract

Stunting merupakan permasalahan gizi yang masih menjadi perhatian khusus di Indonesia. Stunting dapat memengaruhi kualitas hidup anak di masa depan. Ibu sebagai penyedia makan dalam keluarga berperan penting dalam kecukupan gizi anak. Pengetahuan ibu yang baik dapat membuat perubahan perilaku sehingga mencegah stunting pada anak. Oleh sebab itu, penelitian ini bertujuan untuk mengetahui tingkat pengetahuan tentang pencegahan stunting setelah diberikan penyuluhan. Metode penelitian ini adalah quasi eksperimen dengan teknik pengumpulan data dilakukan dengan menggunakan kuisioner yang terdiri dari pertanyaan untuk mengukur tingkat pengetahuan responden berupa pilihan ganda. Sampel berjumlah 59 responden. Mayoritas ibu berusia 17-25 tahun dengan Pendidikan SMP dan sebagai ibu rumah tangga. Tingkat pengetahuan ibu sebelum diberikan penyuluhan “baik” sebanyak 28.81%, “cukup” sebanyak 67.8%, dan “kurang” 3.39%. Sedangkan tingkat pengetahuan setelah diberikan penyuluhan meningkat menjadi 72.88% untuk “baik”, 23.73 untuk “cukup” dan 3.39% untuk kurang. Uji statistik menunjukkan perbedaan pengetahuan bermakna sebelum dan sesudah penyuluhan (p< 0.00). Kesimpulan: Penyuluhan terbukti meningkatkan pengetahuan tentang pencegahan stunting secara signifikan pada ibu dengan balita di Desa Sungai Batu Kabupaten Mempawaah, Kalimantan Barat.
POTENSI DAUN KEMUNTING (Melastoma malabathricum) SEBAGAI OBAT TRADISIONAL SUKU DAYAK DESA DALAM PENYEMBUHAN LUKA Edmond Daniel Beltsazar; Carla Jean Marshellina; Andre Safitdra; Syarifah Nurul Yanti Syahab Asseggaf; Mistika Zakiah
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 11 No. 1 (2024): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v11i1.236

Abstract

Suku Dayak Desa merupakan sub-suku dari rumpun suku Dayak Ibanik yang menempati beberapa wilayah di Kecamatan Kelam Permai Kabupaten Sintang, Kalimantan Barat. Berbagai tanaman obat dimanfaatkan oleh masyarakat suku Dayak Desa untuk pencegahan atau pengobatan penyakit. Daun kemunting menjadi salah satu obat tradisional yang digunakan oleh suku Dayak Desa dalam penyembuhan luka. Studi literatur ini bertujuan untuk menelaah potensi daun kemunting terhadap penyembuhan luka dalam konteks pengobatan tradisional suku Dayak Desa. Disimpulkan bahwa kemunting berpotensi besar dalam meredakan inflamasi, mempercepat penyembuhan luka, dan mencegah infeksi sebab memiliki sifat-sifat antiinflamasi, antioksidan, dan antimikroba. Artikel ini menggarisbawahi pentingnya eksplorasi kemunting sebagai tanaman obat tradisional suku Dayak Desa dalam penyembuhan luka sebagai dasar untuk penelitian dan pengembangan pengobatan tradisional di wilayah tersebut.
The Relationship of Characteristics of Hypertensive Patients to the Level of Adherence to Taking Hypertension Medication at the Pal Tiga Health Center, Pontianak Mistika Zakiah; Restu Saputra; Muhammad Redha; Muhammad Deni; Ansharullah Ansharullah
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1179

Abstract

Background: One of the non-communicable diseases that is a serious health problem today is hypertension. It is often referred to as the silent killer because sufferers usually do not know they have hypertension before checking their blood pressure. Objective: To determine the relationship between patient characteristics (education, level of knowledge, and BPJS safety) and the level of adherence to hypertension medication at the Pal Tiga Pontianak Health Center. Method: This research uses a cross-sectional method. The sample in this study was 89 hypertension patients at the Pal Tiga Pontianak Health Center. The research instrument used in this study was in the form of a questionnaire filled out by the respondents. The questionnaires used were the Morisky Medication Adherence Scale (MMAS-8) and the Hypertension Knowledge-Level Scale (HK-LS). The correlation test used is a Spearman test. Result: the relationship between education, knowledge level, and BPJS participation on the level of adherence to hypertension medication of respondents, respectively p-value was obtained of 0.879; 0.189; and 0.802.  Conclusion: There is no relationship between education, knowledge level, and BPJS participation in compliance with taking hypertension medication at the Pal Tiga Pontianak Health Center. this is done by interviewing patients with an MMSA compliance questionnaire abstract that does not need to be divided into.
Co-Authors Andre Safitdra Andriani Andriani Anggita Serli Verdian Ansharullah Ansharullah Ari Widiyantoro Asseggaf, Syarifah Nurul Yanti Rizki Syahab Athira Syafika Carla Jean Marshellina Danang Mustofa Dewinta Putri Utami Diana Natalia Edmond Daniel Beltsazar Mahyarudin, Mahyarudin Mardhia Mardhia Muhammad Deni Muhammad Ibnu Kahtan Muhammad Redha Puji Astuti Restu Saputra Ridha Ulfah Sari Rahmayanti Syarifah Nurul Yanti Syarifah Nurul Yanti Syahab Asseggaf Virhan Novianry